Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “MEPROBAMATE”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,567 records · Page 87Linked to original sources
PubMed1979

The Geller-Seifter conflict paradigm with incremental shock.

The typical Geller-Seifter conflict paradigm for predicting clinical efficacy of anxiolytics is a mult VI/CRF schedule in which response rates in the CRF (conflict) portion are depressed by response-contingent electric shock. In 1-h sessions, anxiolytics raise the depressed conflict rates. Recently it was shown that replacing the single shock level with an arrangement whereby shock begins at zero and is increased with each response in the conflict portion produced more orderly data and facilitated training and maintenance of experimental subjects; chlordiazepoxide was the test drug. In the present study, those results are replicated in 30-min sessions, and the incremental paradigm is demonstrated to be as specific for anxiolytics as the standard Geller-Seifter paradigm. The possibility of very short sessions is suggested.

Animals↗
PubMed1980

Dynamic study of the acoustico-facial reflex by impedance measurement.

Dynamic study of the acoustic reflex has brought into evidence that 1. age has a significant influence on various reflex response parameters 2. study of dynamic parameters of the acoustic reflex enables changes in the reflex arc to be objectified. This is therefore an objective measurement of recruitment in impedance measurement. The author proposes to study the following parameters: rise time, recovery time, and the variations of maximum amplitude as function of sound stimulation intensity. Study of these three parameters provides a highly sensitive test of change in the dynamics of the acoustic reflex, for indeed this test reveals pathology well before the Reflex Decay Test does so.

Acoustic Impedance Tests↗
PubMedDate not supplied

Effect of hypnotic and anxiolytic agents on regional concentration of acetylcholine in rat brain.

Pentobarbital (30 and 60 mg/kg) and chloral hydrate (300 and 600 mg/kg) administered in anesthetic/hypnotic doses produced significant increases in acetylcholine concentration in the cerebral cortex, striatum, hippocampus and brainstem. Hypnotic/anxiolytic agents like diazepam, flurazepam (100 mg/kg each) and triazolam (30 mg/kg) significantly increased the acetylcholine concentration only in the cerebral cortex and striatum. Alprazolam and ketazolam had no significant effect on regional distribution of acetylcholine in the brain. The results have been discussed with respect to the role of central cholinergic system in anesthetic and hypnotic actions of these drugs.

Acetylcholine↗