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Semantic acquisition without memories: evidence from transient global amnesia.

Transient global amnesia (TGA), characterised by a profound anterograde amnesia, is a model of interest to study the acquisition of novel meanings independent of episodic functioning. Three patients were tested during a TGA attack, two in the early recovery phase and the third during the acute phase of TGA, with a semantic priming task involving a restructuring process of conceptual knowledge. During TGA, all patients demonstrated priming effects. Results obtained the day after the episode with the same task showed that these effects persisted at least one day. Episodic memory seems not to be critical for the formation of novel connections among unrelated semantic representations, in accordance with Tulving's model of memory, i.e. episodic memory is not necessary for the acquisition of semantic information.

Acute Disease↗

Deep electrode insertion in cochlear implants: apical morphology, electrodes and speech perception results.

Morphological examination of the human temporal bone in the apical region supports the benefits of deep electrode insertion. Initiation of spikes on peripheral processes close to the basilar membrane would provide improved channel selectivity during electrical stimulation but recruiting of nerve fibres requires a higher current. A clinical study was performed on 10 users of the MED-EL COMBI 40 + implant to evaluate the effect of the insertion depth of the cochlear implant electrode on speech perception. All subjects were implanted with the standard COMBI 40 + electrode with an insertion depth of > 30 mm. Acute speech tests were carried out in which stimulation was restricted to the apical, middle and basal regions of the cochlea in turn, and using electrode arrangements in which contacts were either distributed over the whole length of the cochlea or concentrated at the basal end, thus mimicking an insertion depth of approximately 20 mm only. The results showed that stimulation of the apical region of the cochlea supports a significant degree of speech understanding, and that distributing the contacts over the whole length of the cochlea improves speech perception in quiet and in noise.

Adult↗

Determinants of cognitive change after coronary artery bypass surgery: a multifactorial problem.

BACKGROUND: Several studies have investigated predictors of cognitive decline after coronary artery bypass grafting (CABG), but there is little consensus as to which specific factors are predictive of poor cognitive outcomes. METHODS: We evaluated 127 patients undergoing CABG with standardized neuropsychological tests preoperatively, at 1 month and at 1 year. The outcome measure was a continuous variable reflecting change in z-scores for eight cognitive domains over time for individual patients. Univariate analyses were performed to evaluate the association between the demographic, operative, and postoperative factors and the cognitive outcome variables. Factors that were significant were included in a multiple linear regression analysis. RESULTS: Among the medical history variables, diabetes was associated with change in executive functions and psychomotor speed. Some of the operative variables were associated with short-term changes, but none with the 1-year outcomes. For example, the surgeon's rating of degree of difficulty in selecting a cross-clamp site was associated with change in attention. Higher mean pump rate during the procedure was associated with improved performance on tests of language. The cognitive domains associated with medical variables were different from those associated with surgical variables, and the associations observed at 1-year were different from those seen at 1-month. CONCLUSIONS: Change in cognition after CABG is associated with both medical and surgical variables. The specifics of these associations depend on the choice of time points after surgery. This suggests that there are multiple etiologies for these changes, with nonspecific effects of anesthesia and prolonged surgery interacting with the more specific effects of the surgical procedure itself.

Aged↗

Verbal deficits in Klinefelter (XXY) adults living in the community.

Forty-two adult males--10 with Klinefelter's syndrome (karyotype XXY), 17 with normal sex chromosome karyotype (XY) but with physical signs of hypogonadism, and 15 presumed to be normal both chromosomally and hormonally--completed tests of Verbal and Nonverbal ability. It was predicted: a) that the XXY group would perform more poorly than the other two groups on tests of Verbal ability, and b) that the XY, hypogonadal group would perform more poorly than the others on tests of Non-verbal ability. The first hypothesis was supported. However, in spite of measurable verbal deficits, the XXY men (whose parents were more highly educated than those of the other two groups) did not appear to be underachievers. Rather, they were, in general, as well educated, as likely to be employed, and of socioeconomic status equivalent to that of the other men in the study. These findings are discussed briefly in terms of implications for early childhood education and genetic counselling. The second hypothesis was not supported: this is attributed to presumed heterogeneity of etiology of hypogonadism in the XY, hypogonadal group.

Adult↗

A clinical report on receptive vocabulary skills in cochlear implant users.

OBJECTIVES: The aim was to measure the rate of vocabulary acquisition for cochlear implant users and compare the pre- and postoperative rates with published data for other groups with normal or impaired hearing. The hypothesis was that the postoperative rate would be greater than the preoperative rate. DESIGN: The Peabody Picture Vocabulary Test (PPVT) was administered to 32 children, adolescents, and prelinguistically deafened adults implanted with the 22-electrode cochlear implant. Age at implantation ranged from 2 yr 6 mo to 20 yr and implant use ranged from 6 mo to 7 yr 8 mo. RESULTS: The group mean postoperative performance at various postoperative intervals was significantly higher than mean preoperative performance. Single-subject data indicated statistically significant gains over time on this test for 13 of the subjects. The mean postoperative rate of vocabulary acquisition of 1.06 times the rate for normally hearing children was significantly greater than the mean preoperative rate of 0.43. CONCLUSION: These rates of improvement were in accord with previous reports on smaller numbers of implant users, but could not be attributed unambiguously to use of the implant because no control group was used for this clinical work. Variables such as age at implantation, duration of profound deafness, communication mode, and speech perception skill failed to significantly predict rate of improvement of the PPVT.

Adolescent↗

Dynamic assessment of cognitive and cardiovascular performance in the elderly.

Dynamic measures of cardiovascular and cognitive performance have been used as a preliminary step toward developing predictors of decline in functional performance in older persons. Both batteries use multiple measures to examine the cooperativity of various aspects of performance, and both examine the subject's response to naturally occurring stresses. In these two senses, the measures are dynamic. For the cardiovascular measure we conducted ambulatory monitoring of blood pressure and pulse at 7.5-min intervals over a 24-h period. These parameters were analyzed simultaneously to examine changes in one relative to the others, using spectroscopy. After appropriate filtering, several dominant ultradian rhythms were noted, with periods of 47 min, 180 min and 6 to 8 h, the latter rhythm being present only in subjects aged greater than or equal to 60. A battery of computer-administered cognitive tests was developed to assess reaction time, visual recognition memory and word recognition memory. This testing allows for both a time and performance level grading. The results of the computer battery correspond well with those for standard neuropsychological tests. In general, performance declined with age, and reaction time increased. The computerized tests are faster, more consistently administered, and do not rely on a skilled professional for administration or analysis. They also provide a wide variety of measures that can be used in isolating components of performance. Once the acceptability and tolerance of older subjects toward such testing was established, attention shifted to questions of measurement stability and discriminant validity. Since the project's primary purpose is to predict subtle measures of decline in function, the battery's ultimate test is in its ability to correctly identify those about to change functional status. However, many different measures of status change are possible, and the predictive accuracy will depend on the outcome chosen. Subsequent work will focus on the predictors to refine measures and compare data collected at one point in time with the predictive power of change scores that reflect the individual subject's "signature." By-products of this work include a wealth of longitudinal physiologic and neuropsychologic data on older persons and tools that may be useful to the practicing physician.

Aged↗

Preventive-comprehensive assessment (PCA): a new screening method for subclinical cognitive problems.

Physicians often need to be able to assess cognition in a simple way, particularly for screening of subclinical processes in aged people. This paper describes a new, quick test battery called preventive-comprehensive assessment (PCA). It consists of six various testing items (repetition of three words, back-spelling of the word "sport", problem searching ina complex picture, recall of the three words, three progressive colored matrices, clock drawing test), evaluating language, recent memory, executive function, judgment and thinking capacities. The total scores. compared to the normal performance of different age groups, allow us to distinguish between normal and pathological status. If abnormal results are recorded, we need to perform further and deeper neuropsychological investigations, in order to obtain the possibly exact diagnosis. The PCA battery is sensitive and reliable; it can be used in itself, or as a part of a more complex battery of an intense comprehensive evaluation (ICE), carried out in population screening aimed at promoting healthy and active aging.

Age Distribution↗

Suggestibility, social support, and memory for a novel experience in young children.

This study examined 5- and 6-year-olds' suggestibility and interviewer demeanor as joint predictors of their memory for a novel experience. Session 1 consisted of children taking part in a novel laboratory event. Session 2 took place after approximately a 1-week delay and consisted of children completing both a memory test concerning what happened during the prior event and the Video Suggestibility Scale for Children (VSSC). During the second session, the interviewer behaved either supportively or nonsupportively. Greater acquiescence on the VSSC was associated with fewer correct responses to misleading questions about the laboratory event in the supportive and nonsupportive conditions and with more errors in response to specific questions in the nonsupportive condition. Results indicate that individual differences in children's suggestibility are related to the accuracy of their memory for separate events, although some of these relations may vary depending on the context in which children are interviewed.

Child↗

Trace deletion, theta-roles, and cognitive strategies.

This paper reports a rather striking distinction found in the performance of agrammatic patients: Their comprehension deficit distinguishes not only different syntactic constructions, but also verbs with different thematic structure. Thus, the coupling of a variety of sentence types with different verb types yields surprising performance patterns, demonstrating once again that the deficit these patients suffer from is highly selective from a grammatical viewpoint. This pattern of selectivity has important implications for linguistic theory, for it describes an error pattern that can be accounted for only by a theory that assumes a (normal) lexicon that encodes thematic labels and refers to a thematic hierarchy. In addition, the results argue for the necessity of a cognitive strategy (first NP = Agent) as part of the structural account of agrammatic comprehension (the Trace-Deletion Hypothesis). It is shown that, contrary to some recent claims, an account lacking such a strategy cannot derive agrammatic performance patterns properly. New data are presented, from an experiment that used an anagram task to test agrammatic comprehension of active and passive sentences containing verbs of three different thematic types. Verbs varied in that their external argument was Agent, Instrument, or Experiencer. The finding was that on all active sentences, performance was above chance, whereas on the passives, performance split: on verbs with Agent or Instrument external arguments, performance was at chance, corroborating previous findings. On Experiencer verbs, though, performance was below chance. These data argue decisively for the TDH as originally presented, namely, for an account that assumes trace deletion, coupled with a strategy. The implications of these results to the theory of brain/language relations are discussed, in the context of the theory of lexical representation.

Adult↗

On crossed apraxia. Description of a right-handed apraxic patient with right supplementary motor area damage.

GP, a right-handed woman, without evidence of familial left-handedness, showed clearcut bilateral ideo-motor apraxia and oro-facial apraxia after a vascular lesion of the right hemisphere, encroaching upon the fronto-mesial region. She scored normally in most other cognitive tests, including language, but showed signs of callosal disconnection, left anarchic hand and mild unilateral spatial neglect. This cognitive profile points to the possibility of praxis being localized to the right hemisphere in this right-handed patient. We argue in favour of individual variability of praxis dominance, and maintain that this dominance might be completely right-sided in some subjects. Moreover the anatomical locus of GP's lesion points to the possible role that the frontal lobes (and more specifically the Supplementary Motor Area) play in the genesis of apraxia.

Agnosia↗

Dysgraphia in two forms of conduction aphasia.

Recent clinical observations, in the absence of experimental data, appear to suggest that written expression in conduction aphasics parallels their speech (Goodglass, 1992). The current study undertakes an analysis of word level writing in two conduction aphasics, and attempts to explore the posited 'parallel' relationship between speech production deficits and deficits in written expression. JL, a 66-year-old female with left posterior parietal lobe lesion and PP, a 65-year-old female with a left posterior temporo-parietal lobe lesion served as subjects of this study. Their response patterns on Boston Naming Test (BNT) and written naming task (John Hopkins Dysgraphia Battery) were utilized to verify the parallel hypothesis. Although both cases have exhibited phonological and semantic paraphasias on BNT, PP's overall performance was far superior to that of JL. JL produced numerous multiple responses to stimuli compared to PP's occasional multiple responses. PP's performance on the written naming task was far inferior to that of JL. JL's predominant error pattern in writing was the production of phonologically similar words to the target words. This paper argues that such seemingly contradictory, unpredicted patterns can be parsimoniously better explained, not by the parallel hypothesis but by current cognitive-neuropsychological models of writing.

Aged↗

Learning to read with underdeveloped phonemic awareness but lexicalized phonological recoding: a case study of a 3-year-old.

Case studies on very precocious readers are useful for examining what sources of knowledge and processes are necessary in the acquisition of reading. This is a case study of a 40-month-old child with a word reading age of 8 years 6 months. Tests indicated that she had no phoneme awareness beyond initial phonemes, and that her productive spelling was undeveloped. In reading she was highly proficient at rapid phonological recoding, both by correspondences that were contextually sensitive and those that were not. The former determined her high level of irregular pronunciations for irregular consistent non-words. Experiments indicated that she had well-specified orthographic lexical representations. It was concluded that her phonological recoding was an implicit process based on sublexical relations induced from her lexical representations rather than explicitly taught letter-sound correspondences. The implications of the results for major developmental models of reading acquisition are examined.

Analysis of Variance↗

Verbal fluency patterns in two subgroups of patients with Alzheimer's disease.

Previous research has identified two subgroups of patients with Alzheimer's disease (AD) based on performance discrepancies on semantic and visual-constructional measures: Left AD (LAD) and Right AD (RAD). In this study, verbal fluency performances (Animal Fluency [AF] and Letter Fluency [FAS]) of these two subgroups were examined. It was hypothesized that LAD patients would perform worse on AF compared to FAS, due to an underlying breakdown of left-hemisphere semantic networks. On the other hand, the RAD group, which theoretically has a relatively preserved semantic system, yet difficulties retrieving overlearned information, was not expected to differ on the two fluency tasks. These predictions were based on the notion that the AF task requires intact retrieval and semantic processes, whereas the FAS task is reliant on retrieval processes alone. Patients were classified into subgroups on the basis of performance discrepancies on the Boston Naming Test (BNT) and Copy tasks: LAD (BNT < Copy); RAD (BNT > Copy). A split-plot ANOVA using demographically corrected standard T-scores revealed a significant main effect for fluency task, and a significant subgroup x fluency task interaction. LAD patients performed poorer on AF compared to FAS; there was no fluency task difference for the RAD group. Analysis of within-subcategory response clustering on AF revealed more instances of serial subclass exemplar responses by RAD members. These results support the loss theory in explaining the semantic deficit of LAD, and suggest that retrieval difficulties underlie the fluency problems of RAD.

Aged↗

Proactive interference and the neuropsychology of schizophrenia.

Gray, Felden, Rawlins, Hemsley & Smith (1991) have proposed a theoretical model of the neuropsychology of schizophrenia. A major feature of this model is that it is a weakening of the influences of memories of previous input on current perception/learning which is basic to the phenomenon of acute schizophrenia. In the present study, proactive interference (PI) was used as a paradigm to test this hypothesis. PI occurs when new learning is diminished as a consequence of previously learned material. According to our reading of the Gray et al. (1991) model, acutely ill unmedicated patients with schizophrenia should demonstrate reduced PI relative to controls. Ten acutely ill unmedicated patients with schizophrenia, 20 patients suffering from major depressive disorder, and 20 healthy controls were assessed using a PI paradigm. No significant differences in PI emerged between the groups. The results do not support this specific feature of the neuropsychological model of acute schizophrenia proposed by Gray et al. (1991).

Acoustic Stimulation↗

Roots, stems, and the universality of lexical representations: evidence from Hebrew.

Is the structure of lexical representations universal, or do languages vary in the fundamental ways in which they represent lexical information? Here, we consider a touchstone case: whether Semitic languages require a special morpheme, the consonantal root. In so doing, we explore a well-known constraint on the location of identical consonants that has often been used as motivation for root representations in Semitic languages: Identical consonants frequently occur at the end of putative roots (e.g., skk), but rarely occur in their beginning (e.g., ssk). Although this restriction has traditionally been stated over roots, an alternative account could be stated over stems, a representational entity that is found more widely across the world's languages. To test this possibility, we investigate the acceptability of a single set of roots, manifesting identity initially, finally or not at all (e.g., ssk versus skk versus rmk) across two nominal paradigms: CéCeC (a paradigm in which identical consonants are rare) and CiCúC (a paradigm in which identical consonants are frequent). If Semitic lexical representations consist of roots only, then similar restrictions on consonant co-occurrence should be observed in the two paradigms. Conversely, if speakers store stems, then the restriction on consonant co-occurrence might be modulated by the properties of the nominal paradigm (be it by means of statistical properties or their grammatical sources). Findings from rating and lexical decision experiments with both visual and auditory stimuli support the stem hypothesis: compared to controls (e.g., rmk), forms with identical consonants (e.g., ssk, skk) are less acceptable in the CéCeC than in the CiCúC paradigm. Although our results do not falsify root-based accounts, they strongly raise the possibility that stems could account for the observed restriction on consonantal identity. As such, our results raise fresh challenge to the notion that different languages require distinct sets of representational resources.

Humans↗

Differential validity of the Defense Mechanism Manual for the TAT between Asian Americans and Whites. Thematic Apperception Test.

Thematic Apperception Test (Murray, 1943) responses of 69 Asian American (hereafter, Asian) and 83 White students were coded for defenses according to the Defense Mechanism Manual (Cramer, 1991b) and studied for differential validity in predicting paper-and-pencil measures of relevant constructs. Three tests for differential validity were used: (a) differences between validity coefficients, (b) interactions between predictor and ethnicity in criterion prediction, and (c) differences between groups in mean prediction errors using a common regression equation. Modest differential validity was found. It was surprising that the DMM scales were slightly stronger predictors of their criteria among Asians than among Whites and when a common predictor was used, desirable criteria were overpredicted for Asians, whereas undesirable ones were overpredicted for Whites. The results were not affected by acculturation level or English vocabulary among the Asians.

Acculturation↗

[Verbal learning and memory test in children. Analysis of it environmental validity].

BACKGROUND: The VLMT (auditory verbal learning and memory test) was constructed for use in children and adults. This study aimed at investigating the ecological validity in children. METHODS: In a retrospective study, data from 384 children were investigated. Correlations between the VLMT and a newly developed questionnaire (AVWS-Q) probing auditory processing skills were calculated. RESULTS: Significant albeit very weak correlations between VLMT items and AVWS-Q items were found. DISCUSSION: Results indicate that VLMT performance cannot be predicted by the AVWS-Q (neither as a sum score nor as questions regarding memory skills alone). Either the ecological validity of the VLMT has to be considered poor or the AVWS-Q does not probe memory skills sufficiently.

Child↗

Function of the left planum temporale in auditory and linguistic processing.

Previous research suggests that the human left planum temporale (PT) plays an important role in language. To test this hypothesis, functional MRI (fMRI) data were collected from 12 normal right-handed subjects during passive and active listening to words and tone sequences. Several left hemisphere areas, including the superior temporal sulcus, middle temporal gyrus, angular gyrus and lateral frontal lobe showed stronger activation during the word conditions. This was not true of the PT, which responded equally to tones and words during passive listening and more strongly to tones during active listening. The PT is likely to be involved in early auditory processing, while specifically linguistic functions are mediated by multimodal association areas distributed elsewhere in the left hemisphere.

Adult↗