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Quality of life and rehabilitation of elderly dialysis patients.

Chronologic age per se does not measure the ability of an individual to benefit from dialysis. Elderly patients gain added lifetime on dialysis that is satisfying, and elderly patients as a group often show better psychosocial adjustment to dialysis than do younger patients. However, the limitations in physical functioning that characterize chronic dialysis patients increase with patient age. The clinical challenge is to identify factors that contribute to patients' compromised functioning and to arrange targeted supportive services. An integrated comprehensive program can address elderly dialysis patients' multiple care needs. Strategies that improve outcomes by reducing the risks of elderly persons for increased disability, assisting them to function in their usual environment whenever possible, can also have benefits.

Activities of Daily Living↗

Determinants in APD selection.

Automated peritoneal dialysis (APD) is the most prevalent form of peritoneal dialysis in the United States. Optimizing the success of this treatment requires appropriate patient selection; however, there are few data available on which patients are most likely to benefit the most from this form of therapy. The key factors to evaluate when APD is being considered include patient preferences and lifestyle, patient age, solute transport characteristics, residual renal function (RRF), cost, dialysis adequacy targets, and the potential for complications of therapy. Patients who prefer home dialysis at night, children, those with high average or high peritoneal transport characteristics, and those with significant RRF are ideal candidates for APD. Because of the flexibility that is possible in prescribing this form of dialysis, APD can be successfully performed in individuals who do not meet this ideal profile, and it can be an excellent form of dialysis, particularly as part of an integrated care program for patients with end-stage renal disease (ESRD).

Adult↗

[Navigation in knee endoprosthesis implantation--preliminary experiences and prospective comparative study with conventional implantation technique].

OBJECTIVES: The efficiency of a computer-integrated instrumentation system in knee arthroplasty was evaluated and compared with a conventional instrumentation system. BACKGROUND: The OrthoPilot System defines the individual axis of the leg by means of an intraoperative kinematic analysis. LED's mounted on rigid bodies and screwed to the pelvis, femur and tibia are localized by a 3D infrared camera which is linked to a UNIX work station. The integrated calculation program leads to definition of the centres of hip, knee and ankle. Thereafter, LED-equipped alignment instruments allow definition of the femoral and tibial main resection planes. METHOD: The first sixty cases were included in the study. In addition, thirty cases each were entered into an OrthoPilot group and in a similar conventional control group. The navigated cohort consists of cases one to thirty, thus enclosing the "learning curve". RESULTS: Leg axes and femoral and tibial angles were assessed radiographically at the three-months postoperative control. Radiological measurements of the OrthoPilot group were clearly superior to those of the manual group. The differences, however, were not statistically different in the parameters "mechanical axis", "femoral axis lat." and "tibial axis ap.". With regard to the parameter "tibial axis lat." a significant difference in favour of the navigation system was observed. The measurements of "femoral axis ap." were insignificantly better in the manual group. In general, a slight tendency towards valgus positioning of the femoral components when using the navigation system has to be discussed. Complications influencing the clinical outcome did not occur. Additional time for navigation is calculated in a range of ten to fifteen minutes. CONCLUSIONS: The OrthoPilot system clearly facilitates proper alignment of endoprosthetic components in femur and tibia. Generally, the obtained values representing endoprosthetic alignment are superior to conventional technique. Marked deviations from ideal alignment can almost be avoided by means of the navigation system. During the learning curve the OrthoPilot system gained in reliability and reproducability.

Aged↗

Initiation of lung immunity: the afferent limb and the role of dendritic cells.

The lung is the largest epithelial surface in the body and constitutes a major portal of entry for microorganisms. Dendritic cells (DCs) are bone marrow-derived cells that populate the respiratory tract from the nasal mucosa to the lung pleura. DCs are dexterous cells playing a role in both the innate and the adaptive immune responses. DCs can respond to dangers in the lung by immediately generating protective cytokines that stimulate natural killer (NK) cells to produce cytokines and kill targets. Direct (by pathogen recognition receptors) and indirect (by inflammatory cytokines) recognition of the infectious agent can also trigger signaling pathways in the DCs that activate an integrated developmental program called maturation, which transforms DCs into efficient antigen-presenting cells (APCs) for naive T cell stimulation. Furthermore, DCs play a role in generating effector B cells in the lymph nodes draining the lung. This review focuses on how DCs sense the health of the lung and translate messages regarding the lung microenvironment to cells of the innate and adaptive immune response to initiate effector functions to clear an invading microorganism [T helper 1 (Th1) or Th2 response] or generate tolerance [T regulatory (Tr), anergy, or deletion] to inhaled antigen when no danger is sensed.

Journal Article↗

[Out-patient palliative care of children with cancer and their families].

Pediatric palliative care is still in its beginning. Most children with life-threatening disorders succumb with incomplete symptom control under in-patient conditions. Due to the limited number of patients and large hospital-home distances the realization of out-patient concepts of palliative care especially for children and adolescents with cancer is purposeful and beneficial. In a pilot project such an a aforementioned concept of pediatric palliative care proved successfully working despite insufficient conditions. Guidelines of pediatric palliative care are to be defined at short notice in order to ascertain autonomy and mobility of patients aiming at highest possible quality of life. The recently initiated program of integrating ambulatory and in-patient care within the regulations set forth in Germany's last health care system reform offers the chance of palliative home care of children in their terminal phase of life.

Adolescent↗

Neonatal imprinting predetermines the sexually dimorphic, estrogen-dependent expression of galanin in luteinizing hormone-releasing hormone neurons.

The incidence of colocalization of galanin (GAL) in luteinizing hormone-releasing hormone (LHRH) neurons is 4- to 5-fold higher in female than male rats. This fact and the finding that the degree of colocalization parallels estradiol levels during the estrous cycle suggest that GAL is an estrogen-inducible product in a subset of LHRH neurons. To analyze further this paradigm we evaluated the effects of gonadectomy and steroid replacement therapy in male and female rats. Ovariectomy resulted in a significant decrease in the number of cells colocalizing LHRH and GAL, whereas estradiol replacement to such animals restored the incidence of colocalization to that observed in controls. In males, however, estradiol treatment failed to enhance the incidence of colocalization of GAL and LHRH, indicating, therefore, that the colocalization of these peptides is gender-determined. This possibility--i.e., gender-specific determination of LHRH neurons coexpressing GAL--was evaluated by neonatal manipulation of hypothalamic steroid imprinting. As mentioned above, male rats did not respond to estrogen or testosterone by increasing GAL/LHRH colocalization as females did. Neonatally orchidectomized rats, whose hypothalami have not been exposed to testosterone during the critical period, when treated with estrogen in adulthood showed an increase in colocalization of GAL and LHRH similar to that seen in female animals. These observations indicate that the colocalization of LHRH/GAL is neonatally determined by an epigenetic mechanism that involves the testis. In summary, this sex difference in the incidence of colocalization of GAL and LHRH represents a unique aspect of sexual differentiation in that only certain phenotypic characteristics of a certain cellular lineage are dimorphic. The subpopulation of LHRH neurons that also produces GAL represents a portion of the LHRH neuronal system that is sexually differentiated and programed to integrate, under steroidal control, a network of LHRH neurons that could synchronize their activity to control the estrous cycle in rats.

Animals↗

Prevention of PID: a challenge for the health service.

The control of sexually transmitted diseases (STD) will reduce the prevalence of pelvic inflammatory disease (PID). In most developing countries, treatment services are limited, coverage of the infected female population is inadequate and women seeking treatment are likely to be mismanaged. Family planning clinics do not usually provide routine screening for non-pregnant women. Screening only at family planning clinics would result in failure to treat some high-risk individuals, especially unmarried adolescents. The use of simplified protocols in the community has been recommended, but these may underestimate the problems of contact tracing, provide no systematic screening and induce passivity in the patient. For pregnant women, STD control has targetted syphilis, which does not cause PID. An integrated service for the management of reproductive health is required, and the development of women's clinics is suggested, using well-trained nurses and affordable technologies.

Community Health Services↗

Integration of schistosomiasis-control activities into the primary-health-care system in the Gizan region, Saudi Arabia.

A few decades ago, the prevalence of Schistosoma haematobium infection in the human inhabitants of the Gizan region of Saudi Arabia was very high (43%-91%). A vertical programme for the control of the disease, by case finding, treatment of infected individuals and by chemical snail control, was begun in 1974 and led to significant reductions in prevalence in most areas. In 1989 the control activities were gradually integrated into the primary-health-care (PHC) system. Several schools in the area recently participated in the detection of ova (among schoolchildren and neighbouring communities) and organized health-education sessions. The records taken during the vertical and PHC programmes indicate that there were more diagnoses and higher chemotherapy coverage in the latter. The PHC programme has maintained the overall prevalence of infection at an extremely low level (< 1%) and the infection has been completely eradicated in several areas. The participation of schools proved to be particularly useful in terms of population coverage and health education.

Animals↗

Event recording in psychiatric care: development of an instrument and 1-year results.

Methods for regular monitoring of care and services are needed for psychiatrists to act on, to refine practice. We developed a computer-based instrument to be used by staff working with schizophrenic patients. The instrument was tested in a group of patients randomly assigned to an integrated-care program. Data on time, place, direct/indirect contacts, and the main elements of the content of care were regularly recorded on a pocket computer and later transferred to a desktop computer for analysis. One-year data on 24 subjects are presented on three levels: individual, case load, and total patient population. Of the encounters 66% were individual patient contacts. Staff spent 59% of the time at patients' homes. A computer-aided system with built-in information on care delivery, program fidelity, and outcome can be the basis of decision-making on different health-management levels.

Adult↗

The Minnesota Cancer Pain Project: design, methods, and education strategies.

The Minnesota Cancer Pain Project (MCPP) is a community-based research project to test various innovative education strategies for improving cancer pain management (CPM) in Minnesota. The main hypothesis is that community-based, multidisciplinary and integrated education programs can improve CPM and change knowledge, attitudes, and behaviors regarding CPM in cancer patients, their families, and community physicians and nurses. The specific aim of the MCPP is to demonstrate effective methods to improve CPM in communities. The MCPP design is a randomized trial with before- and after-intervention assessments of cancer pain and CPM knowledge, attitudes, and behaviors among cancer patients and their families, physicians, and nurses. The unit of randomization and study is the community, with six Minnesota communities participating in the MCPP. This paper describes the hypotheses, design, methods, and education strategies of the MCPP. Baseline data from the participating communities and the cancer patient sample are reported.

Family↗

Hospice and palliative care education in medical school: a module on the role of the physician in end-of-life care.

BACKGROUND: As a part of a program to integrate comprehensive palliative care education at the University of Maryland School of Medicine, a new teaching module was incorporated into the Introduction to Clinical Practice course for freshman medical students. METHODS: The module is entitled "The Role and Responsibility of the Physician in Palliative and End-of-life Care: the Inter-disciplinary Team Approach." The teaching objectives are: 1) describe the value of palliative and end-of-life care as a professional practice; 2) delineate the barriers to physician competence in end-of-life care; 3) describe the concept of hospice and the multidisciplinary approach to the care of the terminally ill; 4) List the fundamental areas of knowledge and skills required for a physician to be an effective member of the palliative care team. The format of the module is a 30-minute didactic/interactive overview of the teaching objectives, followed by a 30-minute videotape "Care Beyond Cure," produced by the National Hospice Organization. The class then breaks up into small groups to discuss, over a two-hour period, a hypothetical illustrative case. RESULTS AND CONCLUSIONS: The module was applied to the freshman medical student class in the 1995-1996 academic year. All freshmen were required to take it. Outcome evaluation utilized tools to assess attitude and cognitive domains. The attitude survey revealed that the majority of the students agreed that care of the dying could be a rewarding experience for the physician (72%) and that the case had helped them to understand the physician's role (93%). Overall, 82% wanted to learn more about the subject. Cognitive assessment tools indicated that the students satisfactorily understood the fundamental definitions of palliative care and hospice.

Attitude to Death↗

Adherence to dietary regimens. 2: Components of effective interventions.

Diet has an important impact not only on health but also on daily functioning, cognitive performance, and, perhaps, psychological well-being. Much is known about the specific dietary changes necessary to improve these factors, yet it becomes ever more clear that information about proper diet is rarely sufficient to change dietary behavior. Interventions aimed at changing diet must consider the typical dietary practices of the population in question and, as a corollary, must deal with the cultural obstacles to eating the "proper" foods. Psychological factors are paramount in setting the stage for dietary change. These include the individual's perception of being at risk, perceived benefits of a change in diet, confidence that the necessary change can be made, and the symbolic and real role food plays in a person's life. Nutrition education has traditionally focused on what changes should be made, and behavioral psychology has emphasized how to make the changes. These two fields must come together, and there must be recognition that nutrition education can provide necessary information, and behavioral change strategies can provide the necessary skills. There is now a considerable amount of information on strategies for nutrition education and on principles and techniques for behavioral change. Many intervention programs to alter dietary behavior have been undertaken. These have varied from programs aimed at an entire country, such as the National Cholesterol Education Program in the United States, to programs aimed at individuals. Although these vary considerably in size, strategy, and effects, collectively they yield valuable information on effective methods for changing behavior and for maintaining behavioral change. Programs that integrate behavioral procedures such as self-monitoring, stimulus control, coping skills, and relapse prevention appear to hold the most promise. Policy is an area that has received little attention as a means of changing dietary behavior. Government officials have made major efforts to enhance food safety, improve nutrition labeling on foods, and educate the public about a balanced diet. Much more may be possible, however. Financial incentives might be offered to increase production of healthy foods, thereby lowering cost and increasing availability. Legislation could govern food advertising and food availability (eg, vending machines) to which the entire population or selected groups (eg, children) are exposed. Existing studies on dietary adherence span different interventions, populations, disease targets, methods of evaluation, and other factors, so it is not surprising that results across studies are mixed. Enough of the studies have shown positive findings, however, to lead to the conclusion that meaningful dietary modification is possible, at least in some individuals making some dietary changes.(ABSTRACT TRUNCATED AT 400 WORDS)

Adult↗

An integrated behavioral medicine approach to improving care of patients with diabetes mellitus.

A detailed approach to integrating behavioral techniques into patient education, case management, and treatment evaluation of persons with diabetes mellitus is offered. The author asks a series of "what if" questions to stimulate new thinking about ways to improve patient-physician relations in overcoming problems in managing the condition, citing recent research findings in the field. Adherence to regimens, self-management, goals of an integrated diabetes program and steps along the way to achieving it, psychophysiologic mechanisms in glucose metabolism, and the function of social support are among the topics covered.

Behavior Therapy↗

AIDS in Africa.

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Acquired Immunodeficiency Syndrome↗

Integrating training systems for occupational health and safety, quality and environmental management.

Quality, occupational health and safety, and environmental issues are three key areas that, along with productivity and service, must be managed effectively. Organizations face the need to develop integrated systems for the management of these areas. As organizations increasingly need to seek efficiencies, one field in which such integration can bring considerable gains is training. The present paper examines how the requirements for training in different areas overlap and how an integrated training program may be developed.

Environmental Health↗