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Contact dermatitis to estradiol benzoate.

Three patients developed facial dermatitis after contact with preparations containing estradiol benzoate. Patch tests were positive to estradiol benzoate 0.1% in MEK but negative to other related estrogens including estradiol. All three patients also had positive tests to resorcinol monobenzoate and two out of three to balsam of Peru. Most likely estradiol benzoate was the primary sensitizer.

Adult↗

Nickel contact dermatitis in a blood bank.

Twenty blood donors developed a dermatitis at the site of venesection within a few hours of giving blood. A local anaesthetic administered with a Dermo-Jet had been used before extracting blood. In only 2 cases was sensitivity to the local anaesthetic found. In the others the reaction was caused by nickel released from the Dermo-Jet. The quantity of nickel released is greater from the anaesthetic solution than from deionised water. It increases with the time that the anaesthetic remains in the Dermo-Jet. The release of nickel is greater from a used Dermo-Jet than from a new one. Histology revealed a lymphohistiocytic infiltrate at the level of the deep dermis.

Adult↗

Contact dermatitis to chlorhexidine.

In a 3-year period, 551 patients were patch tested with chlorhexidine gluconate 1% in water. 14 patients showed a strong and obviously relevant reaction. A severe dermatitis developed during treatment with a chlorhexidine preparation in 10 patients with venous or traumatic ulcers of the leg, and in 4 patients with skin infection on the face and/or scalp. So far the sensitizing potential of chlorhexidine has probably been underestimated.

Aged↗