Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “ADRENAL CORTEX”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,549 records · Page 86Linked to original sources
PubMed2005

Male aging and hormones: the adrenal cortex.

The hypothalamic-pituitary-adrenal (HPA) axis in the aging male (adrenopause) is characterized by an unexplained reduction of DHEA secretion while ACTH and cortisol show no major changes, except for a lower amplitude of 24-h fluctuations and a tendency to higher cortisol values in the evening and night (especially in dementia). As a consequence, the cortisol/DHEAS ratio tends to be higher. Adrenocortical morphology reveals an age-related reduction in the thickness of the zona reticularis, and an increase of microhemorrhagic events. This may be one of the underlying causes of the age-dependent high frequency of adrenal nodules incidentally found in the elderly, which may seldom be hormonally active.

Adrenal Cortex↗
PubMedDate not supplied

Adrenomedullin and CGRP receptors mediate different effects in the rat adrenal cortex.

Adrenomedullin (AM) exerts its effects through two distinct receptor subtypes: the AM receptor, and the CGRPI receptor. In most tissues activation of these subtypes brings about similar effects, with only the magnitude of the effect varying. In the rat adrenal cortex, however, this does not appear to be the case. Both CGRPI and AM receptors are present in the rat adrenal cortex. Incubation of zona glomerulosa cells with AM caused an increase in aldosterone secretion, but AM had no effect on angiotensin II-stimulated aldosterone secretion. The action of AM was not affected by CGRP8-37, the CGRP receptor antagonist, suggesting that its effect was mediated by the adrenomedullin receptor. CGRP on the other hand, did not significantly affect basal aldosterone although it attenuated the response to angiotensin II. These data suggest that the CGRP receptor and the AM receptor mediate different effects in the rat adrenal zona glomerulosa.

Adrenomedullin↗
PubMed2002

[Adrenal cortex response to prolonged administration of low doses of magnesium chlorate in rats].

Rat adrenals were studied using histological and histochemical methods during prolonged intoxication with pesticide magnesium chlorate which was administered in a dose equal to 1/100 of LD50 (41 mg/kg of body weight). Animals that received distilled water and were kept in similar conditions were used as control. It was demonstrated that intoxication of rats for 3-7 days results in increased secretory activity of all the zones of adrenal cortex. Later (after 14-90 days) the zonal response to pesticide administration was variable. Magnesium chlorate treatment results in the disturbances of hormonal synthesis in adrenocorticocytes. Compensatory-adaptive capacities of zona fasciculata were found to be greater than those in zona glomerulosa and zona reticularis.

Administration, Oral↗
PubMed1996

[Adrenal cortex adenomas. A retrospective series of twenty cases].

The authors report 20 cases of adrenal cortex tumours which were collected over a period of 12 years (1984-1995). Sixty five per cent of patients were females. They were aged between 27 months and 85 years with a mean of 40 years. Clinical symptoms were dominated by hypertension (11 cases). Seven cases were discovered incidentally and a precocious puberty syndrome presented in the form of 2 cases. Surgery was performed in 18 cases. Adrenalectomy was performed in 16 cases and tumor removal in 2 others. Four patients underwent other procedures such as nephrectomy or splenectomy. Three adrenal tumors were considered to be malignant. Postoperative follow-up was marked by two deaths; otherwise the postoperative course was uneventful.

Adenoma↗