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At least 1,549 records · Page 86Linked to original sources
PubMed2001

Dendritic cells recruitment and in vivo priming of CD8+ CTL induced by a single topical or transepithelial immunization via the buccal mucosa with measles virus nucleoprotein.

The buccal mucosa, a prototype of pluristratified mucosal epithelia, contains a network of directly accessible class II(+) epithelial dendritic cells (DC), similar to skin Langerhans cells. We showed that a single buccal immunization with measles virus nucleoprotein (NP), by either topical application onto or intradermal injection in the buccal mucosa, induced in vivo priming of protective class I-restricted specific CD8(+) CTL. Both routes of immunization with NP induced a rapid recruitment of DC into the mucosa, which peaked at 2 h and decreased by 24 h. Treatment of mice with Flt3 ligand resulted in an increased number of DC in the buccal mucosa and enhanced the frequency of IFN-gamma-producing NP-specific effectors and the NP-specific CTL response generated after buccal immunization with NP. Finally, NP-pulsed bone marrow-derived DC induced NP-specific IFN-gamma-producing cells upon adoptive transfer to naive mice. These data demonstrate that a viral protein delivered to DC of the buccal mucosa induces in vivo priming of protective anti-viral CD8(+) CTL.

Adjuvants, Immunologic↗
PubMedDate not supplied

[Development of a rapid method, based on the latex agglutination reaction, for diagnosing carnivore plaque].

A highly effective rapid method for detecting carnivore plague virus antigen in dogs, based on the latex agglutination test, is developed. Latex conjugate is synthesized on the base of polystyrene suspension, representing a copolymer of styrene and methacrylic acid. The immunospecific reagent is gamma-globulin fraction of rabbit serum containing antibodies specific to carnivore plague virus. The resultant latex conjugate can be used in practical veterinary as a diagnostic agent for screening dogs for carnivore plague virus.

Animals↗