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PubMed1995

'The Elephant Man' as 'self' and 'other': the psycho-social costs of a misdiagnosis.

'The Elephant Man's Disease' acquired enormous notoriety through the portrayals of the life of Joseph Merrick, 'The Elephant Man', on American stage, screen and television. These portrayals, inspired by Ashley Montagu's book, The Elephant Man (1971) parleyed the designation of Merrick's condition into a household phrase, a metaphor for the grimmest extreme of ugliness. This paper explores the impact of 'The Elephant Man' as the chief referent and role model for persons who believed they shared the condition of neurofibromatosis 1, a neurological genetic disorder, which was erroneously believed at the time his story was popularized to have affected Joseph Merrick. Data were gathered through interviews with sixty affected individuals and families about their responses to the media representations of 'The Elephant Man'. Informants were recruited from three NF Support Groups and two urban hospital caseloads in Northern California.

Adaptation, Psychological↗
PubMed1996

Children's assignment of gender to animal characters in pictures.

In previous research (DeLoache, Cassidy, & Carpenter, 1987), mothers' descriptions of gender-neutral animal characters were influenced by subtle gender stereo-types. The present research was an investigation of children's assignment of gender to the same neutral characters. The youngest children, 4 to 5 years old, usually assigned their own gender to the characters (bears). The 7- to 8-year-old and 10- to 11-year-old children were influenced by gender stereotypes. Solitary or noninteracting bears were less likely to receive female gender labels than were bears involved in adult-child interactions. Boys in the oldest age group were most influenced by the stereotypes.

Adult↗
PubMed2002

Tagatose, the new GRAS sweetener and health product.

Tagatose, a low-calorie, full-bulk natural sugar, has just attained GRAS (Generally Recognized As Safe) status under U.S. Food and Drug Administration (FDA) regulations, thereby permitting its use as a sweetener in foods and beverages. This paper presents all current aspects of tagatose with respect to demonstrated food and beverage applications and the potential health and medical benefits of this unique substance. Summarized studies are referenced to detailed peer-reviewed papers. The safety studies followed the recommendations in the FDA "Red Book." Results were submitted to an Expert Panel for determination of GRAS status under FDA regulation. Small phase 2 clinical trials showed tagatose to be effective in treating type 2 diabetes. The results, buttressed by the references cited, support the efficacy of the various applications disclosed for tagatose. Tagatose has been found to be safe and efficacious for use as a low-calorie, full-bulk sweetener in a wide variety of foods, beverages, health foods, and dietary supplements. It fills broad, heretofore unmet needs for a low-calorie sweetener in products in which the bulk of sugar is important, such as chocolates, chewing gum, cakes, ice cream, and frosted cereals. Its synergism with high-intensity sweeteners also makes it useful in sodas. Various health and medical benefits are indicated, including the treatment of type 2 diabetes, hyperglycemia, anemia, and hemophilia and the improvement of fetal development.

Consumer Product Safety↗
PubMed2005

[Childhood anxiety and assessment instruments: a systematic review].

OBJECTIVE: To make a survey of the principal anxiety instruments available for children, when they appeared, the type of methods used, verifying which countries have the highest number of children anxiety instruments and also how is the Brazilian reality on this matter. METHODS: A systematic review on electronic databases--Psychoinfo (1940--May 2002), Psyclit (1887--May 2002), Medline (1966--May 2002) e Eric (1966--May 2002). Information collected on personal communications and books chapters. The inclusion criterion utilized: studies realized with children, where the anxiety were evaluated with some psychometric instrument. The exclusion criterion: adolescents, adults and animal research articles, articles utilizing projective instruments or studies without any reference of assessment instruments. The indexed articles found in 2 or more databases were considered only once. RESULTS: This review pointed out 1911 studies used at least one assessment instrument to identify the presence of anxiety and 118 instruments were used for this purpose. CONCLUSIONS: There are a large number of children anxiety instruments available, however, in Brazil, the only one available in the market isn't updated and the modern ones are found only in clinic academic centers.

Anxiety↗
PubMed2004

[Breastfeeding in premature infants: in-hospital clinical management].

OBJECTIVE: To describe the importance of breastfeeding and its promotion in the in-hospital clinical management of premature newborns. SOURCE OF DATA: The authors made an extensive literature review on the topic, including technical books, theses, publications of national and international organizations, and search on MEDLINE database (1990 to 2003), using the following key words and boolean operators: "breastfeeding AND low birth weight" and "breastfeeding AND preterm infant". Some significant references cited in the reviewed publications were used as well. SUMMARY OF THE FINDINGS: After this review we conclude that many aspects make the breast milk particularly suitable to the premature newborn feeding. Despite being highly desirable, little success in breastfeeding preterm infants is generally observed, particularly in special care neonatal units, although there is evidence suggesting that a highly supportive hospital environment can make it possible to breastfeed these infants. CONCLUSIONS: Although breastfeeding premature infants represents a challenge, it is feasible if appropriate help and support are provided. Mothers of premature infants need information and support to make informed decisions about their infant's feeding.

Breast Feeding↗
PubMed1993

Accuracy of references and quotations in veterinary journals.

The accuracy of references and quotations used to substantiate statements of fact in articles published in 6 frequently cited veterinary journals was examined. Three hundred references were randomly selected, and the accuracy of each citation was examined. A subset of 100 references was examined for quotational accuracy; ie, the accuracy with which authors represented the work or assertions of the author being cited. Of the 300 references selected, 295 were located, and 125 major errors were found in 88 (29.8%) of them. Sixty-seven (53.6%) major errors were found involving authors, 12 (9.6%) involved the article title, 14 (11.2%) involved the book or journal title, and 32 (25.6%) involved the volume number, date, or page numbers. Sixty-eight minor errors were detected. The accuracy of 111 quotations from 95 citations in 65 articles was examined. Nine quotations were technical and not classified, 86 (84.3%) were classified as correct, 2 (1.9%) contained minor misquotations, and 14 (13.7%) contained major misquotations. We concluded that misquotations and errors in citations occur frequently in veterinary journals, but at a rate similar to that reported for other biomedical journals.

Periodicals as Topic↗
PubMed2000

Barriers to care for patients with neurologic disease in rural Zambia.

The awesome burden of treatable yet untreated neurologic disease in the developing world presents a humanitarian crisis to those of us with neurologic expertise from more privileged situations. Although increased economic resources are critically needed, a shortage of personnel to care for these patients is as great a problem. It is neither feasible nor desirable to propose training neurologists to work in these regions. However, COs could be selected to receive additional training and return to their home regions to serve as resources for referrals and as community educators. Such a training program would not require massive financial commitments. A handful of dedicated neurologists could conceivably accomplish this in 6- to 8-week training sessions. Ideally, educational materials, such as posters and pamphlets in both English and the native language of the various regions, would be provided at no cost. Existing textbooks in neurology are written for physicians and often focus on diagnostic evaluations and therapies far beyond the services available in developing countries. A text for practical use by COs and community health workers that discusses the application of available medicines and therapies for common neurologic problems would be invaluable. Similar books exist that address general medical and obstetrical problems (for example, Where There Is No Doctor: A Village Health Care Handbook). Where There Is No Neurologist could be developed as a primary teaching tool and a valuable reference for COs with neurologic expertise. Neuroscience researchers, clinical neurologists, and neurology residents from industrialized countries have much to offer and to gain by working in the Third World. Research to monitor the incidence and resource utilization of emerging problems such as stroke is needed to influence public policy. The economic burden and lost productivity caused by neurologic disease in this part of the world has not been appreciated or explored. Disease beyond the scope of Western experience manifests daily in places like Chikankata. Entities such as tabes neurosyphilis, which previous generations of neurologists used as the basis for their training, still abound in Zambia. Much personal satisfaction can be gained in providing care to this vulnerable and underserved population.

Adult↗
PubMed1979

Annotated bibliography of health care books for children.

We present a comprehensive bibliography of books aimed to help physicians, other health care providers, and parents prepare children for medical contacts. Publications have been annotated and rated on the basis of use and cost. We propose that this will be a useful reference for those responsible for the health care of the pediatric population.

Bibliographies as Topic↗
PubMed2003

Dermatologic and nondermatologic uses of thalidomide.

OBJECTIVE: To review published data on thalidomide, with emphasis on current knowledge about mechanism of action, new and/or potential dermatologic and nondermatologic therapeutic applications, well-known and emerging adverse effects, and current indications for its safe use. DATA SOURCES: Review articles, in vitro research studies, references from retrieved articles, case reports, and clinical trials were identified from a computerized literature search using MEDLINE and OVID (1966-January 2003) and on the Cochrane Clinical Trials Register (January 2003). Information available from meetings' abstract books, Internet, or pharmaceutical companies was also considered. STUDY SELECTION AND DATA EXTRACTION: All articles identified as relevant, including those from non-English literature, were considered in an attempt to provide to the reader both the theoretical basis and practical guidelines for thalidomide pharmacotherapy. DATA SYNTHESIS: Thalidomide has hypnosedative, antiangiogenic, antiinflammatory, and immunomodulatory properties. Moreover, it has been shown to selectively inhibit the production of tumor necrosis factor-alpha and reduce the expression of various integrin receptors on the membrane of leukocytes and other cell types in a dose-dependent fashion. Controlled trials demonstrated the efficacy of thalidomide in a number of diseases, including erythema nodosum leprosum, lupus erythematosus, aphthosis, graft-versus-host disease, prurigo nodularis, and actinic prurigo. Single case reports or studies in small series have also suggested a possible role for thalidomide in numerous other dermatologic and nondermatologic disorders. Possibly severe and sometimes irreversible risks related to the clinical use of thalidomide include teratogenicity and neurotoxicity. CONCLUSIONS: Although teratogenicity and neurotoxicity are significant adverse effects requiring cautious use, thalidomide is an effective therapeutic modality in a variety of difficult-to-treat disorders and, providing careful selection of patients, should offer an acceptable risk-to-benefit ratio.

Angiogenesis Inhibitors↗
PubMed1999

[Judging the date of Neijing (Inner Canon) through study on semantic changes].

In the pre - Qin literature, the characters "ti", "pi", "nian" refer to "tear", "beast skin" and "year" respectively and it became "nasal discharge", "man's skin" and "age" respectively in the Han dynasty, which never appeared in the pre - Qin period. By studying the semantic changes in books of different times, the meanings of the above 3 characters, that frequently occurred in Neijing, are identical with those books of the Han dynasty. Hence, it can be concluded that Neijing can only be completed not early than the Han dynasty.

China↗
PubMed2005

[Problem of sexuality in Polish medical aids. The first half of XX century - to 1939].

The article presents an analysis of sexuality-related problems as they are covered in the health guidebooks so well known to her. There are a few topics addressed in Urbanek's text. She describes the evolution of the health guidebooks which was taking place at the end of the 19th and in early 20th centuries and of their users. Women increasingly often were authors and readers of these books. Some of the female authors were medical doctors with an additional passion for writing on public matters. Foreign authors and their works are also mentioned in Urbanek's article. She points to the links between sexology and personal hygiene and even cosmetology. Sexology is present in the guidebooks discussed also as an important ingredient of successful marriage. In this context, Urbanek stresses the changing role of a woman and her strife for acquiring equal rights. Another valuable element in the article is reference to other spheres of culture, such as custom and religion. The 20th century filled these spheres with medical knowledge on childbirth pathologies and their complications. Medical and hygiene-related topics motivate Urbanek to set the question of sexuality in a context of eugenic ideas often debated in the pre-war years. She also points to the multicultural character of the Polish-language health books, identifies various angles of view presented in them, and supports her reflection with well-selected examples. This applies eg. to Soviet books. Although this is not her main subject, Urbanek also writes about health books dealing with sexual matters and destined for men. The author of the article gives a fine description of the variability of sexuality-related contents carried by these books which offered adequate coverage of changes occurring in medical, hygienic, cultural, and even economic fields. The paper is, therefore, not only an analysis of sexuality-related issues but it also presents a broad social context in which these books were conceived and written.

History, 20th Century↗
PubMed2005

Sound and sight: acoustic figures and visual phenomena.

The impact that the analysis of sound waves has made on theories of light is well known, and is touched upon here. However, the acoustic figures described initially by Robert Hooke in 1665 and in more detail by Ernst Chladni in 1787 (often referred to as Chladni figures) were instrumental in vision in two specific respects. First, their representation by Tyndall [1867 Sound. A Course of Eight Lectures Delivered at the Royal Institution of Great Britain (London: Longmans, Green)] in a book on sound resulted in the description of a visual illusion, the Hermann grid. Secondly, attempts to render the acoustic figures visible (on the basis of briefly persisting images) led to the discovery of instruments that could synthesise movement. These two developments are discussed in their historical contexts.

Acoustics↗
PubMed2006

Sabina Spielrein: out from the shadow of Jung and Freud.

Since the 1982 publication of Aldo Carotenuto's book, A Secret Symmetry: Sabina Spielrein Between Jung and Freud, there has been renewed interest in the life and work of Sabina Spielrein. She was Jung's first psychoanalytic case at the Burghölzli Hospital in 1904, and was referred to several times in The Freud/Jung Letters. Spielrein recovered, enrolled in medical school, and went on to become a Freudian analyst. Her most famous paper, published in 1912, 'Destruction as a cause of coming into being', was referred to by Freud in 1920 in relation to his Death Instinct theory. In the few Freudian publications on this controversial theory since 1920, Spielrein's contribution is consistently omitted. Jung also neglected to refer to her 'Destruction' paper in his early 1912 version of 'Symbols of transformation', even though he had edited her paper and had promised to acknowledge her contribution. He did refer extensively to Spielrein's first paper, her medical thesis, 'On the psychological content of a case of schizophrenia', published in 1911, as yet unpublished in English. In her paper Spielrein sought to understand the psychotic delusions of Frau M, a patient at the Burghölzli, much in the style of Jung's 'Psychology of dementia praecox' (1907). The purpose of this paper is to explore to what extent Spielrein's Frau M paper, and its companion 'Destruction' paper, make an original contribution to both Jung and Freud's emerging theories on the possible creative versus destructive outcomes of neurotic or psychotic introversion, culminating in Jung's concept of the 'collective unconscious' (1916) and Freud's concept of a 'Death instinct' (1920).

Female↗
PubMedDate not supplied

[Protective effect of breastfeeding against childhood obesity].

OBJECTIVE: To review the literature concerning the hypothesis that breastfeeding has a protective effect against obesity. The biological plausibility of this hypothesis and the potential mechanisms involved are discussed. SOURCES OF DATA: Articles published in indexed scientific journals, books and graduate theses and dissertations. Most articles were obtained from the Medline and Scielo databases using the keywords "breastfeeding," "overweight," "obesity," "children" and "adolescents" for the period between 1980 and 2002. Some articles were identified from the references cited in the first articles. SUMMARY OF THE FINDINGS: Most studies report a protective effect of breastfeeding against childhood obesity. Some studies found no association between breastfeeding and obesity. One study including a small sample reported greater adiposity in breastfed children. Different definitions of exposure and outcome were used in different studies, making comparison difficult. Metabolic imprinting is suggested as a potential mechanism to explain the association. Behavioral aspects may also be involved. CONCLUSION: Breastfeeding seems to have a protective effect against childhood obesity, but this issue still deserves further investigation.

Breast Feeding↗
PubMed1982

The identification of Linda Agostini: the significance of dental evidence in the Albury Pyjama Girl case.

The partly burned and battered body of a young woman was found in a culvert near Albury, New South Wales, Australia, on September 1, 1934. Although identification was delayed for 10 years, it was finally achieved by dental comparison, following which the crime was quickly solved and the woman's husband brought to trial for murder. The mystery surrounding this bizarre case attracted international attention at the time. The dental identification was hotly disputed and even today is a subject of controversy. This paper briefly reviews some of the circumstances that contributed to the long delay in establishing identification and contrasts the identification procedures used then with those available now. Some important lessons may be learned from the experience of this case that have particular relevance to forensic odontology today. Apart from occasional references to this case in the scientific literature, a number of stories about it have been published in the popular press from time to time. The most recent, reliable, and comprehensive account was published in 1978 in a book by Robert Coleman entitled The Pyjama Girl. This paper has drawn heavily from Mr. Coleman's research, as well as from original court files.

Adult↗
PubMedDate not supplied

Transcultural nursing. A source guide.

The concept of transcultural nursing is relatively new to the nursing literature. It had been less than 30 years since Madeleine Leininger first began to develop a theory of transcultural nursing as part of a doctoral study in anthropology. Much has changed in that time, and nursing staff development and inservice educators need to provide educational offerings within a multicultural context in a timely manner. Cultural diversity is the standard in the mid-1990s, and those nursing staff development programs that are sensitive to this fact produce employees with advantages over those from settings that do not prepare staff for practice in a constantly changing world. This annotated bibliography about transcultural nursing details key references for staff development and inservice programs. It is not intended as an exhaustive review but rather focuses on the most relevant, timely, and useful of the ever increasing number of publications concerning this important subject. Six major books and four of the most pertinent recent journal articles are included. Conclusions and implications for nursing staff educators are offered.

Education, Nursing, Continuing↗
PubMed2006

Cross-sectional study of weight gain and increase in BMI throughout pregnancy.

OBJECTIVE: To generate reliable new reference ranges for weight gain and increase in body mass index (BMI) during pregnancy from a large population. STUDY DESIGN: In a prospective cross-sectional study at the Obstetric outpatient clinic, Zurich University Hospital, weight gain and BMI, before gestation and at the booking visit, were determined in 4034 pregnant women with accurately dateable singleton pregnancies (Caucasian: N = 3242, Asian (predominantly from Sri Lanka, Thailand and the Philippines): N = 578 and Black: N = 214). Women with known insulin-dependent diabetes mellitus before pregnancy were excluded. Fifth, 50th and 95th centiles were presented for Caucasians and corresponding centile curves for Asians and Blacks. Simple and multiple regression analyses were performed for various risk factors. A significance level of P < 0.05 was used in all tests. RESULTS: Mean weight gain was 15.5+/-5.9 kg (34.2+/-13.0 lb) at term with values >25.4 kg (56.0 lb) and <5.7 kg (12.6 lb) for the 95th and the 5th centile, respectively. Mean BMI increased slightly and steadily to 28 kgm(-2) at term. Parity and pre-pregnancy BMI were significant determinants in Caucasians. Weight gain and BMI was slightly lower in Asians and Blacks. CONCLUSIONS: BMI centile curves have the advantage in that they consider height during the whole course of pregnancy. It may be an additional helpful tool in controlling weight gain in pregnancy. Further studies are required to determine the prognostic implications of values > or = 95th centile and < or = 5th centile.

Adult↗
PubMed1996

Prevalence of diabetes in elderly patients requiring permanent cardiac pacemaker insertion.

Diabetes mellitus increases the rate of atrioventricular block after a myocardial infarction; right bundle branch block is more common than expected in the diabetic outpatient population. We decided to assess whether diabetic subjects were more likely to need permanent cardiac pacemaker insertion. Data from patients in Leicestershire who had undergone permanent cardiac pacemaker insertion during a 4-year period were analysed. The capture recapture technique was used: Hospital Activity Analysis data as capture, ward admission book and case note confirmation as recapture. Diabetes coding accuracy was confirmed from the central register and from an analysis of 100 sets of case notes. The number of these patients with diabetes was then recorded. Data for the reference population was obtained using a survey of a market town in Leicestershire. There were 688 patients, most (79%) aged over 65 years. Our analysis was performed on this group. Of this age group undergoing pacemaker insertion. 11.1% was diabetic. In the same age group, 8.3% of the controls were diabetic: a relative risk of 1.34 (P < 0.01, 95% confidence interval 1.25-1.44). This relative risk is likely to be an underestimate. The aetiology of this excess risk is uncertain: it is most likely due to ischaemic heart disease, but microangiopathy or increased cholinergic sensitivity may play a role.

Adult↗