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PubMed1990

Histochemical and biochemical plasticity of muscle fibers in the little brown bat (Myotis lucifugus).

Fiber composition, and glycolytic and oxidative capacities of the pectoralis, gastrocnemius, and cardiac muscles from active and hibernating little brown bats (Myotis lucifugus) was studied. The data were used to test two hypotheses: First, since hibernating bats maintain the capability of flight and make use of leg muscles to maintain a roosting position all winter, the fiber composition of the pectoralis and gastrocnemius muscles should not change with season. Second, we tested the hypothesis of Ianuzzo et al. (in press), who propose that the oxidative potential of mammalian cardiac muscle should increase with increasing heart rate while glycolytic potential should not. Our results indicate that the fiber composition of the pectoralis muscle was uniformly fast-twitch oxidative (FO) regardless of the time of year, as predicted. However, the gastrocnemius muscle exhibited a change in FO composition from 83% in active to 61% in hibernating animals. Contrary to the variable change in histochemical properties with metabolic state, a trend of reduced maximal oxidative (CS) and glycolytic (PFK) potential during hibernation in both flight and leg muscles was apparent. The oxidative potential of flight and leg muscles decreased by 15.2% and 56.5%, respectively, while the glycolytic potential of the same muscles decreased by 23.5% and 60.5%, respectively. As predicted, the glycolytic potential of cardiac muscle remained constant between active and hibernating bats, although there was a significant decrease (22.0%) in oxidative potential during hibernation.

Animals↗
PubMedDate not supplied

Myotonic electromyographic activity in complexus muscles of normal and dystrophic chicks.

Myotonic-like, "dive-bomber" discharges were recorded from complexus ("hatching") muscles of both normal and dystrophic chicks at 5 days ex ovo and were recordable from dystrophic, but not from normal, pectoralis major muscles at 28 days ex ovo. The complexus muscle, therefore, provides the opportunity to study in young, normal animals, a form of electrophysiological activity previously considered a sign of neuromuscular abnormality.

Age Factors↗
PubMed1977

Direct visualization of contractile proteins in pertubular cells of the guinea-pig testis using antibodies against highly purified actin and myosin.

Antibodies against actin and myosin from smooth muscle, which may react with contractile elements from both muscular and muscle-like cells, were applied to fresh frozen sections of adult guinea-pig testis. Sections stained with an antibody against pectoralis (striated) muscle myosin or with non-immune globulin were used for controls. Peritubular cells of the lamina propria surrounding seminiferous tubulus contained large amounts of actin and myosin as judged by the intensity of immunofluorescence. Sertoli cells did not stain with the antibodies. Our results support the concept of peritubular cells being the critical force for the contractility of seminiferous tubules.

Actins↗
PubMed1988

Electrophysiological and morphological study of polyneuronal innervation in the cutaneous pectoris muscle of adult frog (Rana esculenta).

The incidence of polyneuronal innervation in the cutaneous pectoris muscle of the adult frog, Rana esculenta, was determined quantitatively using electrophysiological and morphological techniques. The mean percentages of multiple innervated endplates obtained with both techniques from a series of 19 muscles examined at all times of the year were in very good correlation: 30.7% (196/639 endplates) by electrophysiology and 30.5% (478/1569 endplates) by morphology. In nine muscles examined during the period from December to March the mean percentages, 36.8% (110/299) by electrophysiology and 38.6% (281/727) by morphology, were significantly higher than those obtained for 10 muscles investigated during the period from May to November, 25.3% (86/340) and 23.4% (197/842) with both techniques respectively. The higher incidence of collateral sprouted branches detected at polyinnervated endplate sites in muscles of winter frogs might be related to these seasonal variations. Most of the 1688 fibres from 26 muscles examined throughout the year exhibited one centrally located endplate. However, around 11% of them were found to be innervated at two separate endplate sites. Muscle fibres exhibiting this type of innervation were invariably the largest fibres in each muscle tested, having an apparent diameter greater than 48 micron. The distance between the endplates of these fibres represented between 10 and 30% of their total length. No significant seasonal variations were observed in the incidence of these dually innervated fibres. In conclusion, both electrophysiological and morphological results show that the normal incidence of polyneuronal innervation in the cutaneous pectoris muscle of adult Rana esculenta is affected by seasonal related factors which influence the nodal sprouting activity. Moreover, they show that a dual pattern of innervation is a common feature in large fibres of this muscle.

Animals↗
PubMed1996

Histological abnormalities of muscle from limb, thorax and diaphragm in chronic heart failure.

The aim of the study was to compare histological findings in limb and respiratory muscles from control subjects and patients with heart failure of two different aetiologies. Biopsies of the quadriceps femoris, strap, diaphragm and pectoralis major muscles were taken from each group. The control subjects all had normal left ventricular function, and comprised seven undergoing surgical ablation of electrical pathways and 10 undergoing coronary artery surgery. The heart failure group had severely impaired left ventricular function, and were undergoing cardiac transplantation in all except one case. Ten patients with idiopathic dilated cardiomyopathy and seven with heart failure of ischaemic origin were studied. Conventional histochemical techniques and specific anti-myosin immunofluorescent stains were used. There were no consistent differences in fibre type prevalence or diameter between the groups. There were no important histological abnormalities in the two control groups. There were minor/major changes in four of seven patients with ischaemic heart failure but no major abnormality, whilst in the dilated cardiomyopathy group there were five of 10 patients with minor/major changes and three of 10 with major abnormalities (P < 0.001 vs controls). A variety of changes were seen in both groups of heart failure subjects. These were more marked in the dilated cardiomyopathy than ischaemic group, and suggest the presence of fibre type regeneration and/or transformation. Amongst the findings were tubular aggregates, internalization of nuclei, bizzare staining of myosin and staining of neonatal myosin (seven of 14) and the presence of cores (five of 14). Such changes were more prominent in the diaphragm than in the other muscles. In conclusion, histological abnormalities are present in the limb and respiratory muscles from subjects with heart failure. The changes are most marked in subjects with idiopathic dilated cardiomyopathy, suggesting that there may be a generalized cardiac and skeletal myopathy in these subjects. The presence of histological abnormalities in the respiratory muscles may contribute to the pathogenesis of dyspnoea in heart failure.

Adolescent↗
PubMed2004

Beta1 integrin mediation of myogenic differentiation: implications for satellite cell differentiation.

Myoblast-extracellular matrix interactions mediated by integrin receptors have been shown to play a pivotal role in skeletal muscle development. In the current study, the avian genetic muscle weakness, low score normal (LSN), which exhibits modified myotube and sarcomere structure and a reduction in beta1 integrin expression during satellite cell differentiation, was used as a model system to further investigate the role of beta1 integrins in myogenic differentiation. During normal satellite cell differentiation, the beta1 integrin was localized at areas of pseudopodial activity and points of cell contact. In contrast, in LSN satellite cell cultures the beta1 integrin was predominantly observed in clusters not associated with points of cell to cell contact. The LSN satellite cells underwent apoptosis at the same time normal satellite cells were fusing to form multinucleated myotubes. During muscle development, the beta1 integrin is regulated by alternative splicing from a beta1A to beta1D form. During both embryonic and posthatch pectoralis major muscle development, regulation of the beta1A and beta1D variants was altered in the LSN. Normal and LSN myogenic satellite cell cultures did not express the beta1D integrin, but the LSN satellite cells expressed higher concentrations of the beta1A integrin than did normal satellite cells. Taken together, these data further demonstrate the importance of the beta1 integrin subunit in the regulation of cell-extracellular matrix signal transduction pathways during muscle growth and differentiation.

Amino Acid Sequence↗
PubMed2000

A force/displacement analysis of muscle testing.

Manual muscle testing procedures are the subject of a force and displacement analysis. Equipment was fabricated, tested, and employed to gather force, displacement, and time data for the purpose of examining muscle-test parameters as used by clinicians in applied kinesiology. Simple mathematical procedures are used to process the data to find potential patterns of force and displacement which would correspond to the testing of strong and weak muscles of healthy subjects. Particular attention is paid to the leading edge of the force pulses, as most clinicians report they derive most of their assessment from the initial thrust imparted on the patient's limb. An analysis of the simple linear regression of the slope (distance vs force) of the leading edge of a force pulse indicates that a significantly large slope is indicative of weak muscles (as perceived by the clinician), and a small slope is indicative of strong muscles. Threshold criteria for slopes are specified to create a model that may discriminate between strong and weak muscles. The model is accurate 98% of the time compared to judgments of clinicians with more than 5 years of experience but is considerably lower for clinicians with less than five years of experience (64%). this accuracy rate indicates that the model is reliable in predicting the clinician's perception of muscle strength, and it also indicates that the testing procedure for muscle strength used by experienced clinicians in applied kinesiology are reliable. The experiment lays the groundwork for studies of the objectivity of muscle-strength assessment in applied kinesiology.

Humans↗