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PubMed1975

Drug induced biogenesis of nitrosamines.

It has been demonstrated that potentially corcinogenic nitroso compounds are readily formed when certain widely used drugs with secondary alkylaminostructures (e.g. nortriptyline and fenfluramine) or drug metabolities with such structures (e.g. norpropoxyphene) are reacted with nitrite in dilute acid aqueous medium or in human gastric juice under simulated gastric conditions. The reactions occur so readily in vitro that new quantitative procedures for the determination of these drugs have been developed and based on these principles. The potential hazards associated with the long term clinical use of such drugs are discussed.

Carcinogens↗
PubMedDate not supplied

[Content of N-nitrosamines in smoked fish and canned food].

The composition and contents of major N-nitrosoamines (NA) in the edible part of herrings and rock trouts exposed to hot and cold smoking and in the Smoked fish in oil type cans were studied. Among NA, only N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA) were detected in all samples. In the cold-smoked fish, the levels of NDMA and NDEA were higher than in the hot smoked fish and cans. Of all the samples, only those of cold smoked herrings and rock trouts had standardized NDMA concentration that was greater than the standard limitation and equal to 3.48 and 3.74 mukg/kg.

Animals↗
PubMedDate not supplied

[The effect of ionizing radiation on nitrosamine formation from anthropogenic precursors].

The kinetics of formation of nitrosoamines from precursors under the effect of ionizing radiation has first been quantitatively estimated, and the optimal conditions of their formation determined. The possibility of formation of nitrosoamines under the effect of low-level radiation has been investigated. Using the mathematical functions obtained from the experiments, the number of nitrosoamines, that may form under the effect of radiation in the aqueous medium, has been determined.

Amines↗