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At least 1,531 records · Page 85Linked to original sources
PubMed2005

A case of canine apocrine sweat gland adenoma, clear cell variant.

A cutaneous mass at the base of the retroauricular region of a 4-year-old, female Golden Retriever was examined pathologically. Histologically, the mass formed multiple nodules consisting of a proliferation of large clear cells with abundant cytoplasm. Mitotic figures among the neoplastic cells were very sparse. The large clear cells were intensely positive for cytokeratins (AE1/AE4, cytokeratin 8 and 18) and moderately positive for lysozyme and contained periodic acid-Schiff-positive granules in the cytoplasm. In addition, small flat cells lined the islands of neoplastic large clear cells, and these were strongly positive for alpha-smooth muscle actin and vimentin, and some were positive for cytokeratin (AE1/AE4), suggesting they were myoepithelial cells. No local recurrence or metastasis has been recognized during the 18 months since surgical excision. On the basis of these findings, the present tumor was diagnosed as apocrine sweat gland adenoma, clear cell variant. There have been few previous reports of canine apocrine adenomas showing a clear cell morphology.

Adenoma, Sweat Gland↗
PubMedDate not supplied

Malignant hidradenoma: a rare sweat gland tumour.

Malignant hidradenoma is a rare sweat gland carcinoma, which can have an aggressive course with recurrence and/or metastasis. A case is reported, in an elderly male. The tumour had a histologic similarity to its benign counterpart, but exhibited additional features of infiltrative growth pattern and invasion of adjacent tissue.

Adenoma, Sweat Gland↗
PubMed1999

[Malignant nodular hidradenoma--sweat gland tumor].

Malignant hidradenoma is a very rare tumor that originates from sweat glands. We present a 61-year-old man with an ulcerated tumor in his right flank, 4 cm in diameter, that was excised with a wide free margin. Histopathologic study showed an ill-defined, epithelial neoformation, formed by lobules of clear polygonal cells in the deep dermis and subcutaneous tissue, diagnosed as malignant nodular hidradenoma. 1.5 years after excision there was enlargement of the right axillary and inguinal lymph nodes, which showed metastatic, adnexal neoplastic cells. Axillary resection and superficial dissection of the right inguinal nodes were performed. After 3 months the tumor had spread to other lymph nodes and acute obstructive renal failure required insertion of a pig-tail catheter into the right ureter. Radiotherapy was followed by chemotherapy, but he died from end-stage metastatic disease in multi-organ failure.

Adenoma, Sweat Gland↗
PubMed1992

[Eccrine hamartoma of the sweat glands simulating localized unilateral hyperhidrosis].

We report on the case of a 31-year-old woman who presented with localized unilateral hyperhidrosis on her lower right arm. Histological features showed a hamartoma of the eccrine sweat glands. Because she was afraid of being overweight, the patient took an appetite depressant. Under this self-medication complete cessation of the localized hyperhidrosis was observed.

Adult↗
PubMed1962

Early diagnosis of leprosy by study of the sweat response to iontophoresis with parasympathomimetics.

The final aim of any leprosy control campaign is the eradication of the disease, or at least its reduction to a point where it no longer constitutes a major public health problem. The only possible ways of achieving this end are, firstly, through intensive case-finding and, secondly, through mass treatment.For obvious reasons diagnosis must be made at the earliest possible moment, which is not always easy by ordinary methods. Thus any technique to improve early diagnosis deserves full study. Observation of the sweat response to iontophoresis using parasympathomimetic drugs seems an easy and objective method of detecting leprosy skin lesions; it may therefore constitute a valuable step forward in the improvement of leprosy control.

Early Diagnosis↗
PubMed1991

Reactivity of HMB-45 monoclonal antibody with sweat-gland tumours of the skin.

HMB-45, a monoclonal antibody claimed to be specific for malignant melanoma, has been observed to react with normal eccrine sweat glands and occasionally with normal mammary and bronchial epithelium. In this study we show that HMB-45 also decorates cells in approximately 15% of various sweatgland tumours of the skin. This finding, along with the reported reactivity on mammary carcinomas further outlines the lack of absolute specificity of HMB-45 for cells of the melanocytic lineage.

Antibodies, Monoclonal↗
PubMed1989

[Ductal tumor of the eccrine sweat glands].

A dermal ductal tumor developed in sweat gland in 82 years old man, is presented. The lesion was located in the left leg. The clinical diagnosis was verrucous carcinoma and pigmented nevus. Histologically, it was a benign tumor.

Aged↗
PubMed1983

Heart rate and sweat rate responses associated with exercise-induced hypervolemia.

The purpose of this study was to determine the relationships between the plasma volume (PV) expansion accompanying exercise training and the associated changes in heart rate (HR) and sweat rate (SR) during sub-maximal and maximal exercise. Eight male subjects (21 +/- 1 yr) rode a cycle ergometer 2 h/d for 8 consecutive days at 65% maximal oxygen uptake (VO2max). Average HR and SR were measured each day during exercise, and PV (T-1824) was measured prior to, on day 4, and the day following exercise training. The VO2max and maximal HR (HRmax) were measured before and after the 8-d exercise period. Following exercise training, VO2max increased by 8.3% (P less than 0.05), HRmax decreased by 4.1% (P less than 0.05), and PV increased by 430 ml (+ 12.2%, P less than 0.05). During the 2-h ergometer exercise, mean SR increased from 0.83 1 . h-1 on day 1 to 0.97 1 . h-1 on day 8 (P less than 0.05) while mean HR decreased from 169 beats per min (bpm) on day 1 to 148 bpm on day 8 (P less than 0.05). The percent change (% delta) in PV was correlated with % delta SR (r = 0.93, P less than 0.05), % delta HR at 65% VO2max (r = -0.89, P less than 0.05), and % delta HRmax (r = -0.82, P less than 0.05). The data indicated that plasma volume expansion may be necessary for the cardiovascular and thermoregulatory adaptations accompanying chronic exercise.

Adult↗
PubMed1979

Quality of sweat test performance in the diagnosis of cystic fibrosis.

The sweat test, correctly performed, appears to be reliable, but results were found to be unreliable about half the time in 84 small community hospitals assessed. The reasons are inexperienced and untrained technicians, the infrequency of test performance, the use of unstandardized equipment, and the lack of appropriate standards. It behooves all clinical laboratory directors to re-examine and standardize their procedures and use the recommendations of the Cystic Fibrosis Foundation. Physicians should be made aware of the current situation and send their patients only to laboratories that perform the test reliably.

Adolescent↗
PubMedDate not supplied

Mixed type sweat gland adenoma: a case report.

We describe a case of a young woman with inguinal sweat-gland adenoma, that had histological characteristics of both hidradenoma papilliferum and clear-cell hidradenoma. The neoplastic risk potential for the 2 conditions is discussed.

Adenoma, Sweat Gland↗
PubMed1975

Eccrine sweat gland tumor of clear cell origin involving the eyelids.

A 47-year-old patient with an unusual tumor involving the right upper and lower eyelids has been followed for almost 6 years. The tumor has remained localized to the eyelids and has recurred locally following attempts at complete or partial excision. The morphological features of the tumor as seen by ordinary light microscopic methods were puzzling, and resulted in a variety of pathologic diagnoses. Light microscopic examination of plastic-embedded semithin sections, and electron microscopic examination indicate that this is a hitherto undescribed eccrine sweat gland tumor of clear cell origin. Its infiltrative growth pattern and tendency to local recurrence suggests that it may be a low-grade malignant neoplasm.

Eyelid Neoplasms↗
PubMed1977

Mucinous (adenocystic) carcinoma of sweat glands with widespread metastasis. Case report with ultrastructural study.

An unusual case of mucinous adenocarcinoma of the sweat glands originating from the right axilla is described. Despite complete control of the primary tumor after local excision, diffuse metastatic lesions continued to appear in the scalp, face, upper and lower extremities, sacral and pelvic bones, and left posterior iliac bone marrow space. The tumors were radioresistant. Multiple trials of various chemotherapeutic regimens, including alkylating agents, antifolates, antipyrimidines, vinca alkaloids, and antineoplastic antibiotics, were ineffective. The cutaneous neoplasms were grossly round, smooth, red, glistening, and cystic and were filled with a gelatinous mucinous material. Microscopic and ultrastructural findings are described.

Adenocarcinoma, Mucinous↗
PubMed1979

Mucinous sweat gland adenocarcinoma of eyelid: a clinicopathologic study of 21 cases with histochemical and electron microscopic observations.

This is a clinicopathologic study of 21 cases of mucinous sweat gland adenocarcinoma involving the eyelid. The tumor occurred in middle-aged adults (median age 60 years) and has a predilection for males. In this series eight patients (40%) had one or more local recurrences, one of whom died with extensive local invasion of the face after multiple recurrences in a 15-year interval. Only one patient had metastasis to the submandibular lymph nodes, which was treated by radical neck dissection. Involvement of the head, especially the face and scalp, was observed in 78% of the cases from the literature. Combining our cases with those previously reported, we found that the eyelid was involved in almost half of the cases (21 out of 45 lesions). We believe that the identification by light microscopy of a mixed population of light and dark secretory cells within the tumor lobules, the histochemical findings (presence of sialomucin and absence of iron as well as periodic acid-Schiff positive, diastase-resistant granules), and the results of ultrastructural studies support the histogenetic postulate that this mucinous adenocarcinoma is probably derived from the secretory cells of the eccrine coil. Our interpretation concurs with Headington's view of origin from the eccrine glands.

Adenocarcinoma, Mucinous↗
PubMed1982

Carcinoembryonic antigen in sweat-gland carcinomas.

Using standard immunoperoxidase techniques, four cases of malignant sweat-gland carcinoma were examined for the presence of carcinoembryonic antigen (CEA). This substance was universally present in these lesions in spite of their wide spectrum of histologic features. CEA was mainly localized within the cytoplasm of tumor cells and in the lumina of neoplastic glands. The findings indicate that the presence of CEA in malignant skin adnexal tumors could help to identify and categorize these lesions as derived from eccrine or apocrine adnexal epithelium.

Adenocarcinoma↗
PubMed1987

Sweat gland carcinoma with bone and visceral metastases. Prolonged complete remission lasting 16 months as a result of chemotherapy.

Sweat gland carcinoma is a rare malignant tumor considered to be radio- and chemo-resistant. A case affecting a labium majorum recurred after surgical resection and was accompanied by bone and visceral metastases. After four cycles of combination chemotherapy consisting of doxorubicin, mitomycin C, vincristine and cisplatin, complete remission lasting 16 months and prolonged survival (50 months) were obtained. A review of the literature also is presented.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed2005

Isolated elevated sweat chloride concentrations in the presence of the rare mutation S1455X: an extremely mild form of CFTR dysfunction.

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) have been shown to cause typical cystic fibrosis (CF) and several milder phenotypes. We report on two asymptomatic sisters who had isolated increased sweat chloride concentrations, and in whom systematic scanning of the whole coding region of the CFTR gene revealed the F508del/S1455X genotype.

Adult↗
PubMed1977

Number of epidermal melanocytes, hair follicles, and sweat ducts in skin of Solomon Islanders.

The number of epidermal appendages and melanocytes in forearm skin of three groups of Solomon Islanders has been determined. There were no significant differences in the number of hair follicles or sweat ducts among Solomon Islander groups, nor between them and a Caucasian group used for comparison. The Nasioi and Kwaio, however, do have a significantly higher melanocyte population than Caucasian groups. This difference may in part be due to the exposure of the Solomon Islander skin used in this study to chronic solar radiation.

Epidermal Cells↗
PubMed1986

Somatosympathetic reflex unilateral sweating and pupillary dilatation in a paraplegic man.

Sympathetic spinal reflex responses to painful stimuli have been studied in experimental animals, but have rarely been demonstrated in human beings. We report the case of a paraplegic man with a high thoracic sensory level to pain, who developed unilateral pupillodilatation and sweating from the head to the midthoracic region as a response to rib fractures below the sensory level. This regional sympathetic reflex response was similar in many ways to that seen in spinally transected animals. Regional sympathetic reflex responses may provide a clinically useful sign of a painful and perhaps dangerous condition which is located below the analgesic level in spinal cord-injured patients.

Adult↗