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At least 1,567 records · Page 87Linked to original sources
PubMed1979

Studies on the hydrolysis of 1-alk-1'-enyl-sn-glycero-3-phosphoethanolamine by microsomes from myelinating rat brain.

Microsomal fractions of 14-day-old rat brain were incubated at pH 7.1 with 1-[1'-14C]-alk-1'-enyl-sn-glycero-3-phosphoethanolamine (lysoplasmalogen). 1-[1'-14C]alkenylglycerol was produced by hydrolyzing enzyme activities, which were stimulated by Mg2 and inhibited by SH-group reagents. Hydrolysis of 1-[1'-14C]alkyl-sn-glycero-3-phosphoethanolamine is very similar in this respect, but the Km value is higher in the former case. The 1-alkyl compound acts as a non-competitive inhibitor of the hydrolyzing enzyme activity described, whereas the hydrolysis of the 1-alkyl derivative is not inhibited by the 1-alkenyl compound.

Animals↗
PubMed1981

Liberation of free aldehyde from 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine (lysoplasmalogen) by rat liver microsomes.

We found an enzyme in the microsomal fraction of 21-day-old-rat liver, which liberates a free aldehyde from 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine (lysoplasmalogen) and which has an activity of about 42 mU/mg protein under the conditions described. Kinetic data are presented. The pH optimum is found around pH 7.1. SH-blocking reagents, as well as deoxycholate, act as strong inhibitors, while Mg2 and Ca2 also inhibit the reaction to some extent. The enzymic activity is specific with respect to the monoradylphospholipid, since the acylated compound 2-acyl-1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine does not serve as substrate. The ether linkage of 1-alkyl-sn-glycero-3-phosphoethanolamine is not hydrolyzed either under these conditions. A similar enzyme activity in liver has only been described for choline-containing lysoplasmalogen.

Animals↗
PubMedDate not supplied

Chemical composition of the lipophylic extract from the tunicate Botryllus schlosseri.

Eighteen sterols were identified in Botryllus schlosseri, stanols being the main sterols. The sterol composition is in agreement with our recent paper on taxonomic separation of tunicates into three groups. Again we found in invertebrates of the Black Sea sterols with a (22Z)-double bond. This confirms the presence of such sterols in nature. The composition of the phospholipids appeared to be complex, and twelve groups of them were identified in Botryllus schlosseri. The main representatives of phospholipids appeared to be phosphatidylcholine and phosphatidylethanolamine. Only four volatile compounds were identified, which is unusual for marine invertebrates.

Animals↗
PubMed1977

Molecular composition of lecithins in the primary hepatoma induced by 3'-methyl-4-dimethylaminoazobenzene.

The lecithins of the primary hepatoma induced by 3'-methyl-4-dimethylaminoazobenzene (DAB) and host liver of rat were isolated, and the individual molecular species were estimated quantitatively by combined thin-layer and gaschromatographic analysis and specific enzymic hydrolysis. The DAB-hepatoma lecithins appeared to have more specific positioning of fatty acids than the transplanted hepatoma lecithins which have been reported by Dyatlovitskaya et al. (1974). However, there were some striking differences to be noted between the DAB-hepatoma and host liver lecithins. The usual type of molecular species of lecithin, saturated-unsaturated species, was the main component in the hepatoma and host liver. The amounts of the unusual species having impaired positional specificity in fatty acid such as the saturated-saturated and the unsaturated-saturated species were high in the DAB-hepatoma when compared with host liver, although the content of the unsaturated-unsaturated species of lecithin were almost similar in both the tissues. The formation of the unusual species of lecithin in tumor tissues was discussed in relation to the impairing in the enzyme systems involved in lecithin synthesis.

Animals↗
PubMed1975

Decrease in myelin content of rabbit sciatic nerve with aging and diabetes.

Previous studies of the amount of peripheral nerve myelin have been based on histologic examination. In this study, myelin content was measured directly after quantitative isolation from sciatic nerve. There was a decrease in the amount of myelin beginning at nine months, the time of maximal myelin content in normal rabbits, and beginning at six months, the amount was decreased in diabetic as compared with control animals. Composition of myelin isolated from young (age three to four months) and old (age nine to thirteen months) rabbit sciatic nerves was also determined and is similar to that of other species. Although the composition was not affected by diabetes, with aging there was a significant decrease in the amount of cholesterol and an increase in glycolipid.

Age Factors↗
PubMed2004

Metabolomic analysis of molecular species of phospholipids from normotensive and preeclamptic human placenta electrospray ionization mass spectrometry.

Electrospray ionization mass spectrometry (ESI/MS) is a highly sensitive, fast and powerful technique for the metabolite and metabolomic analysis of mixtures of lipids in a biological extract. We have exploited this technique to identify and characterize various phospholipids present in the placenta of preeclamptic and normal pregnant women. Multiple major molecular species can be detected in each phospholipid class have arachidonic acid as major fatty acid constituent. There is no remarkable difference in the molecular composition in each of these phospholipids in both the extracts. However, there seems to be lower amounts of the plasmenyl phosphatidylethanolamine and greater amounts of free fatty acids in preeclamptic placenta.

Arachidonic Acids↗
PubMed1983

Homogenized milk and atherosclerotic disease: a review.

The theory that consumption of homogenized milk containing active xanthine oxidase is a causative factor in development of atherosclerosis is reviewed. Biologically available xanthine oxidase in consumed milk products may be absorbed in the small intestine and enter the blood stream. However, there appears to be no unequivocal evidence that the absorbed enzyme has any pathological effects that may contribute to development of atherosclerotic heart disease.

Allopurinol↗