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PubMed1983

Rat vitamin-D-dependent calcium-binding proteins. Specificity of mRNAs coding for the 7500-Mr protein from duodenum and the 28000-Mr protein from kidney and cerebellum.

mRNA extracted from rat duodenum, kidney and cerebellum was translated in a cell-free reticulocyte lysate system in the presence of L-[35S]methionine. Vitamin-D-dependent calcium-binding proteins (D-CaBPs) were identified by immunoprecipitation using antibodies specific to duodenal D-CaBP (7500 Mr) and cerebellar D-CaBP (28000 Mr). When duodenal mRNA was translated, the immunoprecipitated polypeptide, obtained using antibodies to duodenal D-CaBP, comigrated with the pure small D-CaBP. Only the addition of unlabeled small duodenal D-CaBP prevented the immunoprecipitation of the major protein. Likewise, when mRNA extracted from the kidney and cerebellum was translated, the product immunoprecipitated by antibodies specific to large mammalian D-CaBP was electrophoretically similar to pure 28000-Mr protein, being displaced only by the addition of unlabeled large D-CaBP. The yield of the duodenal D-CaBP synthesized in the reticulocyte lysate assay was remarkably high (about 10%) compared to that of the large D-CaBP with renal (1%) or cerebellar (0.4%) mRNA. In the absence or presence of microsomal membranes, proteins of similar molecular weight were synthesized, suggesting that the biosynthesis of both large and small D-CaBPs do not involve the processing of leader sequences. Moreover in our experimental conditions duodenal poly(A)-rich RNA was unable to direct the synthesis of large D-CaBP while the mRNAs extracted from kidney and cerebellum did not code for the small D-CaBP. Our data indicate that two distinct mRNAs, coding for small and for large vitamin-D-dependent CaBPs, are expressed in specific tissues of the rat.

Animals↗
PubMed1978

[Peptic ulcers evoked by retention of the antral portion of mucous membrane at the duodenum after a Bilroth II stomach resection].

From the authors' data the retained mucous membrane of the antral region at the duodenum following gastric resection for peptic ulcer results in the development of gastric ulcers. It has been found that only the removal of the retained antral mucous membrane stops the production of HCl and promotes the healing of ulcer. The reflux of the duodenal contents into the isolated pylorus does not constitute a cause of the gastrin production, the continuation of which is mainly due to the vagal denervation of the glands producing the antral hormone.

Animals↗
PubMed1980

Arteriovenous malformation of the duodenum.

In their report of a 55-year-old woman with an arteriovenous malformation of the duodenum, the authors illustrate some of the interesting clinical features of this uncommon cause of chronic gastrointestinal bleeding. The lesion was treated by surgical resection. Arteriovenous malformations have been classified according to location, age of the patient and family history. In this patient the malformation was considered to be a type 2 or congenital lesion. The authors review the literature on arteriovenous malformations and emphasize the use of selective visceral angiography for diagnosing arteriovenous malformations of the gastrointestinal tract.

Arteriovenous Malformations↗
PubMed1982

[Closed injuries of the retroperitoneal portion of the duodenum].

Closed injuries of retroperitoneal segment of the duodenum are very rare due to its small length and covering by the other organs. Almost half of these injuries are associated with injuries of the other organs. Pathoanatomical lesions are in the form of contusions, which may be overlooked by the surgeon if they are isolated, or as ruptures which require an operation. The author has treated four cases with ruptures which were most often located on the horizontal duodenal part and on the crossing from descending to the horizontal part. They were as consequences of kicks in the abdomen, traffic accidents and falls from heights. The mechanism of the injury involves hyperextension of the spinal column and sudden movement of the gastric and intestinal content. In the clinical picture dominate: pain irradiating to thorax, shoulder or flank, local tenderness and radiologically retroperitoneal and paravertebral collection of air. Because of quick deterioration of the signs, a clinical picture of peritonitis can develop, especially in association with the rupture of the other hollow-organs. In the injuries of the parenchimatous organs the signs of bleeding in the peritoneal cavity will dominate. Two of the four treated patients died.

Adolescent↗
PubMed1982

An electron microscopic study of heme uptake by rat duodenum.

The uptake of heme by mucosal absorptive cells of rat duodenum was studied by electron microscopy; normal and iron-deficient animals were used. Heme was administered as hemoglobin or hemin chloride by means of an intragastric tube and also by injection into a closed duodenal loop. The peroxidatic activity of heme was utilized to locate it on the cell surface and within the cell; aldehyde-fixed mucosal tissue was incubated in a solution of 3,3'-diaminobenzidine. Heme was observed first on the surfaces of the microvilli of the absorptive cell and in apical pits between individual microvilli. Shortly thereafter, heme appeared within membrane-bound tubules which apparently communicated with the apical pits. At later intervals, secondary lysosomes, located in apical cytoplasm and in the supranuclear region of the cell, contained heme; the manner of heme transfer from the apical pit-tubular system to the lysosomal compartment was not defined. Gradual loss, with time, of 3,3'-diaminobenzidine reaction product from secondary lysosomes indicated cleavage of heme therein. Normal and iron-deficient rats handled heme in a similar manner.

3,3'-Diaminobenzidine↗
PubMed1982

Acid secreting gastric heterotopia in the duodenum.

Heterotopic gastric mucosa was found in the duodenum of a female patient with duodenitis and acid hyposecretion. The heterotopic isolated fundic glands were shown to accumulate 14C-aminopyrine in basal state and on stimulation with histamine suggesting that the heterotopic mucosa secreted acid. The ectopic acid secretion in the duodenal bulb suppressed gastric acid secretion, and might have caused the duodenitis and at least partly the clinical symptoms. The heterotopic gastric mucosa could be removed surgically by local excision. This procedure, combined with a Nissen fundoplication for suspected reflux oesophagitis, was followed by total symptomatic relief and normalization of gastric acid secretion.

Choristoma↗
PubMed1980

Glycosaminoglycans from pig duodenum.

A polysaccharide extract from pig duodenum, used in therapy as antilipemic, was shown by chromatographic and electrophoretic methods to be a mixture of the glycosaminoglycans (GAG) heparin (HEP), heparan sulfate (HS), dermatan sulfate (DeS), chondroitin sulfates (ChS) and hyaluronic acid (HA), in the ratio 24:31:23:9:13. The GAG mixture was fractionated with alkyl-ammonium salts, and, for DeS, with copper salts. Further purification of the fractions either by repeated complexation or by removal of residual impurities using specific enzymes or chemical reactions, permitted obtaining individual GAG more than 97% pure by electrophoretic and 1H-NMR analysis. These preparations will be used to assess the contribution of individual GAG to the biological activity of duodenal GAG extracts.

Animals↗
PubMed1982

Surgical procedure for modifying the duodenum in cattle to measure bile flow and the diurnal variation in biliary manganese, iron, copper and zinc excretion.

A surgical procedure is described for modifying the duodenum of cattle so that bile can be sampled and its rate of flow measured for long periods. In 12 steers, aged three months to three years and weighing between 50 and 650 kg, bile flow ranged from 2 to 12 ml per minute, the rate of flow increasing with bodyweight. The rate of flow expressed as ml per minute per 100 kg bodyweight decreased as bodyweight increased, the regression equation being in (ml per minute per 10 kg) = 1.65-0.0022 x where x = bodyweight (kg), r = 0.871. The mean concentrations of copper, iron, manganese and zinc in bile were 8.2, 6.2, 17.1 and 3.3 mumol per litre respectively. The concentration of iron was the least variable between the steers. The average total cholate concentration was 100 mmol per litre and total solids ranged from 5.4 to 7.2 per cent. Diurnal patterns in bile flow and trace element excretion were measured in four adult steers during a period of 38.5 hours. Although the rate of excretion of iron, zinc and copper and bile flow varied throughout the period, changes could not be associated with feeding or time of day. The concentration of manganese in bile and its excretion rate varied in a reproducible manner which may be related to feeding activity. The mean output of the four trace elements in bile from the four steers during 24 hours was, copper 37.7 mumol, iron 68.0 mumol, manganese 80.3 mumol and zinc 59.6 mumol.

Animals↗
PubMed1980

Gastric and intestinal mucosal morphology before and after interposition of a reflux-preventing valve between the gastric remnant and the duodenum. An experimental study in dogs.

A gastric mucosal reaction characterized by inflammatory cells and oedema in the lamina propria and proliferation of surface epithelium was found in 5 out of 12 dogs subjected to partial gastrectomy and examined 1-6 months after the operation. A normal gastric mucosa was found in 14 dogs 1-12 months after interposition of a reflux-preventing valve between the gastric remnant and the duodenum. In 4 dogs with histologically verified gastritis after partial gastrectomy, transposition of a jejunal segment provided with an intussusception valve resulted in normalization of the gastric mucosal morphology.

Animals↗
PubMed1981

[Crohn's disease in the stomach and duodenum, a diagnostic problem (author's transl)].

Six cases reports are given of patients with Crohn's disease localized in the stomach or the duodenum, and problems of diagnosis are discussed. In many cases the disease cannot be differentiated from other inflammatory conditions or from gastric carcinoma by means of radiological or endoscopic examination. Careful search for other localisations of the disease, and multiple, accurate biopsies as well as histological examination will allow to establish the diagnosis. If this cannot be done by the before mentioned means, laparotomy has to be performed in order to allow removal of enough tissue for extended histological examination needed to rule out malignancy.

Adult↗
PubMed1980

[Experiences with duodenum-sparing pancreas head resection in chronic pancreatitis].

1. A duodenum-preserved resection of the pancreas head was performed in 12 patients with chronic pancreatitis and tumor of the pancreas head without malignancy. The defect of the pancreas was repaired by an interposition of an jejunal 100p. -- 2. The clinical lethality was 0%. Follow-up after an average of three years showed 75% of the patients were completely able to return to work. -- 3. This resection procedure saves the patient from partial gastrectomy, common duct resection, and duodenectomy as compared to duodenopancreatectomy.

Adult↗
PubMed1980

[Errors and risk in the surgery of closed trauma to the pancreas and duodenum].

Errors and risk in the surgery of closed traumas of the pancreas in 10 patients and ruptures of the duodenum in 4 patients are analyzed. It is emphasized that a suspicion of a trauma of these organs is a sufficient ground for surgery. At all stages of the treatment of these patients the intensive complex therapy is indicated.

Adult↗
PubMed1995

[Pancreatic head resection with preservation of the duodenum--the optimal surgical procedure in chronic pancreatitis].

Surgical procedure appears as an optimal curative method for the treatment of advanced stages of all 4 types of chronic pancreatitis. Progress in diagnostic methods and defining of classification with more precision in last years led us to the idea to optimalize also surgical procedure for the treatment of chronic pancreatitis. Since 1985 we have been performing duodenum preserving pancreas head resection followed by pancreatogastroanastomosis in symptomatic form of chronic pancreatitis. Checking up of 28 patients operated on by this procedure confirm best results of all used methods. With regard to the character of the disease we are not able to improve external secretory function of the pancreas by this operation. External secretory insufficiency has to be substituted permanently by medicaments. Substantial contribution of this operation is in improvement of the quality of the life of the people suffering from chronic pancreatitis.

Anastomosis, Surgical↗
PubMed1995

[Presence of Helicobacter pylori in the duodenum, antrum, and fundus in control subjects and patients with duodenal ulcer, gastric ulcer, gastritis, or erosive duodenitis. Histological analysis of 357 subjects].

The prevalence of Helicobacter pylori infection was studied in 152 subjects with a normal upper gastrointestinal endoscopy, 125 with duodenal ulcer, 25 with gastric ulcer, 46 with erosive gastritis and 9 with erosive duodenitis. Two biopsies from duodenum, antrum and fundus were obtained from each subject during endoscopy for histological diagnosis and Helicobacter pylori search. None of the patients with normal endoscopy and 2% of patients with duodenal ulcers had Helicobacter pylori in duodenal biopsies. These last patients had a significantly higher frequency of Helicobacter pylori in the antrum (71%) than the rest of the studied groups. Five percent of subjects with normal endoscopy and 5% of those with duodenal ulcers had Helicobacter pylori in the antrum. An active gastritis was demonstrated in almost all patients with Helicobacter infection. Intestinal metaplasia occurred almost exclusively in the absence of Helicobacter pylori infection.

Adolescent↗
PubMed1994

[Postoperative complications and mortality in peptic ulcer of the duodenum and stomach].

During 19 years (from 1974 to 1992) 5205 operations for complicated ulcer disease of duodenum (4201 observation), stomach (915) and of double localization (89) were conducted. In 585 of 5205 patients complications occurred: of operative wound healing-in 17.4%, in the region of intervention--in 56%, dysfunction of other organs and systems--in 26.6%, 44 (0.84%) of them died. The mortality after conduction of stomach resection according to Bilroth-I was 0.8%, according to Bilroth-II--5.5%, after vagotomy--1%.

Adolescent↗
PubMed1994

Rupture of pancreaticoduodenal artery aneurysm in duodenum. Report of a case.

We report the case of a 74 year-old woman presenting a rupture in the duodenum of pancreaticoduodenal artery aneurysm treated with success by an aorto-mesenteric by-pass and ligature of gastroduodenal artery. The pancreaticoduodenal artery is an uncommon aneurysmal localization; surgical treatment of which is often difficult on account of the proximity of the pancreatic parenchyma and arteriography is essential to guide the surgical procedure.

Aged↗
PubMed1994

[Surgical treatment of peroperative injuries of the duodenum].

Operative duodenal lesions are rare, but often fatal complications of certain abdominal procedures. This was reported in small series with an incidence of 0.2% of all abdominal operations. The management of these injuries requests the surgeon to be familiar with a number of specific operative approaches, which are to be used according to the operative situation. In the 1985-1992, year period, 21 cases of the operative injury of duodenum were managed without mortality, and with 3 cases of transient postoperative fistula, which healed spontaneously. The most important factors in the management of this complication are the early operative recognition of duodenal injury, or early reoperation, if, in a case of duodenal fistula, distal outflow is considered insufficient. The particularities of the duodenal suture and perioperative treatment are to be well understood. Roux en Y covering of the duodenal defect by open jejunal loop is the best method in management of these injuries.

Adult↗