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PubMed1985

[Acquired epidermolysis bullosa (acquired dermolytic bullous dermatoses) (study of 2 patients)].

The authors studied two patients with bullous lesions with onset at adult age. There were no relatives with bullous disease. After minor traumas, mainly in hands, feet, elbows and knees, one could see the onset of the blisters, which vanished leaving atrophic scars. Nails and mucosae were involved in both patients. The female patient had cyst of milia. One of the patients had lymph node tuberculosis as associated disease. Through exhaustive clinical examination and laboratory investigation, the authors excluded other types of bullous diseases. Histopathology of the lesions, electron microscopy, direct and indirect immunofluorescence, supported the diagnosis of Acquired Dermolytic Bullous Dermatosis.

Adult↗
PubMed1986

Tuberculosis in renal failure: a high incidence in patients born in the Third World.

We report 11 cases of tuberculosis among patients with chronic renal failure being treated in our unit. All were born outside the United Kingdom, and represent 25% of the non-europid patients in the unit. This is about a seventy-fold increased incidence of tuberculosis in this group. Diagnosis is difficult and mortality high if the diagnosis is delayed. Culture of tissue biopsies is the most reliable investigation and chemotherapy should be commenced promptly or a therapeutic trial considered in doubtful cases. Chemoprophylaxis may be beneficial in patients from these ethnic groups or in any uremic patient with evidence of old tuberculosis. Three patients with advanced disease died despite antibiotic treatment, but in the remainder, triple therapy with normal doses of rifampicin, isoniazid and pyrazinamide proved safe and effective.

Adult↗