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Medical research at the Faculty of Medical Sciences, UWI, Mona Campus 1960-1990.

The objective of this study was to evaluate research output in relation to undergraduate teaching output of the Faculty of Medical Sciences, Mona Campus, University of the West Indies between 1960 and 1990. The Departmental Reports published by the University of the West Indies were examined using a successive independent sample design with sentinel years at ten-year intervals for the 30-year period under review. The numbers of reported peer-reviewed publications for each department were disaggregated and analysed. Ten of the fourteen departments (10/14, 72%) of the Mona Faculty showed a decline in output of peer-reviewed publications of up to 100% between 1960 and 1990 (p < 0.001). The number of academic staff had risen from 41 in 1960 to 143 in 1990 (249%) while the publication/staff ratio had fallen from 1.73 in 1960 to 0.48 in 1990 (p < 0.0001). Student/staff ratios had declined significantly over the 30-year period (p < 0.005) as had the graduate/staff ratio (p < 0.01). The Faculty reports indicated that the research-in-progress reported far exceeded the actual publication rate in 1990, whereas the opposite was the case in 1960. There was a statistically significant decline in the number of international conference abstracts published and an increase in the number of regional conference abstracts (p < 0.01) and also a significant decrease in the number of papers presented at conferences compared with the number of conferences attended without a paper being presented (p < 0.0001). The research publication record and the medical graduate/staff ratio of the Mona Faculty had declined significantly over the 30 years under review. There was also a significant decline in the graduate/staff ratio in the same period. Some of the conventional reasons given for this decline such as staff shortages and increased clinical service or teaching load are discussed.

Bibliometrics↗

Quality of life in survivors of colorectal carcinoma.

BACKGROUND: Colon carcinoma is a common malignancy that accounts for a substantial share of all cancer-related morbidity and mortality. However, little is known with regard to general and disease specific quality of life in survivors of colorectal carcinoma, particularly from community-based samples of cases across stage and survival times from diagnosis. METHODS: Subjects with colorectal carcinoma were recruited from the National Cancer Institute's Surveillance, Epidemiology, and End Results cancer registry. Subjects completed two self-administered surveys: the Functional Assessment of Cancer Therapy Scales for Colorectal Cancer (FACT-C) and the Health Utilities Index (HUI) Mark III. RESULTS: One hundred seventy-three respondents (average age: 70.4 years, 71.4% female) completed the survey. In the first 3 years after diagnosis, quality of life was lower and varied substantially among respondents. After 3 years, respondents in all TNM stages of disease except Stage IV reported a relatively uniform and high quality of life. Pain, functional well-being, and social well-being were affected most substantially across all stages and times from diagnosis. Low income status was associated with worse outcomes for pain, ambulation, and social and emotional well-being. Only emotional well-being scores improved significantly over time in both surveys. CONCLUSIONS: Those individuals who achieve a long term remission from colorectal carcinoma may experience a relatively high quality of life, although deficits remain for several areas, particularly in those of low socioeconomic status. Sampling design may have excluded the most severely ill patients.

Activities of Daily Living↗

Acupuncture and chronic pain management.

INTRODUCTION: Although acupuncture has been widely used to treat a variety of pain conditions, convincing scientific evidence for its efficacy is lacking. Earlier randomised controlled trials attempted to follow a double-blind, placebo-controlled model. This approach has encountered many problems such as the virtual impossibility of blinding the acupuncturist and the uncertainties inherent in choosing control acupuncture points. The objective of this review is to assess if acupuncture is an effective treatment for chronic pain. In addition, a number of key methodological issues that arise in the controlled evaluation of acupuncture will be discussed. METHODS: This review is based on the result of previous reviews, meta-analyses and consensus conference. The search was performed with MEDLINE (from 1966), EMBASE (from 1980) and Cochrane library (1999, volume 1). Only randomised trials of acupuncture (involved needling) for subjects with chronic pain published in English were included. RESULTS: Basic science research has demonstrated convincingly that at least in the context of acute pain, acupuncture's effects are related to the release of a variety of natural opioids. Acupuncture has been shown to be effective for postoperative dental pain. There are reasonable studies showing relief of pain with acupuncture on diverse pain conditions such as menstrual cramps, tennis elbow, low back pain and fibromyalgia. This suggests that acupuncture may have a more general effect on pain. However, there are also studies which provide equivocal results because of design, sample size and other factors. The issue is further complicated by inherent difficulties in the use of appropriate controls, such as placebo and sham acupuncture groups. CONCLUSION: As most of the studies were of poor methodological quality, there is a need for further high quality randomised controlled trials. Future studies should also have larger sample sizes, use a valid acupuncture treatment, and have both a short-term and long-term follow-up.

Acupuncture Therapy↗

Nontreatment variables affecting return-to-work in Tennessee-based employees with complaints of low back pain.

UNLABELLED: Disability and health care-related costs continue to rise as a result of work-related low back injury. Our investigation examined treatment-independent variables that influenced return-to-work outcome in a sample of workers employed in Northeast Tennessee. METHODS: The review collected 11 variables from two different outpatient physical therapy clinics utilizing a balanced quota sampling design. The patients were enrolled if the documented complaint was low back pain and was an employment-related injury. The patients were grouped according to whether or not they returned to full-time pre-injury work. Twenty-five patients were enrolled in the positive outcome group, those who returned to full-time pre-injury work. Twenty-two patients who did not achieve this goal were enrolled in a separate group. RESULTS: Return-to-work for these patients was not dependent upon age, gender, insurer, number of physical therapy treatments attended, or previously reported low back injury. Those who returned to work had (1) a higher percentage of patients working full-time at their pre-injury position during the rehabilitation process (28% vs. 0%); (2) a higher compliance with the treatment schedule (97% vs. 93%); (3) a lower cancellation rate (0.5 vs. 2.4); (4) a shorter interval in days between reporting the injury and initiation of physical therapy rehabilitation (27 vs. 58); and (5) a lower percentage of previous surgeries resulting from low back injuries (12% vs. 36%), than those who did not. A relationship was also demonstrated between previous surgery and the interval prior to beginning treatments (P < or = 0.0001). However, no relationship was observed between previous surgery and compliance, or between the interval prior to beginning treatments and compliance. DISCUSSION: These results document two variables representing independent factors affecting return-to-work in this population. The first was previous injury influencing the current injury, as documented by both previous surgery and the interval between the current injury and beginning of treatments. The second was compliance with the treatment schedule for the current injury. The psychosocioeconomic aspects of these results are discussed.

Adult↗

Hirudin monitoring using the TAS ecarin clotting time in patients with heparin-induced thrombocytopenia type II.

OBJECTIVE: To assess the reliability of the TAS/ecarin clotting time (ECT) for on-line monitoring of r-hirudin in cardiovascular surgery with and without cardiopulmonary bypass (CPB). DESIGN: Samples were spiked with r-hirudin (0 to 5 microg/mL) and calibration curves constructed. Reproducibility was evaluated by measurement of the sample five times at each concentration. The influence of variations in hematocrit, plasma factors, and platelet count on the test results was examined. Samples were obtained from patients during cardiovascular surgery with CPB (n = 8), without CPB (n = 3), and from volunteers (n = 5) and compared with the laboratory reference tests. All tests were performed in duplicate. SETTING: Deutsches Herzzentrum Berlin. PARTICIPANTS: Five healthy volunteers and 11 patients undergoing cardiovascular surgery. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The TAS/ECT showed linearity and reliability to an r-hirudin concentration of 5 microg/mL and was not influenced (p < 0.005) by the varying conditions of the in vitro setup. The correlation to the laboratory method was 0.74 for the CPB group and 0.87 for the non-CPB group. CONCLUSIONS: The TAS/ECT is a reliable assay for monitoring r-hirudin at the point of care. With this information, the use of r-hirudin during surgery or angioplasty should become more effective and safer.

Adult↗

Tobacco use by youth: a surveillance report from the Global Youth Tobacco Survey project.

The Global Youth Tobacco Survey (GYTS) project was developed by the World Health Organization and the US Centers for Disease Control and Prevention to track tobacco use among youth in countries across the world, using a common methodology and core questionnaire. The GYTS is school based and employs a two-stage sample design to produce representative data on smoking among students aged 13-15 years. The first stage consists of a probabilistic selection of schools, and the second consists of a random selection of classes from the participating schools. All students in the selected classes are eligible for the survey. In 1999, the GYTS was conducted in 13 countries and is currently in progress in over 30 countries. This report describes data from 12 countries: Barbados, China, Costa Rica, Fiji, Jordan, Poland, the Russian Federation (Moscow), South Africa, Sri Lanka, Ukraine (Kiev), Venezuela, and Zimbabwe. The findings show that tobacco use in the surveyed age group ranged from a high of 33% to a low of 10%. While the majority of current smokers wanted to stop smoking, very few were able to attend a cessation programme. In most countries the majority of young people reported seeing advertisements for cigarettes in media outlets, but anti-tobacco advertising was rare. The majority of young people reported being taught in school about the dangers of smoking. Environmental tobacco smoke exposure was very high in all countries. These results show that the GYTS surveillance system is enhancing the capacity of countries to design, implement, and evaluate tobacco prevention and control programmes.

Adolescent↗

Epidemiology of smoking among Kuwaiti adults: prevalence, characteristics, and attitudes.

INTRODUCTION: In 1996 we conducted a cross-sectional survey to study the epidemiology of smoking among Kuwaiti adults. METHODS: The 4000 participants were selected using a three-stage stratified cluster sampling design. Altogether 3859 participants (1798 males, 2061 females) returned a completed self-administered questionnaire. RESULTS: The prevalence of smoking was 34.4% (95% confidence interval (CI) = 32.2-36.6) among men and 1.9% (95% CI = 1.3-2.5) among women. Among men, the highest prevalence (56.5%; 95% CI = 36.2-76.8) was observed in the youngest age group (< or = 20 years). Among women the highest prevalence was observed in one of the older age groups (46-50 years) (7.1%; 95% CI = 3.1-11.1). Multiple logistic regression analysis showed that the following factors were independently associated with smoking: lower levels of education (odds ratio (OR) 3.5; 95% CI = 1.5-8.4), lower employment grade (OR = 4.1; 2.5-6.7), and being a separated, divorced, or widowed woman (OR = 4.9; 95% CI = 2.0-11.8). The majority of smokers (68%) began smoking when younger than 20 years; significantly more men (70%) than women (33%) began smoking at these ages (P < 0.0001). On average, men began smoking at an earlier age (18 years vs 21 years; P < 0.001) and therefore had smoked for a longer period (15 years vs 12 years; P < 0.05); men also consumed a higher number of cigarettes each day (26 vs 17; P < 0.05). A large proportion of smokers were ignorant about the health consequences of passive smoking: about 77% of those with children reported that they smoked in the presence of their children. Almost half (47%) of all smokers stated that they wanted to stop smoking, and about 56% had attempted to quit. The biggest perceived barrier to quitting was uncertainty about "how to quit". A total of 338 respondents (8.8%; 95% CI = 5.8-11.9) were classified as former smokers. About half of the former smokers had quit between the ages of 20 and 29 years; the average age of quitting was 28 years. Former smokers were more likely to have smoked fewer cigarettes per day and to have smoked for significantly less time than current smokers. DISCUSSION: Given the fact that free education is provided at all levels by the government, anti-tobacco education and awareness should be included as an integral part of the curriculum in schools and colleges.

Adult↗

In vitro quantitative chemical analysis of tattoo pigments.

BACKGROUND: The composition of cosmetic tattoos might prove relevant to their treatment by high-powered lasers. OBJECTIVES: To test the accuracy and completeness of information supplied by the tattoo ink manufacturers and to perform an elemental assay of tattoo pigments using scanning electron microscopy with energy-dispersive x-ray analysis. DESIGN: Samples of 30 tattoo inks were examined using "standardless" energy-dispersive spectrometry. This technique uses quantitative electron x-ray microanalysis. The technique reliably identifies all elements with the exception of those elements with atomic numbers less than 11. SETTING: A major national referral laboratory for microscopic examination and biochemical analysis of tissue. These results were compared with ink compositions compiled from manufacturer-supplied material safety data sheets. MAIN OUTCOME MEASURES: (1) The percentage of any given element in whole tattoo pigments. (2) The presence or absence of elements and/or compounds as recorded in material safety data sheets supplied by the tattoo ink manufacturers. RESULTS: Of the 30 tattoo inks studied, the most commonly identified elements were aluminum (87% of the pigments), oxygen (73% of the pigments), titanium (67% of the pigments), and carbon (67% of the pigments). The relative contribution of elements to the tattoo ink compositions was highly variable between different compounds. Overall, the manufacturer-supplied data sheets were consistent with the elemental analysis, but there were important exceptions. CONCLUSION: The composition of elements in tattoo inks varies greatly, even among like-colored pigments. Knowledge of the chemical composition of popular tattoo inks might aid the clinician in effective laser removal.

Electron Probe Microanalysis↗

[Soil contamination with Toxocara sp. eggs in squares and public places from the city of La Plata. Buenos Aires, Argentina].

This study consisted of a stratified sampling, randomly taken, of the soil from the squares and parks of the city of La Plata, Province of Buenos Aires, in order to establish the prevalence of contamination caused by Toxocara sp. A total 242 soil samples was examined. From each sample a 10 grams aliquot was taken, washed in a 0.2% Tween 80 solution, and processed using the technique of concentration by flotation with sugar solution. There was a prevalence of 13.2%. In each positive sample, the quantity of eggs varied from 1 to 4. Toxocara sp. eggs were observed in 15 out of 22 squares and parks investigated. The sampling design and the processing method employed were satisfactory for the recovering and identification of Toxocara sp. eggs.

Animals↗

[Pair bonding and attachment. A meta-analysis of 63 studies published between 1987 and 1997].

UNLABELLED: Starting with Hazan and Shaver (1987) [8] a new field of research has been opened, couple relationship and attachment, which is attracting increasing interest worldwide. METHOD: 63 primary studies, published between 1987 and 1997, on partner relationship and adult attachment were systematically content analysed with regard to their methodology (samples, designs, methodology of data-collection with regard to attachment status and to couple relationship) and their results (demographic data and sex/gender effects; concordance of attachment classifications within couples; correspondence between one partner's AAI and the other's CRI; associations between attachment and relationship stability/relationship satisfaction/partner related explanations/couple interaction/psychophysiological data/sexuality; relationship specific effects; interactions of attachment, sex/gender and relationship quality). Conceptual and methodological problems with regard to the measurement of adult attachment are critically discussed (the two "camps": AAI-researchers and self-report questionnaire researchers; categorical versus dimensional assessments; global trait or relationship specific construct; conscious or unconscious) and research conclusions derived.

Humans↗

In their own words: using the common sense model to analyze patient descriptions of cancer-related fatigue.

PURPOSE/OBJECTIVES: To describe cancer-related fatigue (CRF) from the perspective of individuals experiencing it and examine the fit of their descriptions with the concepts from the Common Sense Model (CSM). DESIGN: Exploratory, qualitative design, SAMPLE: A convenience sample of eight patients with cancer known to be experiencing fatigue from the outpatient clinic. METHODS: Content analysis of data obtained from focus groups. FINDINGS: All statements describing CRF could be classified using the major constructs of the CSM: representation, coping, and appraisal. The majority of statements were classified as representations of fatigue (67%), with smaller proportions classified as coping (26%) and appraisal (7%). CONCLUSIONS: This study provides evidence to support the validity of the CSM constructs as an organizing framework in the conduct of research. IMPLICATIONS FOR NURSING PRACTICE: This study demonstrates the usefulness of the model In clinical assessment of patient representations of CRF as well as coping strategies for managing it The model is particularly useful in targeting knowledge deficits and inaccuracies.

Adaptation, Psychological↗

[Growth of Octopus maya (Mollusca: Cephalopoda) of the Yucatan coast, Mexico: a long-term analysis].

Growth of the octopus (Octopus maya) off Yucatan (Mexico) was estimated from a long-term study (seven years) by the length-based methods ELEFAN, PROJMAT and SLCA. Some 19,251 octopuses with a range of mantle length between 50 and 240 mm were sampled from commercial landings in 1983-1987, 1989 and 1992. The jackknife technique was applied to deal with uncertainty in growth estimates resulting from chance variations in sampling design. The growth index phi' was used for comparative purposes. Results differed markedly among methods: ELEFAN produced parameter estimates within the range reported in the literature, whereas PROJMAT and SLCA showed problems to converge in an optimum combination of parameters, and tended to underestimate them. Jackknife analysis revealed very low intraannual variability in phi' but high variability among years, especially when applying PROJMAT. No significant differences were found in precision parameters--percent error and coefficient of variation--among methods. Estimates of phi' derived by ELEFAN varied between 4.19 and 5.23 and agreed with those reported in the literature (between 4.25 and 4.91), whereas PROJMAT and SLCA estimates were significantly lower. We suggest the use of ELEFAN, together with jackknife, to estimate growth parameters of Octopus maya.

Animals↗

Methylthioadenosine phosphorylase gene deletions are common in osteosarcoma.

PURPOSE: Methylthioadenosine phosphorylase (MTAP) is an enzyme essential in the salvage of cellular adenine and methionine synthesis. The MTAP gene is located in the 9p21 chromosomal region and its loss is frequently associated with deletion of the tumor suppressor genes p15(INK4b) and p16(INK4a). The aim of this study was to investigate the frequency of molecular alterations in MTAP in osteosarcoma. EXPERIMENTAL DESIGN: Samples from patients with high-grade osteosarcoma (n = 96) and three osteosarcoma cell lines (HOS, SaOS-2, and U2OS) were analyzed. Genomic DNA was analyzed for MTAP gene deletions by PCR, RNA expression was measured by semiquantitative reverse transcription-PCR, and the protein levels were measured by immunohistochemistry. RESULT: Deletion of at least one MTAP exon was found in 36 of 96 (37.5%) osteosarcoma patient samples and in one of the three cell lines (HOS). In all cases in which an MTAP gene deletion was observed, there was absence of detectable mRNA and protein. Furthermore, in four osteosarcoma patients, an MTAP deletion which was not evident at diagnosis was detected in subsequent tumor samples. CONCLUSIONS: The MTAP gene is commonly deleted in osteosarcoma patient samples, leading to an absence of mRNA and protein expression; these results indicate that inhibitors of de novo purine synthesis or methionine depletion may be effective as treatments for osteosarcoma patients whose tumors fail to express MTAP.

Adolescent↗

How well do antenatal clinic (ANC) attendees represent the general population? A comparison of HIV prevalence from ANC sentinel surveillance sites with a population-based survey of women aged 15-49 in Cambodia.

BACKGROUND: The purpose of this study was to evaluate whether HIV-1 prevalence among antenatal clinic (ANC) attendees in Cambodia provided a reasonable estimate of HIV-1 prevalence among all women 15-49 years. METHODS Antenatal clinic attendees in five HIV sentinel surveillance sites (five provinces) were selected by consecutive sampling (n = 1695). The population survey of females by household was carried out in the same five areas. Household females aged 15-49 years were selected using a three-stage cluster sampling design (n = 3066). Serum-based HIV ELISA testing was done for both ANC attendees and household females. The HIV prevalence for ANC attendees and household females were compared by age group and urban versus rural location. RESULTS: The overall prevalence of HIV-1 infection among ANC attendees (1.62%, 95% CI : 1.26-1.98) was similar to the overall prevalence obtained from the general population of household females (1.24%, 95% CI : 0.92-1.55) in the same catchment areas in Cambodia. In the rural areas, the overall HIV prevalence among ANC attendees (2.18%, 95% CI : 1.59-2.77) was significantly higher than among the household females (0.86%, 95% CI : 0.49-1.23) after adjustment for age distribution and education level. In the 15-24 age group in rural areas, the HIV prevalence of ANC women was 2.71% (95% CI : 0.96-4.46) compared with 0.77% (95% CI : 0.02-1.53) in household females. CONCLUSIONS: Although ANC data can be used to estimate trends over time, it should be realized that ANC data may overestimate the actual prevalence in the younger age group in rural areas in Cambodia.

Adolescent↗

Labor Supply of Poor Residents in Metropolitan Miami, Florida: The Role of Depression and the Co-Morbid Effects of Substance Use.

BACKGROUND: Depression represents one of the most common behavioral health problems among the workforce in the United States, with about 1 in every 20 employees experiencing this condition. A recent study estimated that in 1990 the economic costs of depressive disorders in the American workplace amounted to as much as $43 billion, with absenteeism alone accounting for $12 billion. Recently, economists have been focusing attention on the relationship between mental health and labor supply, but a lack of quality data sets containing detailed information on mental health and labor market variables represents a significant barrier to rigorous research. AIMS OF THE STUDY: The primary aims of the present study were to (i) examine the relationship between depression and employment, (ii) conditional on being employed, estimate the effect of depression on annual weeks worked, and (iii) examine the stability of the model estimates to the co-morbid effects of substance use (illicit drugs and alcohol), which has been consistently found to be a correlate of depression. DATA: The study used a unique set of survey data collected between 1996 and 1997 in crime-ridden and low-income neighborhoods of Miami-Dade County, Florida. A targeted sampling strategy was used to recruit chronic drug users (including injection drug users) and non-drug users to examine local health care delivery system characteristics in relation to the population of substance users. The final analysis sample for the present study included 1,274 adults, aged 18 to 65. Depression status was measured from the 20-item Zung Self-Rating Depression Scale (SDS) that classified 384 individuals as depressed and 890 as non-depressed. According to the definition developed by the U.S. Office of National Drug Control Policy for chronic drug use (CDU), about 46 percent of the depressed individuals were found to be CDUs compared to 30 percent of the non-depressed sample. The survey instrument collected information on alcohol use and problem drinking as defined by the 10-item Michigan Alcoholism Screening Test (MAST-10). Based on criteria defined in the MAST-10, 26 percent of the depressed individuals were problematic alcohol users (PAUs) compared to about 16 percent of the non-depressed sample.METHODS: The labor supply measures included employment in the past 30 days and number of weeks worked in the past 12 months. The analysis estimated a univariate probit model of employment as well as a bivariate probit model of depression and employment, which accounted for the possible correlation between the unobserved determinants of depression and employment. The annual weeks worked specification was estimated by a standard Tobit model as well as an instrumental variable (IV) Tobit model, which, in addition to the censoring of the observations, accounted for the possible endogeneity of depression. The stability of the estimated effects of depression to comorbid illicit drug and alcohol use was assessed, by controlling for CDU and PAU in these models. RESULTS: Results from both the univariate probit and the bivariate probit models indicate that depression significantly decreased the probability of being employed. Specifically, depression reduced the probability of employment by an average of 19 percentage points in both models, from a sample average of 43 percent for the non- depressed to 24 percent for the depressed. Estimates from the Tobit models revealed that depression also significantly reduced the number of weeks worked. Conditional on being employed, depressed individuals worked an average of 7 fewer annual weeks than the non-depressed sample in the univariate Tobit model and 8 fewer weeks in the IV Tobit. The findings also showed that the effects of depression on employment and annual weeks worked may be over-estimated if the analysis does not account for the comorbid influence of substance use. IMPLICATIONS FOR HEALTH CARE PROVISION AND USE: The results suggest that prevention and/or treatment of mental health problems such as depression may yield economic benefits by promoting employment and enhancing labor supply. While expansion of public mental health services may not lead to overall increases in employment, it may be justified on social grounds given the high unemployment rate in low-income and crime-ridden neighborhoods. Further insights can be gained by estimating these models with national and international data if one applies appropriate econometric tools to account for complex sample designs.

Journal Article↗

Health hazards and preventive measures of farm women. Emerging issues.

Currently, an increasing number of farms are family owned and women are directly involved in the farming operations as an independent manager or partner. Women play an important role in farm management by marketing farm products, purchasing materials, and financial planning. Because of this involvement, women can be exposed to potential health hazards that can result in chronic illness, debilitation, or death. This study explored and described health hazards affecting farm women in southeast Louisiana, preventive measures used by farm women, and their consistency in using protective equipment with varying levels of time commitment toward farm operations. This cross sectional study included women older than 18 whose family participated in farming operations. A stratified, random sample design with parishes comprising the strata and simple random selection without replacement within each stratum was used to select family addresses. A total of 519 women who met the criteria completed a structured 30 minute telephone interview conducted using The Louisiana Farm Health and Injury Survey instrument. Information elicited included farm work characteristics, prevention practices, and demographics. Results showed that women working 1 to 20 hours per week were less likely to wear personal protective equipment (PPE) than women working more than 20 hours per week. This included wearing seat belts on tractors; using hearing, eye, or breathing protection; and wearing gloves or boots. No differences were found between groups for use of skin protection, hair holders, or helmets on all terrain vehicles (ATVs). The researchers concluded that if nursing interventions such as teaching and counseling related to prevention methods could be provided, the incidence of acute and chronic illnesses and traumatic injury would decline.

Adult↗

Status of soil transmitted helminthic infections in India--observations on sample surveys using Kato-Katz technique.

Results of surveys conducted in eight different ecologically homogenous zones in the country, using WHO sampling design methodologies and Kato-Katz technique are presented in this communication. Hilly and coastal areas had high STH prevalence ranging from 34%-36% with total epg ranging from 53,952-4,67,976. Apart from this, Chitradurga urban area had STH prevalence of 39.6% with epg of 81,792. However, except in few cases, in all these surveyed areas, intensity of STH infection was found to be light. A national programme for control of soil transmitted helminthic infections is advocated.

Animals↗

Self-collected breath sampling for monitoring low-level benzene exposures among automobile mechanics.

Automobile mechanics are exposed to benzene through their contact with gasoline vapor and engine exhaust. This study investigated the benzene uptake associated with these exposures. We first evaluated the reliability of self-collected breath samples among a subset of subjects and found good agreement between these samples and those collected under expert supervision (intraclass correlation coefficient 0.79, n = 69). We then used self-monitoring together with a longitudinal sampling design (with up to three measurements per worker) to measure benzene in air and benzene in end-exhaled breath among 81 workers from 12 automobile repair garages in North Carolina. A statistically significant difference (P < 0.0001, Mann-Whitney rank sum test) was observed between non-smokers and smokers for post-exposure benzene concentration in breath (median values of 18.9 and 39.1 micro g/m(3), respectively). Comparing pre- and post-exposure breath concentrations within these two groups, the difference was significant among non-smokers (P < 0.0001) but not significant among smokers (P > 0.05). Mixed effects regression analysis using backwards elimination yielded five significant predictors of benzene concentration in breath, namely benzene exposure (P < 0.0001), pre-exposure benzene concentration in breath (P = 0.021), smoking status (P < 0.0001), fuel system work (P = 0.0043) and carburetor cleaner use (P < 0.0001). The between-person variance component comprised only 28% of the total variance in benzene levels in breath, indicating that differences among individuals related to physiological and metabolic characteristics had little influence on benzene uptake among these workers.

Automobiles↗