[Suprofen in oral medicine].
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The efficacy of oral fentiazac (100 mg QID) was compared with that of paracetamol (500 mg QID) in a single-blind trial in 30 patients suffering from post-endodontic periodontitis secondary to infiltrative or abscessed pulpitis. Patients were allocated at random to two treatment groups and treated for four days. Over each of the four days, patients scored the severity of spontaneous pain and induced pain. The same symptoms were assessed by the investigator at 0, 48, and 96 hours. Special attention was paid to the occurrence of adverse reactions. A statistically significant difference favoring fentiazac was seen in the patients' assessments of induced pain (while eating) but not in the investigator's assessment of induced pain (percussion). There was no significant difference in the analgesic effects of fentiazac and paracetamol with respect to spontaneous pain scored by patients or the investigator. No side effects were seen. Fentiazac was shown to be an effective analgesic for use in this painful inflammatory condition.
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Depending on the clinical setting, vital pulp therapy can be managed with an indirect or direct pulp-capping procedure. The determination of which therapy to employ is a decision that must be made by the clinician at the time of treatment. It is hoped that the preceding discussion has informed the clinician as to both the indications and contraindications for each type of treatment and the rationale for selection. Because every possible clinical situation cannot be presented, it is anticipated that by understanding the principles presented in this article, the clinician will be able to correctly identify which therapeutic modality will most benefit the patient. Table 1 is presented as a quick reference to aid in selecting appropriate candidates for pulp-capping procedures.
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We examined the relative analgesic potency of aspirin and placebo in a within-subject-repeated-measure experiment using a precision tooth pulp stimulation technique with long-term stability (r = 0.93) for more than two months between measures. The attenuation of pain perception was evaluated using a standardized magnitude estimation procedure and constructing an individual psychophysical function for each trial. The data were fit equally well by either a straight line (Y = mX + b) or a power function (Y = mXa + b). Using the line fit and distribution insensitive conservative statistical tests, the effect of each treatment was compared to baseline and the treatments were compared to each other. In randomized, double-blind trials we found reliable effects of both aspirin (p less than 0.001) and placebo (p less than 0.001) but no difference (p = 0.08) between these two treatments. However, on an individual basis, 12 of 17 subjects displayed a larger analgesic response to aspirin than to placebo (p less than 0.05).
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