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PubMed1996

Is carotid endarterectomy cost-effective? An analysis of symptomatic and asymptomatic patients.

BACKGROUND: The North American Symptomatic Carotid Endarterectomy Trial (NASCET) and the Asymptomatic Carotid Atherosclerosis Study (ACAS) showed significant risk reductions for carotid endarterectomy (CE) but did not consider the cost-effectiveness of CE. METHODS AND RESULTS: We developed Markov models based on NASCET and ACAS to simulate hypothetical cohorts of patients with carotid stenosis and calculated quality-adjusted life expectancies and direct medical costs for those receiving either CE or medical therapy. For symptomatic patients, we used a surgical stroke risk of 5.8%, a 2-year stroke risk of 27.6% for medical patients, and a post-30-day surgical risk reduction of 87% for ipsilateral strokes. For symptom-free patients, we used a surgical stroke risk of 1.7%, a 5-year stroke risk of 17.5% for medical patients, and a post-30-day surgical risk reduction of 74% for ipsilateral strokes. Cost and quality-of-life estimates were estimated from the literature. The incremental cost-effectiveness ratio of CE versus medical therapy was $4100 and $52700 per quality-adjusted life year (QALY) gained for symptomatic and symptom-free patients, respectively. Incremental cost effectiveness ratios were < $50000/QALY gained for symptomatic patients for wide variations in baseline assumptions. For asymptomatic patients, the incremental cost-effectiveness ratio was $100900/QALY gained if the perioperative risk was 4%, $36400/QALY gained if the risk of untreated patients was doubled, and $13500/QALY gained if the cost of CE was halved. CONCLUSIONS: Performance of CE is associated with favorable incremental cost-effectiveness ratios compared with other accepted medical interventions; however, the analysis for symptom-free patients was sensitive to a number of parameters.

Aged↗
PubMed1996

Intraoperative color-flow duplex ultrasonography following carotid endarterectomy.

Intraoperative color-flow duplex ultrasonography represents the state-of-the-art imaging following carotid endarterectomy. At a reasonable cost and at no risk to the patient, it provides a high-resolution image of the operative site and reproducible hemodynamic velocity measurements. Although significant technical abnormalities have been noted in approximately 10% of patients, important lesions are found in only 5% of common or internal carotid arteries. In our opinion, these common and internal carotid artery defects represent the lesions that should be re-explored and corrected prior to leaving the operating room. The most cost-effective way to utilize intraoperative color-flow duplex ultrasonography is to arrange a 15- to 20-minute visit to the operating room by a technologist bringing a duplex scanner from the vascular laboratory or department of radiology. If the surgeon is not experienced in performing duplex ultrasonography, the test should be performed in conjunction with another physician, surgeon, or radiologist who specializes in ultrasound. In our experience, color-flow duplex ultrasonography enhances endarterectomy technique and consequently minimizes postoperative strokes and restenosis.

Endarterectomy, Carotid↗
PubMed1996

Myocardial revascularization procedures on multisegment diseased left anterior descending artery: endarterectomy or multiple sequential anastomoses (jumping)?

Complete revascularization is the primary goal in coronary surgery because of its superior long term results. However, in some patients the extent of the coronary artery disease is such that the usual coronary bypass technique may not allow to perform a complete myocardial surgical revascularization and, consequently, a satisfactory myocardial perfusion: so complementary revascularization techniques may become mandatory, especially when the diseased vessel is LAD or its branches. As a consequence, alternative procedures should be undertaken: coronary endarterectomy (EA) and multiple sequential anastomoses on a single vessel (jump), which guidelines are actually somehow controversial. Between January, 1989, and May, 1992, 53 patients underwent a myocardial revascularization procedure on LAD system unsuitable for single distal bypass; of them 35 (66%) underwent coronary endarterectomy, while in 18 (34%) multiple sequential anastomoses (jumping) were performed on the same vessel. About preoperative variables, average NYHA class (2.7 jump vs 2.1 EA group, p < 0.05), the history of more than 1 myocardial infarction (22.2% jump vs 2.9% EA, p < 0.04) and the presence of preoperative nitrates e.v (33.3% vs 8.6%, p < 0.04) were statistically higher in the jump group, suggesting a more unstable clinical status, while other clinical echocardiographic and catheterization features were not statistically different. For what operative and postoperative features are concerned, the number of anastomoses performed was statistically higher in the jump group, as exasperated (3.8 vs 2.7, p < 0.002) while perfusion (138 vs 141 min) and crossclamp time (103 vs 106 min) were similar. Furthermore we found a statistically lower incidence of perioperative myocardial infarction (0% jump is 22.8% EA group, p < 0.04); the postperfusion inotropic drugs requirement (22.2% vs 37.1%), the need of an intraaortic counterpulsation (0% vs 2.9%) and the in-hospital mortality (0% vs 5.7%) were lower in the jumping group too, also if they didn't reach statistical significance. Our experience suggest, also with the limits imposed by a retrospective case review and by a low number of cases reported, that myocardial revascularization of a multisegment diseased LAD system may be safely performed with the jumping technique with a low incidence of postoperative complications: it should be the first choice technique when conventional revascularization procedures are not enough to achieve complete myocardial revascularization. We advocate the use of EA technique only in that cases characterized by a diffuse atherosclerotic core and a well delimited plane of dissection, associated to a very poor runoff, which really excludes any chance to multiple anastomoses.

Aged↗
PubMed1996

The value of routine computed tomography of the brain in the pre-operative assessment of patients for carotid endarterectomy.

OBJECTIVE: To determine the prevalence of brain infarcts and other intracranial pathology on computed tomography (CT) in patients with greater than 50% internal carotid artery stenosis. DESIGN: Descriptive study of CT findings. SETTING: Referral-based cohort at Groote Schuur Hospital. PARTICIPANTS: Sixty-three patients aged 40-82 years who had CT of the head prior to carotid endarterectomy. MAIN OUTCOME MEASURES: Prevalence of brain infarct in patients presenting with transient ischaemic attack (TIA) or stroke, and yield of unsuspected intracranial pathology other than ischaemic necrosis. RESULTS: Brain infarcts were diagnosed in 54% of patients presenting with TIA and in 73% of patients with stroke. True-positive CT scans were present in only 19% and 44% of patients with TIA and stroke, respectively. A single incidental frontal lobe granuloma, unrelated to the patient's clinical presentation, was noted. CONCLUSIONS: In the selected group of patients referred for carotid endarterectomy, routine use of CT of the head is not indicated and can be reserved for cases with extraordinary clinical features.

Adult↗
PubMed1996

Colour-coded duplex assessment alone before carotid endarterectomy.

This study assessed whether carotid colour-coded duplex imaging can provide sufficient information to investigate patients before carotid endarterectomy. One hundred patients with symptomatic carotid artery disease (amaurosis fugax 24, transient ischaemic attack 38 and established stroke 38) were assessed by both colour-coded duplex imaging and arch angiography. Stenoses were graded at angiography using the linear method from the European Carotid Surgery Trial and on duplex using peak systolic velocity criteria. Angiograms were also analysed for any arch or intracerebral pathology which would alter surgical management. In defining 70-99 per cent stenoses, duplex had a sensitivity of 98 per cent, specificity 96 per cent, positive predictive value of 96 per cent, negative predictive value 98 per cent and accuracy 97 per cent compared with angiography for both symptomatic and asymptomatic carotids (chi 2 = 1.22, 1 d.f., P = 0.25). With respect to the symptomatic carotid arteries angiography gave different information from duplex in six patients (6 per cent): definition of 70-99 per cent carotid stenosis was different (four), visualization was poor on duplex (one) and an intracerebral aneurysm was identified by angiography. One patient died following arch angiography as a result of mesenteric thrombosis. Carotid duplex imaging alone would appear to be sufficient to assess most patients before carotid endarterectomy as an accurate, safe and relatively cheap investigation compared with angiography. In cases where duplex assessment does not allow full visualization of the carotid bifurcation angiography is required.

Adult↗
PubMedDate not supplied

[Carotid endarterectomy: what postoperative care is needed?].

With the introduction of the diagnosis-related groups system (DRGs), hospital cost containment without compromising quality of care is recommended. Carotid endarterectomy is an effective stroke prevention treatment; the need for routine postoperative intensive care unit (ICU) admission is questionable and is herein evaluated. Between January 1994 and November 1995, 68 patients underwent 79 carotid endarterectomies (CEAs), under general anesthesia, and were postoperatively monitored in a post-anesthesia care unit. 13 patients presented postoperative hypertension and 3 arrhythmia, while 5 patients (7.3%) experienced postoperative complications. Only 8 patients (11.7%) were admitted in ICU for treatment of persistent hypertension (3 cases) with continuous vasoactive drug infusion or because of postoperative complications. One patient (1.4%) died of post-CEA hyperperfusion syndrome. The use of a step down unit for monitoring patients undergoing CEAs is safe and cost-effective and also may identify patients requiring ICU admission.

Aged↗
PubMed1996

[Pulmonary thrombo-endarterectomy].

Chronic pulmonary thromboembolism is an underdiagnosed condition with major morbidity and mortality. Over the past year and a half, we diagnosed 6 new cases of which 3 underwent successful, pulmonary thrombo-endarterectomy (2 in San Diego, 1 in Jerusalem). All recovered fully and returned to normal, active life. We conclude that pulmonary thrombo-endarterectomy is a viable option for patients with chronic pulmonary thromboembolism.

Adult↗
PubMed1997

Regional/local anesthesia: a safe and reasonable choice for patients undergoing carotid endarterectomy.

PURPOSE: The study compares the outcome of carotid endarterectomy in the community hospital setting using regional versus general anesthesia. METHODS: Two hundred thirty-six consecutive operations performed on 200 patients (99 operations using superficial and deep cervical block with local supplementation, and 137 procedures using general anesthesia) during a three-year period were analyzed retrospectively. Noncontinuous data were analyzed using Pearson chi-square, continuous data using Student's t-test. RESULTS: Demographic data and risk factors were similar for both groups. However, patients in the regional anesthesia group had a higher incidence of contralateral stroke and a lower incidence of peripheral vascular disease than patients in the general anesthesia group. Shunts were used less frequently for the regional anesthesia group. The neurologic complication rate was 2.2% for the general anesthesia group and 2.0% for the regional anesthesia group. The single death (fatal stroke) occurred in the general anesthesia group. Four of five major cardiopulmonary complications occurred in the general anesthesia group. CONCLUSIONS: Carotid endarterectomy can be performed with an acceptable neurologic complication rate under either type of anesthesia. Use of regional anesthesia decreases intraoperative shunting and may decrease the rate of cardiopulmonary complications.

Aged↗
PubMed1996

[Carotid endarterectomy combined with myocardial revascularization: report of 27 patients].

Atherosclerosis is a systemic disease that may involve more than one territory. Myocardial infarction can occur after carotid endarterectomy and stroke is a well documented morbidity of coronary artery bypass grafting. To optimize results, we have performed concomitant carotid endarterectomy and myocardial revascularization in selected cases, with severe disease in both territories. During a 13-year period, 27 patients were submitted for this procedure, 21 (77.8%) were male and the average age was 67.6 years (range 59-81). All patients had high-grade internal carotid artery stenosis, five (18.5%) were symptomatic. Coronary artery disease symptoms were: unstable angina in 12 patients (44.4%) and effort angina in 15 (55.6%). Two patients (7.4%) required reintervention for postoperative bleeding. Two cases (7.4%) had transient renal dysfunction. One patient, with multiple organ failure, died on the 16th postoperative day (3.7%). Follow up was obtained in 26 patients (96.3%). Survival at 5 years was 80.6%, 95.7% of those patients were free of any neurologic symptom. Combined carotid and coronary surgery is a safe treatment option for atherosclerosis of multiple territories in selected patients; long term benefits are also obtained.

Aged↗
PubMed1997

Computerised audit of carotid endarterectomy: audit loopholes closed?

The number of carotid endarterectomies being performed in the UK is increasing. The role of carotid endarterectomy (CEA) in the prevention of stroke depends on the procedure being associated with as few operative strokes as possible. Good clinical practice, with minimum morbidity, depends upon the integration of recent advances. Continuing audit has been used to examine changes in surgical practice and in case mix. There was a combined death and permanent stroke rate of 3.6% after 333 CEAs in a 6-year period (1990-1995) compared with 4.4% in 203 CEAs in an earlier 5-year audit period (1985-1989). The impact of an increase in the number of operations performed after recovered strokes, those performed by trainees and the use of prosthetic patches on the results of CEA has been assessed. Specific areas to be targeted in future audits are identified.

Adult↗
PubMed1997

The changing indications for carotid endarterectomy in the UK.

In early series the majority of carotid endarterectomies were performed in patients with amaurosis fugax (AFx) or transient ischaemic attacks (TIAs) who were thought to have atheromatous ulcers of the carotid bifurcation or the internal carotid artery (ICA). The degree of stenosis was considered to be of secondary importance. We compared our own data with two British series undertaken in the early and late 80s/early 90s. This reflects the broadening of indications and the change of practice for carotid endarterectomy over the years, on the one hand towards including patients who are at greater risk of perioperative stroke (previous CVAs vs TIAs, crescendo TIAs and stroke in evolution), and on the other towards patients who have had no symptoms attributable to the carotid lesion (asymptomatic cases, combined carotid and cardiac procedures).

Arteriosclerosis↗
PubMed1976

Complications associated with carotid endarterectomy.

A discussion of some of the complications associated with carotid endarterectomy is presented. Accurate knowledge of anatomy is essential in preventing injury to nerves, blood vessels and other regional anatomical structures. Complications following carotid artery operation may be severe and must be avoided if possible. Indications for carotid endarterectomy are still controversial. The final decision for or against operation rests on the judgment of the vascular surgeon.

Blood Vessels↗
PubMed1998

MR angiographic and sonographic indications for endarterectomy.

PURPOSE: Our objective was to determine whether appropriate criteria could be developed for performing an endarterectomy on the basis of sonographic and MR angiographic findings. METHODS: Fifty patients were examined prospectively with sonography, MR angiography, and conventional angiography. All three imaging studies were performed within 2 weeks of one another, and conventional angiography served as the reference standard. RESULTS: All 10 carotid occlusions were detected with sonography and MR angiography. Sonography accurately showed flow in two arteries, and MR angiography showed flow in one of three nearly occluded arteries with extremely slow flow. Multislab three-dimensional time-of-flight MR angiographic sequences underestimated the degree of stenosis in 12 arteries, and in two cases this resulted from high T1 signal within the atherosclerotic plaque. With conventional angiography as the reference standard for 70% to 99% stenosis, sonography had a sensitivity of 96%, a specificity of 91%, and a positive predictive value of 90%, while concordant sonographic findings and the presence of a signal void on multislab 3-D time-of-flight sequences had a sensitivity of 72%, a specificity of 98%, and a positive predictive value of 97%. CONCLUSION: Endarterectomy performed on the basis of sonographic findings of 70% to 99% stenosis and of a signal void on multislab 3-D time-of-flight MR angiographic sequences is appropriate.

Adult↗
PubMed1998

[Clinical course of restenosis after carotid endarterectomy].

Angiologic and neurologic examinations, ultrasonic dopplerography were performed in 89 patients after operation of carotid endarterectomy. Period of observation was 6-182 months after operation (61 months on the average). Positive clinical effect (absence of disorders of cerebral circulation-DCC) was achieved in 91% of cases. The frequency of both repeated transitory ischemic attacks and the strokes was 9%, the best frequency being in patients with initially asymptomatic course. It was found that the degree of restenosis directly correlated with frequency of neurologic symptom development: there were no repeated DCC in normal state of the operated artery. Meanwhile DCC frequency was less than 4% in cases with the degree of restenosis less than 60% and was equal to 15.8% in more than 60% restenosis. DCC were more frequently found in occlusion of internal carotid artery. Rather favourable course of restenosis of carotid artery was also conditioned by low content of the plaques dangerous in terms of embolism. Progression of atherosclerotic damages in other parts of extracranial arteries promoted clinical manifestation of cerebral ischemia. Moreover, negative neurologic dynamics developed in 7% of the patients with restenosis less than 60%, and in 13.8% of cases with restenosis more than 60%. The conclusion was made about efficiency of carotid endarterectomy in patients with atherosclerotic damages of carotid arteries. For prevention of repeated DCC it is recommended both to perform conservative therapy after the operation and to examine dynamically the patients using ultrasonic dopplerography beginning 6 months after the operation.

Adult↗
PubMed1998

Fast tracking carotid endarterectomy: practical considerations.

The diagnosis-related groups (DRG) and managed care economics have encouraged physicians to be more cost and resource efficient. In response to this demand, a fast track program for elective carotid endarterectomies has been established at Sewickley Valley Hospital. The essential components of this four-step program are operation based on duplex ultrasonography alone, same-day admission, a short recovery room stay to limit intensive care use, and discharge on the first postoperative day. Overall, 79% of patients for elective carotid endarterectomy successfully completed all four steps of the protocol at our institution. This has resulted in marked cost savings.

Carotid Stenosis↗
PubMed1998

Carotid stenting versus carotid endarterectomy: update on the controversy.

Carotid stenting has been a controversial subject from the outset. This discussion examines three areas: What is the basis for clinical investigation of carotid stenting? How do the results seem to compare with current surgical practice? Are there important things we do not know about carotid stenting? Does carotid stenting produce equal or better stroke prevention over a significant period than conventional therapy? Is the short-term morbidity, both neurological and general, better than with carotid endarterectomy? Does carotid stenting reduce cost? The results of recent series of carotid endarterectomy, some from National Institutes of Health (NIH)-funded randomized studies with peer-reviewed data, others from large referral centers or large regional experiences, and the results of several single-institution case series of carotid stenting that are reported in complete manuscript form are summarized. At least four industry-sponsored trials of carotid stent technology use are being undertaken in the United States as of the fall of 1997. Considering that angioplasty and stenting in other vessels has been used in many thousands of patients for over a decade, it is surprising that some basic issues are not resolved more clearly than they seem to be. Specifically in relation to the carotid lesion, seven questions are posed that frame some controversial aspects of the role of carotid stenting in stroke prevention.

Carotid Stenosis↗
PubMed1997

[Cerebral hyperperfusion syndrome following carotid endarterectomy].

Three patients with a severe symptomatic carotid stenosis developed headache, epileptic seizures and focal neurologic deficits several days after carotid endarterectomy. CT of the brain revealed hypodensities, indicative of cerebral oedema with haemorrhagic components. This is caused by cerebral hyperperfusion, a complication after carotid endarterectomy as a result of increased cerebral perfusion on the side of the operated carotid stenosis. Dysfunction of the cerebral autoregulation believed to be the cause of this hyperperfusion. Sometimes these complications are incorrectly attributed to one of the better known types of stroke.

Aged↗
PubMed1998

Randomised trial of endarterectomy for recently symptomatic carotid stenosis: final results of the MRC European Carotid Surgery Trial (ECST)

BACKGROUND: Our objective was to assess the risks and benefits of carotid endarterectomy, primarily in terms of stroke prevention, in patients with recently symptomatic carotid stenosis. METHODS: This multicentre, randomised controlled trial enrolled 3024 patients. We enrolled men and women of any age, with some degree of carotid stenosis, who within the previous 6 months had had at least one transient or mild symptomatic ischaemic vascular event in the distribution of one or both carotid arteries. Between 1981 and 1994, we allocated 1811 (60%) patients to surgery and 1213 (40%) to control (surgery to be avoided for as long as possible). Follow-up was until the end of 1995 (mean 6.1 years), and the main analyses were by intention to treat. FINDINGS: The overall outcome (major stroke or death) occurred in 669 (37.0%) surgery-group patients and 442 (36.5%) control-group patients. The risk of major stroke or death complicating surgery (7.0%) did not vary substantially with severity of stenosis. On the other hand, the risk of major ischaemic stroke ipsilateral to the unoperated symptomatic carotid artery increased with severity of stenosis, particularly above about 70-80% of the original luminal diameter, but only for 2-3 years after randomisation. On average, the immediate risk of surgery was worth trading off against the long-term risk of stroke without surgery when the stenosis was greater than about 80% diameter; the Kaplan-Meier estimate of the frequency of a major stroke or death at 3 years was 26.5% for the control group and 14.9% for the surgery group, an absolute benefit from surgery of 11.6%. However, consideration of variations in risk with age and sex modified this simple rule based on stenosis severity. We present a graphical procedure that should improve the selection of patients for surgery. INTERPRETATION: Carotid endarterectomy is indicated for most patients with a recent non-disabling carotid-territory ischaemic event when the symptomatic stenosis is greater than about 80%. Age and sex should also be taken into account in decisions on whether to operate.

Age Factors↗