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PubMedDate not supplied

Serum beta 2-microglobulin in patients with monoclonal gammopathies.

Beta-2-microglobulin concentrations were determined in serum samples from 45 patients with benign and malignant monoclonal gammopathies. In the group of patients suffering from multiple myeloma or Waldenström macroglobulinemia the mean beta 2-microglobulin level was significantly higher than in the group with monoclonal gammopathy of undetermined significance. Values above 3 mg/L were highly indicative of a neoplastic process and were observed in all the Waldenström patients and in greater than 90% of myeloma patients. No significant correlation was noticed between beta 2-microglobulin and monoclonal protein levels in any of the groups examined.

Adult↗
PubMed1988

An immunoassay to detect human embryonic epsilon globin chains by a murine monoclonal antibody.

Human embryonic epsilon globin chains were isolated from lysates of cultured human leukemic K562 cells induced with hemin. Mice were immunized with epsilon globin chains, and a murine hybridoma cell line was established that secreted monoclonal anti-epsilon globin antibody. A sensitive and specific slot blot immunoassay for epsilon globin chains has been developed. epsilon Globin chains were shown to be present in hemolysates from fetuses of 20 weeks' gestation but were not detected in normal cord blood hemolysates. This immunoassay is useful for the study of epsilon globin ontogeny during embryonic and fetal development as well as for searching for inappropriate epsilon globin chain expression in hematologic disorders resulting from genetic abnormalities or neoplastic processes.

Animals↗
PubMed1987

[Leishmaniasis of the genital organs].

Five cases of leishmaniasis in genital organs are exposed. The patients are males, farmers, with less than 30 years old (except one), residents of high leishmaniasis incidence zones. The majority of lesions were in penis, and of scabies ulcer type, destructive, painless and of slow evolution. In this cases generally, the clinic diagnosis was difficult to corroborate by the habitual laboratory methods and we insist that the principal differential diagnosis are the neoplastic process of the zone. The suspicion high index is important even to proceed to the therapeutic test and solve this kind of problems.

Adult↗
PubMed1987

[Metastatic pericardial effusions. Apropos of 12 cases. Review of the literature].

The authors report 12 cases of metastatic pericardial effusions with clinical manifestations. Primary bronchial cancer is the most frequent with 7 cases; in 3 of these patients, the original manifestation is a tamponade. The contributions of sonocardiography to the diagnosis are analyzed: evaluation of hemodynamic tolerance and visualization within the effusion, in 4 out of 7 patients undergoing bidimensional sonocardiography, of dense masses, implanted on the visceral layer of the pericardium; the frequent epicardic location of these metastases may be explained by preferential invasion of the visceral layer by retrograde lymphatic route. The advantage of pericardial cytology is discussed. From the therapeutic standpoint, a pleuro-pericardial window or tetracycline instillation tend to prevent a recurrence of the effusion and the risk of tamponade; the neoplastic process is controlled with local and/or general chemotherapy and radiotherapy; therapeutic strategy depends on the sensitivity of the primary tumor. The prognosis remains very dim with a mean survival of 3.7 months in our series.

Adult↗
PubMed1987

Chromosomes and cancer families.

At the beginning of this century Theodor Boveri predicted that specific chromosome changes would be found to have a causal role in neoplasia. We are now beginning to acquire the evidence to substantiate this hypothesis. The evidence comes from two particular sources, (i) genetic environmental interactions and (ii) specific constitutional chromosome aberrations. Cancer incidence varies throughout the world. This is often due to the interaction of an environmental agent with a genetically varied population. Using UV and ionising radiation as examples it is argued that some individuals are more susceptible to genetic damage by these agents. Moreover, the genetic lesions which are caused by these agents are now being shown to be relevant to cancer. In the radiosensitive syndrome ataxia-telangiectasia for example, specific chromosome rearrangements have been defined which seem likely to be directly involved in the development of leukaemia in these patients. The second line of evidence comes from the study of patients who have constitutional chromosome abnormalities associated with susceptibility to specific cancers. It has now been shown that these chromosome changes mark the location of genes which are involved in the development of cancer and that these same loci are also important in the non-familial forms of these diseases. Thus we are beginning to understand for the first time the mechanistic pathway that leads from environmental agents, through chromosome damage, to the alteration of specific genes which control the neoplastic process.

Chromosome Aberrations↗
PubMed1988

[Primary malignant mesenchymoma of the lung].

A case of a primary malignant mesenchymoma of the lung with elements of rhabdomyo-, leiomyo-, osteo-, fibro- and lipo-sarcoma is described. The tumor developed in a man of 58 with a long history of smoking, complaints of chest pains and cough with scanty sputum expectoration. The neoplastic process involved the upper lobe of the left lung and microscopically contained smooth muscle, endothelial, fibroblast-like cells, multinuclear giant cells resembling osteoclasts, strips of osteoid-like hyalinized connective tissue. Electron-microscopic examination revealed myoid-type cells with clusters of myofilaments and Z-type material, cells resembling fibroblasts, osteoclasts and lipocytes. It is suggested that there should be a common histogenesis of primary lung sarcomas arising from a stem cell precursor of mesenchymal origin in lung stroma, bronchial and vascular walls, pleura.

Humans↗
PubMed1977

["Primary" reticulum-cellsarcoma of the retina. I. Clinico-pathologic study of 5 patients (author's transl)].

Between 1964 and 1974 a primary reticulum-cellsarcoma of the retina was diagnosed histologically in 5 patients (between 44 and 71 years), in one already clinically. The initial diagnosis had been "uveitis" (2), "panuveitis" (1), "iridocyclitis with central retinal artery occlusion" (1), and "chorioretinitis" (1). The usual antiinflammatory therapy was without effect in every instance. All patients showed neurological symptoms with cerebral manifestations. Twice the cerebral biopsies had been misinterpreted initially as "atypical glioblastoma multiforme", once as Neuro-Behçet. The disease progressed over a course of 2--10 years from the initial ophthalmic symptoms to death. A review of the literature is given and the differential-diagnosis to necrotizing forms of retinitis, dissiminated chorioiditis neoplastic processes of retina and uvea and degenerative diseases are discussed. The primary reticulum-cellsarcoma of the retina must be considered in the differential-diagnosis of uveitis or panuveitis if 1. there is progression in spite of the usual antiinflammatory therapy, 2. the initial infiltrations are seen in the deep layers of the sensory retina.

Adult↗
PubMed1978

Islet cells as a component of pancreatic ductal neoplasms. I. Experimental study: ductular cells, including islet cell precursors, as primary progenitor cells of tumors.

The ductular complex of the Syrian hamster pancreas represents a system of conduit which encompasses intercalated (intralobular), periinsular, and intrainsular ductules. The intercalated (intralobular) ductules comprise centroacinar and intercalated cells. A meshwork of small ductules (invisible by usual histologic procedures) surrounds islets (periinsular ductules) and extends in the form of often ramified tiny channels within the islet (intrainsular ductules). Although the function of the latter ductules is obscure, their cells seem to make up one of the undifferentiated cellular units of the pancreas, and as such are also the progenitors of beta-cells of the islets (islet cell precursor = IP). Systematic histologic examination of the pancreas in this species treated with pancreatic carcinogen N-nitrosobis(2-oxopropyl)amine indicated that ductular cells, especially those of periinsular and intrainsular origin, are the most responsive to this carcinogen. The neoplastic process was initiated with hyperplasia of intercalated (intralobular) ductular and interlobular ductal cells associated with newly formed islets (nesidioblastosis). This process was followed by excess formation of mature but especially of immature islet cells and their precursors (IP) in the islet periphery, as well as with the appearance, distention, and multiplication of periinsular and particularly of intrainsular ductules. The hyperplasia, metaplasia, and malignant alteration of these periinsular and intrainsular ductules (including IP) and, to a lesser degree, of intercalated ductules indicated their histogenetic relationship and their potency for reproducing embryonic tissue on carcinogenic stimulus. The similarity of some induced lesions to diabetes has been emphasized.

Animals↗
PubMed1986

Erythrocyte sedimentation rate/zeta sedimentation rate.

Sedimentation rates are a vital laboratory adjunct to the clinical skills of the emergency physician. A patient with an elevated rate in the emergency department needs further evaluation and appropriate referral. If the test is markedly elevated, there is a 95 per cent chance of an infectious, inflammatory, or neoplastic process as the underlying cause.

Aging↗
PubMedDate not supplied

Diagnosis of xanthogranulomatous cholecystitis by fine needle aspiration biopsy. A case report.

Xanthogranulomatous cholecystitis is an uncommon benign thickening of the gallbladder wall characterized histopathologically by extensive histiocytic infiltration. A case is presented in which a 62-year-old woman with clinical cholecystitis was found at surgery to have a markedly thick-walled, adherent gallbladder, raising the differential diagnosis of an inflammatory versus an infiltrating neoplastic process. Intraoperative fine needle aspiration (FNA) biopsy revealed abundant foamy histiocytes ("xanthoma cells"), both dispersed and in clusters associated with capillaries suggestive of organization. Occasional multinucleated giant cells and columnar epithelial cells were also present. The differential diagnosis of histiocytic processes sampled by FNA biopsy is reviewed.

Biopsy, Needle↗
PubMedDate not supplied

[X-ray computed tomographic aspects of neoplastic pathology of the parapharyngeal space].

The parapharyngeal space is a fat-filled region situated deep in the head between the basicranium and the oral floor. It can be divided in two parts: the prestyloid and the poststyloid space. The mandibular nerve is contained in the prestyloid space, while the carotid artery, jugular vein, IX, X, XI, XII cranial nerves, cervical sympathetic chain and junctional lymph nodes are situated in the poststyloid compartment. The normal CT anatomy and CT findings in 22 patients with proven lesions of the parapharyngeal space are described. Three different groups of neoplastic processes can be distinguished: primary tumours, secondary tumours and enlarged lymph nodes. The nature of the lesions developing in the parapharyngeal space can be diagnosed by CT in many cases.

Adipose Tissue↗
PubMed1987

Epidemiological data on cervical carcinoma relevant to cytopathology.

Epidemiological studies based on cervical cytopathology have aroused widespread interest since it was realized that they could be a useful tool for measuring the effectiveness of screening programs and defining practical measures for the prevention of invasive neoplasms and deaths. In the present article, published evidence from screening programs, cohort investigations and case-control studies is reviewed, and possibilities for further analyses and applications are discussed. In particular, when estimates of the relative protections conveyed by Pap smear from various case-control studies conducted on different populations and using different criteria of selection were pooled, a surprisingly close concordance emerged, with overall risk estimates of invasive cervical cancer of 0.42 for women reporting one smear, and of 0.20 for two or more smears in the past. This protection appeared to be long-lasting in a considerable proportion of cases, since the major determinant of invasive cancer risk was the number of previous smears rather than the interval since last smear, and a noticeable residual effect was evident even more than 10 years after the last smear. Besides providing a measure of the effectiveness of cytological screening and helping define the optimal frequency of screening using the limited resources available, case-control studies should permit accurate estimates of the sensitivity of the test and quantify the probability of transition and the duration of various stages of the neoplastic process, i.e., permit a better understanding of the natural history of the disease.

Carcinoma↗
PubMed1986

[Participation of neutrophils in the cytotoxic reaction against lymphatic leukemia cells in mice].

The studies were performed on the mice, male, at the age 10 weeks, with the high-leukaemia content strains (AKR and BALB/Mo) and low-leukaemia strains (BALB/c and DBA/2) in which were observed the development of lymphatic leukaemia of virus-derivative and the stimulation of lead acetate and cadmium acetate also. Were performed: sectional and histopathological examinations, and also examined the neutrophils amount in the blood, the activity of beta-glucoronidase in these cells and the magnesium level (the roentgen microanalysis method-MAR). The investigations were conducted after 8, 16 and 35 weeks of experiment. It was found, that the strong progressive granulopenia with the simultaneous lower level of magnesium and the decrease of the beta-glucoronidase activity in these cells, accompanied the leukemia. The obtained results manifest about the increase of the inertia in the cytotoxicity of blood granulocytes in relationship to leukaemia cells moderately of the development of the neoplastic process.

Animals↗
PubMed1987

The transitional polyp of the colorectal mucosa.

45 cases of small polypoid lesions occurring in the colorectal mucosa free of inflammatory or neoplastic disease are presented. The lesions were removed at colonoscopy and displayed neither features of hyperplastic (metaplastic) polyps nor features of a neoplastic proliferation. Morphologically these small lesions were characterized by elongated and widened crypts, enlarged goblet cells with an increase in mucous production. Histochemically there was a reversion of the usual pattern of mucin production in the colorectal mucosa: an increase in sialomucin production and a decrease in sulfomucins. Thus these lesions demonstrate the same morphological and histochemical features as the transitional mucosa surrounding carcinoma and adenoma in the large bowel. These "transitional" polyps could represent an early step in the development of neoplastic processes in the colorectal mucosa and precede adenomas.

Colonoscopy↗
PubMed1986

Pseudotumor of the pterygomaxillary space presenting as anesthesia of the mandibular nerve.

Pseudotumor is a term used to describe a space occupying inflammatory lesion which mimics a true neoplastic process in its clinical presentation. In this paper, we report a pseudotumor of the pterygomaxillary space that presented with anesthesia and paralysis of the mandibular nerve. The importance of this case is to call attention to pseudotumors as a clinical entity and to document a case of an extraordinarily aggressive variant that required a surgical approach usually reserved for malignant tumors.

Cranial Nerve Diseases↗
PubMed1986

Oncocytic change in adult rhabdomyoma.

An adult rhabdomyoma was studied with the light and electron microscopes. The source of eosinophilia of the cytoplasm on light microscopy can be attributed to two components: a filamentous and a granular components. Ultrastructural studies displayed numerous banded myofilaments and mitochondria exhibiting varying degrees of abnormalities. These mitochondrial alterations were similar to those described in oncocytes and oncocytomas. The latter morphologic findings suggest that the mitochondrial abnormalities in adult rhabdomyomas represent an oncocytic change and that they are an integral part of the neoplastic process. Though primarily affecting epithelial cells, oncocytic change, may, under unusual circumstances, involve mesenchymal cells.

Aged↗
PubMedDate not supplied

Comparative immunohistochemical demonstration of difucosylated carbohydrate antigens and CEA in adenomas and carcinomas of the rectum and rectosigmoid.

The present immunohistochemical investigation reveals that difucosylated carbohydrate antigens (DFCA) are extensively expressed in rectal and rectosigmoid carcinomas while normal mucosa and hyperplastic polyps are mainly negative. The adenomas showed intermediate staining patterns where adenomas with villous structures and moderate-severe dysplasia resembled of carcinomas. CEA was more extensively expressed in both normal, premalignant, and malignant tissue. Thus, DFCA is better than CEA as a discriminator between normal and malignant tissue in the distal large bowel, and may be used in future studies with the intention of advancing our understanding of the neoplastic process and assessing clinical relevance.

Adenoma↗
PubMed1986

Carcinoma in situ of the vulva: a review of 31 treated and five untreated cases.

Thirty six patients with carcinoma in situ of the vulva have been followed from two to 23 years. Among 31 patients managed by surgical excision, there were four recurrences of vulvar carcinoma in situ and one patient developed a vulvar carcinoma 17 years later. Four middle-aged and elderly women managed only by biopsy all progressed to invasive vulvar carcinoma in two to eight years; one additional patient progressed to invasion after inadequate primary treatment. These last five cases all represented multifocal lower genital tract neoplasia. Untreated vulvar carcinoma in situ, when seen as part of a multifocal lower genital tract neoplastic process, in middle and later life is likely to progress to invasion.

Adult↗