Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “OLEIC ACID”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,531 records · Page 85Linked to original sources
PubMed1991

Effects of dietary fatty acids on the early stages of neoplastic induction in the rat pancreas. Changes in fatty acid composition and development of atypical acinar cell nodules.

Diets enriched with fat, especially unsaturated fat, promote experimental pancreatic carcinogenesis, but little is known of the effects of individual fatty acids. The effect of stearic and oleic acid on pancreatic fatty acids and atypical acinar cell nodules (preneoplastic lesions) was studied in 14-day-old weanling male Leeds strain rats (n = 60) given the carcinogen azaserine. Rats were allocated to one of six groups: untreated controls (n = 10), 20% stearic acid diet (n = 10), 20% oleic acid diet (n = 10), carcinogen alone (n = 10), carcinogen plus 20% stearic acid diet (n = 10) or carcinogen plus 20% oleic acid diet (n = 10). Azaserine was administered by intraperitoneal injection in a dose of 30 mg/kg at 2, 3 and 4 weeks of age. When total lipid extracts of pancreas were examined, there was an increase in stearic acid in the stearic acid fed group and an increase in oleic acid in the oleic acid fed group, irrespective of carcinogen treatment. The relative content of all other pancreatic fatty acids was suppressed by feeding oleic acid. At 26 weeks, the number and volumetric indices of pancreatic atypical acinar cell nodules was increased only in rats given azaserine and oleic acid. The enhancing effect of oleic acid on pancreatic carcinogenesis may be associated with pancreatic fatty acid changes.

Animals↗
PubMed1987

The effect of donor specific transfusions and dietary fatty acids on rat cardiac allograft survival.

A rat heterotopic cardiac transplant model was used to study the effect of dietary lipids on the immune response. Animals receiving linoleic acid (LA), oleic acid (OA), and fish oil (FO) enriched diets showed significant prolongation of allograft survival when compared to the control diet fed animals. When LA was given to animals who had received a single donor specific transfusion (DST) augmentation of the beneficial DST effect was observed, while the OA and FO fed groups showed no differences from control DST animals. Dietary regulation of the immune response, possibly through manipulation of arachidonic acid metabolism, is implied.

Animals↗
PubMed1978

Fluid overload and post-traumatic respiratory distress syndrome.

A series of dogs was given massive fluid infusions at two dose levels, 60 cc/kg and 100 cc/kg. The dogs were prepared in three ways: shock induced by bleeding; intravenous injection of oleic acid; and combined oleic acid injection and shock. The studies showed that type of injury was a more important determinant of lung dysfunction than the fluid dose. Shock animals were not hurt by fluid infusion; in oleic acid-injected dogs, the fluid infusion magnified the effect of oleic acid. When shock, oleic acid, and high fluid dose were combined, all animals died. The animals that died had high pulmonary artery diastolic pressures.

Animals↗
PubMed1999

Comparison of the postprandial release of peptide YY and proglucagon-derived peptides in the rat.

Endocrine L-cells of the distal intestine synthesize both peptide YY (PYY) and proglucagon-derived peptides (PGDPs), whose release has been reported to be either parallel or selective. Here we compare the release mechanisms of PYY, glucagon-like peptide-1 (GLP-1), and oxyntomodulin-like immunoreactivity (OLI) in vivo. Anaesthetized rats were intraduodenally (ID) given either a mixed semi-liquid meal or oleic acid, or they received oleic acid or short chain fatty acids (SCFA) intracolonically (IC). The ID meal released the three peptides with a similar time-course (peak at 30 min); ID oleic acid produced a progressive release of PYY and OLI, while GLP-1 release was less. IC oleic acid or SCFA released smaller (but significant) amounts of PYY but no OLI or GLP-1. Hexamethonium inhibited most of the response to the ID meal and ID oleic acid, but did not change the PYY response to IC oleic acid. NG-nitro-l-arginine methyl ester (l-NAME, a nitric oxide synthase inhibitor) inhibited meal-induced PYY release and left OLI and GLP-1 unaffected. BW10 (a gastrin-releasing peptide antagonist) had no effect on the meal-induced release of either peptide. These results suggest a parallel initial release of PYY, OLI and GLP-1 after the ID meal, or oleic acid, by an indirect mechanism triggered in the proximal bowel, using nicotinic synapses, and involving nitric oxide release for PYY and an unknown mediator for PGDPs. For PYY there is a later phase of peptide release, probably induced by direct contact between nutrients and colonic L-cells.

Animals↗
PubMed1982

Reversal of oleic acid-induced respiratory distress by prostacyclin (PGI2).

The effects of Prostacyclin (PGI2) on gas exchange were investigated in 13 adult mongrel dogs with acute pulmonary edema induced by oleic acid (0.09 ml/kg). The time course of changes in gas exchange was measured during spontaneous ventilation with room air. In the Control group, with oleic acid induced respiratory distress, there were marked decreases in arterial PO2 and PCO2, and marked increases in respiratory frequency, expired minute volume, alveolar (end tidal)-arterial PO2 difference, arterial-alveolar (end tidal) PCO2 difference and physiological dead space to tidal volume ratio. In the Test group, respiratory distress was also induced by the oleic acid injection, however, subsequent infusion of PGI2 (200 ng/kg/min) reversed the values of these parameters, which were significantly different from those in the Control group. The results suggest that PGI2 has a protective action against impairment of gas exchange in the presence of increased pulmonary vascular permeability.

Animals↗
PubMed1965

LIPIDS OF ISOLATED NEURONS.

1. Lipids were extracted from neurons isolated from the lateral vestibular nucleus of ox (Bos taurus L.) and the ganglia of Aplysia punctata Cuvier. 2. Thin-layer chromatography of ox-neuron lipid revealed three major fractions corresponding to neutral lipid, phosphatidylethanolamine and phosphatidylserine. Part of the phosphatidylethanolamine was present as the plasmalogen. 3. Aplysia-neuron lipid contained neutral lipid, phosphatidylethanolamine and phosphatidylserine. Both phospholipids appeared to be present predominantly as the plasmalogen form. 4. The fatty acids of alkali-labile lipids of ox neurons were examined by gas-liquid chromatography. The major fatty acids were oleic acid, stearic acid and palmitic acid.

Animals↗
PubMed1987

Increased arachidonic acid levels in phospholipids of human colonic mucosa in inflammatory bowel disease.

1. Colonic mucosa from 19 patients with ulcerative colitis, eight with Crohn's disease and 14 controls were analysed for arachidonic acid (C20:4), linoleic acid (C18:2), oleic acid (C18:1), stearic acid (C18:0) and palmitic acid (C16:0). 2. Gas-liquid chromatography of lipid extracts showed that arachidonic acid was significantly higher in ulcerative colitis (19 +/- 4) and Crohn's disease (20 +/- 3) than in controls (13 +/- 5 micrograms/mg of protein) (means +/- SD). Neither the degree of inflammation nor treatment with sulphasalazine or prednisolone appeared to influence the fatty acid concentrations. 3. Seventy-five to ninety-five per cent of the arachidonic acid was found in the phospholipid fraction after separation by thin-layer chromatography. There were no significant changes in the concentrations of the other fatty acids measured, although oleic acid was lower in inflammatory bowel disease. The ratios of oleic acid to stearic acid and to palmitic acid were lower in inflammatory bowel disease. 4. The alteration in the fatty acid profile may partly explain the increased synthesis of eicosanoids in colonic mucosa in inflammatory bowel disease.

Adolescent↗
PubMed1988

Pulmonary effects of crystalloid and colloid resuscitation from hemorrhagic shock in the presence of oleic acid-induced pulmonary capillary injury in the dog.

The effects of resuscitation with crystalloid and colloid solutions in the presence of increased pulmonary capillary permeability were studied. Twenty-four hours after oleic acid administration, dogs were anesthetized and bled to produce hemorrhagic shock. One hour later, resuscitation was performed with saline, 5% albumin, or 6% hydroxyethyl starch solution to restore and then maintain cardiac output at pre-oleic acid values for 6 h. Dogs were recovered and, 24 h later, were reanesthetized for final measurements. Oleic acid administration resulted in increases in pulmonary artery pressure, pulmonary vascular resistance, and extravascular lung water (EVLW). Resuscitation from hemorrhagic shock restored pulmonary hemodynamics to pre-hemorrhage levels and did not affect EVLW, PaO2, shunt fraction, dead-space-to-tidal-volume ratio, or pulmonary compliance. There were no differences in these parameters related to the choice of resuscitation fluid. Saline resuscitation markedly reduced plasma oncotic pressure and the plasma oncotic-pulmonary artery occlusion pressure gradient. Values for these two variables were markedly lower with saline than with colloid resuscitation. The authors conclude that the pulmonary effects of crystalloid and colloid solutions are similar in the presence of moderate increases in pulmonary capillary permeability.

Animals↗
PubMedDate not supplied

[Characteristics of the autoregulatory factor d2 causing autolysis of Pseudomonas carboxydoflava and Bacillus cereus cells].

In the course of organoheterotrophous growth, Pseudomonas carboxydoflava Z-1107 and Bacillus cereus 504 were found to synthesize the autoregulatory factor d2, a membranotropic lipid metabolite, and to accumulate it in the growth medium. At a low concentration, the factor activated respiration of the cells: at a high concentration, it inhibited respiration and induced autolysis of the cells. The physiological action of d2 was shown to be due to the effect of free fatty acids, in particular, palmitic, stearic and oleic acids. Oleic acid displayed the highest physiological activity, P. carboxydoflava Z-1107 became more susceptible to high concentrations of d2 and oleic acid, and respiration of the cells was activated by low concentration of these compounds when the culture passed from the exponential growth phase to the linear one. These results as well as data reported in literature about the action of fatty acids on biological membrane suggest that low concentrations of the factor d2 uncouple respiration and oxidative phosphorylation whereas high concentrations of the factor disorganize the structure of the cytoplasmic membrane by increasing its fluidity.

Autolysis↗
PubMed1999

Antioxidant activity associated with lipid and phenolic mobilization during seed germination of Pangium edule Reinw.

Seeds of the tropical tree Pangium edule Reinw. are widely eaten in Southeast Asia after some treatment or processing. Fermented seeds are a specialty in Indonesia and have been used as spices. Because the tree is wild and has not been cultivated commercially, the physiology of germinated seeds of this tree for food uses is not known. This study reports some biochemical changes during seed germination associated with antioxidant activity and the mobilization of lipids and phenolics. Lipid content decreased, whereas the dominant fatty acids did not change significantly. The dominant fatty acids were oleic acid (C(18:1(n-9))) and linoleic acid (C(18:2(n-6))). During germination, oleic acid decreased while linoleic acid increased proportionally. The hypocotyl synthesized chlorophyll and the tocol composition also changed substantially. The antioxidant activity of phenolic extract increased in proportion to the total phenolics. Guaiacol peroxidase and glucose-6-phosphate dehydrogenase, selected enzymes association with phenolic metabolism, showed that the increased activities coincided with increased total phenolics and free proline.

Antioxidants↗
PubMed1994

Complex modulation of cytokine induction by endotoxin and tumour necrosis factor from peritoneal macrophages of rats by diets containing fats of different saturated, monounsaturated and polyunsaturated fatty acid composition.

1. Responses to cytokines and other inflammatory stimuli have been shown to be enhanced by fats rich in n-6 polyunsaturated fatty acids and suppressed by fats rich in n-3 polyunsaturated fatty acids and oleic acid or poor in n-6 polyunsaturated fatty acids. 2. Corn oil is rich and coconut oil, olive oil and butter are poor in n-6 polyunsaturated fatty acids. Olive oil and butter are rich in oleic acid. Fish oil is rich in n-3 polyunsaturated fatty acids. 3. The present study examines the effects of feeding standard chow or corn, coconut, fish and olive oils and butter for 4 and 8 weeks on subsequent cytokine production by peritoneal macrophages of rats. 4. Tumour necrosis factor production in response to a lipopolysaccharide stimulus and interleukin-1 and interleukin-6 production in response to a tumour necrosis factor challenge were studied. 5. All fats produced a small, but statistically insignificant, reduction in tumour necrosis factor production, which was greatest for olive oil at 8 weeks. 6. After 4 weeks, fish and olive oil significantly reduced interleukin-1 production. After 8 weeks, coconut oil suppressed production of the cytokine, and the inhibitory effect of fish oil was still apparent. After 8 weeks, corn and olive oil enhanced interleukin-1 production. 7. After 4 weeks of feeding, fish and olive oil enhanced interleukin-6 production. After 8 weeks, the enhancement by these fats increased, and corn oil and butter also enhanced production. Coconut oil produced no modulatory effect.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed2006

A quantitative trait locus for oleic fatty acid content on Sus scrofa chromosome 7.

A partial genome scan using microsatellite markers was conducted to detect quantitative trait loci (QTLs) for 10 fatty acid contents of backfat on 15 chromosomes in a porcine resource population. Two QTLs were discovered on Sus scrofa chromosome 4 (SSC4) and SSC7. The QTL on SSC4 was located between marker loci sw1336 and sw512, and this QTL was detected (P < 0.05) only for linoleic acid. Its position was in proximity of those mapped for linoleic acid content in previous studies. The QTL on SSC7 was mapped between markers swr1343 and sw2155, and it was significant (P < 0.05) only for oleic acid. A novelty of the QTL for oleic acid was suggested because the QTL was located far from any other QTLs previously mapped for fatness traits. The QTL on SSC7 explained 19% of phenotypic variation for oleic acid content. Further studies on fine mapping and positional comparative candidate gene analysis would be the next step toward better understanding of the genetic architecture of fatty acid contents.

Animals↗
PubMed1995

Cretan Mediterranean diet for prevention of coronary heart disease.

As a result of the Seven Countries Study, the Mediterranean diet has been popularized as a healthy diet. Nevertheless, it has not replaced the prudent diet commonly prescribed to coronary patients. Recently, we completed a secondary, randomized, prospective prevention trial in 605 patients recovering from myocardial infarction in which we compared an adaptation of the Cretan Mediterranean diet with the usual prescribed diet. After a mean follow-up period of 27 mo, recurrent myocardial infarction, all cardiovascular events, and cardiac and total death were significantly decreased by > 70% in the group consuming the Mediterranean diet. These protective effects were not related to serum concentrations of total, low-density-lipoprotein (LDL), or high-density-lipoprotein (HDL) cholesterol. In contrast, protective effects were related to changes observed in plasma fatty acids: an increase in n-3 fatty acids and oleic acid and a decrease in linoleic acid that resulted from higher intakes of linolenic and oleic acids, but lower intakes of saturated fatty acids and linoleic acid. In addition, higher plasma concentrations of antioxidant vitamins C and E were observed. We conclude that a Cretan Mediterranean diet adapted to a Western population protected against coronary heart disease much more efficiently than did the prudent diet. Thus, it appears that the favorable life expectancy of the Cretans could be largely due to their diet.

Adult↗
PubMed2003

Squalene synthase inhibitors suppress triglyceride biosynthesis through the farnesol pathway in rat hepatocytes.

We recently demonstrated that squalene synthase (SQS) inhibitors reduce plasma triglyceride through an LDL receptor-independent mechanism in Watanabe heritable hyperlipidemic rabbits (Hiyoshi et al. 2001. Eur. J. Pharmacol. 431: 345-352). The present study deals with the mechanism of the inhibition of triglyceride biosynthesis by the SQS inhibitors ER-27856 and RPR-107393 in rat primary cultured hepatocytes. Atorvastatin, an HMG-CoA reductase inhibitor, had no effect on triglyceride biosynthesis, but reversed the inhibitory effect of the SQS inhibitors. A squalene epoxidase inhibitor, NB-598, affected neither triglyceride biosynthesis nor its inhibition by ER-27856 and RPR-107393. The reduction of triglyceride biosynthesis by ER-27856 and RPR-107393 was potentiated by mevalonolactone supplementation. Treatment of hepatocytes with farnesol and its derivatives reduced triglyceride biosynthesis. In addition, we found that ER-27856 and RPR-107393 significantly reduced the incorporation of [1-(14)C]acetic acid into oleic acid, but not the incorporation of [1-(14)C]oleic acid into triglyceride. Though ER-27856 and RPR-107393 increased mitochondrial fatty acid beta-oxidation, the inhibition of beta-oxidation by RS-etomoxir had little effect on their inhibition of triglyceride biosynthesis. These results suggest that SQS inhibitors reduce triglyceride biosynthesis by suppressing fatty acid biosynthesis via an increase in intracellular farnesol and its derivatives.

Animals↗
PubMed1988

The influence of dietary low and high unsaturated fats and cholesterol on the fatty acid pattern of serum and aortic cholesteryl esters and the lipid deposits of pig aorta.

16 three-month-old female pigs were divided into 3 groups. 6 animals received a semi-synthetic diet containing 15% sunflower oil (g/100 g food) and 1.25% cholesterol (SF group). In 6 animals the sunflower oil was replaced by beef tallow (BT group). 4 control animals 1.5% sunflower oil and without cholesterol. The serum cholesterol levels of the SF group rose moderately, those of the BT group moderately or highly. The relative lipid infiltrated intima area (LIA) and the cholesteryl ester (CE) content of aortas were generally lower in the SF group than in the BT group in comparison to the serum cholesterol levels. The dietary fatty acid pattern determined the fatty acid composition of CE in the serum and extracellular lipid of the aortic lesions. With regard to the intracellular changes of fatty acid pattern of CE (decrease in dienoic acid, predominantly linoleic acid, and increase in monoenoic acids, predominantly oleic acid, and in trienoic acids and higher unsaturated fatty acids), there were important differences between the 2 dietary groups. The dienoic acid content of CE decreased intracellularly from 61% to 30.5%, at the most, in the SF group, and then stopped. In the BT group only 26-35% dienoic acid was available from the extracellular CE and was reduced intracellularly to 9% at the most. In the SF group the intracellular increase in monoenoic acid content of CE was related to the decrease in dienoic acid content. In the BT group this was true only for some lipid deposits of the aorta; in other lesions the monoenoic acid content remained nearly constant or even decreased with decrease in linoleic acid whereas the increase in trienoic acid content was especially high suggesting that an unphysiological trienoic acid (20:3 delta 5, 8, 11), originating from oleic acid, was formed in greater amounts. Our findings point to the development of an essential fatty acid deficiency in the foam cells of aortic lesions in the BT group which may result in an unfavorable influence on the cholesterol clearance from the cells and the arterial wall.

Animals↗
PubMed1998

Individual saturated fatty acids and effects on whole blood aggregation in vitro.

OBJECTIVES: In two studies we have compared the effects of four different saturated fat diets (medium chain fatty acids (MCFA), and lauric, myristic and palmitic acids) with those of a monounsaturated oleic acid diet on in-vitro whole blood aggregation in healthy women and men. DESIGN: Study 1 had a cross-over design with three diet periods of each six weeks, and studied the effects of diets enriched in lauric, palmitic or oleic acids. Study 2 had a parallel design. After a three week oleic acid run-in diet, three groups of subjects were formed which consumed either an MCFA, myristic acid or oleic acid rich diet for six weeks. SUBJECTS: Eighteen women and 14 men in Study 1 and 37 women and 23 men in Study 2. All subjects were healthy and were aged 20-60 y. INTERVENTIONS: The experimental diets were the same in nutrient composition except for on average 8 En% (Study 1) or 10 En% (Study 2) which was provided by either MCFA, lauric acid, myristic acid, palmitic acid or oleic acid. Blood samples were taken at the end of each dietary period. Whole blood platelet aggregation, anticoagulated with recombinant hirudin was assessed after administration of collagen (final concentration (fc): 0.38 microgram/mL) in Study 1 and collagen (fc: 0.22 microgram/mL) or ADP (fc: 1.25 mumol/L) in Study 2. Collagen-induced formation of thromboxane (Tx)A2, measured as thromboxane (Tx)B2, was evaluated in Study 1 only. RESULTS: The aggregation velocity between the saturated fatty acid diets and the monounsaturated fatty acid diet did not differ. TxB2 concentrations measured in collagen activated blood samples, which correlated significantly with aggregation velocity, did not differ between the lauric or the palmitic compared with the oleic acid diet. A stepwise regression analysis indicated that collagen-induced aggregation was negatively correlated with the number of red blood cells. ADP-induced aggregation also correlated negatively with red blood cell count, and positively with platelet count. CONCLUSIONS: The exchange of 7-10 En% from oleic acid for MCFA, lauric, myristic or palmitic acid does not affect in-vitro whole blood aggregation induced by collagen. ADP-induced aggregation is not affected when 10 En% from oleic acid is exchanged for MCFA or myristic acid.

Adenosine Diphosphate↗
PubMed1992

Release of endothelin in the oleic acid-induced respiratory distress syndrome in rats.

Rats injected intravenously with oleic acid developed pulmonary edema leading to hypoxia and hypercarbia. These changes were accompanied by an increase in immunoreactive endothelin (ir-ET) in plasma as early as 15 min after injection. At 45 min after injection plasma levels peaked at 114 +/- 19 pg/ml plasma (n = 8) and reached basal levels again after 240 min. In contrast, much larger amounts of ir-ET were found in the bronchoalveolar lavage fluid, with a peak at 120 min (2878 +/- 258 pg/lung, n = 7) preceding the maximum hypoxia observed at 180 min. In both plasma and bronchoalveolar lavage fluid samples ir-ET was characterized by reverse-phase HPLC as a mixture consisting mainly of ET-1 and smaller amounts of big ET-1, ET-2 and ET-3. In light of the biological effects of ET, the data suggest that these peptides might be of pathophysiological significance in this model of adult respiratory distress syndrome.

Animals↗
PubMed1984

Correlation of changes in oxygenation, lung water and hemodynamics after oleic acid-induced acute lung injury in dogs.

Changes in oxygenation after oleic acid (OA)-induced acute lung injury were correlated to changes in extravascular lung water (EVLW) and hemodynamics in 19 mongrel dogs. Three patterns seemed apparent. In group 1 (seven dogs) EVLW increased by 88% from control values but PaO2 fell only 15%. The change in PaO2 in this group was related directly to the change in mixed venous O2 tension (PvO2) after the OA-induced fall in cardiac output. In group 2 (eight dogs), EVLW rose by 120% and PaO2 fell 53%, 90 min after OA administration. In this group, there was a subsequent spontaneous improvement of PaO2 to 75% of control values, without any measured change in EVLW. In group 3 (four dogs), the fall in PaO2 was comparable to that of group 2, but the increase in EVLW was greater (148%) and there was no spontaneous improvement in oxygenation. Cardiac index fell in all three groups. A small but significant increase in PvO2 partially explains the improvement in oxygenation in group 2. We conclude that changes in oxygenation are a poor index of injury during this model of acute lung injury and that the course of oxygenation is directly related to measured changes in EVLW and hemodynamics.

Animals↗