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At least 1,531 records · Page 85Linked to original sources
PubMed1986

Pathways of transcytosis in the fenestrated endothelium of pancreatic capillaries.

A procedure which covalently attaches an electron dense tracer to cell surface sialoglycoconjugates was used in order to label the luminal surface of capillary endothelium in rat pancreas. Mild oxidation of the vasculature by perfusion with 1 mM sodium periodate, followed by a 30-90 min incubation with ferritin hydrazide (FH) at 37 degrees C, led to a characteristic decoration of the endothelial surface. FH was taken up by the endothelium in coated vesicles and, to a much lesser extent, in plasmalemmal vesicles or vacuoles. Though rarely, FH was found at the abluminal front of the endothelium in coated vesicles opened to the extracellular space either directly or via a smooth-surfaced vesicle, thus suggesting the involvement of coated structures in transendothelial transport (transcytosis). A conjugate of wheat germ agglutinin with ferritin, which binds noncovalently to cell surface glycoconjugates containing N-acetylneuraminyl and N-acetylglucosaminyl residues, was transported transcellularly in monomeric form, mainly through smooth-surfaced (plasmalemmal) vesicles and transendothelial channels. Cationized ferritin (CF), pI approximately 8.4, which binds to cell surface acidic sites via an electrostatic noncovalent interaction, was rapidly internalized by the oxidized endothelium in coated structures and in vacuoles. Big aggregates of CF were transported and delivered to the abluminal front of the endothelium via large vacuoles, vesicles, and through coated structures and multivesicular bodies. These results show that the capillary endothelial cell possesses multiple mechanisms for transporting macromolecules across the cell, involving vacuoles, smooth or coated vesicles, channels, and lysosomal-related compartments. They also indicate that, besides molecular weight and electric charge of macromolecules, other characteristics of the ligands (e.g., type of bond with cell surface components, state of aggregation) are factors influencing the transendothelial transport.

Animals↗
PubMed1986

[Therapeutic limits of endonasal fenestration of the maxillary sinus].

The endoscopical examination of the diseased maxillary sinus is a common procedure. In cases with obstruction of the ostium the intranasal antrostomy is carried out. 117 operations were followed up 1-7 years postoperatively. In 25.6% of the cases the windows into the inferior meatus were closed. The operation did not yield any improvement of the clinical features in 37% of the cases. There was no correlation to a open or closed window. In these patients the endoscopical and radiological examinations now revealed a diseased ethmoid. Instead of intranasal antrostomy, endoscopical endonasal surgery of the anterior ethmoid (technique of Messerklinger) is recommended. With this procedure, reestablishment of free ventilation of the maxillary sinus is combined with the diagnosis and the therapy of the diseased anterior ethmoid.

Adult↗
PubMed1985

Fenestral and cochlear otosclerosis: computed tomographic evaluation.

Computed tomography has replaced conventional multidirectional tomography in the imaging of patients with the presumed diagnosis of otosclerosis. In addition to obliterative disease, which was easily diagnosed with multidirectional tomography, anterior and posterior foci of varying sizes can now also be visualized preoperatively. Active cochlear otosclerosis (otospongiosis) is diagnosed in the presence of foci of demineralization in the otic capsule. Diagnosis of these entities has been of great interest to our referring otologic surgeons.

Adult↗