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Results for “ALDOLASE”

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Substrate-selective mechanisms in biocatalysis demonstrated with a versatile and efficient aldolase antibody.

A structure-activity relationship study with a series of aldol substrates shows that the mechanism of the antibody 38C2-catalyzed retrograde aldol reaction depends on the nature of the substrate With electron-deficient substrates an early deprotonation precedes the C-C bond cleavage while with electron-rich substrates the catalytic mechanism involves an initial C-C bond cleavage leading to a positively charged intermediate.

Antibodies, Catalytic↗