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At least 1,531 records · Page 85Linked to original sources
PubMed1977

A simple method for the estimation of glomerular filtration rate.

A simple method is presented for indirect estimation of the glomerular filtration rate from two venous blood samples, drawn after a single injection of a small dose of [125I]sodium iothalamate (10 muCi). The method does not require exact dosage, as the first sample, taken a few minutes (t = 5 min) after injection, is used to normalize the value of the second sample, which should be taken in between 2-4 h after injection. The glomerular filtration rate, as measured by standard inulin clearance, may then be predicted from the logarithm of the normalized value and linear regression formulas with a standard error of estimate of the order 1-2 ml/min/1.73 m2. The slope-intercept method for direct estimation of glomerular filtration rate is also evaluated and found to significantly underestimate standard inulin clearance. The normalized 'single-point' method is concluded to be superior to the slope-intercept method and more sophisticated methods using curve fitting technique, with regard to predictive force and clinical applicability.

Adult↗
PubMed1980

Effects of contrast media on aortic endothelium. Experiments in the rat with non-ionic monomeric and monoacidic dimeric contrast media.

Injury to the aortic endothelium in rats was evaluated under a light microscope by a silver staining method after application of ionic monomeric (diatrizoate and metrizoate), non-ionic monomeric (C29 with different pH and buffers, 593, iohexol and metrizamide) and monoacidic dimeric (ioxaglate) contrast media, and iso- and hypertonic solutions of sodium chloride. In iodine equivalent concentrations the ionic monomers were significantly more toxic than the other contrast media. No significant was found between the non-ionic monomers, monoacidic dimer and sodium chloride solutions equiosmolal to the ionic monomers. Isotonic saline was the least harmful solution.

Animals↗
PubMed1982

Beta 2-microglobulin determined by radioimmunoassay with monoclonal antibody.

In this sensitive radioimmunoassay for beta 2-microglobulin (beta 2-M) involving a commercially available monoclonal antibody, we used a second monoclonal antibody, produced in our laboratory, for affinity-chromatographic purification of beta 2-M. Both monoclonal antibodies bound to all of the charge isomers of beta 2-M identified by two-dimensional gel electrophoresis. Polyethylene glycol was used to separate the phases after incubation for 3 h at room temperature. Sensitivity was 0.25 ng of beta 2-M. Within-assay CVs were less than 5.4%, between-assay CVs less than 7.3%. Analytical recovery was 95-102%. The reference interval was 1.2-2.2 mg/L for 49 healthy subjects. The correlation coefficient for comparison with a polyclonal antibody assay was 0.997 for 44 patients. In a study correlating serum beta 2-M and creatinine concentrations with glomerular filtration rate for 50 patients, correlation coefficients for log-log transformed data were -0.94 and- 0.95, respectively. Concentrations of beta 2-M were increased in serum of patients with imparied renal function and also in patients with normal renal function who had disorders involving the immunologic response. We found no clear-cut advantage of measuring serum beta 2-M over serum creatinine in the estimation of glomerular filtration rate.

Adult↗
PubMed1984

Newer contrast agents for urography.

New low-osmolality ratio-3 contrast media have been shown to have less toxicity than currently used contrast media. In intravenous excretory urography, these agents give significantly higher urinary iodine concentrations, produce less diuresis, and are better tolerated by patients because of fewer unpleasant side effects. These newer low-osmolality contrast media have significant advantages in intravenous urography.

Animals↗