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PubMed2006

Intelligence: is there a sex difference in IQ scores?

Arising from: S. Blinkhorn Nature 438, 31-32 (2005); Blinkhorn replies. Steve Blinkhorncriticizes our study of samples of university students, in which we found that the average IQ of men is 4.6 points higher than that of women, as measured by the Progressive (or Raven's) Matrices. He maintains that there is a negligible sex difference in adult intelligence. We believe that the principal error of Blinkhorn's criticism is that he does not consider our result in the context of several other studies showing that adult males have an IQ advantage of around 4-6 IQ points.

Adolescent↗
PubMed2003

Neural mechanisms of general fluid intelligence.

We used an individual-differences approach to test whether general fluid intelligence (gF) is mediated by brain regions that support attentional (executive) control, including subregions of the prefrontal cortex. Forty-eight participants first completed a standard measure of gF (Raven's Advanced Progressive Matrices). They then performed verbal and nonverbal versions of a challenging working-memory task (three-back) while their brain activity was measured using functional magnetic resonance imaging (fMRI). Trials within the three-back task varied greatly in the demand for attentional control because of differences in trial-to-trial interference. On high-interference trials specifically, participants with higher gF were more accurate and had greater event-related neural activity in several brain regions. Multiple regression analyses indicated that lateral prefrontal and parietal regions may mediate the relation between ability (gF) and performance (accuracy despite interference), providing constraints on the neural mechanisms that support gF.

Adolescent↗
PubMed1978

Long term studies of untreated phenylketonuria I: intelligence or mental ability.

A group of 90 patients over the age of 2 years with untreated phenylketonuria was studied by 3 independent observers in 3 different ways for evidence of mental deterioration. In a small subset (N = 10), psychometric tests showed a fall in Intelligence or Developmental Quotients between the ages of 4 and 18 years; the same was found in a matched group of nonphenylketonuric patients from the same institution. In a second subset (N = 83), a Habit Score derived from the observations of the patients' caretakers showed a small overall improvement in adaptive behaviour over an average span of 19 years. In a third subset (N = 81), clinical assessment by one observer detected no significant change in mental ability over an average span of 11 years. No evidence of progressive mental deterioration was found in untreated phenylketonuria from middle childhood to middle age.

Activities of Daily Living↗
PubMedDate not supplied

[Concerning specific language impairment: intelligibility in expressive language].

BACKGROUND: Even in the age of two years toddlers with Expressive Language Impairment (SLI-E) differ regarding their phonetic inventories compared with an age-matched group developing normally. METHOD AND PATIENTS: PCC-R scores of 19 children with expressive language disorder, aged between four and six years, are compared with age and sex matched controls with normal language acquisition. RESULTS: There are significant differences between PCC-R scores, children with expressive language disorder show lower scores than children with normal language acquisition. Age, sex and nonverbal intelligence do not influence performance measured with PCC-R. Analysis regarding early, middle and late consonants shows, that expressive language disordered children show bigger problems in aquiring late than early and middle consonants.

Age Factors↗
PubMed1999

Serial intelligence test scores in pediatric moyamoya disease.

Serial intelligence tests in 38 patients with childhood moyamoya disease were evaluated. A total of 98 tests were administered. The IQ scores were classified into three categories: tests performed between the time of onset of symptoms and 5 years after the onset of symptoms (n = 44), tests performed 5-10 years after the onset of symptoms (n=32), and tests performed more than 10 years after the onset of symptoms (n=22). When more than one test was performed during each period, the mean of the IQ scores was used. The IQ tests were administered two or more times to 10 patients in the onset-5-years category, and 5 of them exhibited lower IQ scores on later tests. The IQ scores were significantly lower in the 5-10 years category and in the more than 10 years category (76.8 +/- 23.1 and 73.9 +/- 31.1, respectively) than in the onset-5-years category (92.9 +/- 22.7). The IQ scores for the 5-10 years category and the more than 10 years category did not differ significantly. The IQ in pediatric moyamoya disease begins to decrease after the onset of symptoms, but the decline eventually stabilizes more than 10 years after the onset of symptoms.

Adolescent↗
PubMedDate not supplied

[Verbal and nonverbal intelligence in children with language development disorders].

Difficulties in language acquisition seem to be serious, if there are additional problems like intellectual and/or emotional/social impairment, which are often reported [10]. These additional problems and the definition of specific language impairment as a developmental disorder, restricted to language acquisition seem to be contradictory [17]. Aim of that study is to look for specific language impaired children with similar cognitive abilities and though to investigate, if there are children without additional cognitive problems considering the definition of specific language impairment. 93 children, between 4;0 and 6;6 years old, were diagnostized as specific language impaired (ICD-10) and were assessed by the "Hannover Wechsler Intelligenztest für das Vorschulalter (HAWIVA)" [6] (german version of WPPSI). Cluster analysis showed, that 1/3 of the specific language impaired children presented no additional cognitive problems and 2/3 of them showed cognitive problems regarding nonverbal and verbal intelligence indeed. These additional cognitive problems indicate that there may be a more basic cognitive defect underlying specific language impairment [15]--at least for a group of specific language impaired children. Furthermore the nonverbal and verbal intellectual difficulties emphasize to general developmental support of specific language impaired children for optimal improvement in language acquisition.

Child↗
PubMed2001

Term infants with fetal growth restriction are not at increased risk for low intelligence scores at age 17 years.

OBJECTIVE: To assess the long-term cognitive outcome of small for gestational age (SGA) compared with appropriate for gestational age (AGA) infants. DESIGN: Data from the Jerusalem Perinatal Study was matched with information from the army draft medical board. SGA and severe SGA were defined as birth weight below the 10th and 3rd percentiles for gestational age, respectively. A multiple linear regression analysis was performed to control for clinical, perinatal, and socio-demographic confounding variables. SUBJECTS: A cohort of 13,454 consecutive singleton term infants born between 1974 and 1976. MAIN OUTCOME MEASURE: IQ at age 17 years. RESULTS: SGA infants had lower adjusted mean +/- SE IQ scores compared with their AGA peers: 102.2 +/- 0.9 versus 105.1 +/- 0.7 (P <.0001) for males and 102.5 +/- 0.9 versus 103.9 +/- 0.7 (P <.015) for females. SGA was not associated with lower academic achievements compared with AGA. CONCLUSION: After controlling for multiple confounders, being born SGA at term is associated with slightly lower intelligence test scores at age 17 years. However, the clinical significance of the small difference is not evident in academic achievements.

Adolescent↗
PubMedDate not supplied

Dentine lead and child intelligence in Taiwan.

It is well known that lead is a developmental neurotoxin, but, because many factors influence a child's development, a safe level of lead for children is still not clear. In this study, personal lead exposure was assessed. A total of 940 deciduous teeth--mostly incisors--was collected from 764 children in grades 1-3 who attended 7 primary schools. Two of the primary schools were near smelters, 4 were in Taipei City, and 1 was located in a coastal village. Teachers were provided with a questionnaire about classroom performance, and 97% completed and returned the questionnaire to the laboratory. Parents were given a questionnaire about family background, pregnancy, and health history (92% returned). Dentine lead levels of shed incisors for children in Taipei City were higher than levels reported in Boston, i.e., mean (standard deviation) of 4.4 (3.5) versus 3.3 (2.5) micrograms/g, respectively (p less than .001). The lead values were significantly higher in children who attended school near a smelter than in children who attended school in Taipei City: 6.3 (3.3) (p less than .001). The mean lead levels in children who attended school in a coastal village was 5.1 (2.8). The ranges for all schools overlapped, which indicated that there were multiple lead sources. Intelligence scores from Raven's Colored Progressive Matrices Test were negatively correlated with lead levels, especially among girls and among children whose parents had less education. We adjusted for other risk factors--most notably parental education, which correlates inversely with lead levels--and found that the role of the lead term was lowered but not eliminated.

Air Pollutants↗
PubMed2000

Effects of bogus feedback on intelligence test performance.

French-Canadian high school students (N = 196) completed different forms of the Wonderlic Personnel Test (WPT; E. F. Wonderlic, 1983) on two occasions. Before the second test, they received negative or positive bogus feedback about their initial performance. Most students (n = 158) were informed that the WPT measured intelligence, and the instruction was issued before either the first (n = 42) or the second test (n = 116). In the latter case, WPT validity either was not mentioned (n = 36) or was described as high or low (ns = 39 and 41, respectively). WPT performance improved on the second test, but it was not related to feedback in any of the instruction conditions. Reasons for these results and their practical implications are discussed.

Adolescent↗
PubMed2001

Concurrent validity of the Test of Nonverbal Intelligence in Parkinson's disease patients.

The Test of Nonverbal Intelligence (TONI-2; L. Brown, R. J. Sherbenou, & S. Johnsen, 1990) and Raven's Colored Progressive Matrices (RCPM; J. C. Raven, 1965) are defined as language-free measures of cognitive ability. The purpose of the present study was to investigate the relation between the RCPM and the TONI-2 for samples of patients with Parkinson's disease (n = 75) and controls (n = 47). A regression equation was computed to evaluate the relation of the RCPM scores to the TONI-2 quotient. Regression equation results indicate that there is a significant overlapping linear variance between the two measures in both patients and controls.

Aged↗
PubMed1986

Focal brain lesions and intelligence: a study with a new version of Raven's Colored Matrices.

Contrasting results have been obtained in previous investigations, which have used the standard version of Raven's Colored Progressive Matrices for studying the effects of localized brain lesion on visual-spatial intelligence. Some of these discrepancies might be due to the fact that specific factors, such as unilateral spatial neglect, could contribute to decreased performance obtained on Raven's test by patients with focal brain lesions. A new set of Colored Matrices, devised to minimize the influence of unilateral spatial neglect without changing the essential features of the original task, was therefore constructed. The test was administered to 76 normal controls, 74 right brain-damaged patients, 87 aphasics, and 61 nonaphasic left brain-damaged patients, in order to study the effect of laterality of lesions and of language impairment on Raven's scores. The results show that, if the influence of unilateral spatial neglect is minimized and Raven's scores are corrected in reference to age, educational level, and lesion size, then: no significant differences are observed between right and left brain-damaged patients; aphasics score worse than nonaphasic left brain-damaged patients; impairment is greater in patients with Wernicke's and Global aphasia (i.e., in patients with severe language comprehension disorders) than in patients classified as Broca's, Anomic, or Conduction aphasia; impairment is greater in patients with semantic-lexical discrimination errors than in patients free from semantic-lexical comprehension disorders.

Aphasia↗
PubMedDate not supplied

Assessment of intellectual functioning of patients with Parkinson's disease using the Satz-Mogel (1962) short form of the Wechsler Adult Intelligence Scale.

The purpose of the present study was to compare the Satz-Mogel (S-M) short form of the Wechsler Adult Intelligence Scale--Revised (WAIS-R) with the full-scale WAIS-R to establish its utility in the assessment of intellectual functioning in patients with Parkinson's disease (PD). PD patients and elderly control subjects were administered a neuropsychological test battery that included the complete WAIS-R or the S-M. Results indicated that the S-M was a reliable measure of IQ. The PD subjects' Verbal, Performance, and Full-Scale IQ scores were inferior to that of controls, regardless of test form. Adjustments for depression and age did not alter these results. PD patients with more severe disease scored lower on some visual-spatial measures. Verbal decrements among PD patients may relate to problems in verbal fluency, categorical thinking, and impaired retrieval of verbal material. PD patients may experience patterns of subtle cognitive changes that include deterioration of some specific abilities as the disease progresses.

Aged↗
PubMed2004

Evaluation of two methods for estimating Premorbid Intelligence on the WAIS-III in a clinical sample.

Two methods of predicting premorbid WAIS-III Full Scale IQ, namely a demographic measure (DP IQ) and the Oklahoma Premorbid Intelligence Estimate-3 (OPIE-3), were assessed in three traumatic brain injury (TBI) groups of varying injury severity and normal controls. On the DP IQ, average scores were in keeping with the general population mean across all groups but range was severely restricted. OPIE-3 IQ scores were not subject to severe range restriction and were comparable with the general population mean in the control and least severely brain injured group. They were significantly lower relative to controls in the severe and extremely severe TBI groups, with differences averaging around 7 and 10 points, respectively. OPIE-3 (Best) proved particularly robust in more severely injured subjects. Effect sizes for the combined TBI sample relative to controls were greatest for OPIE-3 measures that included two non-verbal subtests and were least for that involving vocabulary only. Implications of the findings for clinical practice and further research are discussed.

Adult↗
PubMed2026

Artificial intelligence in molecular diagnostics for pandemic preparedness.

INTRODUCTION: Molecular diagnostics focusing on the detection and analysis of nucleic acids are indispensable tools for early pathogen identification, transmission monitoring, and genomic surveillance during pandemics. Recent technological advances have broadened the diagnostic landscape, incorporating PCR-based methods, isothermal amplification, high-CRISPR-based amplification detection, and sequencing. Despite their diagnostic potential, widespread implementation remains limited by high validation costs, time and logistical constraints, the need for specialized professional knowledge, and a lack of adaptability in resource-limited settings. Artificial intelligence (AI) is increasingly recognized as a promising but challenging approach, offering tools that streamline assay development, automate data interpretation, and optimize real-time diagnostic performance. AREAS COVERED: This review introduces recently published AI tools with potential to enhance the in-silico design validation process of oligonucleotides for molecular assays. These cover tools for initial assay design and optimization to validation and continuous assay updates. The limitations, including concerns regarding data accuracy, the lack of transparency in data processing ('black box' models), and unresolved licensing and regulatory issues, are highlighted for each tool and as expert opinion. EXPERT OPINION: Collectively, these challenges currently confine most AI-based approaches to research settings and prevent their routine implementation in clinical molecular diagnostics. Their widespread adoption depends on addressing remaining technical, regulatory, and practical challenges.

Humans↗
PubMed2004

Cognitive aging, childhood intelligence, and the use of food supplements: possible involvement of n-3 fatty acids.

BACKGROUND: Food supplement use is widely promoted, but little is known about the cognitive effects of food supplements. OBJECTIVE: We examined the effects of food supplement use on cognitive aging. DESIGN: This was an observational study of subjects born in 1936 whose mental ability was tested in 1947 and who were followed up in 2000-2001, at which time cognition, diet, food supplement use, and risk factors for vascular disease were assessed. In a nested case-control study, fish-oil users were matched with nonusers, and cognitive function was related to erythrocyte n-3 fatty acid composition. RESULTS: Childhood intelligence quotient (IQ) did not differ significantly by category of food supplement use (ie, none, fish oil, vitamins, and other). At the age of 64 y, cognitive function was higher in food supplement users than in nonusers before adjustment for childhood IQ. After adjustment for childhood IQ, digit symbol (mental speed) test scores were higher in food supplement users. Fish-oil supplement users consumed more vitamin C and vegetable and cereal fiber than did non-supplement-users. In a nested case-control study, erythrocyte membrane n-3 content was higher in fish-oil supplement users than in nonusers, but cognitive function did not differ significantly between groups. Total erythrocyte n-3 fatty acids and the ratio of docosahexaenoic acid to arachidonic acid was associated with better cognitive function in late life before and after adjustment for childhood IQ. CONCLUSIONS: Food supplement use and erythrocyte n-3 content are associated with better cognitive aging. If associations with n-3 content are causal, optimization of n-3 and n-6 fatty acid intakes could improve retention of cognitive function in old age.

Aging↗
PubMed1992

On a common structure of intelligence in biological and technical systems.

This is a survey of the general structure of an electronic computer-implemented, operation-oriented system, designed by the authors, which uses artificial intelligence mechanisms and is intended for the control of technical objects that function both in predictable and random environments. The system is based on processing knowledge, which is stored in a hierarchically arranged Knowledge Bank, and program mechanisms for adapting to and interacting with the External and Internal Worlds. The system has distributed program mechanisms, which are 'designed' with a constant structure. It is independent of the purpose and environment of the system operation and the specific features of the controlled object. None of the program mechanisms are concentrated in any program module. They are distributed in many modules, and therefore there is no single module responsible for the execution of a particular external function. The system is structured into separate program modules by internal procedures. The conceptual organisation of the Knowledge Base presupposes that the framework is structured according to functional, semantic and tier indications, i.e. the structured description of knowledge, by the system, of the external environment and its possible behaviour in it. The possibility of multiple use of the same elements of the lower tiers of the Knowledge Base by higher-tier elements makes the proposed Knowledge Base very efficient. If the cerebrum is considered at a structural level, there appears to be an amazing similarity between the structure and the mechanisms of the above system and the structure of the cerebral cortex, as suggested previously by Edelman and Mountcastle. Each mechanism of the cerebral cortex structure has a structural analogue in the described system.(ABSTRACT TRUNCATED AT 250 WORDS)

Algorithms↗
PubMed1991

Inspection time, psychometric intelligence and clinical estimates of cognitive ability in pre-senile Alzheimer's disease and Korsakoff's psychosis.

Ten pre-senile Alzheimer's patients, 11 patients with Korsakoff's psychosis and 11 age- and pre-morbid intelligence-matched controls were given a test of Inspection Time, which estimates the efficiency of visual encoding or iconic memory. Alzheimer's patients had impaired Inspection Time while the Korsakoff group performed very similarly to the controls. Inspection Time performance correlated significantly with psychometric tests of cognitive ability and with clinical tests of cognitive ability (Mini Mental State Examination and Cambridge Mental Disorders of the Elderly Examination). The early stage of information processing measured by the Inspection Time procedure appears to be damaged by the Alzheimer's disease process, and to impose a rate-limiting effect on a wide variety of mental tests.

Alcohol Amnestic Disorder↗
PubMed2026

Environmental antibiotic contamination and AMR: Integrating pathways, impacts, and artificial intelligence-driven mitigation.

The widespread contamination of the environment with antibiotic residues is a significant factor contributing to the global crisis of antimicrobial resistance (AMR). Antibiotics from various sources, such as effluents from municipal and hospital wastewater treatment plants, agricultural runoffs, discharges from pharmaceutical manufacturing and improper disposal of expired or unused medicines, create selective pressures in the spread of antibiotic resistance genes. These environmental reservoirs act as hotspots for horizontal gene transfer, facilitating the emergence of multidrug-resistant pathogens. Conventional detection methods including culture-based assays, chromatographic quantification, and molecular diagnostics, provide essential insights but are limited by low throughput, reduced sensitivity to new Antibiotic Resistance Genes, and challenges in real-time monitoring across complex environments. Recent advances, such as whole-genome sequencing, metagenomics, and biosensor-based detection, help to address these gaps by enabling more comprehensive surveillance of the resistome. Artificial intelligence further enhances these approaches by improving data interpretation and pattern recognition, thus complementing traditional and molecular methods rather than replacing them. This review examines the pathways of environmental antibiotic contamination, ecological and health impacts of AMR, and limitations of conventional detection methods. It aims to clarify how these pathways contribute to the AMR crisis, assess the effectiveness of existing surveillance techniques, and identify gaps in current research.

Anti-Bacterial Agents↗