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Supervised learning of semantic classes for image annotation and retrieval.

A probabilistic formulation for semantic image annotation and retrieval is proposed. Annotation and retrieval are posed as classification problems where each class is defined as the group of database images labeled with a common semantic label. It is shown that, by establishing this one-to-one correspondence between semantic labels and semantic classes, a minimum probability of error annotation and retrieval are feasible with algorithms that are 1) conceptually simple, 2) computationally efficient, and 3) do not require prior semantic segmentation of training images. In particular, images are represented as bags of localized feature vectors, a mixture density estimated for each image, and the mixtures associated with all images annotated with a common semantic label pooled into a density estimate for the corresponding semantic class. This pooling is justified by a multiple instance learning argument and performed efficiently with a hierarchical extension of expectation-maximization. The benefits of the supervised formulation over the more complex, and currently popular, joint modeling of semantic label and visual feature distributions are illustrated through theoretical arguments and extensive experiments. The supervised formulation is shown to achieve higher accuracy than various previously published methods at a fraction of their computational cost. Finally, the proposed method is shown to be fairly robust to parameter tuning.

Algorithms↗

Handling interaction in fuzzy production rule reasoning.

When fuzzy production rules are used to approximate reasoning, interaction exists among rules that have the same consequent. Due to this interaction, the weighted average model frequently used in approximate reasoning does not work well in many real-world problems. In order to model and handle this interaction, this paper proposes to use a nonadditive nonnegative set function to replace the weights assigned to rules having the same consequent, and to draw the reasoning conclusion based on an integral with respect to the nonadditive nonnegative set function, rather than on the weighted average model. Handling interaction in fuzzy production rule reasoning in this way can lead to a good understanding of the rules base and an improvement of reasoning accuracy. This paper also investigates how to determine from data the nonadditive set function that cannot be specified by a domain expert.

Algorithms↗

Pose-oblivious shape signature.

A 3D shape signature is a compact representation for some essence of a shape. Shape signatures are commonly utilized as a fast indexing mechanism for shape retrieval. Effective shape signatures capture some global geometric properties which are scale, translation, and rotation invariant. In this paper, we introduce an effective shape signature which is also pose-oblivious. This means that the signature is also insensitive to transformations which change the pose of a 3D shape such as skeletal articulations. Although some topology-based matching methods can be considered pose-oblivious as well, our new signature retains the simplicity and speed of signature indexing. Moreover, contrary to topology-based methods, the new signature is also insensitive to the topology change of the shape, allowing us to match similar shapes with different genus. Our shape signature is a 2D histogram which is a combination of the distribution of two scalar functions defined on the boundary surface of the 3D shape. The first is a definition of a novel function called the local-diameter function. This function measures the diameter of the 3D shape in the neighborhood of each vertex. The histogram of this function is an informative measure of the shape which is insensitive to pose changes. The second is the centricity function that measures the average geodesic distance from one vertex to all other vertices on the mesh. We evaluate and compare a number of methods for measuring the similarity between two signatures, and demonstrate the effectiveness of our pose-oblivious shape signature within a 3D search engine application for different databases containing hundreds of models.

Algorithms↗

Children with large heads: a practical approach to diagnosis in 557 children, with special reference to 109 children with megalencephaly.

Among 557 children who presented a diagnostic problem of a large head, 109 had megalencephaly as the primary diagnosis. A clinical approach to the differentiation of this numerically important group from the various other causes of large head is outlined. The group is characterised by a familial incidence of large head in at least 50 per cent of cases; a male to female preponderance of four to one; an above-normal rate of head growth in 80 per cent of the children in the first four months after birth, and in a further 12 per cent in late infancy. The vast majority of these children were normal. Only seven children were retarded, and they also had a variety of neurological and other somatic abnormalities.

Birth Weight↗

Effects of prenatal exposure to PCBs on the neurological function of children: a neuropsychological and neurophysiological study.

To determine the long-term neurotoxicity of prenatal exposure to polychlorinated biphenyls (PCBs), 54 children--27 'Yu-Cheng' ('oil disease') children and 27 controls--were administered a battery of tests, including the WISC-R, auditory event-related potentials (P300), pattern visual evoked potentials (P-VEPs) and somatosensory evoked potentials (SSEPs). Full-scale IQ scores on the WISC-R were lower for the Yu-Cheng group than for the control group. Mean P300 latencies were significantly longer, and P300 amplitude significantly more reduced, in the Yu-Cheng group than in the control group at Cz and Pz. There were no significant difference in peak latencies and amplitudes between the two groups for P-VEPs and SSEPs. These findings suggest that prenatal exposure to PCBs tends to affect high cortical function rather than the sensory pathway in the developing brain.

Child↗

Congenital hypothyroidism: age at start of treatment versus outcome.

We studied 27 patients with congenital hypothyroidism by neurological and psychometric methods. 7 healthy siblings served as a control group for the psychometric evaluation. In 7 patients treatment had been started before the age of 1 month and in 10 patients after the age of 3 months. Our findings suggest that the progressive loss of intelligence potential starts from birth but if treatment is begun before the age of 1 month, then intelligence remains within normal range. The neurological damage seems to originate partly before birth, but more serious injuries arise if treatment is delayed beyond the age of 3 months.

Age Factors↗

Use of the magnitude estimation technique for assessing the performance of text-to-speech synthesis systems.

As text-to-speech systems develop, it becomes necessary to compare various solutions and to evaluate whether a change in the synthesis procedure has an effect on the listener's attitude to the system. The possibility of directly scaling intelligibility, naturalness, and user's satisfaction (i.e., acceptability) with the magnitude estimation technique is investigated. A magnitude estimation protocol suitable for this purpose is described. In general, within the limits of the methodological constraints discussed in this paper, the procedure appears to be reliable and valid for quantifying the perceived attributes of synthesized speech.

Communication Devices for People with Disabilities↗

Neurological and adrenal dysfunction in the adrenal insufficiency/alacrima/achalasia (3A) syndrome.

Review of 20 patients with glucocorticoid deficiency (three cases also with salt loss) associated with absent tear secretion (19 cases) and achalasia of the cardia (15 cases) revealed neurological abnormalities in 17 including hyper-reflexia, muscle weakness, dysarthria, and ataxia together with impaired intelligence and abnormal autonomic function, particularly postural hypotension. These findings indicate that significant neurological problems are common in this multisystem disorder.

Addison Disease↗

Depth sense aesthesiometry: an advance in the clinical assessment of sensation in the hands.

Fingertip depth sense threshold has been examined in fifty normal subjects using the simple pocket aesthesiometer invented by Renfrew. Index fingers possessed the lowest thresholds and little fingers the highest, whilst there were no significant differences between the same fingers of either hand. Sex and age (at least up to 70 years) had no significant influence on depth sense threshold, but thickened skin and low intelligence tended to raise thresholds. Fingertip depth sense thresholds were then compared with the results of conventional sensory testing in fifty patients with sensory symptoms in the hands. The depth sense threshold of affected fingers was more often abnormal than were the results of clinical tests for light touch appreciation, joint position sense and two-point discrimination. Depth sense aesthesiometry is recommended as a simple, sensitive and quantifiable routine technique for the evaluation of sensory disturbance in the hands.

Age Factors↗

A multi-clustering fusion scheme for data partitioning.

A multi-clustering fusion method is presented based on combining several runs of a clustering algorithm resulting in a common partition. More specifically, the results of several independent runs of the same clustering algorithm are appropriately combined to obtain a distinct partition of the data which is not affected by initialization and overcomes the instabilities of clustering methods. Subsequently, a fusion procedure is applied to the clusters generated during the previous phase to determine the optimal number of clusters in the data set according to some predefined criteria.

Algorithms↗

Deriving pathway maps from automated text analysis using a grammar-based approach.

We demonstrate how automated text analysis can be used to support the large-scale analysis of metabolic and regulatory pathways by deriving pathway maps from textual descriptions found in the scientific literature. The main assumption is that correct syntactic analysis combined with domain-specific heuristics provides a good basis for relation extraction. Our method uses an algorithm that searches through the syntactic trees produced by a parser based on a Referent Grammar formalism, identifies relations mentioned in the sentence, and classifies them with respect to their semantic class and epistemic status (facts, counterfactuals, hypotheses). The semantic categories used in the classification are based on the relation set used in KEGG (Kyoto Encyclopedia of Genes and Genomes), so that pathway maps using KEGG notation can be automatically generated. We present the current version of the relation extraction algorithm and an evaluation based on a corpus of abstracts obtained from PubMed. The results indicate that the method is able to combine a reasonable coverage with high accuracy. We found that 61% of all sentences were parsed, and 97% of the parse trees were judged to be correct. The extraction algorithm was tested on a sample of 300 parse trees and was found to produce correct extractions in 90.5% of the cases.

Abstracting and Indexing↗

Learning beyond finite memory in recurrent networks of spiking neurons.

We investigate possibilities of inducing temporal structures without fading memory in recurrent networks of spiking neurons strictly operating in the pulse-coding regime. We extend the existing gradient-based algorithm for training feedforward spiking neuron networks, SpikeProp (Bohte, Kok, & La Poutré, 2002), to recurrent network topologies, so that temporal dependencies in the input stream are taken into account. It is shown that temporal structures with unbounded input memory specified by simple Moore machines (MM) can be induced by recurrent spiking neuron networks (RSNN). The networks are able to discover pulse-coded representations of abstract information processing states coding potentially unbounded histories of processed inputs. We show that it is often possible to extract from trained RSNN the target MM by grouping together similar spike trains appearing in the recurrent layer. Even when the target MM was not perfectly induced in a RSNN, the extraction procedure was able to reveal weaknesses of the induced mechanism and the extent to which the target machine had been learned.

Action Potentials↗

Architecture for an artificial immune system.

An artificial immune system (ARTIS) is described which incorporates many properties of natural immune systems, including diversity, distributed computation, error tolerance, dynamic learning and adaptation, and self-monitoring. ARTIS is a general framework for a distributed adaptive system and could, in principle, be applied to many domains. In this paper, ARTIS is applied to computer security in the form of a network intrusion detection system called LISYS. LISYS is described and shown to be effective at detecting intrusions, while maintaining low false positive rates. Finally, similarities and differences between ARTIS and Holland's classifier systems are discussed.

Animals↗

The ontological basis of strong artificial life.

This article concerns the claim that it is possible to create living organisms, not merely models that represent organisms, simply by programming computers ("virtual" strong alife). I ask what sort of things these computer-generated organisms are supposed to be (where are they, and what are they made of?). I consider four possible answers to this question: (a) The organisms are abstract complexes of pure information; (b) they are material objects made of bits of computer hardware; (c) they are physical processes going on inside the computer; and (d) they are denizens of an entire artificial world, different from our own, that the programmer creates. I argue that (a) could not be right, that (c) collapses into (b) and that (d) would make strong alife either absurd or uninteresting. Thus, "virtual" strong alife amounts to the claim that, by programming a computer, one can literally bring bits of its hardware to life.

Artificial Intelligence↗

Effect of cognitive impairment and premorbid intelligence on treatment preferences for life-sustaining medical therapy.

OBJECTIVE: This study examines the influence of cognitive impairment, premorbid intelligence, and decision-making capacity to complete advance directives on the treatment preferences for life-sustaining medical therapy in the elderly. METHOD: One hundred elderly individuals were recruited. Fifty were first referrals to specialist services with a DSM-IV diagnosis of dementia, and 50 were volunteers. Each person was asked about treatment preferences in three clinical vignettes. RESULTS: Elderly individuals who had cognitive impairment and were incapable of completing advance directives were significantly more likely to opt for life-sustaining interventions. There was no association between premorbid intelligence and treatment preferences. CONCLUSIONS: Cognitive impairment appears to influence treatment preferences for life-sustaining medical therapy. With increasing cognitive impairment, elderly individuals tend to opt for treatment interventions.

Advance Directives↗

Cognitive performance in relation to MRI temporal lobe volume in schizophrenic patients and healthy control subjects.

The aim of this study was to identify whether specific deficits in cognitive processing are present in schizophrenia and whether these are related to the volume of temporal and limbic structures. Twenty-seven schizophrenic outpatients were compared with 19 matched control subjects. Compared with control subjects, patients performed complex tasks disproportionately worse than they performed simple tasks. No group differences were found with regard to temporal and limbic volume. Volume of the parahippocampal gyrus was correlated with cognitive performance. The findings are interpreted as evidence for a dysfunction in the maintenance of task-relevant information and the inhibition of irrelevant information.

Adult↗