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Contact screening procedures for tuberculosis in Auckland.

A five year audit of tuberculosis notifications for the three Auckland health districts revealed that 10.7% of notifications were the result of contact screening procedures. Most notifications from this source were children (73.2%) up to 16 years of age. By far the greatest yield from contact screening procedures was among contact of patients with infectious pulmonary tuberculosis (whose sputum is smear positive on direct microscopy): 78.8% of cases found by contact procedures were contacts of these infectious patients. The yield was particularly high for children who were close contacts of these cases: 23.8% of such children were considered to be infected by tubercle bacilli compared with only 1.1% of children who were casual contacts of these infectious cases. Few adults were found by contact procedures because: (a) only those with pulmonary disease were found, whereas among children all those who had been infected, the majority of whom had not developed tuberculous disease (so-called primary occult tuberculosis) were found, and (b) many adult contacts of smear positive pulmonary index cases were not followed with chest radiographs for long enough: only one half had six months of surveillance. By restricting contact screening procedures to contacts at highest risk the workload could be substantially reduced with minimal reduction in the yield of new cases.

Adolescent↗

[Sentinel networks. The national public health network. State information].

In the area of health, the information system used by the authorities is based on a series of networks that need to be coordinated. 1. State information: State information as regards health epidemiology was for a long time fragmented. The reasons for this relative ignorance are varied, and are based both on professional and technical factors (preference of physicians for personal exchange rather than for statistical analysis, difficulties in data collection and mathematical processing), and on socio-political factors (the euphoria of years of economic growth). For a long time only the causes of death were appropriately documented (cf. Mme Facy's report). In the last decade, a variety of initiatives has been directed towards all fields, and morbidity is becoming better defined thanks to the ORS (Regional Health Observatories) (cf. M. Garro's speech) and health registers (cf. M. Schaffer). Warning systems are becoming a principal preoccupation for most people in positions of authority, and explain the proliferation of surveillance networks. 2. Sentinel networks: A 'sentinel network' is an interactive surveillance system involving the collection of health data on a routine basis by a group of doctors (general physicians, biologists, etc.). Initially conceived for the surveillance of communicable diseases, they are also used for all diseases requiring early warning and rapid intervention (effects of sudden pollution, surveillance of drugs and poisons, etc.). These sentinel networks have expanded in our countries to complement the compulsory notification systems for infectious diseases, whose 'passive' nature often leads to under-notification (and therefore a non-representative selection) and delayed notification of cases, and whose range of influence does not cover all communicable diseases.(ABSTRACT TRUNCATED AT 250 WORDS)

Community Networks↗

The role of the physician in effecting change in hospital charge for radical prostatectomy.

BACKGROUND: Continuing effort is being made to provide the best medical care in a cost-effective manner, requiring an evaluation of factors that control charges. The number of cases of carcinoma of the prostate gland and the number of radical retropubic prostatectomies performed have increased in recent years, with an estimate of several hundred million dollars being spent annually on this procedure in the United States of America. Because physicians are reported to effect the majority of charges for a hospitalization, this study examines the influence of notification of the physician of hospital charges on the overall hospital charges for radical retropubic prostatectomy. STUDY DESIGN: Total hospital charge and duration per hospitalization were determined for all patients having radical prostatectomies performed at five community hospitals in Richmond, VA, between January 1991 and December 1993. Patients included 625 males diagnosed with carcinoma of the prostate gland undergoing radical prostatectomy by one of 20 urologists from several different private practice groups. Halfway into the time period studied, physicians were notified of data collection and of factors that seemed to have a role in hospital charges. Total hospital charges before and after physician notification were measured to determine whether or not physicians could effect hospital charges. RESULTS: Overall, hospital charges decreased significantly after notification of physicians in the study. The decline in total charges continued throughout the follow-up period. Duration of hospitalization decreased throughout the entire study period, while total charge per hospital day increased. CONCLUSIONS: Physician awareness of hospital charges for operative procedures and accompanying hospitalizations may influence the overall decrease in charges.

Adult↗

[Diabetes in Mexico: what does the National Health Survey tell us?].

The purpose of this monograph is to describe the sociodemographic and health characteristics of individuals who identified themselves as diabetics (through self-notification) in a national health survey that was conducted in Mexico in 1988 and in which information about more than 200,000 persons was collected by interviewing an adult member of each household. Of the population surveyed, 1.2% stated being diabetic, and it was noted that the frequency of the disease increased with age and socioeconomic status and that it was 30% higher in women than in men. Diabetics had higher notification rates for hypertension, heart disease, and blindness than the rest of the population. Twenty percent of diabetic patients and 12% of nondiabetic individuals smoked. People with diabetes consulted physicians twice as often as nondiabetics and their chances of being hospitalized were four times higher. At the end we discuss the limitations and possible biases of self-notification as a method for detecting diabetics. Finally we conclude that diabetes is an important health problem in Mexico and that it warrants more attention from epidemiologists and other public health specialists.

Adolescent↗

Congenital syphilis as a notifiable disease.

A review of the notification of congenital syphilis at Johannesburg Hospital from 1 May 1991 to 30 April 1992 was conducted to evaluate the effect of the recently introduced notification programme. A total of 209 Wassermann reaction (WR)-positive mothers were delivered during this time; 12 pregnancies (5.7%) resulted in stillbirths and 8 (3.8%) in incomplete abortions, and there were 2 (0.96%) early neonatal deaths. Only 45 (21.5%) of this group of WR-positive mothers had received antenatal care, and of these 9 (20%) had had adequately documented treatment. There were thus 200 potentially notifiable cases of congenital syphilis according to the Centers for Disease Control classification, of which 24 (12.0%) were actually notified. The goals of the notification programme, namely to increase awareness of congenital syphilis among health care providers and to evaluate the extent of the problem accurately, are clearly not being met.

Health Personnel↗

[Adverse reactions to drugs reported by the primary care physicians of Andalusia. Analysis of underreporting].

OBJECTIVE: To discover the sort of adverse reactions to medication (ARM) notified by Primary Care doctors and identify the under-notification of those cases having special clinical-epidemiological interest. DESIGN: Retrospective study in which 2,597 ARM corresponding to 1,467 Yellow Cards (YC) were analysed. These were notified by Primary Care doctors to the Centro Andaluz de Farmacovigilancia (Andalusian Drug-watch centre) during the period from 1/6/90 to 31/12/92. To assess the seriousness of the ARM, their terminological classification and imputability, the criteria used in the WHO's international "Yellow Card" programme of spontaneous notification were followed. MEASUREMENTS AND MAIN RESULTS: 77.2% of all notifications were from Primary Care, of which 7.4% were of special interest due to their serious or novel character. However an undernotification of serious and well-known ARM was detected, such as digestive haemorrhages (1.07/10(6) inhibitants per year), anaphylactic shock (0.34/10(6) inhab/year), agranulocytosis (0.23/10(6) inhab/year) and aplastic anaemia (0.05/10(6) inhab/year), among others. CONCLUSIONS: Most of the main under-notified ARM are generated in the community but treated in hospital Casualty departments. Therefore it would be useful to develop specific Drug-watch programmes in the hospitals themselves.

Adverse Drug Reaction Reporting Systems↗

Outbreak of primary and secondary syphilis--Baltimore City, Maryland, 1995.

From 1993 to 1995, the number of primary and secondary syphilis cases reported in Baltimore City (1990 population: 736,014) increased 97%, from 179 to 352 cases per year (Figure 1). To identify potential reasons for this increase, CDC, in collaboration with the Baltimore City Health Department (BCHD) and the Maryland Department of Health and Mental Hygiene, analyzed data about primary and secondary syphilis cases during 1992-1995 and about temporal trends in factors that may affect syphilis rates (e.g., partner-notification results, access to medical care, and community illicit-drug use). In addition, data were analyzed from the two public sexually transmitted disease (STD) clinics in Baltimore City. BCHD collects demographic data for all cases of reported syphilis among patients who reside in Baltimore City and attempts to interview and provide partner notification and treatment for these patients. This report summarizes the results of the analysis, which suggest the outbreak has been associated with decreases in partner notification and health department clinical services and a substantial increase in community cocaine use.

Adolescent↗

Meningococcus: a menace in Cork?

A review of laboratory isolates and notifications of meningococcal disease in the Cork area was conducted for the period 1989-93. The study aimed to describe the epidemiology of meningococcal disease in the area. The incidence of meningococcal disease is high in the Cork area and has been increasing since 1991 with a peak incidence of laboratory confirmed cases of 6.5 per 100,000 in 1993. In the five year review period 113 notifications of meningococcal disease were identified of which 61 (54%) were laboratory confirmed and 52 (46%) were clinically diagnosed only. All laboratory confirmed cases had been notified to the local Director of Community Care/Medical Officer of Health. Group C organisms comprised two-thirds of isolates in 1992 and 1993. Comparison of regional and national incidence rates must be based on laboratory confirmed cases as the criteria for diagnosis and completeness of notifications may vary. A National Infectious Disease Surveillance Centre is vital for monitoring trends and for the coordinated development of a national policy on control and prevention of meningococcal disease.

Age Distribution↗

[Knowledge, attitude and behavior among patients with Chlamydia. Perspectives for prevention].

Patients with chlamydial infections (Ct) attending the outpatient Venereal Disease Clinic of Copenhagen from July 1-November 30 1995 were asked to fill in a questionnaire focusing upon knowledge, attitude and behaviour related to sexually transmitted diseases (STDs) in order to strengthen the future prevention of Ct. The questionnaire was answered by 37 men and 35 women with a median age of 27 and 21 years and a median number of three and two sexual partners within the last six months, respectively. Half of the patients had previously had an STD, and 92% had been tested for HIV, of whom one homosexual man was known HIV-positive. Notification about exposure from a partner was the reason for attending for 24%. All but one were in favour of partner notification, but only 6% wanted provider referral. During last intercourse condoms had neither been used with a steady partner by 75% especially by the young and women, who thought themselves safe, nor with a casual partner by 52% especially among the young and men, mainly because of thoughtlessness or perception of low risk. Before the actual STD diagnosis only 49% were able to name one symptom and 35% one complication related to Ct. A majority (79%) stated, that fear of catching another Ct would lead to better protection, and 70% found that more information would have a preventive effect. Future Ct prevention programs in Denmark should include intensified chlamydial screening and partner notification together with centrally produced mass media information supplemented by individual counselling.

Adolescent↗

The tuberculosis program of Catalonia's Central Health Region (1986-1993).

SETTING: Catalonia's Central Health Region antituberculosis program, which began in 1985. OBJECTIVE: To evaluate the cooperation of health staff and the program's effectiveness after 8 years. METHOD: The following data from the nominal notifications and the expanded case reports were processed: epidemiological, clinical and treatment data, each patient's end results and the outcome of the contact investigation. The implementation of the program was evaluated by means of the number of notifications and contact investigations received, and its effectiveness was assessed by the percentage of sputum smear positive cases having completed treatment. RESULTS: There was an increase in the number of patients with an expanded case report (from 74% to 100%), with a final notification (from 61% to 99%) and with contact investigation (from 29% to 79%). The sputum smear positive cases who completed the treatment after 1990 exceeded 85%. CONCLUSION: The implementation of the program in the Region's health system is good and is improving in parallel with the control of the disease.

Acquired Immunodeficiency Syndrome↗

[Hepatitis A epidemic in Heerlen in late 1996, importance of immunization in immigrant children].

OBJECTIVE: Description of a local epidemic of hepatitis A in 1996 in Heerlen, the Netherlands. DESIGN: Descriptive. SETTING: Regional Health Service Oostelijk Zuid-Limburg, Heerlen, the Netherlands. METHOD: Semistructured questions were asked by telephone of patients, patients' parents, general practitioners, the day-care centre manager and the head of the primary school, to collect information about cases. RESULTS: In the last four months of 1996, 41 persons (23 children and 18 adolescents and adults) were infected in a city of some 50,000 inhabitants. The primary case was most likely a three-year-old boy from Moroccan parents, who prior to his disease had visited his family in Morocco and although non-immune had not been immunised. From the boy's family the virus spread to a day-care centre and a primary school. In this epidemic patients of 15 different general practitioners were affected. An intervention with hepatitis A immunoglobulin in the day-care centre and primary school and immunoglobulin prophylaxis in affected families was effective in halting the epidemic. CONCLUSION: Special attention is needed for immunisation of children of travelling immigrant parents. Immunoglobulin prophylaxis in affected families and notification of cases to the regional health institute by general practitioners may prevent cases. Serological notification by the regional laboratory as well as notification of infectious diseases by day-care centres and schools will add to the regional infection surveillance and control.

Adolescent↗

Notifying patients exposed to blood products associated with Creutzfeldt-Jakob disease: theoretical risk for real people.

BACKGROUND: In July 1995 the Canadian Red Cross Society recalled blood products because of the hypothetical risk of transmission of Creutzfeldt-Jakob disease (CJD) through those blood products. The authors undertook a survey to determine the views of patients and parents of patients about being notified that they or their child had received such blood products. METHODS: The study population consisted of 528 transfusion recipients, of whom 453 (85.8%) were under 16 years of age, notified by the Hospital for Sick Children, Toronto, of the CJD recalls in 1995 and 1996. Families attending an information session were asked to complete a self-administered questionnaire (85 cases). Ninety-seven families randomly selected from those who did not attend the session were interviewed by telephone. The questionnaire was adapted from a questionnaire used to evaluate families' responses to notification of transfusion and risk of HIV infection. RESULTS: More than 80% of the respondents said they wanted to be notified and would want to be notified if there were another recall. On initial receipt of the notification about two-thirds of the respondents had been anxious, fearful or angry. There was no one method of conveying the information that suited all, but a personalized letter was seen as the most acceptable method. INTERPRETATION: Most parents of children who have received blood products are in favour of being informed about the risk of CJD, despite the uncertainty of the information on risk and the anxiety that such information causes.

Adolescent↗

An evaluation of the actual incidence of tuberculosis in French Guiana using a capture-recapture model.

In order to estimate the level of under-reporting and to improve estimates of the incidence of tuberculosis (TB) in the vicinity of Cayenne, French Guiana, we performed capture-recapture analysis from 1996 through 2003. We cross-linked data from the Institut Pasteur, the Département d'Information Médicale of Cayenne Hospital, and the Service de Lutte Anti-Tuberculeuse. The estimate of 381 TB cases obtained after matching those three sources was revised to 425 (95% confidence interval: 407, 453) using the capture-recapture model based on sample coverage. The corresponding average annual incidence was 63.1 TB cases per 100,000 population. The evaluated sensitivity of the compulsory notification system was 35.3%, indicating wide under-notification of TB in the vicinity of Cayenne. The estimated coverage reported by the three sources was fairly accurate (i.e. 85.9%), but not sufficient to evaluate the risk of transmission of TB in the Ile-de-Cayenne (Cayenne and its suburbs).

Disease Notification↗

A simulation model of brucellosis spread in British cattle under several testing regimes.

Brucellosis is a widespread, economically devastating and highly infectious zoonosis. In cattle, infection predominantly is caused by Brucella abortus, and is usually detected in pregnant females through abortions. Great Britain (GB) has been declared free from brucellosis (officially brucellosis free (OBF)) since 1993 and as such is required by European Union (EU) regulations to test > or =20% of both beef and dairy cattle >24 months old routinely. Currently, however, GB serologically tests more cattle than required and the issue of reducing the level of testing has come under consideration. We developed a simulation model to determine the rate of spread of brucellosis under a variety of testing regimes. For dairy herds, we found that reducing the level of testing would have a major effect on the rate of spread of infection, should it be imported. For beef herds, reducing the level of testing would have much less effect. We also found that abortion notification is a very-important additional means of surveillance. As a result of our predictions, policy-makers decided not to reduce the level of testing and actively to promote abortion notification.

Abortion, Veterinary↗

Influence of physicians' attitudes on under-notifying infectious diseases: a longitudinal study.

OBJECTIVES: To identify practitioners' demographic and professional characteristics associated with reporting of mandatory-reporting diseases (MRDs), and to identify attitudes associated with MRD reporting. DESIGN: Longitudinal study. SETTING: Regional Health Service of Galicia (North-western Spain). SUBJECTS: Random sample of 600 physicians. MAIN OUTCOME MEASURES: A postal questionnaire was used to measure the physicians' beliefs, knowledge and attitudes regarding MRDs. Associations between the independent variables and outcomes (notification or non-notification of MRDs every week during 1998) were modelled using the Andersen-Gill proportional hazards model. RESULTS: The response rate was 60.1%. The following beliefs, knowledge and attitudes were statistically associated with a smaller probability of reporting any given MRD: (1) I would only notify an MRD after confirming diagnosis; (2) the MRD reporting system interferes with my daily clinical practice; (3) besides the legal requirements, I would have to report MRDs as a medical professional; and (4) only the reporting of relevant or severe MRDs is necessary. Under-reporting was not associated with specialization (general or paediatric) or the type of contract (fixed or temporary), but was associated with gender. CONCLUSIONS: Some physicians' beliefs, knowledge and attitudes regarding MRDs are associated with under-reporting. This suggests that modification of certain attitudes and knowledge in physicians could greatly reduce the under-reporting of MRDs.

Attitude of Health Personnel↗

Waning immunity and sub-clinical infection in an epidemic model: implications for pertussis in The Netherlands.

In The Netherlands, an epidemic outbreak of pertussis took place in 1996-1997. Understanding of the causes of the epidemic is hampered by the fact that many cases of infection with Bordetella pertussis go by unnoticed, and by the fact that immunity against infection does not last lifelong. Motivated by these observations, we develop and analyze an age-structured epidemic model that takes these factors into account. A distinction is made between infection in immunologically naive individuals, and infection in individuals whose immune system has been primed before by infection or vaccination. While the former often lead to severe symptoms and thus are more often diagnosed and notified, the latter are largely sub-clinical. The main questions are: (1) to what extent do sub-clinical infections contribute to the circulation of B. pertussis; and (2) what might be the causes for the recent epidemic? To answer these questions, we first present a new method to estimate the force of infection from notification data. The method is applied to the 1988-1995 case notification data from The Netherlands. Estimates of the force of infection vary greatly, depending on the rate at which immunity is lost, and on the fraction of sub-clinical infections. For the 1988-1995 period, our analysis indicates that if immunity is lost at a small rate and if a majority of infections is sub-clinical, the contribution of infection in adults to the transmission process cannot be neglected. Our results furthermore indicate that a decrease in the duration of protection after vaccination due to a change in the pathogen is the most likely factor to account for the 1996-1997 epidemic.

Adolescent↗

Spatial patterns of tuberculosis incidence in Cologne (Germany).

In many European countries, the decline of tuberculosis notification rates levelled off in the mid 1980s. Germany has been facing only a very modest resurgence of tuberculosis (TB) in the early 1990s, but until now, the notification rate does not yet fulfil the WHO definition of a low incidence country. Mainly immigration from high incidence countries is held responsible for the delayed decline and temporary increase of TB. This paper seeks to investigate the inner-urban strength of association between tuberculosis and several potential risk factors in the city of Cologne using geographical and statistical methods within a small-area division based, GIS-supported ecological study, which never before has been conducted for a German city. Standardised annual TB incidence rates for 78 urban subdistricts between 1986 and 1997, disaggregated by age, have been analysed. Twelve independent variables representing contemporary ethnic and socioeconomic conditions are used to calculate Poisson regression models. For the entire population and for the <60 age group, a strong positive association was found between tuberculosis incidence and share of immigrants. Interestingly enough the share of German-origin immigrants from eastern Europe was seen not to be instrumental in increasing TB rates. Reflecting strong ecological correlations between variables depicting economic conditions and TB as well as immigration variables, the deprivation of certain ethnicities rather than high prevalence immigration background is inferred to be significant to TB level. As for the 60 + age group regression analysis fails to model the TB incidence patterns sufficiently it seems reasonable to assume an autonomous, spatially disaggregated TB epidemic of the elderly, echoing a severe post-war epidemic by reactivation, only marginally associated with contemporary living conditions, but contributing substantially to the current TB incidence level. This assumption is reinforced by further results of the statistical analysis (deviance of regression null models, testing for Normal distribution, time trends). It could be shown that in Cologne the HIV/AIDS epidemic is not significantly influencing the TB incidence rate of men aged 30-49 being the most AIDS-afflicted population subgroup.

Adult↗

[Measles, pertussis, rubella and mumps completeness of reporting. Literature review of estimates for industrialized countries].

BACKGROUND: Surveillance data for infectious diseases in industrialized countries have been providing useful epidemiological information for several years. However, surveillance is complex and notifications underestimate the true disease incidence. The goal of this paper is to determine the completeness of reporting of measles, pertussis, rubella and mumps through notification in industrialized countries. METHODS: A thorough literature review of papers published (in French or English) on surveillance data of measles, pertussis, rubella and mumps was undertaken with PUBMED. The review was limited to studies conducted in industrialized countries that quantitatively assessed the completeness of the reporting of these diseases. RESULTS: Fourteen studies published from the 1920s met the inclusion criteria. For measles, the studies suggest that 64-85% of symptomatic patients sought medical care, 13-57% of those were diagnosed with measles and 22-81% of the diagnosed cases were reported for a completeness of reporting ranging from 7% to 63% between 1920 and 1980 and 3% to 41% in recent years. For pertussis, it was estimated that 49-59% of symptomatic patients sought medical care, 12% of those were diagnosed and 19-47% of the diagnosed cases were reported for a completeness of reporting ranging from 5% to 25% between 1920 and 1980 and from 3% to 12% in recent years. Very few studies on rubella and mumps were found and none allowed the determination of the global completeness of reporting. CONCLUSION: Reporting has been found to be considerably incomplete. Continued efforts to improve the recognition and reporting of these diseases are needed.

Developed Countries↗