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PubMed2003

Models for predicting dry matter intake of Holsteins during the prefresh transition period.

The objectives of this study were to develop and validate a model for predicting dry matter intake (DMI) of Holsteins during the prefresh transition period. The original database (ODB) for model development was established by compiling parity, body condition score (BCS), and DMI data during the final 3 wk of gestation from 366 Holsteins fed 24 different diets that were used in eight experiments conducted at three universities. For model validation, a validation database (VDB) was established by compiling data from 333 prefresh transition Holsteins fed 25 different diets that were used in eight experiments conducted at five universities. Dry matter intake during the prefresh transition period was fitted to an exponential function: DMI(t) = a + pe(kt), where DMI(t) = DMI as a percentage of body weight (BW) at time t, a = asymptotic intercept at time--infinity, p = change in intake (kg) from the asymptotic intercept until parturition, k = rate constant influencing the shape of the curve, and t = day relative to parturition expressed as days pregnant--280. The model developed from the ODB predicted DMI of heifers in the VDB with satisfactory accuracy and precision. However, this was not true for cows, probably due to differences in BCS of cows and diets fed to cows from the two data sets. When a subset of cows was selected from each data set that had similar BCS (> 4.0) and were fed similar diets, accuracy and precision of the model predicting DMI was improved. Finally, both databases were combined to develop final models for predicting DMI of heifers and cows. Proposed models for predicting mean daily DMI of heifers and cows during the prefresh transition period were DMI(t) = 1.713-0.688e(0.344t) (R2 = 0.96) and DMI(t) = 1.979-0.756e(0.154t) (R2 = 0.97), respectively. Adjustment factors for animal and dietary factors were generated to demonstrate the plausibility of adaptive fitting of the prediction. The regression coefficients of prediction models (a, p, and k) were affected by BCS and dietary organic macronutrient concentrations.

Animal Nutritional Physiological Phenomena↗

PubMed1999

Degradability of forage proteins by in situ and in vitro enzymatic methods.

The overall objective of these two studies was to evaluate the efficacy of using the proteolytic enzyme from Streptomyces griseus to estimate concentrations of ruminally degradable protein (RDP) in a wide array of forages. In the first study, alfalfa and prairie hays that previously had been evaluated in vivo for RDP were incubated in a replicated 3 x 3 factorial combination of enzyme concentrations (6.6, 0.66, and 0.066 activity units/ml of incubation medium) and incubation times (2, 4, and 48 h). Two treatment combinations (6.6 activity units for 4 h and 0.066 activity units for 48 h) yielded respective RDP estimates for alfalfa and prairie hay that were close to the known in vivo values. In the second study, 20 diverse forages were evaluated for RDP by using the in situ technique. These forages also were evaluated for RDP with the two enzyme concentrations identified in the first study, but incubation times were expanded to include 1, 2, 3, 4, and 5 h at the high concentration and 24, 30, 36, 42, 48, and 54 h at the low concentration. At the high enzyme concentration, r2 statistics from linear regressions of enzymatic estimates of RDP on corresponding estimates obtained by the in situ procedure were high (r2 > or = 0.898) at all incubation times; in addition, slopes (range = 0.88 to 1.00) and intercepts (range = -9.4 to 3.5%) approached unity and 0, respectively. At the lower enzyme concentration, r2 statistics were still good (> 0.81), but slopes (0.59 to 0.67) and intercepts (18.5 to 21.9%) for all incubation times did not meet the respective goals of unity and 0.

Animal Feed↗

PubMed1998

Aerosolized hyaluronic acid decreases alveolar injury induced by human neutrophil elastase.

This laboratory has previously shown that an intratracheally instilled solution of hyaluronic acid (HA) protects the lung from elastase-induced airspace enlargement. In those studies, fluorescein-labeled HA was found to bind preferentially to lung elastic fibers, suggesting a mechanism for the protective effect. The current investigation extends these findings by examining the capacity of an aerosol preparation of HA to similarly inhibit elastase-induced lung injury. Syrian hamsters were exposed to aerosolized bovine tracheal HA (0.1% solution in water) for either 25 or 50 min, then immediately instilled intratracheally with 80 units of human neutrophil elastase. One week later the lungs were examined for airspace enlargement, using the mean linear intercept method. Animals exposed to HA for 50 min showed a significant decrease in airspace enlargement compared to controls exposed to aerosolized water alone (68.2 microm vs 85.9 microm; P < 0.05). The 25-min exposure to the HA aerosol also reduced the mean linear intercept compared to controls (73.7 microm vs 85.9 microm), but this decrease was not statistically significant. With regard to possible inflammatory effects of HA, there was no difference in the percentage of lavaged neutrophils between HA-treated and control lungs at 24 hr (1.4% vs 1.8%, respectively). As with earlier experiments using intratracheally instilled HA, aerosolized fluorescein-labeled HA was found to bind to lung elastic fibers. These results suggest that aerosolized HA may prevent elastase-mediated injury in pulmonary emphysema.

Administration, Inhalation↗

PubMed1990

Energy metabolism of broiler breeder hens. 1. The partition of dietary energy intake.

The partitioning of AME intake (MEI) and recovered energy (RE; defined as MEI minus heat production) was investigated on Hubbard broiler-breeder hens (BB) by using indirect calorimetry and energy balance. The regression of RE on MEI was linear (R2 = .96; P less than .01) with a slope of .817 +/- .024 (SE) and a y-intercept of -238.3 +/- 10.7 (SE). The maintenance energy requirement was 292 kilojoule (kJ) per kg per day (367 kJ per kg.75 per day). The regression of body RE, defined as RE minus egg energy, on MEI was linear (R2 = .96; P less than .01) with a slope of .799 +/- .045 (SE) and a y-intercept of -344.9 +/- 19.7 (SE). Therefore, an MEI of 432 kJ per kg per day was required by BB hens to maintain body energy equilibrium when they were laying at approximately 85% production. At an MEI of less than 432 kJ per kg per day, body energy was used for egg production. The AME cost of depositing 1 kJ of body, egg, protein, or fat energy was (mean +/- SE) 1.21 +/- .06, 91 +/- .32, 1.96 +/- .71, and 1.05 +/- .15 kJ, respectively. The results indicate that individually caged BB hens between 28 and 36 wk of age in a thermal-neutral environment (21 C) require approximately 1.6 megajoule (MJ) of AME per bird per day for normal growth (3 g/per day) and egg production (85%).

Animals↗

PubMed2003

The difference engine: a model of diversity in speeded cognition.

A theory of diversity in speeded cognition, the difference engine, is proposed, in which information processing is represented as a series of generic computational steps. Some individuals tend to perform all of these computations relatively quickly and other individuals tend to perform them all relatively slowly, reflecting the existence of a general cognitive speed factor, but the time required for response selection and execution is assumed to be independent of cognitive speed. The difference engine correctly predicts the positively accelerated form of the relation between diversity of performance, as measured by the standard deviation for the group, and task difficulty, as indexed by the mean response time (RT) for the group. In addition, the difference engine correctly predicts approximately linear relations between the RTs of any individual and average performance for the group, with the regression lines for fast individuals having slopes less than 1.0 (and positive intercepts) and the regression lines for slow individuals having slopes greater than 1.0 (and negative intercepts). Similar predictions are made for comparisons of slow, average, and fast subgroups, regardless of whether those subgroups are formed on the basis of differences in ability, age, or health status. These predictions are consistent with evidence from studies of healthy young and older adults as well as from studies of depressed and age-matched control groups.

Cognition↗

PubMed2003

Is there a magnitude effect in tipping?

The present study examined nearly 1,000 tips recorded for two taxicabs, two hair salons, and two restaurants. In each of the six cases, amount of tip increased linearly as a function of the amount of the bill. Contrary to standard microeconomic theory, there was a magnitude effect in that as the amount of the bill increased, the percent tip tended to decrease. The present results extend the findings of Chapman and Winquist (1998), obtained using hypothetical scenarios, to real-world tipping behavior. Chapman and Winquist argued that a magnitude effect in tipping reflects the shape of the utility function for money. We suggest, however, that the magnitude effect may be the mathematical consequence of replotting the fundamental relationship between tip and bill amounts in terms of percent tip, given that the observed linear relation between tip and bill amounts has a positive intercept. We suggest further that the positive intercept arises because a tip represents a judgment as to what constitutes a fair or equitable wage, and part of what constitutes a fair wage is independent of the amount of the bill, reflecting compensation for simply being there when needed. The present account implies that different explanations may be needed for magnitude effects observed in different domains.

Choice Behavior↗

PubMed1996

Locus equations as phonetic descriptors of consonantal place of articulation.

This experiment tested whether locus equation coefficients, slope, and y-intercept could serve as indices of place of articulation for obstruents sharing the same place of articulation across different manner classes. Locus equations for 22 speakers were derived from CV/t/ words with initial voiced stop /d/, voiceless aspirated stop /t/, nasal /n/, voiced fricative /z/, and voiceless fricative /s/ preceding 10 vowel contexts. Post hoc tests revealed /d/ = /z/ = /n/ for slope means. Voiced /d/ and voiceless /t/ were also equivalent when F2 transition onset measurement points were equated. Scatterplots of locus equation coefficients revealed three nonoverlapping and distinct clusters when the diverse coronal group was compared with labials and velars. A discriminant analysis using slope and y-intercept as predictors successfully categorized all five coronals into one alveolar group with 87.1% accuracy. The collective results support the contention that locus equations can serve as effective phonetic descriptors of consonant place of articulation across manner classes.

Adult↗

PubMed1989

Distance perception as a function of photographic area of view.

Distance perception of depicted objects was examined as a function of photographic area of view. Subjects viewed slides of natural outdoor scenes and directly estimated the distances to specified objects. Area of view was manipulated by means of photographing each scene with lenses of five different focal lengths: 135, 80, 48, 28, and 17 mm. Distance perception along the pictorial depth plane was systematically transformed through changing the photographic area of view: the shorter the focal length of the camera lens, the wider the area of view, and the greater the perceived distance. Linear functions for each subject's distance judgments revealed a very high goodness of fit. Both the y-intercepts and the slopes increased as focal length decreased. The increasing y-intercepts suggest that viewers place themselves farther away from the depicted scene as focal length decreases, compensating for the advancing proximal edge. The increasing slopes suggest that distance information throughout the pictorial depth plane appears to change with focal length. The subjects also made direct judgments of foreground truncation, revealing that foreground truncation decreased as focal length decreased, but that this decrease did not account for the considerable expansion in distance perception.

Adult↗

PubMed1998

On the relevance of locus equations for production and perception of stop consonants.

We examined the possible relevance of locus equations to human production and perception of stop consonants. The orderly output constraint (OOC) of Sussman, Fruchter, and Cable (1995) claims that humans have evolved to produce speech such that F2 at consonant release and F2 at vowel midpoint are linearly related for consonants so that developing perceptual systems can form representations in an F2ons-by-F2vowel space. The theory claims that this relationship described by locus equations can distinguish consonants, and that the linearity of locus equations is captured in neural representations and is thus perceptually relevant. We investigated these claims by testing how closely locus equations reflect the production and perception of stop consonants. In Experiment 1, we induced speakers to change their locus equation slope and intercept parameters systematically, but found that consonants remained distinctive in slope-by-intercept space. In Experiment 2, we presented stop-consonant syllables with their bursts removed to listeners, and compared their classification error matrices with the predictions of a model using locus equation prototypes and with those of an exemplar-based model that uses F2ons and F2vowel, but not locus equations. Both models failed to account for a large proportion of the variance in listeners' responses; the locus equation model was no better in its predictions than the exemplar model. These findings are discussed in the context of the OOC.

Adult↗

PubMed1999

Prism adaptation to dynamic events.

In the present study, we explored adaptation to prism-displaced dynamic and static events under conditions of minimal information. Many of our interactions with the world are dynamic and involve reaching for or intercepting moving objects. The consequences (or feedback) of those interactions entail the presence or absence of physical contact with the moving objects. In this study, humans learned, with only heptic feedback, to intercept optically displaced falling balls. To eliminate visual feedback, the falling balls disappeared behind an occluder (which systematically varied in size across groups) prior to either striking or missing a subject's hand. As occluder size decreased, adaptation increased. With minimum occluder sizes, the greatest adaptation occurred around the training position, and adaptation decreased as distance between training and testing positions increased. The results can best be described in terms of a generalization gradient centered around the training position. This generalization gradient was not present when subjects were trained with ecologically similar static arrays. Implications for models of adaptation are discussed.

Adult↗

PubMed2026

miR-197 Targets NLRP3 3' UTR and Correlates with NLRP3/Caspase-1/IL-18 Signaling in Hyperoxia-Stimulated Neonatal BPD Mouse Model.

Reduced circulating miR-197 was previously observed in preterm infants who later developed bronchopulmonary dysplasia (BPD), but its relationship with NLRP3 inflammasome signaling remains unclear. This study examined miR-197 expression, NLRP3 inflammasome-related markers, and the interaction between miR-197 and the NLRP3 3' UTR in a neonatal hyperoxia model. Neonatal C57BL/6J mice were exposed to 60% oxygen or room air from birth, and lung tissues were collected on postnatal days 1, 7, 14, and 21. Lung injury and alveolar development were assessed by histology, radial alveolar count, mean linear intercept, and lung wet-to-dry ratio. miR-197 and NLRP3 expression and NF-κB-, caspase-1-, and IL-18-related proteins were evaluated by RT-qPCR and Western blotting. A dual-luciferase reporter assay in MLE12 cells tested the interaction between miR-197 and the NLRP3 3' UTR. Hyperoxia increased lung wet-to-dry ratios and mean linear intercept, reduced radial alveolar count, and caused progressive alveolar simplification. miR-197 expression decreased, whereas NLRP3 mRNA increased, at all examined time points; NLRP3 protein and inflammasome-related protein changes were most evident from postnatal day 7 onward. The miR-197 mimic reduced luciferase activity in the wild-type but not mutant NLRP3 3' UTR reporter. These findings show that neonatal hyperoxia is associated with reduced miR-197 and increased NLRP3/inflammasome-related signaling and support a sequence-specific interaction between miR-197 and the NLRP3 3' UTR, although causal regulation in vivo requires further investigation.

Animals↗

PubMed1990

[Inhibitory effect of nasal mucus on the absorption of drugs through respiratory epithelium].

The absorption of Dibekacin (DKB) through rabbit's tracheal mucosa with and without nasal mucus were examined in vitro. The modified double chamber method was used for the purpose of this study. DKB solution (20 mg/ml) and Hanks' balanced salt solution were put into the donor compartment (DC) and the receiver compartment (RC), respectively. A plate with a hole and the tracheal mucosa were inserted between the compartments in the order of DC, dialytic membrane, the plate, the rabbit tracheal mucosa and RC. The hole of the plate was filled with nasal mucus or Hanks' solution. The latter was used as the control. The chamber was incubated in a humidified atmosphere of 5% CO2 in air for 3 hours at 37 degrees C. The absorption rate (AR) was obtained by dividing the concentration of DKB in RC by that in DC. The nasal mucus from patients with chronic sinusitis significantly decreased the AR of DKB compared with that in the control (P less than 0.05). The AR significantly decreased with increments in the thickness of nasal mucus by chronic sinusitis. This decreased AR was improved by the addition of N-Acetyl-L-cysteine (NAC) to DKB solution in DC. NAC can cleave disulfied bonds of mucus glycoprotein and this results in the decrease of viscoelasticity of nasal mucus. The results indicate that nasal mucus by chronic sinusitis intercept the absorption of drugs through respiratory epithelium in vitro. One of the mechanisms of the intercepter may be due to the high molecular-reticular structure of nasal mucus.

Absorption↗

PubMed2003

Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression.

IL-6 is known to be an important pro- and anti-inflammatory cytokine, which is up-regulated during sepsis. Our previous work has suggested a role for IL-6 in the up-regulation of C5aR in sepsis. We reported earlier that interception of C5a or C5aR results in improved outcomes in experimental sepsis. Using the cecal ligation/puncture (CLP) model in mice, we now demonstrate that treatment with anti-IL-6 Ab (anti-IL-6) results in significantly improved survival, dependent on the amount of Ab infused. CLP animals showed significantly increased binding of 125I-labeled anti-C5aR to organs when compared to either control mice at 0 h or CLP animals infused with normal rabbit 125I-labeled IgG. Binding of 125I-labeled anti-C5aR to lung, liver, kidney, and heart was significantly decreased in anti-IL-6-treated animals 6 h after CLP. RT-PCR experiments with mRNA isolated from various organs obtained 3, 6, and 12 h after CLP demonstrated increased C5aR mRNA expression during the onset of sepsis, which was greatly suppressed in CLP mice treated with anti-IL-6. These data suggest that IL-6 plays an important role in the increased expression of C5aR in lung, liver, kidney, and heart during the development of sepsis in mice and that interception of IL-6 leads to reduced expression of C5aR and improved survival.

Amino Acid Sequence↗

PubMed2001

Rapid assessment of the bacteriological quality of raw milk using ATP bioluminescence.

Research was conducted to assess the practical use of an ATP bioluminescence assay to evaluate the bacteriological quality of raw milk. Filtration was used to precondition samples before ATP determination, which was measured in relative light units (RLUs). The Lumac ATP bioluminescence assay results were compared with standard plate counts (SPCs) of samples to estimate the microbial load for 246 raw milk samples that were split and either tested immediately or subjected to two preliminary incubation temperatures, 12.8 and 15.6 degrees C, for 18 h. Linear regression analysis procedures were used to analyze the data. Preincubation treatments were analyzed separately. For all treatments, linear regression coefficients were significantly different from zero (P < 0.01). The R2 values calculated using log10-transformed SPC and log10-transformed RLUs for samples tested immediately and samples preliminarily incubated at 12.8 and 15.6 degrees C were 0.58, 0.78, and 0.80, respectively. The R2 for all samples combined was 0.78. Differences in regressions among treatments were tested using a multiple slope and intercept model. Treatment intercepts and slopes were significantly different (P < 0.01). A linear regression equation was used to predict SPC from ATP values. Comparison of predicted values with actual SPCs indicated that ATP could be useful in predicting SPC in raw milk.

Adenosine Triphosphate↗

PubMed2002

Cross-sectional investigation on the accuracy of alternate site glucose testing using the Soft-Sense glucose meter.

QUESTIONS UNDER STUDY: The aim of this study was to evaluate possible differences in the results of blood glucose testing with the Soft-Sense blood glucose monitoring system (Abbott MediSense, Wiesbaden, Germany; not yet available in Switzerland) using different sites for drawing whole blood samples. METHODS: In total, 66 patients participated in the study. Blood glucose measurements were performed with the Soft-Sense device taking capillary blood from the forearm and the fingertip. The results were compared with blood glucose measurements by means of a laboratory reference method using blood from the fingertips. RESULTS: 276 blood glucose data sets could be obtained and were used for the examination of the accuracy of blood glucose measurements at both different sites. Blood glucose results obtained from the arm with Soft-Sense correlated well and were nearly parallel with the results achieved from the fingertip with a laboratory reference method (regression analysis: slope = 0.981; intercept = 0.045 mmol/l (0.819 mg/dl); correlation coefficient r = 0.943). Error grid analysis showed 99.2% of the measurements within clinically acceptable zones A and B. In addition, finger stick measurements done with the Soft-Sense device and the reference method revealed a strong correlation (regression analysis: slope = 0.959; intercept = -0.042 mmol/l (0.748 mg/dl); correlation coefficient r = 0.972). Error grid analysis showed 98.9% of all blood glucose readings within clinically acceptable zones A and B. Mean absolute percent deviations were 9.3+/- 8.1% for the finger tests and 11.2+/- 8.7% for the arm tests. If blood glucose values exceeded 11.1 mmol/l (200 mg/dl), measurements revealed from the forearm were slightly lower than the measurements obtained from the fingertips. CONCLUSIONS: The results indicate that the automated blood glucose monitoring device Soft-Sense provides accurate results independent of the measuring site. As with other alternate site testing devices, nearly painless blood collection at the forearm might help to increase patients readiness to perform more frequent measurements by self blood glucose monitoring, which is a known prerequisite of improved blood glucose control.

Bias↗

PubMed1987

[An experimental analysis on the relation between reward value and choice behavior ].

Six undergraduate students were tested in a two choice situation, exposed to concurrent VI-VI schedules. For group 1-5, tokens earned by pressing the left button were exchanged for one yen, and tokens earned by pressing the right button were exchanged for five yen after the experiment. For group 3-2, tokens earned by pressing the left button were exchanged for three yen, and tokens earned by pressing the right button were exchanged for two yen. The results between log response ratio (time allocation ratio) and log reinforcement ratio were examined by linear regression analysis. The average value of the regression coefficient of group 1-5 was .795 (.832), and the average value of the groups intercept was -.228(-.243). The average coefficient of group 3-2 was .524(.590), and its average intercept was -.033(.021). The results of all subjects revealed undermatching. As for group 1-5, subjects preferred five yen about two times as often as one yen. In group 3-2, however, subjects didn't show a clear pattern of preference.

Adult↗

PubMed2006

Thin basement membrane nephropathy: diffuse and segmental types.

CONTEXT: Diffuse thinning of the glomerular basement membrane (GBM) is the ultrastructural diagnostic criterion of thin basement membrane nephropathy (TBMN). However, there is no consensus regarding what diagnosis should be made if the attenuation is segmental. OBJECTIVE: To develop a diagnostic approach to TBMN in cases with segmental GBM thinning. DESIGN: We compared the diagnostic sensitivities of 2 methods used for the quantitative expression of GBM width in a consecutive series of renal biopsies from 26 patients (median age, 36 years; range, 15 to 59 years) with dysmorphic hematuria (a variable degree of proteinuria in 19 patients), a thin GBM, and absence of other renal disease. The harmonic GBM width was determined from orthogonal intercepts, and the actual width in the thinnest loops was obtained by direct measurement. The GBM attenuation was categorized into diffuse or segmental types by conventional inspection. RESULTS: Segmental TBMN accounted for one third of the series. In neither type did the male patients have a higher harmonic mean GBM width than the female patients. Focal-global glomerulosclerosis was more common in diffuse TBMN. The laborious orthogonal intercept method proved insensitive for the verification of segmental TBMN, whereas the much simpler direct measurement technique captured all the cases. CONCLUSIONS: A considerable number of patients with TBMN display segmental GBM attenuation. Because the routine criterion excludes these cases from the diagnosis, we propose to define TBMN as a clinicopathologic entity of dysmorphic hematuria and a diffusely or segmentally thinned GBM confirmed by the direct measurement technique.

Adolescent↗

PubMed2004

Class 3 dental treatment time.

OBJECTIVE: Dental emergencies take soldiers away from their assigned duties. The objective of this project was to determine the average clinical treatment time needed to correct nondeployable dental conditions using actual treatment times noted in an electronic scheduler. METHODS: The Fort Hood Class Three Intercept Clinic forwarded their daily treatment logs to the Dental Command for each week from November 1, 2002 through February 13, 2003. Clinical treatment times and types of services provided for dental fitness category (DFC) 3 conditions were tracked with the Corporate Dental Application scheduler. RESULTS: The project identified 398 DFC 3 soldiers who were scheduled to receive treatment at the Fort Hood Class Three Intercept Clinic between November 1, 2002 and February 13, 2003. Twenty-three of those soldiers did not receive treatment; therefore, the total sample size was 375. On average, it required 2.2 hours of clinical dental treatment time to make a DFC 3 soldier dentally deployable. CONCLUSIONS: The findings of this study suggest that treating DFC 3 conditions is time-intensive but most DFC 3 soldiers can be treated in approximately 2 hours in an efficient and properly staffed dental clinic. Without proper preventive education and maintenance, these soldiers may develop additional oral disease and may require repeated episodes of increasingly intensive dental treatment.

Appointments and Schedules↗