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PubMed2005

Clinical observation on 96 cases of primary osteoporosis treated with kidney-tonifying and bone-strengthening mixture.

OBJECTIVE: To objectively evaluate the therapeutic effect and safety of Mixture for Nourishing Kidney and Strengthening Bone. METHOD: Among 160 cases of osteoporosis under clinical observation, 96 patients in the treatment group were treated with Mixture for Nourishing Kidney and Strengthening Bone, 32 patients in the control group were given Shen Gu Capsule and 32 patients in the blank group were given no drug in half a year. Observation and determination were conducted on bone mineral density (BMD), clinical symptoms, bone gla protein (BGP), pyridinoline (PYD), estradiol (E2), testosterone (T), blood urea nitrogen (BUN), transaminase and routine test on blood and urine. RESULT: The comprehensive effect in the treatment group was remarkably superior to that in the control group. CONCLUSION: The safe and reliable Chinese drug can enhance BMD, promote osteogenesis and inhibit bone absorption, hence treating osteoporosis with marked effect.

Aged↗
PubMed1975

Accuracy of the Bing and Rinne tuning fork tests.

Fifty children seen in an ENT clinic received the Bing and Rinne tuning fork tests, otoscopic examination, and puretone audiometry to determine the accuracy of the tuning fork tests in predicting otoscopic abnormality or conductive hearing loss. Neither tuning fork test showed high accuracy. The Bing test overidentified by yielding negative results (conductive loss) for many ears with normal hearing or sensorineural loss. It correctly identified conductive loss or otoscopic abnormality only slightly better than chance57% to 66% of the time. The Rinne test identified with high accuracy those ears with a 40 dB or greater air-bone gap. For air-bone gaps of 10-35 dB, only 27% of the ears gave negative results, meaning correct identification. However, when a negative Rinne occurred, the result was in error only 2% of the time.

Adolescent↗
PubMed1993

Posterior crus stapedectomy.

The results of stapedectomy were compared between 162 otosclerotic ears operated on using the posterior crus technique and 182 otosclerotic ears undergoing Teflon piston stapedectomy. The large fenestra technique with fascia seal to the oval window was used in all cases. Mean follow-up period was 9.6 years. Neither short-nor long-term hearing results showed any significant differences between the two surgical technique groups. Complications of surgery were more common in patients undergoing Teflon piston stapedectomy. On the other hand, a re-operation for recurring conductive deafness was performed significantly more often in patients undergoing posterior crus stapedectomy.

Adult↗
PubMed1982

Physiological factors related to delayed auditory feedback and stuttering: a review.

Delayed auditory feedback (DAF) generally produces speech disturbances in normal speakers and improved fluency in stutterers. Several theorists have proposed that the speech disruptions of normal persons under such delayed feedback are an analog of stuttering. Related research has linked delayed auditory feedback and stuttering to several physiological factors. A review of familial relationship, age, sex, stress, speech characteristics, and sound conduction is presented. A brief integration of the factors and directions for research is presented.

Age Factors↗
PubMed1989

Comparison of acridine orange and Giemsa stains in several mouse bone marrow micronucleus assays--including a triple dose study.

Data from four mouse bone marrow micronucleus assays are presented in which sister slides were stained with Giemsa or Acridine Orange (AO). These data are used to support our decision to change from Giemsa stain to AO when conducting rodent bone marrow micronucleus assays. The AO method leads to definitive assessments of the incidence of micronucleated polychromatic erythrocytes on a slide, and in so doing, it saves reading time and increases confidence in data. Preliminary experiments with DMBA using the triple-dose/single sample protocol of MacGregor are also described, and it is concluded that this protocol shows great promise.

Acridine Orange↗
PubMed2004

Superior semicircular canal dehiscence presenting as conductive hearing loss without vertigo.

OBJECTIVE: The objective of this study was to describe superior semicircular canal dehiscence (SSCD) presenting as otherwise unexplained conductive hearing loss without vestibular symptoms. STUDY DESIGN: Retrospective. SETTING: Tertiary referral center. PATIENTS: The study comprised 8 patients (10 ears), 5 males and 5 females aged 27 to 59 years. All 10 ears had SSCD on high-resolution computed tomography scan of the temporal bone. DIAGNOSTIC TESTS AND RESULTS: All 10 ears had significant conductive hearing loss. The air-bone gaps were largest in the lower frequencies at 250, 500, and 1000 Hz; the mean gaps for these 3 frequencies for the 10 ears were 49, 37, and 35 dB, respectively. Bone-conduction thresholds below 2000 Hz were negative (-5 dB to -15 dB) at one or more frequencies in 8 of the 10 ears. There were no middle ear abnormalities to explain the air-bone gaps in these 10 ears. Computed tomography scan and laboratory testing indicated lack of middle ear pathology; acoustic reflexes were present, vestibular evoked myogenic potentials (VEMPs) were present with abnormally low thresholds, and umbo velocity measured by laser Doppler vibrometry was above mean normal. Middle ear exploration was negative in six ears; of these six, stapedectomy had been performed in three ears and ossiculoplasty in two ears, but the air-bone gap was unchanged postoperatively. The data are consistent with the hypothesis that the SSCD introduced a third mobile window into the inner ear, which in turn produced the conductive hearing loss by 1) shunting air-conducted sound away from the cochlea, thus elevating air-conduction thresholds; and 2) increasing the difference in impedance between the oval and round windows, thus improving thresholds for bone-conducted sound. CONCLUSION: SSCD can present with a conductive hearing loss that mimics otosclerosis and could explain some cases of persistent conductive hearing loss after uneventful stapedectomy. Audiometric testing with attention to absolute bone-conduction thresholds, acoustic reflex testing, VEMP testing, laser vibrometry of the umbo, and computed tomograph scanning can help to identify patients with SSCD presenting with conductive hearing loss without vertigo.

Acoustic Impedance Tests↗
PubMed1995

Hearing loss in the 4-8 kHz range following tympanic membrane perforation from minor trauma.

This study looked at the incidence of sensorineural hearing loss in the 4-8 kHz range in patients with unilateral tympanic membrane perforations from minor trauma who presented to the department in the past year. Eleven patients conformed to our inclusion criteria, one was lost to follow-up. Perforation was present in all patients in the pars tensa and no treatment was required in nine patients. The mean sensorineural hearing loss at 4,6 and 8 kHz was 28.2 dB on initial examination and 14.6 dB by Day 30. All 11 patients had normal hearing in the contra-lateral ear (mean 13.5 dB). In this group of patients with a tympanic membrane perforation from minor trauma the conductive hearing loss was accompanied by a significant (P = 0.001) but reversible high frequency sensorineural deafness.

Adolescent↗
PubMed2002

Posterior and attic wall osteoplasty: hearing results and recurrence rates in cholesteatoma.

OBJECTIVE: To assess the efficacy of a surgical technique, the temporary attic and posterior canal wall osteoplasty, in preventing cholesteatoma recurrence. DESIGN/PARTICIPANTS: The records of 94 patients submitted to tympanoplasty for cholesteatoma in the ear, nose, and throat department of a main city hospital between 1989 and 1997 were retrospectively reviewed. INTERVENTIONS: Intact canal wall procedure with attic and posterior canal wall temporary removal was performed in 47 cases. A canal wall down operation was performed in the 47 remaining cases. The follow-up ranged from 22 to 84 months. METHODS AND MAIN OUTCOME MEASURES: The patients from one group could be exactly matched for the main prognostic factors (type of cholesteatoma, ossicular status, and preoperative auditory status) with the patients from the other group. Auditory results were defined according to the Committee on Hearing and Equilibrium Guidelines. A 1-way analysis of variance was used to determine group differences. A probability value of p < 0.05 was the level of significance selected. RESULTS: All of the patients in the 2 groups were cholesteatoma free at the last follow-up, and significantly better hearing results were observed in the osteoplasty group. CONCLUSIONS: The osteoplasty with temporary removal of the posterior and attic canal wall is a useful adjunct to tympanoplasty in cholesteatoma cases as far as the hearing results and recurrence rates are concerned. This method combines the functional advantages of canal wall up operations with the safety yielded by canal wall down procedures.

Adult↗
PubMed1995

Body sway and vibration perception thresholds in normal aging and in patients with polyneuropathy.

Body sway and vibration perception in the lower limbs were measured in 32 normal subjects and 25 patients with peripheral neuropathies; nerve conduction studies were also performed in the patients with neuropathies. Body sway was measured by means of force-plate posturography, and three methods were used to assess vibration perception: a neurothesiometer, a semiquantitative tuning fork, and the bone vibrator of a conventional audiometer. Body sway and vibration perception were increased in the patients with peripheral neuropathies and there was significant correlation between these measures.d These findings, together with the lack of correlation between sway and muscle strength, indicate that the main source of unsteadiness in these patients is the loss of proprioceptive information. Vibration perception and body sway did not correlate with the electrophysiological variables, indicating that these measures assess different aspects of peripheral nerve function. In all subjects there was close correlation between vibration perception as assessed by the neurothesiometer and the audiometer could be used to screen proprioceptive function in patients with balance disorders. In normal subjects age correlated with vibration perception (measured with the neurothesiometer and audiometer) and also with body sway standing on foam. This suggests that the increased body sway in elderly people may partly be due to redue proprioception in the lower limbs.

Adult↗
PubMed1990

[Audiological evaluation of the middle ear implant--temporal auditory acuity].

Temporal auditory acuities provided by the middle ear implant (MEI) and by the hearing aid (HA) were compared in ten patients implanted with the MEI. Test sounds used in the experiment were tone bursts [rise and fall time: 25 msec, duration (t): 982-1000 msec, interval (T): 1000 msec] of 500 Hz or 2000 Hz at 70 dBSPL. A speaker was placed in front of a subject one meter apart. At first, the subject adjusted the gain control of outer unit at the most comfortable loudness level. He heard totally fifty times of the test sounds, which varied in duration each 2 msec difference between 982 and 1000 msec and were provided in random manner. Therefore, sound of each duration was given 5 times. The notch [= (T-t) x 2] of the test sounds recognized by the patients was regarded as time gap. Fifty percent discrimination thresholds, which were indicated by the gap times of the test sounds half identified, were obtained as the index of the temporal auditory acuity. Following the above test, performance of the HA was investigated by use of the same procedure. The results indicated that the temporal auditory acuities of the MEI were superior to those of the HA at 500 Hz (P less than 0.01) and 2000 Hz (P less than 0.001). When the intensity of the test sound at 2000 Hz decreased from 70 dBSPL to 60 or 50 dBSPL, the temporal auditory acuities of the MEI and the HA were almost depreciated together with consistent difference in the test of 6 patients (P less than 0.01, 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed2000

[Surgery of the external auditory canal in familial bilateral auditory canal atresia].

BACKGROUND: Inherited isolated bilateral atresia of the external auditory canal is rare. Ear canal surgery procedure is difficult. METHODS: Basing on a case report of a family with inherited isolated bilateral atresia of the external auditory canal in 4 cases the way of preoperative diagnostics including human genetics and our surgical concept is described. RESULTS: Resulting clinical findings showed complete epithelialization of the ear canal and ear drum with slight conductive hearing loss. CONCLUSIONS: Canaloplasty in atresia can be easily and successfully accomplished by our modified technique.

Adolescent↗
PubMed1975

[Facial neuroma without facial paresis (author's transl)].

Over a 15 year period during which 12156 operations were performed for improvement in hearing 2 facial neuromas were diagnosed. In both patients aged 55 and 61 years no treatment was considered indicated. One case which had a conductive deafness for 5 years, had a diagnostic tympanotomy and biopsy in 1961 and during the subsequent 10 years no paresis developed.

Bone Conduction↗
PubMed1975

[10 years of tympanoplasty in the hands of an ear, nose and throat surgeon. An analysis of successes and failures (author's transl)].

The successful performance of a tympanoplasty by an otologist working for the health service is guaranteed when the operative results are systematically checked and critically evaluated against clinical-scientific advances. Certain criteria are discussed, based on an experience of 827 tympanoplastics, such as preoperative treatment, assessment of the pathological-anatomical conditions, restoration of sound conduction, tubal function, the problem of the drum transplant, reconstruction of the meatal wall and especially attocotomy which proved very satisfactory in 72 cases.

Bone Conduction↗