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PubMed2004

Social opportunity and ethanol drinking in rats.

Two experiments were designed to evaluate the effects of pairings of ethanol sipper conditioned stimulus (CS) with social opportunity unconditioned stimulus (US) on ethanol sipper CS-directed drinking in rats. In both experiments, rats were deprived of neither food nor water, and initiation of drinking of unsweetened 3% ethanol was evaluated, as were the effects of increasing the concentration of unsweetened ethanol (3-10%) across sessions. In Experiment 1, Group Paired (n=8) received 35 trials per session wherein the ethanol sipper CS was presented for 10 s immediately prior to 15 s of social opportunity US. All rats initiated sipper CS-directed drinking of 3% ethanol. Increasing the concentration of ethanol in the sipper CS [(3%, 4%, 6%, 8%, 10% (vol./vol.)] across sessions induced escalation of daily g/kg ethanol intake. To evaluate the hypothesis that the drinking in Group Paired was due to autoshaping, Experiment 2 included a pseudoconditioning control that received sipper CS and social opportunity US randomly with respect to one another. All rats in Group Paired (n=6) and in Group Random (n=6) initiated sipper CS-directed drinking of 3% ethanol and daily mean g/kg ethanol intake in the two groups was comparable. Also comparable was daily g/kg ethanol intake, which increased for both groups with the availability of higher concentrations of ethanol in the sipper CS, up to a maximum of approximately 0.8 g/kg ethanol intake of 10% ethanol. Results indicate that random presentations of ethanol sipper CS and social opportunity US induced reliable initiation and escalation of ethanol intake, and close temporally contiguous presentations of CS and US did not induce still additional ethanol intake. This may indicate that autoshaping CR performance is not induced by these procedures, or that high levels of ethanol intake induced by factors related to pseudoconditioning produces a ceiling effect. Implications for ethanol drinking in humans are discussed.

Alcohol Drinking↗
PubMed2005

Relation of smoking and drinking to sleep disturbance among Japanese pregnant women.

BACKGROUND: Pregnant women suffer from sleep disturbance, which may be aggravated by smoking and/or drinking. We investigate here the joint effect of smoking and drinking with respect to sleep disturbance during pregnancy. METHODS: Survey of about 16,000 pregnant women in Japan, conducted in 2002 using a self-administered questionnaire. RESULTS: Both smoking and drinking increased the odds of sleep disturbances, such as subjective insufficient sleep, difficulty in initiating or maintaining sleep, early-morning awakening, short sleep duration, excessive daytime sleepiness and restless legs syndrome. The joint odds ratios for smoking and drinking corresponded more or less to the products of the odds ratio for smoking or drinking. CONCLUSION: Smoking and drinking are independently associated with increased sleep disturbance during pregnancy, in addition to their other well-known side-effects.

Adult↗
PubMed2006

Problem drinking: rural and urban trends in America, 1995/1997 to 2003.

OBJECTIVE: Studies examining trends in problem alcohol use for U.S. adults residing in rural locations are lacking. This study examines recent trends in heavy and binge drinking in urban counties and three types of rural counties. METHODS: Random-digit telephone survey of adults aged 18 years or older residing in states participating in the Behavioral Risk Factor Surveillance System, in the years 1995/1997 (n = 247,255), 1999/2001 (n = 362,077) and 2003 (n = 257,659). Analyses were performed in 2006. RESULTS: Metropolitan counties experienced higher prevalence of heavy and binge drinking than rural counties in all years, and all geographic areas showed upward trends in both drinking behaviors. Trends in heavy drinking were sharper in rural counties (3.8% to 5.4% compared with 4.9% to 6.0% in metro counties). Metropolitan and rural counties overall saw similar increases in binge drinking, however, the greatest increase occurred in remote micropolitan counties (12.7% to 15.7%). CONCLUSION: Heavy and binge drinking are problems that continue to increase in rural areas nationwide. Because of the difficulties inherent in accessing and administering substance abuse treatment in rural areas, special attention should be given to tailoring alcohol abuse interventions to the needs of rural residents.

Adolescent↗
PubMed2002

Spatio-temporal dynamics of brain activated regions during drinking behavior in rats.

Spatio-temporal dynamics of activated brain areas induced by drinking were investigated and visualized in behaving rats using functional magnetic resonance imaging (fMRI). The rats were trained to drink in the magnet bore, and the images were taken during and after drinking glucose and distilled water. During glucose ingestion, the signal intensity was increased continuously and maximally in the lateral hypothalamic area (LHA) and the ventromedial hypothalamus (VMH). Somewhat less intense activation in the central nucleus of the amygdala (AMc), and transient activation in the piriform cortex and the mediodorsal nucleus of the thalamus were observed. The signal intensities of other regions measured were largely unchanged. During post-ingestive periods, the signals re-increased in the hypothalamic areas and AMc. When water was given, LHA and VMH were similarly activated, however, the signal intensity in the amygdala was not significantly increased. The results indicate that these brain regions are activated differentially during drinking behavior, and that LHA and VMH play a central role in the control of not only feeding but also drinking. The regional activities in LHA and VMH are not principally related to the gustatory sensation, and the reactivation after drinking may be related to satisfaction or post-ingestive nutritional information. Also, the responses of AMc are probably due to reward value difference. To the best of our knowledge, this is the first report of mapping of brain areas using fMRI in behaving rats. The improved method described in this study for collecting fMRI data in behaving animals will be useful for studying functional network during animal behavior.

Animals↗
PubMed1997

Odor of specific alcohol solutions selectively alters locomotor activity of alcohol-drinking P rats.

Evidence exists that the olfactory property of alcohol affects cerebral processes to influence the pattern of alcohol drinking in an experimental animal. In this study, the level of activity was quantified in the genetically selected alcohol-preferring P rats during exposure to the odor of 4 concentrations of alcohol. A Mini-Mitter transmitter was implanted intraperitoneally in each animal to record individual locomotor activity continuously, in terms of counts per unit time. In the first experiment, each rat was exposed between 1730 and 1930 h to the odor of 5%, 15%, 30%, or 60% alcohol placed in 2 petri dishes flanking both sides of each cage. The control condition was identical, except that the petri dishes were empty. In the second experiment, each rat was offered water and its individually preferred solution of alcohol in the drinking tubes during 1730 to 1930 h on alternate days of exposure to the odor of alcohol. During the odor condition alone, the 30% concentration of alcohol increased the activity counts significantly from the control level of 228.8 +/- 23.9 to 303.5 +/- 28.1 over the first 30 min of the 2-h test period. Plots of activity every 30 min for each alcohol solution, calculated as percent of control, also showed that the odor of 30% alcohol evoked significantly greater activity during the first and fourth intervals, in contrast to the exposure to 5%, 15%, and 60% alcohol, which failed to shift activity beyond the control level. When the P rats were exposed to 30% alcohol 24 h after 2 h of alcohol drinking, their profile of activity was concordant with that prior to alcohol drinking. These results demonstrate that the odor of a specific concentration of alcohol (i.e., 30%) selectively enhances the activity of the P rat. This could reflect an association of the sensory quality of alcohol with an anticipation of drinking. Finally, these experiments provide the first quantitative evidence that an olfactory cue associated with the unique odor of a specific solution of alcohol may determine the nature of the drinking response.

Alcohol Drinking↗
PubMed1997

Food deprivation and food-delay effects on the development of adjunctive drinking.

Twelve rats were food-deprived to 90% or 70% of their free-feeding weights. Food pellets were then delivered every 60 s (Fixed Time 60-s schedule), and the development of adjunctive drinking was measured by the water consumed and the number of licks. For "master" rats, each lick was followed by 10-s delays in food delivery. Yoked control rats received food at the same time as their master rats and independently of their own behavior. At 70% deprivation, both master and control rats developed similar levels of schedule-induced licking, but the master rats drank less water. At 90% deprivation, master animals showed little drinking and licking, but the development of adjunctive drinking was not completely prevented. Drinking by yoked control rats did not differ as a function of deprivation level. In showing that lick-dependent delays in food delivery reduce the asymptotic development of adjunctive drinking as a function of the rats' level of food deprivation, these results support the view that environmental influences on schedule-induced drinking are modulated by motivational factors.

Animals↗
PubMed1997

Physicochemical quality of drinking and hot waters in Finnish buildings originated from groundwater or surface water plants.

The physicochemical quality of drinking and hot waters of 67 buildings in different parts of Finland was studied. Some of the buildings used processed groundwater and some processed surface water. Drinking water samples were taken from the first tap after the water was led into the building. Hot water samples were taken from taps and showers and from circulating hot water systems. Thy physicochemical quality of drinking water was affected by the origin of raw water used in the water plants. Drinking water from surface water plants contained more organic matter and less metals than water from groundwater plants. The quality goal for total organic carbon (TOC; < 2 mg l-1) was exceeded by all drinking water samples. In groundwaters, the variation in the content of non-purgeable organic carbon (NPOC) was great, probably because artificial groundwaters processed from surface waters were included in this group. Unlike in natural waters, the correlation between KMnO4-number and NPOC in the processed waters was weak. This result shows that KMnO4-number is an inaccurate estimate for organic carbon in processed waters. Corrosion of pipe materials was seen as elevated concentrations of iron and copper. In general, the physicochemical quality of drinking and hot waters in the buildings was rather similar.

Carbon↗
PubMed1985

Suppression of schedule-induced drinking and food-reinforced bar pressing by tail-pinch is not reversed by naloxone.

In Experiment 1 eleven food-deprived rats were tested in a schedule-induced drinking paradigm under both tail-pinch and non-tail-pinch conditions. Tail-pinch produced a strong suppression of schedule-induced drinking, licking, licks per milliliter, bar presses, and number of reinforcers received during 30-min test sessions. Experiment 2 showed that the narcotic antagonist naloxone (2 and 4 mg/kg) did not reverse the tail-pinch suppression of schedule-induced drinking and food-reinforced bar pressing. Experiment 3 demonstrated that the suppression of schedule-induced drinking by tail-pinch could not be attributed to a suppression of drinking behavior in general, as tail-pinch had no effect on deprivation-induced drinking. The failure of naloxone to reverse this blockade suggests that endogenous opiate systems do not play a very important role in the suppression of schedule-induced polydipsia by tail-pinch. It was suggested that the combination of both the schedule-induction paradigm and the tail-pinch procedure increased arousal levels to such a high level that all behaviors were suppressed.

Animals↗
PubMed1998

Plasma neuropeptide-Y levels, monoamine metabolism, electrolyte excretion and drinking behavior in children with attention-deficit hyperactivity disorder.

Against a background of (a) increased drinking behavior in children with attention-deficit hyperactivity disorder (ADHD); (b) the parallel between some behaviors associated with ADHD and hypertension; (c) the use of the spontaneously hypertensive rat as a model for ADHD; and (d) similarities in the changes of neuropeptide Y (NPY) and catecholamine in studies of hypertension and drinking, NPY, catecholamines and electrolyte balance were compared in the plasma and urine of healthy children and those with ADHD. Drinking was monitored during 3 h of neuropsychological tests over 2 days in 14 ADHD and nine healthy children. Patients drank four times as much water and showed twice the levels of NPY found in controls. In controls there were positive and in patients there were negative relationships for NPY with drinking and restless behavior. Patients' plasma levels of norepinephrine (NE) and epinephrine were slightly elevated, but urinary levels of NE and the serotonin metabolite were markedly increased. Urinary excretion rates for sodium (not potassium), phosphate and especially calcium were decreased in patients even after covarying for less urine production in the ADHD group. NPY levels were inversely related to calcium excretion and drinking was inversely related to circulating sodium. Increases of drinking and circulating NPY in ADHD children and decreased electrolyte excretion may reflect a common disturbance in metabolic homeostasis.

Adolescent↗
PubMed2001

Angiotensinergic and noradrenergic mechanisms in the hypothalamic paraventricular nucleus participate in the drinking response induced by activation of the subfornical organ in rats.

The present study was done to investigate the contribution of the hypothalamic paraventricular nucleus (PVN) to the drinking response caused by activation of the subfornical organ (SFO) following angiotensin II (ANG II) injections in the awake rat. Microinjection of ANG II into the SFO elicited the drinking response. Previous injections of either saralasin, an ANG II antagonist, or phentolamine, an alpha-adrenoceptor antagonist, bilaterally into the PVN resulted in the significant attenuation of the drinking response to ANG II. Similar injections of any of the beta-adrenoceptor antagonist timolol, the muscarinic antagonist atropine, or saline vehicle into the PVN had no significant effect on the drinking response. In an attempt to clarify the neural mechanisms in the PVN involved in the drinking response to ANG II injected into the SFO, the effect of microinjection of ANG II into the SFO on noradrenaline (NA) release in the PVN was examined using intracerebral microdialysis techniques. The injection of the ANG II, but not saline vehicle, significantly enhanced the NA release in the region of the PVN. These results indicate the involvement of both the angiotensinergic and alpha-adrenergic systems in the PVN in the drinking response caused by angiotensinergic activation of the SFO, and imply that the angiotensinergic projections from the SFO to the PVN may serve to increase NA release which results in mediating water intake.

Adrenergic alpha-Antagonists↗
PubMed2002

The acquisition and maintenance of voluntary ethanol drinking in the rat: effects of dopaminergic lesions and naloxone.

Wistar male rats were microinfused bilaterally with 6-hydroxydopamine or vehicle into the ventral tegmental area. After recovery, ethanol drinking was established using a sucrose-fading paradigm, i.e. rats were given twice a day access to drinks containing increasing amounts of ethanol and decreasing amounts of sucrose. Mean daily intakes at each ethanol/sucrose concentration were similar irrespective of the level of dopamine depletion that, in some animals, reached 80-90%. The percentage of rats testing as ethanol preferers in a two-bottle choice test also appeared similar in both the lesioned and control groups. After completing the sucrose-fading protocol, all rats were switched to one access per day during which they were presented with a drink containing 10% ethanol with 5% sucrose. Naloxone administration (15 min before the daily access period) decreased ethanol beverage consumption by about 50%, irrespective of the level of dopamine depletion. Total daily water intake was not altered by naloxone. In a two-bottle choice situation, naloxone suppressed intake of an ethanol drink (10% ethanol/5% sucrose), but not the intake of 5% sucrose alone. Thus, a lesion of the dopaminergic cell bodies that results in extensive depletion of dopamine in mesolimbic target regions produced no measurable effect on intake of the sweetened ethanol drinks during the acquisition phase of the sucrose-fading paradigm. Furthermore, during the maintenance phase of drinking, the marked effect of naloxone in inhibiting ethanol beverage ingestion (but not water ingestion or sucrose alone solutions) occurred despite extensive loss of dopaminergic innervation to telencephalic target regions. A preliminary account of these experiments appeared in an abstract form and as an Internet publication. (Supported by NIAAA grants P50-03510 and T32-0720).

Alcohol Drinking↗
PubMed1984

The effect of naloxone on schedule-induced and other drinking.

A dose-response study of the effect of naloxone on schedule-induced drinking confirmed that this type of drinking is resistant to the opiate antagonist at doses which depressed drinking induced by water-deprivation, hypertonic saline and salbutamol. Naloxone also failed to reduce intake of saline solution in the presence of scheduled food presentation. The findings support the suggestion that schedule-induced drinking is regulated by a system of neural control which differs from that involved in deprivation and other forms of drinking. It would appear that opiate receptors do not play a part in the regulation of schedule-induced drinking.

Albuterol↗
PubMed2002

Multilevel analysis of situational drinking among Canadian undergraduates.

Using a multi-level approach, we examined the contribution of drinking setting characteristics and of individual characteristics on the alcohol intake per drinking occasion. The data are drawn from the Canadian Campus Survey, a national mail survey conducted in 1998 with a random sample of 8,864 students in 18 universities. For each student, up to five drinking occasions were investigated, resulting in 26,348 drinking occasions among 6,850 drinkers. At the individual level this study focused on the university life experience. At the situational level, information about alcohol intake was recorded relative to why, when, where and with whom drinking occurred. Our results show that drinking setting is as important as the individual characteristics in explaining the alcohol intake per occasion. Policies aimed at reducing students alcohol intake may be more beneficial if they address both situational and individual factors.

Adolescent↗
PubMedDate not supplied

Motives for not drinking alcohol among Australian adolescents: development and initial validation of a five-factor scale.

Why people drink has been the subject of much research, however, why people do not drink has been largely neglected. The aim of the present study was to develop a Motives for Abstaining from Alcohol Questionnaire (MAAQ) based on Cox and Klinger's [Journal of Abnormal Psychology 97 (1988) 168; Why people drink (1990) 291] motivational model of alcohol use to investigate reasons for not drinking alcohol either at all or on certain occasions. An initial 35-item version of the MAAQ was administered to 187 Australian high school students (years 10 and 12). Analyses supported a five-factor model with the final 19-item version explaining 60% of the variance. The factors were easily interpretable and were labeled: fear of negative consequences, dispositional risk, family constraints, religious constraints, and indifference toward alcohol. Regression analyses showed that different motives for not drinking predicted different aspects of alcohol use. Results are discussed in terms of theories of alcohol use that emphasize the interface of opponent motivational pathways toward decisions to drink.

Adolescent↗
PubMedDate not supplied

A prospective evaluation of the relationship between reasons for drinking and DSM-IV alcohol-use disorders.

Previous research has demonstrated an association between self-reported reasons for drinking and alcohol consumption. The most consistent relationships have been demonstrated between alcohol consumption and drinking for positive affect enhancement and coping with negative affect. However, most of the results have been from cross-sectional research designs that have not controlled for diagnostic status. The present study was a prospective investigation of the relationship between reasons for drinking and the Diagnostic and Statistical Manual of Mental Disorders (4th ed.), diagnoses of alcohol abuse and dependence. Subjects consisted of 508 community residents (264 male and 244 female) who did not meet DSM-IV criteria for an alcohol-use disorder at a baseline interview, who completed a completely structured interview (AUDADIS) and a self-report assessment battery, and who were re-interviewed approximately 1 year later. Results indicated a significant relationship between baseline reasons for drinking and follow-up diagnostic classification. Drinking to reduce negative affect predicted having a DSM-IV alcohol dependence diagnosis at follow-up, but not a diagnosis of alcohol abuse. No significant association was demonstrated between the baseline motive of drinking for positive affect enhancement and a follow-up DSM-IV alcohol-use disorder.

Adult↗
PubMedDate not supplied

College students' self-reported reasons for playing drinking games.

Two samples of college students who engage in drinking games completed questions about their drinking behavior, a set of items concerning their reasons for playing drinking games, and various self-report measures of personality. Principal components analysis using the first sample yielded four factors: Relaxation & Disinhibition, Fun & Celebration, Conformity, and Sexual Manipulation. A similar factor structure was also obtained in the second sample. In both samples, Fun & Celebration and Sexual Manipulation reasons were most strongly predictive of frequency of play and quantity of alcohol consumed while playing. In men, Sexual Manipulation reasons for play predicted frequency of taking sexual advantage of others during play. Endorsement of Conformity and Relaxation & Disinhibition reasons were associated with high social anxiety and low assertiveness. Reasons for play predicted consumption, both in drinking-game situations and overall, even after removing variance due to general reasons for drinking. Psychometric properties of the current measure are less than ideal, but the constructs identified appear to have important implications for prevention. Assessment of self-reported reasons for drinking in specific situations may be a generally useful strategy.

Adolescent↗
PubMed1999

Trends in situational norms and attitudes toward drinking among whites, blacks, and hispanics: 1984-1995.

The purpose of this study was to explore trends in situational norms and attitudes toward drinking and to assess the associations of norms and attitudes with current drinking and frequent heavy drinking patterns among whites, blacks, and hispanics between 1984 and 1995. Data were obtained from two nationwide probability samples of US households. Results indicated that there were no broad trends in situational norms and attitudes toward drinking between 1984 and 1995 among whites, blacks, and hispanics in the US. The variations in norms and attitudes detected between 1984 and 1995 were ethnic and gender-specific. For all of the groups studied, situational norms and attitudes were highly predictive of both current drinking and frequent heavy drinking patterns.

Adolescent↗
PubMed2003

Longevity-associated mitochondrial DNA 5178 A/C polymorphism modulates effects of daily drinking and cigarette consumption on serum triglyceride levels in middle-aged Japanese men.

Mitochondrial DNA 5178 adenine/cytosine (mt5178 A/C) polymorphism is one of the longevity-associated mitochondrial DNA polymorphisms. The frequency of the mt5178A genotype is significantly higher in Japanese centenarians than in the general population. We previously reported that serum high-density lipoprotein cholesterol levels were significantly higher in men with mt5178A than in those with mt5178C. However, this significant difference disappeared after adjusting for drinking frequency. To investigate the interaction between mt5178 A/C polymorphism and habitual drinking on serum lipid levels, we performed an association study in 321 healthy middle-aged Japanese men. Interaction between mt5178 A/C polymorphism and daily drinking on serum triglyceride (TG) levels was observed (P=0.019). Moreover, interaction between mt5178 A/C polymorphism and cigarette consumption on serum TG levels was also observed (P=0.022). Multiple regression analysis showed that, in men with mt5178A, daily drinking decreased TG levels (P=0.025), and cigarette consumption increased TG levels (P<0.001), while in men with mt5178C, the effects of daily drinking and cigarette consumption on TG levels were unclear. No interaction was observed on other lipid levels. Longevity-associated mitochondrial DNA 5178 A/C polymorphism thus influences the effects of daily drinking and cigarette consumption on TG levels in middle-aged Japanese men.

Alcohol Drinking↗