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Memory: proline induces retrograde amnesia in chicks.

Intracerebral injection of L-proline, 1 minute after one-trial avoidance training of chicks, impaired memory 24 hours later. Chicks injected with proline 1 or 4 hours after training and controls injected with L-isoleucine at intervals after training, showed no impairment of memory 24 hours after training. The retrograde impairment of long-term memory induced by proline occurred without the convulsions or electrographic events usually associated with retrograde amnesic treatments.

Amnesia↗

Bromolysergide and methysergide protection against ECS-induced retrograde amnesia.

Bromolysergide (BOL 148) and methysergide (UML 491), 2 mg/kg intraperitoneally, and saline were administered to rats 45 min before one-trial passive-avoidance conditioning followed by electroconvulsive shock (ECS) or sham-ECS (ECS). On test session (24 h later), the groups treated with both BOL 148 and UML 491 exhibited a clear-cut retention in comparison to saline-ECS rats. On the other hand, all drugged groups, regardless of their submission to ECS, showed a little less pronounced consolidation than saline-ECS rats. The antiamnestic effect brought about by the two drugs was discussed in terms of receptor antagonism against ECS-released brain serotonin, whereas the lower passive-avoidance level observed in treated animals was considered in relation to a possible antipunishment effect of antiserotoninergic treatment.

Amnesia↗

Amnesia.

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Amnesia↗

Dissociation between specific personal episodes and other aspects of remote memory in a patient with hippocampal amnesia.

In this paper, we describe some features of remote memory in a single-case, Y.K., with amnesic syndrome. His ability to access remote memory was investigated through a variety of tests and then analyzed in terms of specific aspects of remote memory, i.e., public events, personal semantic memory, and specific personal episodes. Although Y.K. showed relatively good performance in recalling public events, personal semantic memory, and general personal events, he was not able to recall specific personal episodes over his entire life span. That is, there appears a clear dissociation between recalling specific personal episodes and other aspects of remote memory. This suggests he lacks "richness" in his remote memory, which is probably necessary to maintain one's own identity.

Amnesia↗