Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Intestinal colonization”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,549 records · Page 86Linked to original sources
PubMed1978

beta-Glucuronidase in schistosomal intestinal polypi of the colon.

The results of a clinical, histopathological and biochemical study on twenty patients with schistosomal polyposis of the large bowel and ten patients with normal colon as a control are reported. The biopsy showed clearly the absence of any malignant or premalignant changes in all the twenty bilharzial patients. Results of the biochemical study showed that there is a statistically significant increase in beta-glucuronidase activity in schistosomal polypi compared to normal mucosa. This enzymatic activity is absent in schistosoma ova. The causes of the increase in the enzyme activity have been attributed to leucocytic infiltration present in schistosomal granulomata and possible to some degree of liver disfunction. The protein content of the excess mucus present in the colon could also activate the enzyme. Our results also show that the increased enzyme activity does not necessarily have carcinogenic properties. We did not come across a single case of malignancy even in a patient with very high level of enzyme activity (11615 units) or in those patients with a prolonged history of the disease.

Colonic Neoplasms↗
PubMedDate not supplied

[Strongyloidiasic hyperinfestation].

A study was made of twelve cases of fatal Strongylodiasis with Hyperinfestation which presented a severe picture of the small intestine and colon, some with localization in the lungs, bronchus, and other organs. Preliminary results are given of a prospective study related to the bacterial flora and its role in the pictures of larvarial aggression, which could lead to greater knowledge about the biology of the parasite, and therefore to interesting findings of a therapeutic nature.

Colon↗
PubMed1990

Novel aspect of Crohn's disease: increased content of platelet-activating factor in ileal and colonic mucosa.

Intestinal mucosal content of platelet-activating factor (PAF-acether) was investigated in Crohn's disease. The PAF-acether content was determined in mucosal biopsies from the ileum and colon in Crohn patients (n = 13), and in normal mucosa of control patients (n = 11). PAF-acether was found in both groups and was raised in Crohn patients, both in the ileum (6.3 +/- 4.7 vs. 0.6 +/- 0.4 pmol/g; p less than 0.01) and colon (6.2 +/- 4.2 vs. 0.7 +/- 0.4 pmol/g; p less than 0.01). Colonic PAF-acether content was raised irrespective of the presence of colonic inflammation as judged macroscopically. These findings add further support to the importance of bioactive lipids in inflammatory bowel disease and suggest a possible role for PAF-acether in Crohn's disease.

Adolescent↗
PubMed2006

Dynamics of gut colonization and source of intestinal flora in healthy newborn infants.

The aim of the study was to evaluate the dynamics of gut colonization and the main source of intestinal bacterial flora in infancy in a quantitative manner using computerized analysis of bacterial cellular fatty acid (CFA) profiles. Each stool was collected from 10 healthy newborn infants during their first 2-7 days of life and a follow-up sample at 6 months of age. Stool samples were collected from mothers and nurses for comparison. Gas-liquid chromatography of the 159 stool samples was used to produce bacterial cellular fatty acid (CFA) profiles by means of a previously developed computerized program. The CFA profiles for the infants fluctuated from hour to hour during the first days of life and resembled those for both the mothers and the nurses, doing so all the more in the case of the five infants examined 6 months after birth. Gut colonization fluctuated markedly from hour to hour in the perinatal period. The effect of the maternal flora on the initial gut colonization may be less than expected as the fecal flora of infants started to resemble both the fecal flora of the mother as well as that of the first nurse.

Birth Weight↗
PubMed1997

[Expression of vasoactive intestinal peptide receptor in human colonic carcinoma cell membranes].

To evaluate the expression of vasoactive intestinal peptide receptor in colonic carcinoma cell membranes in men and to assess the relationship between the receptor characteristics and the histopathologic features, the authors labelled vasoactive intestinal peptide and measured vasoactive intestinal peptide receptor sites with radio-ligand bind assay on 12 specimens from colon cancer and its adjacent normal tissues. The number of the vasoactive intestinal peptide receptor sites of colon cancer was significantly smaller than that of the adjacent normal tissues (2.66 +/- 3.84 pmol/mg versus 10.54 +/- 17.99 pmol/mg, and the number of the receptor sites of colon cancer was not well related to the degrees of cancer differentiation. This study has laid the basis for the regulation of the receptor-ligand binding to inhibit the growth of colon cancer.

Adenocarcinoma↗
PubMed1991

Effect of fructooligosaccharide on Salmonella colonization of the chicken intestine.

The influence of fructooligosaccharide (FOS) on the ability of Salmonella typhimurium to grow and colonize the gut of chickens was investigated. In vitro studies showed that Salmonella did not grow when FOS was the sole carbon source. When FOS was fed to chicks at the .375% level, little influence on Salmonella colonization was observed. At the .75% level, 12% fewer FOS-fed birds were colonized with Salmonella compared with control birds. When chicks given a partially protective competitive exclusion (CE) culture were fed diets supplemented with .75% FOS, only 4 of 21 (19%) chickens challenged with 10(9) Salmonella cells on Day 7 became colonized as compared with 14 of 23 (61%) chickens given CE alone. When chickens were stressed by feed and water deprivation on Day 13 and challenged with 10(9) Salmonella on Day 14, 33 of 36 (92%) chickens fed a control diet were colonized compared with only 9 of 36 (25%) chickens fed a .75% FOS diet. Chickens treated with FOS had a fourfold reduction in the level of Salmonella present in the ceca. Feeding FOS in the diet of chickens may lead to a shift in the intestinal gut microflora, and under some circumstances may result in reduced susceptibility to Salmonella colonization.

Animal Feed↗
PubMed1986

Adaptation of electrolyte transport in rat large intestine after proximal resection. II. Colon after 50% jejunoilectomy combined with cecectomy.

Electrolyte transport was studied in rat colon adapting to 50% small intestinal resection with cecectomy. Four weeks after surgery, colonic gross surface area, dry and wet weight were increased compared to sham-operated controls. Net absorption in vivo of sodium, chloride and volume was stimulated per organ and per unit tissue mass, and net potassium secretion was diminished. The electrical potential difference, mucosal Na-K-ATPase specific activity and cAMP concentration remained unaffected. In vitro, measurements of unidirectional fluxes and electrical parameters across isolated mucosa indicated enhanced electrically neutral sodium chloride absorption in the proximal and possibly diminished bicarbonate secretion in the distal colon. Thus, removal of the cecum in addition to partial jejunoilectomy induces profound adaptive changes in the colon, involving not only mucosal growth but also a functional reaction of the individual epithelial cell.

Animals↗
PubMed1988

Altered intestinal chloride transport in cystic fibrosis.

Sodium ion and chloride transport was studied in vitro in small intestinal and colonic tissue from patients with cystic fibrosis (CF) and from non-CF control subjects matched as to age and sex. Normal histological appearance and substantial response to mucosal glucose (5 mM, ileum) or mucosal amiloride (10(-5) M, colon) indicated normal tissue viability in both control and CF tissues. Electroneutral NaCl absorption was demonstrated in the small intestine of control subjects and CF patients. Small intestinal and colonic tissues of control subjects responded to four secretagogues (theophylline, 5 mM; prostaglandin E2, 10(-6) M; calcium ionophore (A23187), 10(-5) M; bethanechol, 5 x 10(-5) M), with electrogenic chloride secretion. The tissues of CF patients, however, did not respond to any of the test secretagogues. These studies demonstrate that an abnormality in chloride transport is present in the small intestinal and colonic epithelia of CF patients. Unlike airway epithelia, which secrete chloride in response to Ca ionophore, the intestinal epithelia of CF patients do not respond to either cAMP- or Ca-mediated secretagogues. This abnormality in intestinal electrolyte transport may play a role in the pathogenesis of meconium impactions in CF patients.

Adult↗
PubMedDate not supplied

Microdissection study of the myenteric plexus in acardia, ataxia-telangiectasia, cystic fibrosis, extrahepatic biliary atresia, pediatric AIDS and Werdnig-Hoffmann disease.

Microdissection-point count morphometric study of the myenteric (Auerbach) plexus or esophagus, small intestine, and colon was done for infants and children with acardia (2), ataxia-telangiectasia (5), cystic fibrosis of the pancreas (CFP) (25), extrahepatic biliary atresia (EBA) (17), pediatric AIDS (10), and Werdnig-Hoffmann disease (WHD) (8). Values for fractional area of neural tissue in the plane of the plexus were compared to those of control patients in same age range as those in each disease category by t-test. Statistically abnormal values included low values for small intestine and colon in Werdnig-Hoffmann disease, high values for small intestine and colon in biliary atresia, and high value for colon but a low value for small intestine in cystic fibrosis. Values for all three loci were within the normal range for ataxia telangiectasia and pediatric AIDS. The mechanisms of the low value for small and large intestines in WHD, which causes chronic constipation as a result of skeletal muscle weakness, and of the high values for colon in CFP and EBA, both causing malabsorption with bulky stools, are unclear. The value for small intestine in acardia was normal for term but lower than expected for fetal bowel of the same size, possibly because of reduced neural crest inflow to the fetal bowel.

Acquired Immunodeficiency Syndrome↗
PubMed1985

Intestinal spirochaetosis of the colon diagnosed with colono-ileoscopy and multiple biopsies.

This paper deals with the clinical history, the histopathological and TEM features of a case of intestinal spirochaetosis associated with ulcerative colitis and tubular adenomas of the colon. It is the fifth described case of intestinal spirochaetosis in Sweden, and the first in the literature in which a complete colonoscopy with multiple biopsies has been performed. Intestinal spirochaetosis might lead to minor complaints as distension and vague abdominal discomfort, as in this case, but also to more prominent symptoms such as diarrhoea. Heavy infestation of the gut surface epithelium by spirochaetes was seen in the total colon, but was not found in the distal ileum.

Biopsy↗
PubMed1993

Relation of symptoms to impaired stomach, small bowel, and colon motility in long-standing diabetes.

Stomach, intestinal, and colonic transit were measured in males with insulin-requiring diabetes of greater than 10 years' duration to compare with symptoms and to estimate the medical significance. For all diabetics only the symptom constipation correlated with the appropriate regional delayed transit. Diabetics with delayed transit in any region, however, had more overall gastrointestinal symptoms. Diabetics with delayed transit had disease of significantly longer duration than those without delay. Delayed transit was common in the diabetics selected for study with 21 of 54 stomachs, 10 of 20 small intestines, and 14 of 20 colons showing impairment. Of 35 diabetics with impaired transit at one or more locations, only seven were judged of medical importance and five of these responded to treatment. In this study, delayed transit was frequent; in the one fifth requiring management, the symptoms related closely to the region impaired.

Aged↗
PubMed1992

Immunochemical localization of aminopeptidase M in the alimentary tract of the guinea pig and rat.

Aminopeptidase M (APM) was localized in the kidney and alimentary tract of guinea pigs and rats by indirect immunohistochemistry. APM was detected in the brush border of the epithelium of the proximal convoluted tubule of the kidney and of the small intestine, and it was localized to cells scattered throughout lymphoid tissue in the small intestine and colon. The gastric mucosa was unstained. APM was localized to numerous fibers supplying the myenteric plexus of the stomach, small intestine, and colon. The submucosal plexus was sparsely supplied by immunoreactive fibers. Occasional cell bodies were stained in the myenteric plexus. Staining was abolished by preabsorption of the primary antibody with APM. APM was characterized in membranes prepared from the muscle and mucosa of the guinea pig and rat stomach, small intestine, and colon by Western blotting. The major immunoreactive protein identified in membranes prepared from all tissues had an apparent molecular weight of 140, corresponding to the monomer of APM. In the brush border APM has a digestive function, whereas in neural tissue it may degrade and inactivate neuropeptides.

Aminopeptidases↗
PubMedDate not supplied

[Intestinal obstruction for malrotation in an adult patient. Report of a case].

We present a case of a 78 year-old man with the pathological antecedent of chronic constipation that comes to our emergency room at the Victor Lazarte Echegaray Hospital. He presented abdominal pain and progressive abdominal distension, nausea and bilious vomits of two days of evolution. The clinical examination showed an evident abdominal distension, and some metallic intestinal noises. A frontal and lateral simple abdominal x- ray showed a considerable distension of the gastric camera and intestinal loops and free fluid all over the abdominal cavity, all of which was compatible with the diagnosis of intestinal obstruction. At the operating room we proceeded with a exploration and we founded an intestinal obstruction at the ascending colon (Ladd's Bands) of high location with bloody fluid in the abdominal cavity, multiple fecalomas in the descending colon, and intestinal ischemia in the distal small bowel, the color, tone and coiling of the intestine recovered after section of the Ladd's bands. The patient evolved favorably.

Abdominal Pain↗
PubMed1991

Kinetics of Saccharomyces cerevisiae elimination from the intestines of human volunteers and effect of this yeast on resistance to microbial colonization in gnotobiotic mice.

When healthy volunteers were given a daily dose of 3 x 10(8) life-dehydrated Saccharomyces cerevisiae cells for 5 days, the volunteers excreted 10(5) living yeast cells per g of feces at first, but the yeast cells disappeared within 5 days of the end of treatment. In gnotobiotic mice, S. cerevisiae administered alone colonized the intestinal tract but did not interfere with previous or subsequent colonization by a variety of potentially enteropathogenic microorganisms. When these microorganisms were present, the intestinal counts of S. cerevisiae were greatly reduced.

Adult↗