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[Transvesical prostatectomy for benign prostatic hyperplasia--a 364 cases analysis].

During a 16 year period from January 1972 to December 1988, transvesical prostatectomies were performed on 364 patients with benign prostatic hyperplasia in the Department of Urology, Kaohsiung Medical College Hospital. The average operational procedure time was 116.1 minutes and the average amount of tissue resected was 38.3 grams. The most common complications were wound infections (6.8%), stress incontinence (1.92%), urethral stricture (4.12%) and impotence (0.27%). In this series, epididymitis and/or orchitis was noted in 4.3% of those who underwent vasectomies and 1.8% of those who did not; thus, epididymitis cannot be prevented by a prophylactic vasectomy. There was one postoperative death (mortality rate-0.27%). The present study found that 6.86% of the transvesical prostatectomy patients will require longer hospitalization and greater amounts of antibiotics due to post-operative wound infection; therefore the use of transvesical prostatectomy will decline and only be recommended for fit patients with others genitourinary diseases such as bladder diverticulum or giant bladder calculus.

Aged↗

[Selection criteria for radical prostatectomy with reference to long-term results].

Between July 1969 and May 1991 radical prostatectomies were performed in 410 consecutive patients with prostate cancer at the Department of Urology, University of Würzburg. The calculated survival rates for these 410 patients up to 15 years after surgery are very similar to the life expectancy of the normal male age-matched population. In 127 of the 410 cases radical prostatectomy was carried out more than 10 years ago, so that the data relating to these cases have been definitely observed, not merely statistically evaluated. In order to permit a comparison of our results with those reported in the literature, the TNM classification of 1979 was utilized in this study. This means that only tumors penetrating through the capsule of the prostate were classified as stage pT3. Those tumors that are only infiltrating the apex or the prostatic capsule, are classified as stage pT2. For patients with stage pT1pN0M0 and pT2pN0M0-tumors, 10-year survival rates (90.5% and 70% respectively) were recorded which are even slightly better than those of the normal male age-matched population. For patients with tumors extending through the capsule, the 10-year survival rate was found to be 60%. Forty percent ot these patients with stage pT3pN0M0 disease are alive tumor-free after more than 10 years and can thus be regarded as cured. When lymph node metastases were present (stage pT2-3pN1-2M0), some of the patients appeared to benefit from radical prostatectomy, since 4 out of 11 patients with this stage disease survived for more than 10 years.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

[Autologous blood transfusion and hemodilution in planned large interventions exemplified by 132 radical prostatectomies].

The hospital records of 132 consecutive patients between May 1988 and August 1991 with biopsy-proven local prostate carcinoma, who were scheduled for radical prostatectomy were reviewed. Seventeen patients had positive lymph nodes at pelvic lymphadenectomy and were subsequently given hormone therapy. The mean blood loss in 115 patients undergoing pelvic lymphadenectomy and radical prostatectomy was 1379 ml. Since September 1988 we have operated a program for predeposit autologous blood donation in all patients prior to radical prostatectomy. Sixty patients were entered into this program and 59 received their autologous blood back during operation. Seventy-eight percent of our patients received only autologous blood. The basis of an efficient autologous blood donation program is a simple logistic schedule for all patients (risk and non-risk), who can choose their dates for autologous blood donation. We hope with this study to encourage other centers to introduce autologous blood donation.

Aged↗

Radical prostatectomy in locally confined prostatic carcinoma.

Because of recent advances in surgical technique with reduced morbidity and wider margins of resection, radical prostatectomy has become more widely accepted. For patients with localized prostatic cancer who have a 10-15-year projected survival, radical prostatectomy is the ideal form of therapy. In addition, in select patients with more advanced disease radical prostatectomy, while not curative, provides excellent palliation of the local lesion with minimal morbidity.

Humans↗

[Transurethral low pressure prostatectomy. Technic, blood loss and water syndrome].

The new procedure for transurethral prostatectomy (TURP with physiologic low pressure irrigation and continuous aspiration of irrigant) reduces complication and mortality in respect to surgical prostatectomy: In 2.500 TURP clinical significant pulmonary embolism was not realised, mortality was 0.3%. The average blood loss was 238 cc. by a weight of 44.8 g, blood transfusion were necessary in only 4%. Low pressure TURP can be performed in most high risk patients, this is not true for open surgical prostatectomy, which has a rate of complications up to 25%. Postoperative recovery and late results are definitely improved by low pressure TURP, teaching is facilitated.

Aged↗

[Cancer of the prostate. Clinical estimation and results of radical prostatectomy].

The authors present their experience about the accuracy of staging and the results of radical prostatectomy in prostatic cancer. From january 1978 to september 1988, 47 patients with clinically localized prostatic carcinoma underwent staging pelvic lymphadenectomy, of whom 36 had proven negative pelvic lymph nodes and 1 had only a micrometastasis in the obturatory nodes. We reviewed the surgical results and survival of these 37 patients who underwent radical prostatectomy. The postoperative complications were compared to those reported in Literature: partial incontinence occurred in 3 patients and there were no symptomatic urethral strictrues. 1 patient died in the early postoperative period by DIC. 35 patients are alive, 27 free of disease, with average follow-up of 36 months. The over-all accuracy of staging was 87%. Our experience suggests that radical prostatectomy with staging bilateral pelvic lymphadenectomy can be performed in a safe manner with minimal postoperative morbidity.

Adenocarcinoma↗

[Long-term results of radical prostatectomy].

Between 1969 and March 1988, 257 patients underwent radical prostatectomy at the Department of Urology at the University of Würzburg, Medical School. The operative mortality was 0.8%. So far, 75 patients with prostate carcinoma, stage pT1-3 pNoMo, have been followed up for more than 10 years (mean 13 years). The 10-year survival rate was 68%. This is equivalent to the expected survival rate of males of comparable age. Only 14 of the 75 patients (18.6%) died of tumor progression after radical prostatectomy. Tumor recurrence was noted in 17 of the 75 (22.6%) patients analyzed within a 10-year follow-up period. In 4 of 9 patients with periprostatic tumor infiltration (stage pT3NoMo) tumor progression occurred. These data demonstrate that radical prostatectomy offers an excellent survival rate for patients with localized prostatic cancer and that this rate is identical to the expected survival rate for males in this age group.

Adult↗

Infrabladder "cup defect" following prostatectomy: recognition on bone scintigram.

Seventeen bone scintigrams, made after prostatectomy for proven or suspected carcinoma, showed a "cup defect" below the bladder. This defect was likely related to the volume of tissue removed at the time of transurethral prostatectomy. In two cases, the defect was not present on images made before prostatectomy but was clearly seen after the operation. The time of persistence of the "cup defect" is discussed, as well as the differential diagnosis of the finding.

Bone and Bones↗

Mortality after transurethral prostatectomy.

In 68 patients aged 80 to 94 who underwent transurethral prostatectomy between 1981 and 1987, the survival rate after the procedure was higher than that of the general population of the same age distribution. In nine patients aged 62 to 92 for whom transurethral prostatectomy was indicated but not performed because of concomitant medical problems (including cardiac problems in four, advanced cancer in two, dementia in two, and pulmonary disease in one), the survival rate was much lower, seven of the nine dying within 13 months. High mortality reported in men undergoing transurethral prostatectomy may be due to concomitant medical problems rather than aftereffects of the surgery.

Actuarial Analysis↗

[The urethral canal in the prostatectomy patient. Echographic aspects].

An evaluation of the urethra has been made in patients who underwent open surgery or endoscopic resection of the prostate, by means of transrectal echography (EG). The technique used is described; studies have been performed both in basal conditions and in various functional phases, including micturation. Echographic findings are compared to those achieved with micturating cystourethrography (MCU). In case of total prostatectomy EG and MCU findings are similar, showing the surgical bladder neck and the urethral aspect even during micturation. EG shows furthermore possible liquid fluid collections. In partial prostatectomies EG and CUM findings differ, showing the first, besides the site of the surgical intervention, the possible presence of calculi, while CUM findings do not differ from those visible in total prostatectomies. Conclusions are that for the whole study of the urethra CUM is necessary, while for the study of the prostatic region EG gives more information. Therefore EG is proposed as method complementary to CUM in the evaluation of the proximal urethra.

Humans↗

Complications of radical prostatectomy and lymphadenectomy.

The technique associated with nerve-sparing radical prostatectomy has improved the likelihood of continence, especially, and certainly potency over previous techniques. With a decline in these complications, patients and physicians in increasing numbers are choosing this surgical method of elimination of the disease. Hence this review of complications of radical prostatectomy using a modified lymphadenectomy and the nerve-sparing prostatectomy (or cytoprostatectomy).

Aged↗

[Results after radical prostatectomy for prostate carcinoma].

35 of 54 patients undergoing radical prostatectomy for localized cancer were asymptomatic and the tumor had been found during a routine check-up by the family physician. In 53 of 54 patients the indication for surgery was based on a positive cytological finding in fine-needle aspiration biopsy of the suspected tumor. In all patients the carcinoma was confirmed by histological work-up of the radical prostatectomy specimen. Cytological and histological grading was identical in three quarters of all patients. However, the preoperative tumor stage (T) was confirmed histologically (pT) only in half of all the patients. The extension of the carcinoma was often underestimated at the preoperative clinical staging. After a mean observation time of close to 4 years, the survival rate in patients undergoing radical prostatectomy for localized cancer is comparable to an age and sex matched control group. Our data suggest that fine-needle aspiration biopsy of the prostate is a very reliable procedure in the diagnosis of prostatic carcinoma, provided the aspiration technique is correct and the smears are interpreted by a well-trained cytologist. Moreover, patients with localized prostate cancer seem to have an excellent chance of survival with low morbidity, provided the indication for surgery is restricted to carefully selected patients.

Aged↗

[Complications of radical prostatectomy].

Between 1969 and 1984 a radical prostatectomy was performed in 175 patients for localized carcinoma of the prostate. This corresponds to a percentage of 18,2% of 962 patients with cancer of the prostate admitted to this hospital during the same period of time. The intra- and postoperative complications following radical prostatectomy in this series of 175 patients are analyzed. In 144 patients a retropubic prostatectomy was performed, whereas in 31 patients the perineal approach was utilized. There was a mortality rate of 1.1% (2 patients). Rectal injuries in 7 patients and ureteral transsection in 2 patients accounted for intraoperative complications. In the early postoperative period non-fatal pulmonary embolism occurred in 4 and myocardial infarction in 3 patients. In 3 cases (1,7%) a transitory hemodialysis became necessary because of renal insufficiency. Lymphoceles had to be treated in 22 patients (12,6%) and hematomas in 9 patients (5,1%). Persistent total urinary incontinence was observed in 8 patients (5%) and stress incontinence of varying degree in 25% of cases. The causes of these complications are analyzed and possible ways of preventing and treating them are discussed.

Adult↗

Prostatectomy. A discourse on the indications for and the choice of operation.

This paper deals with the indications for prostatectomy; the differential diagnosis of the symptomatology of bladder neck obstruction; and the factors influencing the choice of operation. Some points in the technique of prostatectomy are mentioned. Finally, the method of prostatectomy when obstruction is complicated by stone, diverticulum, or growth is discussed.

Body Weight↗

[Antibiotic therapy after prostatectomy? (author's transl)].

This prospective study shows, that, neither an antibiotic prophylaxis of abacteriuric patients nor postoperative treatment of an asymptomatic urinary tract infection after transurethral prostatectomy have a significant influence on the clinical complications or the microbiologic results. After suprapubic prostatectomy complications in the control group were not significantly more frequent than in the group with antimicrobial prophylaxis. Patients with asymptomatic urinary tract infections before suprapubic prostatectomy had better clinical results, if they were treated with antibiotics as compared to a control group, although the difference control group was not significant. The correlation between consumption of antibiotics and development of resistant in pathogenic organisms forced us to use a more critical approach in the use of antimicrobial prophylaxis and therapy. This study shows clearly, that aseptic operations do not need an antibiotic protection and that faulty of asepsis cannot be corrected by antibiotics.

Anti-Bacterial Agents↗

[Chemotherapy after prostatectomy--effects of long term administration of Pivmecillinam (PMPC)].

The therapeutic efficacy of Pivmecillinam (PMPC) against urinary tract infections after prostatectomy was investigated. PMPC was orally administered at the dose of 300 mg/day for 2-14 weeks after initial intravenous postoperative chemotherapy with other antibiotics for 0-24 days (average 5.7 days). Thirty patients underwent retropubic prostatectomy and the other 59 patients received TUR-P. The chemotherapeutic efficacy for 19 patients who had over 10(3) CFU/ml of microorganisms was as follows: The effective rate was 48.4% after 2 weeks, 53.8% after 4 weeks, 66.7% after 5-6 weeks and 100% after 7-9 weeks. The prophylactic efficacy for 70 patients who had no or less than 10(3) CFU/ml of microorganisms was 64.3% after 2 weeks, 79.6% after 4 weeks, 86.7% after 5-6 weeks and 90.0% after 7-9 weeks. The overall clinical efficacy of PMPC for 89 patients was 60.7% after 2 weeks, 74.2% after 4 weeks, 83.3% after 5-6 weeks, 90.0% after 7-9 weeks and 100% after 10-14 weeks. No severe side effects were found in these 89 cases. In conclusion, PMPC is a useful drug for the long term treatment after prostatectomy.

Administration, Oral↗

[Surgical method of retropubic prostatectomy].

The retropubic prostatectomy is performed mostly for prostatic hypertrophy. By performing the preventive suture-ligation of the bilateral prostatic arteries which are running among the vesicoprostatic pedicle before prostatectomy, massive bleeding from bladder neck and prostatic bed can be controlled well, and ligation of bilateral spermatic cord prevents retrograde epididymitis. This surgical procedure makes retropubic prostatectomy easy.

Aged↗

VACURG studies of post-prostatectomy survival.

In the first Veteran's Administration Cooperative Urological Research Group (VACURG) study all stage I and II patients were assigned to radical prostatectomy and were randomized to either placebo or 5 mg diethylstilbestrol (DES) daily by mouth. Results indicated worse survival in those treated with DES in stage I, but there was no difference in stage II. In Study 2, stage I and II patients were randomly assigned to either placebo or placebo plus radical prostatectomy. An analysis based upon time to progression failed to show a significant advantage for radical prostatectomy. Both the size of the primary lesion at diagnosis and the histological grade of the tumor using the Gleason system were related to the probability of progression.

Evaluation Studies as Topic↗