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PubMed1997

Auditory localization, detection of spatial separateness, and speech hearing in noise by hearing impaired listeners.

In two groups, one with sensorineural and the other with conductive-mixed hearing loss, measures were made of single-source localization and speech intelligibility in both spatially separate and nonseparate noise. There was also a test for detecting when two sounds came from the same location or from separate ones. Localization test results confirmed earlier findings, namely, disruption of vertical plane ability generally, and a further, particular disturbance to horizontal plane localization in the conductive-mixed group. Compared with a normal control group, there were only slight signs of benefit from separation of speech and noise in the region lateral to the listener, and virtually none in the frontal region. The new test, spatial separateness, had elements in common with both of the other tests, and links were observed from localization to separateness detection, and from separateness to benefit from separation of speech and noise. Localization was also related to speech hearing in nonspatially separated noise.

Aged↗
PubMed1997

Discrimination of atrial fibrillation from regular atrial rhythms by spatial precision of local activation direction.

This study tests the hypothesis that atrial fibrillation (AFib) can be discriminated from regular atrial rhythms by a measure of the variation in local activation direction. Human endocardial atrial recordings of AFib, sinus rhythm, atrial flutter, and supraventricular tachycardia were collected using a catheter with orthogonally placed electrodes, and the direction of each activation was calculated using methods previously described by our laboratory. Each recording was divided into segments containing 100 activations, and the spatial precision for each segment was calculated in three dimensions, as well as in each of the three two-dimensional (2-D) planes. The three-dimensional (3-D) spatial precision for 1161 segments of AFib in 11 recordings ranged from 0.09-0.85 (mean = 0.45), whereas the spatial precision for 138 segments of regular rhythms in 28 recordings was > or = 0.91 in all but four instances. The 2-D spatial precision values overlapped for all rhythms. The results indicate that 3-D spatial precision of local activation direction is a useful discriminator of AFib.

Algorithms↗
PubMed2000

Experimental observation of localization in the spatial frequency domain of a kicked optical system

An experimental realization of an optical "kicked" system is presented. It exhibits localization analogous to that of the quantum "kicked-rotor." In the experiment, free space propagating light is periodically kicked by thin sinusoidal phase gratings, which produce high order diffractions and tend to increase the spatial frequency band. The wave property suppresses this diffusive spread. The localization is realized in a regime near anti-resonance of the system, which is also studied theoretically. The behavior in this regime is similar to that of electronic motion in incommensurate potentials. A crucial part of the experimental system is the grating in-phase positioning, which is done by using the Talbot effect.

Journal Article↗
PubMed1994

Is global motion really based on spatial integration of local motion signals?

Previous studies have shown that a random-dot kinematogram (RDK) comprising dots, each of which takes a random walk in direction or speed over time, can appear to flow in a single direction. This has been interpreted as evidence for the existence of a co-operative network linking neurons sensitive to different directions/speeds and different spatial locations. We have investigated the possibility that global motion perception in such patterns might simply reflect motion energy detection at a coarse spatial scale (such that many dots fall in the receptive field of one energy detector) without the need to encode local dot motions on a fine spatial scale and then integrate their motions over space. We created random-walk RDKs and then spatially high-pass filtered them to remove low spatial frequencies. Perception of global motion was unimpaired for both direction and speed random walks, showing that the phenomenon is not reliant on low spatial frequencies and must, therefore, involve integration of local motion signals across space, as originally postulated.

Discrimination, Psychological↗
PubMed1998

Habitat Destruction and Competitive Coexistence in Spatially Explicit Models with Local Interactions.

We investigate the competition-colonization trade-off in a two-species competition model in various heterogeneous environments. The competitiveness of species is hierarchically ordered and the dynamics of the model are described by spatially local interactions of individuals. The size of the local neighborhood may depend on the species. The habitat consists of inhabitable and permanently destroyed sites. It was previously observed (Nee & May, 1992; Tilman et al., 1994, 1997) that destruction of habitat may aid the inferior species and cause the superior species to go extinct. These conclusions were based on an n-species model in which the spatial arrangement of destroyed sites was ignored. We examine the effects of different spatial arrangements of destroyed sites on survival and coexistence of the two species. We conclude that the spatial arrangement plays an important role and can influence the outcome qualitatively. The key quantity for predicting the outcome of habitat destruction on species survival is the relationship between the mean dispersal distance and the mean distance between inhabitable and destroyed sites. We contrast the hierarchical model with a version of the Lotka-Volterra model of interspecific competition and show that habitat destruction can alter the dominance relationship between species by reducing intraspecific competition.Copyright 1998 Academic Press

Journal Article↗
PubMed2001

Biodiversity of terrestrial protozoa appears homogeneous across local and global spatial scales.

Free-living microbes are by far the most abundant group of organisms in the biosphere, yet estimates of global species richness remain nebulous, and there is no consensus regarding the likely geographical distribution of species. Both uncertainties are addressed by the suggestion that the vast abundance of microbes may drive their ubiquitous random dispersal; for this would also make it likely that global species richness is relatively low. Here we test the idea of ubiquitous dispersal of testate amoebae and ciliates living in soil. We analysed their abundance and species richness in 150 soil samples collected from the one-hectare grassland site at Sourhope in Scotland, and in comparable published data from 1500 soil samples collected worldwide. Following taxonomic revision and removal of synonyms, there remained a total of 186 taxa (91 testate and 95 ciliate) recorded from both Sourhope and other places in the world. A fundamental pattern of random spatial distribution of species was revealed in species that are relatively rare. This probably arises from random dispersal, for when localised population growth occurs, the distributions become aggregated, as in virtually all metazoan species. We find no evidence for geographically-restricted protozoan morphospecies at spatial scales of 4 m2, 10,000 m2, or worldwide. Species that are locally rare or abundant are similarly rare or abundant on a global scale. Approximately one third of the global diversity of soil protozoa was found at the one-hectare grassland site in Scotland, but this is a minimum figure, for recorded species richness is proportional to sampling effort, as shown here.

Amoeba↗
PubMed2005

Spatial propagation and localization of blood coagulation are regulated by intrinsic and protein C pathways, respectively.

Blood coagulation in vivo is a spatially nonuniform, multistage process: coagulation factors from plasma bind to tissue factor (TF)-expressing cells, become activated, dissociate, and diffuse into plasma to form enzymatic complexes on the membranes of activated platelets. We studied spatial regulation of coagulation using two approaches: 1), an in vitro experimental model of clot formation in a thin layer of plasma activated by a monolayer of TF-expressing cells; and 2), a computer simulation model. Clotting in factor VIII- and factor XI-deficient plasmas was initiated normally, but further clot elongation was impaired in factor VIII- and, at later stages, in factor XI-deficient plasma. The data indicated that clot elongation was regulated by factor Xa formation by intrinsic tenase, whereas factor IXa was formed by extrinsic tenase on activating cells and diffused into plasma, thus sustaining clot growth. Far from the activating cells, additional factor IXa was produced by factor XIa. Exogenously added TF had no effect on the clot growth rate, suggesting that plasma TF does not contribute significantly to the clot propagation process in a reaction-diffusion system without flow. Addition of thrombomodulin at 3-100 nM caused dose-dependent termination of clot elongation with a final clot size of 2-0.2 mm. These results identify roles of specific coagulation pathways at different stages of spatial clot formation (initiation, elongation, and termination) and provide a possible basis for their therapeutic targeting.

Blood Coagulation↗
PubMed2005

Global shape recognition is modulated by the spatial distance of local elements--evidence from simultanagnosia.

Simultanagnosia is a rare deficit that impairs individuals in perceiving several objects at the same time. It is usually observed following bilateral parieto-occipital brain damage. Despite the restrictions in perceiving the global aspect of a scene, processing of individual objects remains unaffected. The mechanisms underlying simultanagnosia are not well understood. Previous findings indicated that the integration of multiple objects into a holistic representation of the environment is not impossible per se, but might depend on the spatial relationship between individual objects. The present study examined the influence of inter-element distances between individual objects on the recognition of global shapes in two patients with simultanagnosia. We presented Navon hierarchical letter stimuli with different inter-element distances between letters at the Local Scale. Improved recognition at the Global Scale was observed in both patients by reducing the inter-element distance. Global shape recognition in simultanagnosia thus seems to be modulated by the spatial distance of local elements and does not appear to be an all-or-nothing phenomenon depending on spatial continuity. The findings seem to argue against a deficit in visual working memory capacity as the primary deficit in simultanagnosia. However, further research is necessary to investigate alternative interpretations.

Agnosia↗
PubMed1981

Single-unit activity in the auditory cortex of monkeys actively localizing sound sources: spatial tuning and behavioral dependency.

Single-unit recordings were made from the auditory cortex of unanesthetized rhesus monkeys which were trained to perform a second localization task. Recordings were made from 196 units in 4 animals. Five sound sources were located at 0 degrees (midline) and on either side at azimuths of 37.5 degrees and 75 degrees. Almost most units responded to each of the 5 sources, 49% of the units had peak firing rates for the source on the contralateral side at 75% azimuth. Another 26% of the units had peak firing rates at the 37.5 degrees contralateral location, while only 11% had peak rates for the ipsilateral locations. In order to determine whether the behavior of actively locating a sound source affected units in auditory cortex, response rates compared under two behavioral conditions: one which required the detection of a sound regardless of location and another condition which required identification of a sound's location. of the 196 units, 16 had different response rates for the two conditions, with 15 of the 16 units having higher evoked rates in the localization task. For the 16 units, the difference in firing rate was typically observed for a single speaker location. No correlation could be determined between a unit's location within the subdivisions of auditory cortex and its spatial tuning response properties or its dependency upon behavioral condition.

Animals↗
PubMed2005

Spatial scale of local adaptation in a plant-pathogen metapopulation.

The rate and scale of gene flow can strongly affect patterns of local adaptation in host-parasite interactions. I used data on regional pathogen occurrence to infer the scale of pathogen dispersal and to identify pathogen metapopulations in the interaction between Plantago lanceolata and its specialist phytopathogen, Podosphaera plantaginis. Frequent extinctions and colonizations were recorded in the metapopulations, suggesting substantial gene flow at this spatial scale. The level of pathogen local adaptation was assessed in a laboratory inoculation experiment at three different scales: in sympatric host populations, in sympatric host metapopulations and in allopatric host metapopulations. I found evidence for adaptation to sympatric host populations, as well as evidence indicating that local adaptation may extend to the scale of the sympatric host metapopulation. There was also variation among the metapopulations in the degree of pathogen local adaptation. This may be explained by regional differences in the rate of migration.

Adaptation, Physiological↗
PubMed2002

Luminance spatial scale and local stereo-sensitivity.

Using filtered, broad band, fractal noise images we measured the dependence of D(min) and D(max) for stereo on luminance spatial frequency. D(min) was found to exhibit a simple dependence on the highest spatial frequency contained in the stimulus. D(max) depended on both image size and spatial frequency in a way that suggests an informational limit. Different rules govern D(min) and D(max) even for first order stereopsis, arguing against a common neural explanation based on independent access to the most pertinent spatial filter.

Depth Perception↗
PubMed1987

Position and spatial frequency in large-scale localization judgments.

The frequency-channel model and the position, or "local-signs," model that have been proposed to account for hyperacuity (i.e. small-scale relative spatial localization) are examined in the context of large-scale relative spatial localization. As a basis for subsequent experiments, localization accuracy is measured over a large range of object separations, and previous findings that the "Weber fraction for localization" is constant are replicated. The effects on localization accuracy of both high- and low-spatial frequency components in the objects being localized are examined in some detail. Localization accuracy is found not to rely exclusively on either the high- or the low-frequency components. Neither the frequency-channel nor the position hypothesis as defined here is consistent with all of the observed results. However, with a slight modification, the position hypothesis can account qualitatively for all of the observed results, whereas no reasonable modification of the frequency-channel hypothesis appears able to do as well.

Humans↗
PubMed1994

Reduction of brain noise influence in evoked neuromagnetic source localization using noise spatial correlation.

In magnetoencephalographic measurements, magnetic fields caused by spontaneous brain activities not related to the neural activities under study are often referred to as brain noise. This is because the accuracy in neural source localization is considerably degraded by such spontaneous neuromagnetic fields. This paper reports the experimental results of applying the previously proposed noise covariance method to reducing the degradation caused by brain noise and to improving the accuracy in localizing auditory-evoked neural sources. Firstly we present the results of our experiments using measured brain noise and computer-generated signal fields. These results confirm that the covariance method can, in principle, improve the accuracy of evoked neural source localization. Next, the method was applied to source localization for actual neuromagnetic fields evoked by speech sounds. The results obtained strongly suggest that the method is effective in processing actual evoked neuromagnetic data.

Adult↗
PubMed1994

Somatosensory evoked response source localization using actual cortical surface as the spatial constraint.

We localized right median nerve somatosensory evoked responses in a normal human subject using an equivalent dipole method applied to magnetic field recordings. High resolution, 3-dimensional MRI data were used to confine source locations to the cortical surface. Results localized in Brodmann area 3b corresponding to location of hand somatosensory cortex derived from direct brain stimulation studies. The solution was unique and total computational time for an exhaustive, brute-force search was small and the results realistic due to applied anatomical constraints. This study demonstrates feasibility of accurate, non-invasive, realistic localization of dynamic human cortical function using spatial constraints provided by MRI images.

Adult↗
PubMed2000

Testing local dependence of spatial structures on images

Associations between two spatial processes can be due to a real dependence between the two processes or to the dependence on common underlying variables. We propose to test the existence of a real dependence by use of local tests, leading to a global test of real dependence and a map of local interactions. We present first how classical interaction tests based on random rotations between completely observed processes such as those developed by Berman (Berman. Appl. Statist. (1986) 35, 54-62), can be integrated in local analyses. For this purpose, tests are first performed locally, and the distribution of their p-values is then compared to the corresponding value under the null hypothesis. A similar approach is proposed to test non-stationarity of a point pattern by using distance statistics popularized by Diggle (Diggle. Statistical Analysis of Spatial Point Patterns. (1983) Academic Press, New York). The problem of testing the interaction between a random field and a censoring area pattern process is discussed and an approach similar to the preceding ones is then proposed. The methods are mainly applied to agricultural examples but they can be applied to any microscopical images for which one wishes to analyse the spatial structure.

Journal Article↗
PubMed2003

Forward masking of faces by spatially quantized random and structured masks: on the roles of wholistic configuration, local features, and spatial-frequency spectra in perceptual identification.

The forward masking of faces by spatially quantized masking images was studied. Masks were used in order to exert different types of degrading effects on the early representations in facial information processing. Three types of source images for masks were used: Same-face images (with regard to targets), different-face images, and random Gaussian noise that was spectrally similar to facial images. They were all spatially quantized over the same range of quantization values. Same-face masks had virtually no masking effect at any of the quantization values. Different-face masks had strong masking effects only with fine-scale quantization, but led to the same efficiency of recognition as in the same-face mask condition with the coarsest quantization. Moreover, compared with the noise-mask condition, coarsely quantized different-face masks led to a relatively facilitated level of recognition efficiency. The masking effect of the noise mask did not vary significantly with the coarseness of quantization. The results supported neither a local feature processing account, nor a generalized spatial-frequency processing account, but were consistent with the microgenetic configuration-processing theory of face recognition. Also, the suitability of a spatial quantization technique for image configuration processing research has been demonstrated.

Adult↗
PubMed1997

Contour integration across polarities and spatial gaps: from local contrast filtering to global grouping.

This article introduces an experimental paradigm to selectively probe the multiple levels of visual processing that influence the formation of object contours, perceptual boundaries, and illusory contours. The experiments test the assumption that, to integrate contour information across space and contrast sign, a spatially short-range filtering process that is sensitive to contrast polarity inputs to a spatially long-range grouping process that pools signals from opposite contrast polarities. The stimuli consisted of thin subthreshold lines, flashed upon gaps between collinear inducers which potentially enable the formation of illusory contours. The subthreshold lines were composed of one or more segments with opposite contrast polarities. The polarity nearest to the inducers was varied to differentially excite the short-range filtering process. The experimental results are consistent with neurophysiological evidence for cortical mechanisms of contour processing and with the Boundary Contour System model, which identifies the short-range filtering process with cortical simple cells, and the long-range grouping process with cortical bipole cells.

Contrast Sensitivity↗
PubMed2001

Dendritic spatial flicker of local membrane potential due to channel noise and probabilistic firing of hippocampal neurons in culture.

Whole-cell recordings and imaging of dissociated hippocampal neurons stained with voltage sensitive dye provide a new microscopic picture of neuronal excitation. This is the first attempt to combine imaging of active channel clusters on the geometry of live neurons and a theoretical approach. During single somatic action potentials and the back-invasion into the neurites, local mean potentials are generated at sites of active channel clusters which are unevenly distributed in the neuronal membrane. Similar mean membrane potentials are observed in the neurites and at the soma. Identical action potentials produce different spatial patterns of mean membrane potentials from trial to trial. This spatial variability is explained by the stochastic behavior of the channels in the clusters. When hippocampal neurons are excited by synaptic inputs, their evoked responses are probabilistic and generate variable spatial patterns of mean membrane potential trial after trial. Our stochastic model reproduces this random behavior by assuming that the voltage fluctuations generated by channel noise are added to the synaptic potentials reaching the soma. We demonstrate that the probability of action potential initiation depends on the strength of the synaptic input, the diameter of the dendrites and the relative positions of the channel clusters, of the synapse and of the soma.

Action Potentials↗