Social implications of sickle cell programs.
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On 4 October 2000, Bill 119 (or the Red Tape Reduction Act, 2000) was introduced and received first reading in Ontario's provincial legislature. Like many of the other similarly titled bills the Harris government has introduced, Bill 119 proposes to change a long list of existing statutes in an effort to make Ontario more business friendly. Schedule G of Bill 119 sets out a mechanism whereby a viatical industry in Ontario would be made legal if a licensing scheme is first put in place by the Ministry of Finance.
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OBJECTIVE: This study was conducted to explore the relationship between body mass index (BMI) and mortality in an insured population issued policies at standard rates or rated only for build using contemporary analytic techniques. BACKGROUND: Many factors influence the relationship between build and mortality. Recent clinical literature on this subject often employs multivariate statistical techniques to better define this relationship and reduce the influence of confounders. BMI, a common surrogate variable for build in clinical literature, is our variable of choice in studying the relationship between build and mortality. METHODS: We studied internal data on direct and reinsurance business issued between 1975 and 1998 at standard rates or rated only for build. The policies were followed till termination (death or lapse) or to the end of 1999. The average policy duration was 4.7 years. Cox proportional hazards model runs were used to study the multivariate relationship between mortality and BMI in moderately over- and underweight insured individuals. RESULTS: During follow-up, 4105 deaths were observed. Mortality was noted to very with BMI, most significantly in middle-aged male nonsmokers. Consistent with reports from the clinical literature, significant factors influencing the BMI-mortality relationship in this insured population included issue age and smoking status. CONCLUSIONS: BMI is a predictor of statistically significant mortality differentials in insured populations. The strength of the BMI-mortality relationship was found to vary by age, gender, and smoking status. In our study population, the male nonsmoker subgroups tended to exhibit the strongest graded relationship between hazard of death and increasing or decreasing BMI.
Approximately 15,000 cases of superior vena cava (SVC) obstruction are diagnosed in the United States annually. Malignancies (primarily lung cancer) are the underlying cause of 80-85% of cases, leaving 15-20% caused by various benign conditions, including sclerosing mediastinitis (the diagnosis in our case). Thrombolytic therapy and major advances in vascular techniques in recent years have improved the outcome and lessened the morbidity of SVC obstruction. However, even though a benign condition, sclerosing mediastitinis is a dynamic, ongoing fibrotic condition that seldom can be totally removed surgically. It frequently causes recurrent episodes of SVC obstruction, requiring further repetitive vascular procedures that can result in major morbidity and even mortality.
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