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Induction of ovulation by cyclical hormone therapy.
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The induction of ovulation with clomiphene and its assessment by biological methods.
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The induction of ovulation and the occurrence of pregnancy following clomiphene therapy in the non-ovulatory woman.
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Pregnancy in a patient with diabetes insipidus following induction of ovulation with clomiphene.
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The induction of ovulation by tamoxifen.
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Biochemical and haematological changes in an unsuccessful twin pregnancy following induction of ovulation by gonadotrophins.
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An evaluation of monitor tests for the induction of ovulation.
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Induction of ovulation resulting in nonuplet pregnancy.
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An appraisal of clomiphene in the induction of ovulation.
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The induction of ovulation in immature rats treated with pregnant mares's serum gonadotrophin and human chorionic gonadotrophin.
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Induction of ovulation in the unmated oestrous ferret.
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Further evidence concerning the role of the hypothalamus in the induction of ovulation in the rabbit following injections of copper acetate.
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Human chorionic gonadotropin: induction of ovulation in the squirrel monkey.
The minimum dose of human chorionic gonadotropin that would cause ovulation in the squirrel monkey (Saimiri sciureus) was found to be between 100 and 250 international units.
Induction of ovulation in immature hypophysectomized rats.
Immature rats given minute doses of highly purified pituitary gonadotropins (follicle-stimulating hormone and luteinizing hormone) 7 to 100 days after hypophysectomy ovulated and formed corpora lutea. Neither hormone alone was effective. Luteinizing hormone repaired in part the atrophied theca interna and interstitial tissue, and follicle-stimulating hormone stimulated the development of the granulosa cells.
New synthetic agent for the induction of ovulation: preliminary trials in women.
A new compound in the triphenylethylene series has been tested for its effect in causing ovulation in secondary amenorrhoea. Twenty patients were given a total of 40 courses of treatment and ovulation resulted in 16 instances. Three patients became pregnant. Probably this compound can induce ovulation in suitable subjects.
Induction of ovulation with synthetic gonadotrophin-releasing hormone in women with constant anovulation induced by contraceptive steroids.
The ovarian response to stimulation with follicle-stimulating hormone/luteinizing hormone-releasing hormone (FSH/LH-RH) was studied in young, healthy, and fertile women with constant iatrogenic anovulation caused by depot medroxyprogesterone acetate or depot chlormadinone acetate injected for contraceptive purposes. Results were compared with those in unstimulated controls. The response was observed directly on the ovaries at laparotomy performed after treatment with FSH/LH-RH. A wedge biopsy provided ovarian tissue for histological and histochemical studies of steroid dehydrogenase activity. Treatment with FSH/LH-RH caused a trophic effect on the ovaries, with evidence of follicular development; ovulation occurred in two out of 16 treated women. Preovulatory mature follicles were found in three others.Clearly the FSH/LH-RH-induced release of FSH and LH caused follicular growth up to Graafian follicles, mature preovulatory follicles, and ovulation. Mitosis in granulosa and theca cells was also observed. A wide individual variation in gonadal response to hypothalamic FSH/LH-RH was evident, however. Nonetheless, our data support the possibility that treatment with FSH/LH-RH may prove valuable in patients with anovulatory sterility of hypothalamic origin.