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Labelling chronic illness in primary care: a good or a bad thing?

Traditionally the management of any chronic condition starts with its diagnosis. The labelling of disease can be beneficial in terms of defining appropriate treatment such as in coronary artery disease. However, sometimes it may be detrimental such as when x-rays are used to diagnose lumbar spondylosis leading to patients inappropriately limiting their activity. Chronic knee pain in the elderly is another example where applying labels is problematical. A common diagnosis in this situation is osteoarthritis, but this label can be applied in two ways: as a radiological diagnosis, or as a clinical one. The x-ray diagnosis, however, does not equate with the clinical syndrome, and vice versa. In addition, diagnosing knee pain as osteoarthritis does not necessarily help in management, since a patient's debility is more dependent upon their clinical signs and symptoms than the presence of radiographic osteoarthritis, and by the same token its clinical counterpart. GPs are consistent in their management of knee pain, but in attempting to diagnose the pain as osteoarthritis, these plans can alter and become more dependent on the actual diagnosis than the clinical picture. As a result management may well diverge from what the current best evidence supports. Diagnosis for diagnosis sake, should therefore be discouraged, and chronic knee pain gives us one example of why this is the case. GPs would be better placed to manage this condition if it was considered more as a regional pain syndrome, perhaps defining it simply as 'chronic knee pain in older people'. This example suggests that there is a pressing need in primary care to carefully consider in chronic disease when it is appropriate to be definitive in diagnosis such that when using disease specific labels, there is definite benefit for the patient and doctor.

Chest Pain↗

[Determination of vertebral fracture threshold by measuring bone mineral content in the lumbar vertebrae].

Bone mineral density (BMD) in the lumbar vertebrae (L2-L4) was assessed by dual energy X-ray absorptiometry (DEXA: QDR-1000), and the values obtained were compared with the frequency of vertebral fracture as assessed by spinal X-ray photographs. Patients with spondylosis or scoliosis, which affect BMD values, were excluded from the study. An essentially linear correlation was observed between the frequency of vertebral fracture and lumbar BMD values: no vertebral fractures were observed in those whose BMD more than 0.8 g/cm2, whereas the frequency of fracture was 100% in patients whose BMD was less than 0.45 g/cm2. Thus, measurement of lumbar vertebrae by DEXA would be very useful in predicting vertebral fractures.

Absorptiometry, Photon↗

Involution of a Borden type 1 cranial dural arteriovenous fistula secondary to local arterial pressure during an anterior cervical discectomy and fusion: case report.

OBJECTIVE AND IMPORTANCE: A cranial dural arteriovenous fistula may undergo configurational changes in response to local arterial pressure. CLINICAL PRESENTATION: A 53-year-old man had two distinct neurosurgical pathological features at presentation: an occipital dural arteriovenous fistula and cervical radiculopathy secondary to spondylosis. INTERVENTION: An anterior cervical discectomy and fusion were performed with the patient's head secured to a horseshoe headrest. After surgery, the patient's bruit resolved, and angiography demonstrated involution of the cranial dural arteriovenous fistula with only a small residual arteriovenous shunt. CONCLUSION: Sustained local pressure on the scalp may produce favorable symptomatic and angiographic changes in cranial dural arteriovenous fistulae.

Central Nervous System Vascular Malformations↗

Prevalence of rheumatic diseases and associated outcomes in rural and urban communities in Bangladesh: a COPCORD study.

OBJECTIVE: To estimate the burden of rheumatic disorders in adults (age >/= 15 yrs) in Bangladeshi rural and urban communities. METHODS: The survey was carried out in a rural community, an urban slum, and an affluent urban community with samples of 2635, 1317, and 1259 adults, respectively. Through door-to-door surveys, trained interviewers identified subjects with musculoskeletal pain. A socio-culturally adapted and validated Bengali version of the COPCORD (Community Oriented Program for Control of Rheumatic Disorders) questionnaire was used. Trained internists and rheumatologists examined the positive respondents using an English COPCORD examination sheet to identify respondents with definite rheumatic disorders and to reach a diagnosis. RESULTS: The overall point prevalence of musculoskeleletal pain was 26.3%. The point prevalence estimates of musculoskeletal pain in rural, urban slum, and affluent urban communities were 26.2% (women 31.3%, men 21.1%), 24.9% (women 27.5%, men 22.6%), and 27.9% (women 35.5%, men 18.6%), respectively. Most commonly affected sites were low back, knees, hips, and shoulders in all 3 communities. The point prevalence of definite rheumatic disorders was 24.0%. The commonest rheumatic disorders were osteoarthritis of the knees, nonspecific low back pain, lumbar spondylosis, fibromyalgia, and soft tissue rheumatism. Their prevalence estimates were 7.5%, 6.6%, 5.0%, 4.4%, and 2.7%, respectively, in the rural, 9.2%, 9.9%, 2.0%, 3.2%, and 2.5%, respectively, in the urban slum, and 10.6%, 9.2%, 2.3%, 3.3%, and 3.3% in the urban affluent community. The point prevalence of functional disability was 25.5%, 23.3%, and 24.8%, respectively, in the rural, urban slum, and urban affluent communities. Among the positive respondents, 22%, 52%, and 22% reported loss of work for durations of 49.3 +/- 47.5, 50.90 +/- 103.3, and 29.25 +/- 56.5 days, respectively, within the previous year. CONCLUSION: Rheumatic disorders are common causes of morbidity, disability, and work loss in rural and urban communities of Bangladesh. Women are affected more frequently than men. Mechanical disorders are more common than inflammatory arthropathies.

Adult↗

[Effects of Yiqi Huayu Recipe on gene expression pattern of normal and apoptotic chondrocytes in cervical intervertebral disc in rats].

OBJECTIVE: To study the effects of Yiqi Huayu Recipe on the gene expression pattern in normal and apoptotic chondrocytes in the cervical intervertebral disc of rats. METHODS: The intervertebral disc endplates of rats were digested enzymatically. The apoptosis of the chondrocytes was induced by anti-Fas antibody. BiostarR-40s microarray chips were used to investigate the gene expression pattern in chondrocytes in the normal control, apoptosis and Yiqi Huayu Recipe groups. The results were scanned with Scan Array 4000 and analyzed with GenePix Pro 3.0, and then subjected to standardization and ratio analysis. RESULTS: In the apoptosis group, 30 kinds of genes expressed in cervical intervertebral disc chondrocytes were screened out, in which 10 were up-regulated (ratio>2) and 20 down-regulated (ratio<0.5) as compared with the normal control group. On the other hand, in the Yiqi Huayu Recipe group, 97 kinds of genes expressed in cervical intervertebral disc chondrocytes were screened out, in which 44 were up-regulated (ratio>2) and 53 down-regulated (ratio<0.5) as compared with the apoptosis group. CONCLUSION: There are some signal transduction pathways that control the apoptosis of the intervertebral disc chondrocytes. Yiqi Huayu Recipe regulates the gene express of the apoptotic chondrocytes in intervertebral disc. The study gives a further understanding to the mechanism of the cervical spondylosis and enriches the theories of qi and blood of traditional Chinese medicine.

Animals↗

[Dynamic motion study of the cervical spine using ultra-fast gradient echo with RF-spoiled GRASS--evaluation of cervical instability].

In order to assess the instability of the cervical spine, ten patients with cervical spondylosis were studied by dynamic MRI using Ultra-Fast RF-Spoiled GRASS which is capable of subsecond imaging. Dynamic MRI has proved to be useful in the evaluation of cervical instability, especially in detecting the transient abnormal mobility of cervical spines which cannot be identified on conventional radiography.

Humans↗

Gold bead implants.

Gold bead implantation is an experimental area of study in the acupuncture field dealing with chronic diseases. Special acupuncture techniques are required to implant the gold beads successfully in the proper location. Gold beads are used to treat degenerative joint disease, osteochondritis, osteochondritis dessicans, ventral spondylosis, and seizures.

Acupuncture Therapy↗

[Evaluation of the effectiveness and limits of balneology therapy for arthrosis in Lacu Sărat Health Resort, Brăila, Romania, in the period of 1994-2003].

This research tried to estimate the importance of the precocious diagnosis in the arthrosis. It also analyzed the efficiency and limits of the balneology therapy based on the facilities offered by Lacu Sărat Health Resort, Brăila. The approaching method consisted of a retrospective analysis of 10565 standard records of patients suffering from arthrosis, hospitalized in the health resort, between 1994-2003. The cases fell into various categories, according to the illnesses, as follows: 2854 (27.01%) gonarthrosis, 1247 (11.82%) coxarthrosis, 2001 (18.91%) spondylosis, 2003 (18.87%) peripheral arthrosis. The balneology treatment was applied individually, taking into consideration the location, clinical stage and associated illnesses. The treatment also included physiotherapy and kinetic therapy, adjusted to the stage of disease. The treatment results were good in 73.30% of cases. The patients' recovery aims at stabilizing the development of the illness, removing the objective as well as subjective suffering and maintaining the mobility and ability of the affected segment. The conclusions of the research underline the particular contribution of the clinical evaluation in diagnosis and the efficiency of external balneology in removing the pain and inflammation, maintaining the articular mobility and ability. Thus, the cure can ensure an appropriate articular comfort for most of the patients, taking into consideration the recurrent character of the illness, with repeated periods of suffering and pain.

Adult↗

[A case of multiple sclerosis with bilateral useless hand syndrome as a main clinical feature].

A 41-year-old, right-handed man was admitted to our hospital on September 12, 2002, due to progressive clumsiness in both hands. The patient had been diagnosed as having multiple sclerosis three years prior to admission. He noticed difficulty in manipulating objects three months before admission. Cervical T2-weighted MRI showed a high signal intensity at the level of C3-4 which was enhanced on T1-weighted image with gadolinium. On admission, neurological examinations revealed impairment of dexterity, deep sensory disturbance, and astereognosis in both hands. The clumsiness of complex finger movements was predominant on the left side, and was exaggerated with the eyes closed in association with pseudoathetosis. After steroid therapy, his clumsy hands improved gradually. This type of clumsiness in multiple sclerosis had been described as useless hand syndrome by Oppenheim. In accordance with our case, useless hand syndrome has been reported to arise from high cervical (C2-4) lesions, mainly involving the posterior cord ipsilateral to the clumsy hand. Although the majority of reported cases with useless hand syndrome had other neurological complications, such as hemiparesis, tetraparesis, and truncal ataxia, our patient exhibited a pure form of useless hand syndrome. In addition, useless hand syndrome is usually unilateral, and bilateral useless hand syndrome is very rare. Clumsiness of fine finger movements with astereognosis in our patient is similar to numb clumsy hands or limb-kinetic apraxia due to cervical spondylosis or postcentral gyrus lesion, respectively. This indicates an important role of the high cervical posterior cord in conveying a kinesthetic sense necessary to guide fine finger movements. It should be kept in mind that high cervical lesions in multiple sclerosis causes clumsy hands mimicking limb-kinetic apraxia.

Adult↗

Intraoperative evaluation of implants in anterior cervical spine surgery by three-dimensional fluoroscopy.

OBJECTIVE: Accurate radiographic documentation of the proper placement of cages, plates, and screws following cervical spine surgery significantly impacts clinical outcome. Postoperative computed tomography scans clearly show that the position of implants is sometimes far from ideal. The morbidity of anterior cervical disc surgery is well documented, but the incidence and influence of the misplacement of interbody spacers, plates, and screws are underestimated. We used isocentered fluoroscopy with three-dimensional image reconstruction intraoperatively to evaluate the extent of bony decompression and position of implants before wound closure. METHODS: From October 2003 through April 2004, 27 patients had anterior cervical procedures: 22 one-level and 5 two-level operations. Herniated cervical discs were diagnosed in 21 individuals, whereas 6 exhibited spondylosis. A radiolucent operating table made of carbon fibers was used in all patients. Before wound closure, intraoperative three-dimensional fluoroscopy was performed to evaluate the location of cervical implants and anterior bone resection. RESULTS: The entire scanning procedure required 5 minutes; the actual scanning time was only 120 seconds. In all patients, we were able to adequately evaluate the placement of cage, plates, and screws. Utilization of intraoperative three-dimensional fluoroscopy revealed that two cages were malpositioned and required revision before wound closure. CONCLUSIONS: Intraoperative three-dimensional fluoroscopy is a valuable tool for the intraoperative imaging of bony decompression and implants in anterior cervical spine surgery. The technique is safe and reliable and should help us to avoid incomplete decompression or misplacement of implants and therefore improve long-term functional outcomes in the future.

Adult↗

SPECT/Spiral-CT hybrid imaging in unclear foci of increased bone metabolism: a case report.

In bone scintigraphy, the differentiation between degenerative processes and bone metastases is still difficult. Therefore, additional radiological studies are regularly needed after bone scintigraphy. The now introduced hybrid-cameras combining single-photon emission computed tomography (SPECT) and spiral-CT are unique in the sense that they offer the opportunity to correlate the functional information with morphology in one session. We herein present two patients in whom this technological setup allowed a definite diagnosis in scintigraphically unclear vertebral lesions. In a patient with breast cancer, hypermetabolic lesions were clearly correlated with osteolyses. In another patient with synovial carcinoma, spondylosis and spondylarthrosis caused focal tracer uptake in the lumbar spine. In addition to an improved diagnostic accuracy, SPECT/Spiral-CT will considerably abbreviate the diagnostic process.

Adult↗

Acquired structural kyphoscoliosis in a captive adult female rhesus macaque (Macaca mulatta).

A female, wild-caught, rhesus macaque (Macaca mulatta), in captivity for 23 years and estimated to be older than 26 years, had an 8-year history of progressive spinal curvature. Scoliosis was initially noted 1 year after a therapeutic bilateral ovariectomy to treat endometriosis. Eight years after the initial diagnosis, the curvature had progressed to a structural (nonflexible), lumbar scoliosis with a curvature to the left and a structural thoracolumbar kyphosis. The spinal curvature was characterized radiographically by a severe, major lumbar curve to the left with vertebral rotation and severe thoracolumbar kyphosis. The Cobb method of measurement identified a major left lumbar curve of 80 degrees. When the animal's condition deteriorated, the animal was euthanized, and a necropsy with postmortem radiographic and microscopic examination was performed. Radiographically and grossly, multiple intervertebral disc spaces were narrowed along the entire spine with ventral bridging intervertebral spondylosis of the lumbar spine. Radiographically, vertebral bodies appeared to be less radiodense and multiple features of degenerative disc disease were present. No clinical evidence of concurrent neuromuscular or mesenchymal disease was noted, and development of lesions after bilateral ovariectomy suggested the kyphoscoliosis was secondary to osteopenia that developed as the result of a surgically induced estrogen deficiency.

Animals↗

[Subclavian steal carotid recovery syndrome--case report].

A case of atherosclerotic changes with rare form of right sided Subclavian Steal Carotid Recovery Syndrom consisted of three elements: critical stenosis of brachiocephalic trunc (80%), mild stenosis of right common carotid artery (35%) and variable, ascendent-descendental filling of right vertebral artery is reported. A patient is in a high risk for developing of arterial occlusive disease and with high total score of 7 out of 10 multiple risk factors (age, personal or familiar history, smoking, hyperlipidaemia, overweight, sedentary lifestyle). A cervical spondylosis accompanied with chronic neural lesion of C7/C8 myotom is verified causing mistreatment of a patient exclusively as neurological or physiatrical case.

Carotid Stenosis↗

Diagnosis of nerve root compression. Myelography, computed tomography, and MRI.

Current technology and published studies support the preferential use of MRI in the diagnosis of cervical myelopathy. In cervical radiculopathy, data support the use of either contrast-enhanced CT or MRI. We prefer MRI as the initial diagnostic test because of the obvious advantage of its noninvasive nature. Similar to myelography, MRI permits visualization of the entire cervical canal and spinal cord. Unlike routine CT, MRI visualizes the spinal cord and nerve roots in two planes and is better in detecting unsuspected pathology at other cervical segmental levels. Because the quality of MRI scans in the cervical spine is subject to more variation than in the lumbar spine, anticipated pathology is sometimes not clearly visualized by cervical MRI. Under such circumstances, we obtain a water-soluble myelogram followed by contrast-enhanced CT. Because inaccurate radiographic diagnosis is one of the identifiable causes of poor outcome in surgical therapy for cervical spondylosis, accurate visualization of pathology in terms of its location, nature, and extent is imperative before performing decompressive cervical spine surgery.

Contrast Media↗

Types of anterior cervical grafts.

Anterior cervical diskectomy and fusion provide satisfactory results in most instances of cervical disk herniation and cervical spondylosis. A variety of interpositioned grafts have been described for such problems at one or two levels. Multiple level anterior decompression and fusion for patients with spondylotic myelopathy produce satisfactory results in most instances and are particularly effective when a degenerative kyphosis is present. Appropriate patient selection and attention to technical aspects of exposure, neural decompression, and graft procurement and placement directly influence the surgical outcome.

Bone Transplantation↗

[Clinical study of cervical myeloradiculopathy with carpal tunnel syndrome, double crush syndrome].

The hypothesis, "double crush syndrome (DCS)", is that neural function could be impaired when single axons, having been compressed in one region, become especially susceptible to damage in another. We retrospectively review our surgical cases with both cervical lesion and carpal tunnel syndrome, i.e., DCS. From January 2001 to January 2005, we have treated 7 patients (Male-4, Female-3, average age-59.9 years old) under the diagnosis of DCS. Cervical lesions were cervical spondylosis in 4 and cervical narrow canal in 3 patients. Peripheral entrapment neuropathy was carpal tunnel syndrome in all 7 cases. Initial operation was performed for cervical lesion in 2, carpal tunnel syndrome in 2, and 3 cases were operated simultaneously. The improvement rate by Neurosurgical Cervical Spine Scale (NCSS) was average 65.8%. The average follow-up period was 18.2 months. Good results can be obtained in 5 cases, and poor results in 2 cases who underwent initial operation under the diagnosis of single lesion. It is well known that a discrepancy between neurological manifestation and neuro-imaging sometimes occurs in cervical lesions, and then DCS should be considered as a possible pathogenetic mechanism.

Adult↗

Anterior cervical interbody fusion with radiolucent carbon fiber cages: clinical and radiological results.

The authors retrospectively evaluated 30 patients with an anterior cervical interbody fusion for cervical spondylosis or disc herniation. Open box carbon fiber cages were used at 45 levels. The visual analogue scales (VAS), respectively for neck and for arm pain, and the neck disability index (NDI) improved significantly (p < 0.001). Fusion occurred in 87% of the operated levels. Subsidence of the cages into the endplates was observed in 49% of the operated levels, which increased to 54% when more levels were fused. No correlation between subsidence of the cage and clinical outcome or radiographic fusion was established. The authors conclude that cervical discectomy and interbody fusion using an open box carbon fiber cage is a satisfactory treatment option for degenerative cervical disease causing neck pain and radiculopathy, despite the relatively high percentage of subsidence of this cage.

Adult↗

[Analysis of select diagnostic examination results and their connection with cervical vertigo diagnosis].

Cervical spine spondylotic changes are known to cause vertigo, but diagnostic criteria are not established. The aim of present study was to asses diagnostic value of classical radiologic, electronystagmographic (ENG) and transcranial doppler ultrasonographic (TCD) examinations in cervical vertigo diagnostic process. Forty patients with vertigo lasting more than 6 months with radiological evidence of cervical spondylosis participated in the study. All patients had ENG and TCD with neck rotation test. Cervical vertigo was diagnosed in patients with positive neck rotation test in: TCD examination (15% decrease of vertebral artery flow) and/or ENG examination (cervical nystagmus). We diagnosed cervical vertigo in 65% of patients. Multivariate model of logistic regression analysis showed that the best statistical predictors of cervical vertigo were: asymmetry of vertebral artery flow in TCD (OR: 92.2; 95% CI: 6,2-1381) and presence of osteophytes and discopathy in radiological examination (OR: 64.1; 95% CI: 1,3-1107). The transcranial doppler ultrasonographic examinations seems to be useful for diagnosing cervical vertigo.

Adult↗