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At least 1,531 records · Page 85Linked to original sources
PubMed1985

[Cardiotoxicity of 5-fluorouracil. Apropos of a new case].

Five - Fluorouracil (5 FU) is widely used in oncology, especially in tumors of the gastrointestinal tract and in carcinoma of the breast. Its side effects (gastrointestinal, haematological, alopecia) are well known. However, its cardiac effects are not widely appreciated, despite an incidence similar to that observed with the anthracyclines (1.6% vs 2.2%) and a high mortality rate (12.5%). A new case of coronary insufficiency is reported illustrating the absence of a dose-effect relationship and the frequency of recurrence of symptoms when 5 FU is reintroduced even with coronary vasodilator therapy. The mechanism of cardiotoxicity in this case seems to be coronary spasm.

Coronary Disease↗
PubMed1975

Ethics of selective treatment of spina bifida. Report by a working party.

Ethical problems in medicine usually arise when normal guiding principles appear to be in conflict. In the case of babies with severe spina bifida, or similar abnormalities, two such fundamental principles may be applied with opposing conclusions. The first is that any decision requires an estimate of the balance of suffering and happiness for those concerned in an action, and the other is the assertion that human life is sacred. Resolution of the conflict between these is possible by looking at the problem in a different and less fundamental way, and one such approach is through the concept of ordinary and extraordinary means. While man does not possess power of absolute ownership over life, his duties of stewardship require him to use ordinary means of safeguarding life; he may use, but is not obliged to use, extraordinary means. The distinction between ordinary and extraordinary means may vary with circumstance, and so the application of this principle involves decisions at a third or more practical level. These include an assessment of the child's abnormality, of the effects of this upon the quality of life possible for the child, and of the burdens that will be placed on the family and society. At each level the ethical decisions involve complex choices, and clearly any present policies must be regarded as temporary unavoidable compromises rather than as final solutions.

Attitude of Health Personnel↗
PubMed1979

[Further studies of prospective conscientious objectors in the years 1974-1976].

This present study is concerned with the prospective objectants to military service in the years 74 to 76. Objectants are men liable for service who, at the enlistment, declare to object any form of serving in the military service. 40% of the 178 objectants were unfit for serving for psychiatric reasons. The main causes being neurotic disturbances and infantilism. 91 objectants belong to the church of Jehovah's witnesses. In objectants, indeed, the objecting itself is a symptom of the psychic disorder. Since 1971, the number of prospective objectants did not rise with statistic significance, the contrary being true for the real objectants (i.e. who do not serve in the military service). The portion of prospective objectants in all men enlisting to military service was never greater than 1.5%.

Adult↗
PubMed1983

[Can western medicine resolve psychological problems in ethnic regions outside Europe? 2 cases from the region of Borneo-Sarawak].

The case histories of two patients healed by animist treatment in the Iban tradition are reviewed by two psychiatrists. Both psychiatrists point to the difficulties in the evaluation of the background of the disease and of the mechanisms of its treatment by people not aware of the cultural and sociological aspects of eastern civilisation. The diagnostic classification of both patients by means of western medicine and the possible treatment of their disease are discussed. The failure of western medicine to understand the psychiatrical aspects of animist religions in the pathogenesis of diseases raises the question whether western medicine will be able to cope with the health problems of Iban (and other animists) sufficiently when their animist tradition will be replaced by western civilisation.

Adult↗