Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “INSEMINATION”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,531 records · Page 85Linked to original sources
PubMed1980

[Psychological aspects relating to artificial donor insemination (ADI) (author's transl)].

Discussed in this paper is the psychic situation of sterile couples who resort to artificial insemination, using donor semen (ADI). --Careful psychodiagnostic checking prior to ADI seems to be essential to forestalling psychic problems. ADI treatment should be applied solely to really sterile couples of stable psychic status and with good communication between the two partners. A method of psychological preparation for ADI is described. Psychodiagnostic examinations should be followed by specific gynaecological checks. Such approach will yield at least two advantages: 1. Gynaecological examination will not be necessary, if contra-indications are concluded from psychological checking 2. Early psychological assessment of sterile couples will become possible. Favourable psychic development of both couples and children born as a result of ADI will be an additional advantage of high probability.

Attitude↗
PubMed1995

[Assessment of the health status of children born as a result of extracorporeal fertilization and artificial insemination].

Comprehensive assessment of the health status of 142 children born In Research Center of Obstetrics, Gynecology, and Perinatology, Russian Academy of Medical Sciences, showed that 92% of children not only survived, but were healthy and their neuropsychic development was normal for age. The hormonal and immunity status was virtually normal. The authors come to a conclusion that extracorporeal fertilization and artificial insemination in the treatment of a sterile marriage are Justified and effective. The health status of the children who are born is normal, provided certain indications are adhered to.

Adult↗
PubMed1977

[First results and experiences with artificial donor insemination (ADI) in the treatment of sterile and infertile couples].

Statement of the importance, indications, contraindications and conditions of the artifical donor insemination (ADI) as a possibility of therapy in sterile and infertile married couples. Report about 34 wifes, in which hitherto in 12 cases the ADI led to a desired pregnancy. One of the pregnancies resulted in abortion, in 7 cases after a normal pregnancy and a normal delivery 7 normal developing infants were born and in 4 wifes present exists regular pregnancy in the 15 th to 30 th week. From these are 3 pregnancies, which obtained with helps of frozen semen (cryo-sperm). The successes are hitherto exclusive in the first cycles of the treatment. The biggest number of conceptions (8) have been reached, if the ADI have been led one day before rise in morning temperature. After strict consideration of all conditions and conscientious selection of the donors, ADI belongs a stable place in the therapy of sterility and infertility

Adult↗
PubMed1977

Human artificial insemination: some social and legal issues.

The demand for human artificial insemination (AI) is increasing as a function of declining numbers of babies available for adoption and greater community awareness. This paper reviews some of the social and legal issues associated with the practice of AI: prevalence of marital infertility; demand for AI; moral objections; effect on marriage; legality of practice; legal position of all the parties to the practice; legislation proposed to regulate the practice; and payment of medical benefits.

Australia↗
PubMed1977

Artificial donor insemination with frozen human semen.

This study describes the experience with artificial donor insemination (AID) using frozen semen in 227 women who began therapy in 1974 and were followed until March 31, 1976. Ninety-one women (40%) conceived during this period. Sixty-five women (37.9%) failed to continue treatment after three or fewer cycles; follow-up on these patients was incomplete and it is presumed that most did not conceive. The cumulative pregnancy rate was 56.5% among women who persisted in AID for four or more cycles. Additional causes for infertility were found in 53 women. Excluding these, the pregnancy rate was 67.4% for apparently fertile women who had had four or more cycles of AID. Fifty-eight per cent of conceptions occurred within the first three cycles and eighty-five per cent within the first six cycles. The pregnancy rate was not significantly affected by age, occupation, cigarette smoking, or prior fertility. The large number of dropouts after a few cycles of AID suggests a need for intensive and continuous educational, emotional, and psychologic support.

Adolescent↗
PubMed1976

Leptospirosis infection through insemination of animals.

The semen of animals in spontaneous and experimental leptospirosis was investigated by bacteriological, immunological and biological methods. It has been found that pathogenic leptospirae (L. pomona, L. hebdomadis) are well preserved in the semen and in media used for its dilution. Leptospirae are eliminated with the semen. The initial strain of the agent was isolated from the semen and secretions of 6 out of 26 experimentally infected rabbits and 4 spontaneously recovered bulls (L. hebdomadis). Specific leptospiral antibodies appear in the semen of infected animals. The dynamics of the titre of these antibodies corresponds to the dynamics of the antibody titre in the blood. It is recommended to use the semen for the agglutination reaction. The application of semen infected with pathogenic leptospirae for artificial insemination causes the animals falling ill with leptospirosis accompanied by abortions, reduced fertility and stillbirths of rabbits.

Animals↗
PubMed1976

[Results and experiences in the artificial maritogenous insemination as a therapeutic possibility in sterile marriages].

Statement of the importance, indications, contraindications and conditions of the artifical maritogenous insemination (AMI) as a form of therapy in the cases of a primary and secondary sterility. Report about 60 married couples during the time 1971 to 1974, in which in 10 cases (16,6%) the AMI led to a desired pregnancy. 4 of the pregnancies resulted in abortion, one of the pregnancies was anextrauterine gravidity. In 4 cases after a normal pregnancy and a normal delivery 4 normal developing boys were born. One women being in the course of treatment in the 20 th. week of her normal pregnancy. The successes are nearly exclusive in the first cycles of the treatment. The biggest number of the conceptions (5) have been reached, if AMI have been led one day before rise in morning temperature. After extensive diagnostic and proof of the generative potency of the wife and probable potency generativ of the husband, belongs AMI a stable place in the therapy of sterility.

Adult↗
PubMed1999

Maternal serum screening for down syndrome in pregnancies conceived by intra-uterine insemination.

The purpose of our study was to assess the influence of intra-uterine insemination (IUI) on the results of maternal serum Down syndrome screening. 43 women with IUI pregnancies and 4507 healthy women who conceived were studied. Ovulation in IUI pregnancies was induced by clomiphene and/or human menopausal gonadotrophin (hMG). Maternal serum levels of free beta-human chorionic gonadotrophin (hCG) and alpha-fetoprotein (AFP) were measured for Down syndrome screening. It was considered screen-positive when the risk of Down syndrome was 1 in 270 or greater in the second trimester. The value of maternal serum AFP was significantly lower in the IUI group (median=0.760 MoM) than in the control group (median=1.050 MoM). However, the value of free beta-hCG was not significantly different between the two groups. The positive rate of maternal serum Down syndrome in IUI pregnancies was similar to that of the control group. Our results indicate that IUI pregnancy may be associated with a lower level of AFP, although the mechanism for this difference remains unknown.

Adult↗
PubMed2006

Intra-uterine insemination for unexplained subfertility.

BACKGROUND: Intra-uterine insemination (IUI) is a widely used fertility treatment for couples with unexplained subfertility. Although IUI is less invasive and less expensive than in vitro fertilisation (IVF), the safety of IUI in combination with ovarian hyperstimulation (OH) is debated. The main concern about IUI treatment with OH is the increase in multiple pregnancy rates. OBJECTIVES: To determine whether for couples with unexplained subfertility IUI improves the live birth rate compared with timed intercourse (TI), both with and without ovarian hyperstimulation. SEARCH STRATEGY: We searched the Cochrane Menstrual Disorder and Subfertility Group Trials Register (searched March 2005), the Cochrane Central Register of Controlled Trials (The Cochrane Library 2005, Issue 4), MEDLINE (1966 to November 2005), EMBASE (1980 to November 2005), SCIsearch and reference lists of articles. Authors of identified studies were contacted for missing or unpublished data. SELECTION CRITERIA: Truly randomised controlled trials (RCTs) with at least one of the following comparisons were included: --IUI versus TI, both in a natural cycle; --IUI versus TI, both in a stimulated cycle; --IUI in a natural cycle versus IUI in a stimulated cycle; --IUI with OH versus TI in natural cycle; --IUI in a natural cycle versus TI with OH. Only couples with unexplained subfertility were included. DATA COLLECTION AND ANALYSIS: Quality assessment and data extraction were performed independently by two review authors. Outcomes were extracted and the data were pooled. Subgroup analyses and sensitivity analyses were done where possible. MAIN RESULTS: In the six trials where IUI was compared with TI, both in stimulated cycles, there was evidence of an increased chance of pregnancy (six RCTs, 517 women: OR 1.68, 95% CI 1.13 to 2.50). A significant increase in pregnancy rate was also found for women where IUI with OH was compared with IUI in a natural cycle (three RCTs, 415 women: OR 2.33, 95% CI 1.46 to 3.71). However, the trials provided insufficient data to investigate the impact of IUI with or without OH on several important outcomes including live birth, multiple pregnancies, miscarriage and risk of ovarian hyperstimulation. There was no evidence of a difference in pregnancy rate for IUI with OH compared with TI in a natural cycle (one RCT, 51 women: OR 4.05, 95% CI 0.39 to 41.87). No RCTs were found for the other two comparisons. AUTHORS' CONCLUSIONS: There is evidence that IUI with OH increases the live birth rate compared to IUI alone. The likelihood of pregnancy was also increased for treatment with IUI compared to TI both in stimulated cycles. There is insufficient data on multiple pregnancies and other adverse events for treatment with OH. Therefore, couples should be fully informed about the risks of IUI and OH as well as alternative treatment options.

Female↗
PubMedDate not supplied

The use of novel semen quality scores to predict pregnancy in couples with male-factor infertility undergoing intrauterine insemination.

The purpose of this study was to determine whether 2 new semen quality (SQ) scores could predict pregnancy in patients undergoing intrauterine insemination (IUI) for male-factor infertility and whether an overall score could help in counseling these couples with assisted reproductive technique (ART) options. Ninety-three couples with male-factor infertility were examined for semen analysis. Samples were prepared by density gradient separation (47% and 90%), and IUI was performed. On the basis of the 2 semen scores (SQ and relative quality [RQ]), the IUI-semen pregnancy score (IUI-SPS) was calculated. Of the 192 IUI cycles, 14% (27 of 192) resulted in pregnancy. Both prewash SQ and RQ scores were significantly related to pregnancy (P =.02 and P <.001), as was the postwash RQ score (P <.001). Of the IUI cycles in which the postwash RQ score was greater than 125, 40% (13 of 32) resulted in pregnancy compared to 9% of cycles (14 of 160) in which the postwash SQ score was less than 125. The prewash IUI-SPS score was significantly related to IUI-induced pregnancy (P <.001). Both the pre- and postwash SQ and RQ scores can predict pregnancy in male infertility patients undergoing IUI. Patients with an IUI-SPS less than 150 may be advised to seek in vitro fertilization (IVF), whereas those with an IUI-SPS greater than 150 may be advised to seek IUI.

Female↗
PubMed1976

Na is essential for activation of the inseminated sea urchin egg.

The presence of at least 2.5 mM Na during the first several min after insemination is required for the activation of sea urchin eggs. Of those chemical species examined that exist entirely as cations, and which did not activate the unfertilized egg, only Li substitutes for Na. Ammonium and other amines, with pKa values between 9 and 10.8, in the complete absence of Na (a) can induce nuclear activation of unfertilized eggs, and (b) permit the development of the early fertilized egg through the stage that normally requires Na.

Animals↗
PubMed1989

Gamete intrafallopian transfer vs superovulation with intrauterine insemination for the treatment of infertility.

Superovulation with intrauterine insemination (SO-IUI) has been suggested as an alternative to gamete intrafallopian transfer (GIFT), despite the absence of controlled or comparative trials. We retrospectively analyzed all GIFT and SO-IUI cycles performed concurrently from January 1985 to August of 1987 at a single university center. Pregnancy rates were significantly better for GIFT than SO-IUI (P less than 0.001), with an odds ratio of 3.25 (P = 0.001). Stepwise multiple logistic regression identified factors that correlate with pregnancy: absence of endometriosis (P = 0.05), infertility less than 3 years' duration (P = 0.002), TMS greater than or equal to 30 X 10(6) (P = 0.005), and treatment with GIFT rather than SO-IUI (P = 0.001). These data give a first approximation of the increased efficacy of GIFT versus SO-IUI and provide valuable insight into significant confounding variables to be considered when planning a randomized, prospective trial to evaluate these techniques.

Adult↗
PubMed1992

In vivo fertilization procedures in infertile women with patent fallopian tubes: a comparison of gamete intrafallopian transfer, combined intrauterine and intraperitoneal insemination, and controlled ovarian hyperstimulation alone.

This prospective study was undertaken to evaluate the relative efficacy of three in vivo methods of assisted fertilization in 150 infertile women with patent fallopian tubes: gamete intrafallopian transfer (GIFT), combined intrauterine and direct intraperitoneal insemination (IUI+DIPI), and controlled hyperstimulation (COHS) alone. The clinical pregnancy rate was highest in the IUI/DIPI and GIFT groups: IUI/DIPI, 29.3%; GIFT, 28.6%; and COHS, 8.9%. We believe that controlled ovarian hyperstimulation combined with IUI and DIPI is a good alternative to GIFT.

Adult↗
PubMed1993

Effect of limited proteolysis with alpha-chymotrypsin on semen with an abnormal sperm penetration assay and possible application for in vitro fertilization or intrauterine insemination.

PURPOSE: This study was designed to assess the impact of limited proteolysis with alpha-chymotrypsin on the sperm penetration assay (SPA) of infertile patients and to identify a group whose results would normalize with this pretreatment. Further, the application of this treatment to semen of these patients during in vitro fertilization (IVF) and intrauterine insemination (IUI) was reported. RESULTS: Three groups were identified. In one, SPA was abnormal and improved to normal with pretreatment; in the second, SPA was abnormal and did not normalize; and in the third, SPA was normal and improved significantly (included in this group are three known fertile controls). CONCLUSION: Chymotrypsin pretreatment and repeat SPA are advocated for patients with abnormal SPA. If normalization occurs, pretreatment of semen for IVF or IUI is a therapy to be considered.

Biological Assay↗
PubMed1996

Abnormal sperm morphology is highly predictive of pregnancy outcome during controlled ovarian hyperstimulation and intrauterine insemination.

PURPOSE: The purpose of this study was to assess the predictive value of a modified form of Kruger's strict criteria for sperm morphology for pregnancy outcomes after intrauterine insemination (IUI) and controlled ovarian hyperstimulation (COH) in the presence of normal sperm concentration and motility. MATERIALS AND METHODS: A retrospective review of 42 couples undergoing COH/IUI was stratified by favorable or unfavorable sperm morphology. End points were pregnancy or failure of treatment as defined by four or more cycles of COH/ IUI without pregnancy. RESULTS: An unfavorable morphology (< 4%) was highly predictive of failure during COH-IUI (94.45%; 17/18). A normal PIF was a sensitive indicator of those patients who became pregnant (93.8%; 15/16) and had a fair specificity for failure to achieve pregnancy after four cycles of treatment (65.4%; 17/26). Couples with a favorable sperm morphology were 28.3 times as likely to achieve a pregnancy within four cycles of treatment as those with unfavorable sperm morphology [95% confidence limits, 3.2 to 250.5; P < 0.001]. CONCLUSIONS: Abnormal strict morphologic assessment is both sensitive and specific for pregnancy outcomes in couples undergoing COH/IUI. Couples with persistently unfavorable sperm morphology should be counseled appropriately and would be better served by more aggressive treatment with in vitro fertilization and embryo transfer.

Adult↗
PubMed1994

Direct intraperitoneal insemination and controlled ovarian hyperstimulation in subfertile couples.

METHOD: We performed direct intraperitoneal insemination in combination with superovulation and washed husband's spermatozoa as the treatment of infertility caused by oligospermia, cervical subfertility, or ovulatory dysfunction or idiopathic infertility in 162 couples during 360 cycles. RESULTS: The pregnancy rate per couple was 21.9% in the cervical-factor group, 20.9% in the idiopathic group, 4.9% in the oligospermia group, and 15.5% in the ovulatory dysfunction group. CONCLUSION: The pregnancy rate was 33.3% for all couples and 15.0% for all cycles.

Adult↗
PubMed1994

Basal follicle stimulating hormone (FSH) predicts response to controlled ovarian hyperstimulation (COH)-intrauterine insemination (IUI) therapy.

PURPOSE: This work investigates the relationship of basal follicle stimulating hormone (FSH) measurements and age to ovarian responsiveness and pregnancy occurrence following controlled ovarian hyperstimulation and intrauterine insemination (COH-IUI). METHOD: Basal FSH was measured retrospectively in sera from infertility patients obtained on cycle day 2, 3, or 4 of a COH-IUI treatment cycle. Basal FSH was then correlated with COH response parameters and treatment outcome in ovulatory (n = 98) and anovulatory (n = 33) patients. Clinical data were collected from retrospective chart review. In the ovulatory group, increasing basal FSH was associated with fewer follicles (P = 0.01) and lower peak estradiol (P = 0.0001). RESULTS: No age related effects were detected in the anovulatory group. Also, there were no pregnancies in this group when basal FSH was > 22.1 mIU/ml. Increasing age in the ovulatory group was associated with fewer follicles (P = 0.0001), lower peak estradiol (P = 0.0001), and fewer pregnancies (P = 0.04). In the anovulatory group, basal FSH did not correlate with follicle numbers or peak estradiol, although more ampoules of hMG were used for stimulation (P = 0.03). CONCLUSIONS: Increasing basal FSH and patient age both correlated inversely with ovarian responsiveness to COH in ovulatory patients. Basal FSH can be used in clinically to identify patients undergoing COH who are unlikely to respond to superovulatory drugs and unlikely to become pregnant.

Adult↗