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[Cerebral angiography with the contrast medium vasobrix 32 (ioxitalamate) (author's transl)].

On the basis of angiograms carried out 168 patients, the contrast qualities achieved with the contrast medium, Vasobrix 32 were compared with those of other contrast media used so far. In the case of carotid angiography, Vasobrix 32 allowed better visualisation in the arterial phase than achieved with the contrast media used so far. The superiority of Vasobrix 32 over other substances was even more evident in the venous phase. As regards visualisation of the branches of the small arterial vessels such as the striothalamic branches, the results achieved with Vasobrix 32 were better than with the contrast media used so far and, therefore, a general improvement in visualization can be expected from Vasobrix 32 (Ioxitalamate). Complications with neurological sequelae were not observed, subjective complaints occurring to a slightly lesser extent than in the case of contrast media with a high sodium salt content.

Cerebral Angiography↗

[Contribution of iodinated cisternography to craniocerebral computed tomography].

Computerized tomography is usually adequate to explore supratentorial lesions of the skull and brain. However, it is often inadequate for a detailed analysis of lesions of the base of the skull and their anatomical rapports. Opacification of the subarachnoid spaces by means of a contrast medium (computerized cisternography) has proved extremely useful in such cases. The contrast media utilized are tri-iodized, water-soluble compounds which are well tolerated. The technique and anatomical data of the method are described, and its applications in different fields of tumoral and non-tumoral pathology are discussed.

Arachnoid↗

Effect of contrast media on femoral blood flow. Comparison between non-ionic and ionic monomeric and monoacidic dimeric contrast media in the dog.

Injections of non-ionic monomeric (metrizamide, C29 and iohexol) and monoacidic dimeric (ioxaglate) contrast media into the femoral artery of dogs caused significantly less increase in the rate of femoral blood flow than the more hypertonic ionic monomeric compound metrizoate at equivalent iodine concentrations. The effect of metrizoate was similar to that of equiosmolal solutions of sodium chloride. Sodium chloride in concentrations equiosmolal with the non-ionic monomers and monoacidic dimer caused less changes in blood flow than these contrast media, but the changes in blood were equal to those of isotonic sodium chloride.

Animals↗

Proteinuria following nephroangiography. VII. Comparison between ionic monomeric, monoacidic dimeric and non-ionic contrast media in the dog.

The degrees of albuminuria induced by nephroangiography in dogs with the ionic monomeric contrast medium diatrizoate, the non-ionic iopamidol, iohexol and C29 and the monoacidic dimeric contrast medium ioxaglate were compared. Diatrizoate induced significantly higher albuminuria than the other contrast media. No significant differences in the degree of albuminuria following angiography were found between iopamidol, iohexol, C29 and ioxaglate.

Albuminuria↗

[Circulatory and adverse effects of nonionic contrast media in arteriography. Results of a double-blind study].

The effect to the local toleration of different concentrations of new non-ionic contrast media (Iopamidol 300 and 370) has been examined by means of a randomized intraindividual double-blind study and by the use of uniform parameters of application. In all cases the pain and heat effect were tolerable for the non-anaesthesized patients. The application of the higher concentration of the contrast media did not strengthen or intensify these side effects, which were formerly connected with the arteriography of the extremities. In cases, where the circulation is heavily disturbed, the opacification of the peripheral branches of the leg arteries can be improved by the use of the higher concentration. The hemodynamic effect was low and disappeared after a few minutes.

Adult↗

Iopamidol for myelography. A clinical trial with a new non-ionic contrast medium.

289 myelographies with the non-ionic, water-soluble, contrast medium iopamidol were performed. These were subdivided into 153 lumbar, 49 ascending thoracocervical and 87 cervical myelographies. For the latter a lateral C1-C2 puncture was used. The iodine concentration given was 200 mg/ml for the lumbar examinations and 300 mg/ml for the cervical and thoraco-cervical examinations. The total iodine never exceeded 3 g. Image quality is not different to metrizamide of equal iodine concentration. Adverse reactions did not exceed those known for metrizamide. Mild and transient side effects occured in 45%.

Clinical Trials as Topic↗

[Possibilities of conventional intravenous subtraction angiography].

Basing on the experiences collected with 127 patients, the pros and cons as well as the indications for intravenous angiography with conventional photographic subtraction technique (ISA) are discussed in comparison with rival procedures. ISA can be performed in every angiography unit without any additional investment, and its possibilities of use are identical with those of the DSA. As a matter of fact, it is a simple and safe method for visualising the renal arteries in the course of intravenous urography in the diagnostic evaluation of hypertension. For the first time, it has become possible to perform transvenous determination of the complete status of the arteries of the pelvis and legs, using a new technical system (simultaneous use of two film changers in the frontal plane--ISA aortoarteriography.

Angiography↗