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At least 1,567 records · Page 87Linked to original sources
PubMed1989

[Complications of Redon drainage following hip joint replacement operations--an analysis of the causes].

After the introduction of Redon high-vacuum drainage, a considerable decrease in post-operative haematomas has been noted. But some of the complications could not be prevented by using the Redon system. They were in fact the result of it. The Redon system cannot be classified as a "closed" wound drainage. During bottle replacement, the system must be disconnected. An effective closed system must remain absolutely tight from application to removal of the drain so no possibility exists of contamination/infection from the outside. After introduction of a continuously absolutely closed system in a prospective study with three different systems the influence after hip joint arthroplasty operations on wound healing was investigated. The wounds were drained with the Redon high-vacuum system or the newly developed, permanently closed drainage system with maximum obtainable low pressure of 80% vacuum and 50% vacuum. Here the maximum obtainable vacuum builds up slowly in relation to the accumulated amount of wound fluids. The loss of low pressure in Redon systems differs between the drains. In the intra-articular drains the mixture of air and blood results in a linear decrease and follows not a hyperbola like in subcutaneous drains. Because of the high suction at the beginning of the Redon drainage necrotic muscle cells adhere to the outside of the drain openings and clogs them up mechanically. The stronger the suction effect on the tissue, the more fatty live cells and small vessels enter the lumen of the drain in the Redon system and 80% vacuum. This mechanisms result in bleeding from the drain canal after removal of the drain and "secondary" haematomas.(ABSTRACT TRUNCATED AT 250 WORDS)

Equipment Design↗
PubMed2006

The predictive power of surface profile parameters on the amount of wear measured in vitro on metal-on-polyethylene artificial hip joints.

Various studies report a weak correlation between the average surface roughness R(a) of metallic ballheads and the observed wear rate of the polyethylene cups coupled to them. The aim of this study is to verify, with controlled in vitro experiments, whether other parameters such as the total roughness R(t), and the skewness R(sk) are better predictors of the polyethylene wear when the metallic heads present a surface conditioning that varies substantially from specimen to specimen, as is usually the case with retrieved specimens. Twelve CoCrMo (cobalt-chromium-molybdenum) ballheads were intentionally damaged in order to reproduce a wide spectrum of surface conditioning and were then subjected to the standard wear test against polyethylene cups, using a hip joint wear simulator. After 2 x 10(6) cycles the weight lost by the cups was assessed with a gravimetric procedure, and the surface roughness of the metallic ballheads was qualified in terms of R(a), R(t), and R(sk). The various parameters were correlated to the weight loss using a linear regression analysis. The skewness R(sk) showed a coefficient linear regression R2 = 0.80, while the average roughness R(a), used in most previous studies, presented an R2 = 0.56. It was concluded that when specimens with substantially different surface conditioning are compared, as in retrievals analysis, it is also important to report the skewness R(sk) so that qualify the surface roughness of the specimens can be qualified.

Coated Materials, Biocompatible↗
PubMed2001

Identification of sequence polymorphisms of the COMP (cartilage oligomeric matrix protein) gene and association study in osteoarthrosis of the knee and hip joints.

Osteoarthrosis (OA) is a common cause of musculoskeletal disability characterized by late-onset degeneration of articular cartilage. Although several candidate genes have been reported, susceptibility genes for OA remain to be determined. Hereditary osteochondral dysplasias produce severe, early-onset OA and hence are models for common idiopathic OA. Among them are pseudoachondroplasia and multiple epiphyseal dysplasia, both of which are caused by mutations in the cartilage oligomeric matrix protein (COMP) gene. Therefore, COMP may be a susceptibility gene for OA. We screened for polymorphisms by direct sequencing of all exons of the COMP gene with their flanking intron sequences and the promoter region. We identified 16 polymorphisms, of which 12 were novel. Using six polymorphisms spanning the entire COMP gene, we examined the association of COMP in Japanese patients with OA of the knee and hip joints. Genotype and allele frequencies of the polymorphisms were not significantly different between OA and control groups, and there was no significant difference in haplotypes. These results do not support an association between COMP and OA in the Japanese population.

Cartilage↗
PubMed1988

Biologic fixation of a press-fit titanium hip joint endoprosthesis.

The rectangular cross section of a straight-stem prosthesis makes a primary stable, rotation-safe fixation possible that is independent of the individual form of the femur. Due to the curvature of the femur, a three-dimensional large-area anchorage is achieved along the entire prosthesis length in the corticalis as well as in the spongiosa. The titanium-aluminum-niobium alloy is extremely biocompatible and enables the fast ongrowth of newly formed osseous tissue to act as secondary stabilization. Pathohistologic examinations on the prostheses of deceased patients show that this osseointegration leads to a complete osseous ingrowth of the implant. The average surface roughness of 3-5 microns, with which the entire prosthesis length is structured, supports this osseointegration. This microroughness is, therefore, totally sufficient for the primary and secondary stabilization of the implant. The osseous fixation of the prosthesis over the entire stem length guarantees a physiologic and functional load transmission to the surrounding femoral bone, thus avoiding stress shielding. The combination of a ceramic ball head with a polyethylene cup results in less wear than is the case with the customary metal-polyethylene combination and, thus, prolongs the life span of artificial hip joints. Good results in the future can only be expected in osseointegrated implants with minimal wear of the synthetic material.

Adult↗
PubMed1996

[Results of a multicenter study of chondroitin sulfate (Condrosulf) use in arthroses of the finger, knee and hip joints].

61 patients, suffering from osteoarthritis of the hip, knee and/or finger joints, were included into this open, multicenter, phase IV trial. Patients were treated with chondroitinsulfate (CS) at the recommended dose for 3 months. Concomitant NSAID-therapy, which was necessary for disease control at the beginning of the observation period could be reduced by 72% throughout the 3 months of CS-therapy. The decrease of pain was revealed to be statistically significant; serious side effects were not to be observed during the study. At the beginning of the observation period patients suffered from overall severe pain, and therefore the decrease of pain down to a level, which could not have been achieved by NSAID therapy alone to a greater extent, is of special interest. The results of this trial represent the first office based Austrian data on CS-therapy. In conclusion it could be demonstrated that a significant reduction of the daily NSAID consumption was possible by concomitant CS-therapy, without the risk of deterioration of the patients' symptoms. The 97% compliance does not give evidence for drop-out bias. Moreover, the results of this trial are comparable to other international double-blind, in part placebo-controlled studies, concerning CS-therapy, indicating beneficial results in the treatment of osteoarthritis.

Administration, Oral↗