[Thioctic acid in experimental liver diseases caused by selenium. Behavior of the transaminase activity and histological picture. Note II].
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We studied the pattern of selenium accumulation in Lycopersicum esculentum Mill plants in conditions of root and extra-root dressing with selenium. At the background of general trend towards predominant selenium accumulation in the fruit coat, a higher level of the microelement accumulation in the pulp was observed for selenates (Se+6) than selenites (Se+4). Application of Epin growth factor favored selenium accumulation in the plants; its concentration in the pulp was comparable to the concentration after selenate application, while the level of the microelement accumulation in the fruit coat, leaves, and roots was 2.2, 2.4, and 1.4 times lower, respectively. Combined application of Epin and sodium selenate had virtually no effect on selenium accumulation in the pulp but increased the microelement content in the fruit coat and roots. Biological significance of the observed "boundary effect" of selenium as a manifestation of plant antioxidant protection is discussed.
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The purpose of the given research work was to study the features of morphologic changes arising during the treatment of chronic hepatitis with NEOSELEN. Chronic active hepatitis was set up in laboratory rats, post-forming in chronic persisting hepatitis and its transformation in a certain part of animals into cirrhosis by administration of HELIOTRINE over the period of 40 days. Morphologically hepatic cirrhosis was small nodular. NEOSELEN was found to have a good therapeutic effect in treatment of chronic hepatitis as we have seen noticeable remittance of destructive necrotic changes in hepatic parenchymatouse elements and reduction in a volume of proliferative inflammatory infiltration along with acceleration of fibrosis process only in periportal zones of hepatic lobules. The therapeutic efficacy of NEOSELEN prevents transmission of chronic hepatitis into cirrhosis in a greater part of animals thus giving morphologic signs of importance of NEOSELEN in a restorative process of destructive and inflammatory changes in the affected liver.
We investigated the effect of selenium form and dose on the total glutathione and non-protein -SH group contents in the edible spinach (Spinacia oleracea L.) and ground tomato (Lycopersicon esculentum Mill.) plants. Our experiments were carried out in a hydroponic culture. Selenium was added to the culture medium in its selenite (Na2SeO3 x 5H2O) and selenate (Na2SeO4) forms. Regardless of the selenium form, we observed an increase in the non-protein thiol content. The non-protein -SH group content depended on the form and dose of selenium as well as on the organ and plant species. Regardless of the selenium form, a higher content of non-protein -SH groups were found in the spinach biomass than in the tomato biomass. Selenite contributed to a larger accumulation of non-protein -SH groups in the roots, whereas selenate contributed to their accumulation in the shoots
Pityriasis (tinea) versicolor, which consists of hyperpigmented and hypopigmented scaly patches, is often difficult to treat. A double-blind comparative study between once-a-day sodium sulfacetamide lotion and selenium sulfide lotion was undertaken. Both treatments were safe and efficacious. Selenium sulfide was statistically more efficacious (76.2% vs 47.8%, P=.013).
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