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[A vestibular model of the course of Menière's disease].

Based on directional preponderance (DP) of the caloric nystagmus of 36 patients with Ménière's disease (MD), 57 calorigrams are divided in three groups: with ipsilateral, contralateral and without DP (neutral). Each calorigram is an unique moment in the course of MD. The age of the patient at that moment, the time since the first symptoms and since the last vertiginous spell, as well as the percentages of caloric response reduction and of DP are recorded. There are significant (Mann-Whitney U-test) differences between duration of the MD, time since the last spell and DP of the ipsilateral group and the same items of the contralateral group. Ipsilateral and contralateral calorigrams become neutral, consequently the neutral group is complex. From a vestibular point of view, MD is characterized by stages with a cyclic interrelation: during the first four years, ipsilateral stages with periferal stimulation or reversible reduction with recovery; one year after the first symptoms, contralateral stages with (partial) loss of function with central compensation; neutral stages--with or without minor spells--without further loss of function. Staging MD is of diagnostic importance; perhaps different stages need a different therapy. Stimulation or reversible loss of function in an ipsilateral stage is probably not caused by hydrops; in a contralateral stage with definite loss of function hydrops could be involved.

Adult↗

[Calvanic test].

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Electric Stimulation↗

Vestibular function and motor proficiency of children with impaired hearing, or with learning disability and motor impairments.

Vestibular status and motor proficiency of 30 hearing-impaired and 15 motor-impaired learning-disabled children were documented to determine whether vestibular loss can account for deficits in motor co-ordination. Vestibular loss was differentiated from sensory organization deficits by means of VOR and postural orientation test results, which were compared with those of 54 normal seven-to 12-year-olds. Reduced or absent vestibular function in 20 hearing-impaired children did not affect development of motor proficiency, except in specific balance activities. However, sensory organization deficits in the learning-disabled group and in three of the hearing-impaired children were associated with widespread deficits in motor proficiency.

Child↗

[Dynamic effects of sulphuric gentamicin on vestibular function in guinea pigs].

Sinusoidal rotation and rotational stimulation tests were used to examine vestibular function in guinea pigs. The results showed that there was no statistically significant difference in the mean number of nystagmus of semi-cycle sinusoidal rotation test and the duration of nystagmus of rotational stimulation test for both the control and test groups before treatment in albinos and pigmented guinea pigs. Meantime, daily subcutaneous injection of gentamicin 125 mg/kg body weight for 12 days in albinos and pigmented guinea pigs showed no significant change in vestibular function until the 7th day of treatment. Significant impairment of vestibular function was noticed on the 10th treatment day. At 5 days after treatment vestibular impairment reached its maximum and minimal recovery was seen at 14 days after treatment. No Further improvement of vestibular function was noticed three months after treatment. The methods are feasible and reliable.

Animals↗

Symmetry measures of vestibular evoked myogenic potentials using objective detection criteria.

Vestibular evoked myogenic potentials (VEMP) has been put forward as a test to evaluate the symmetry of saccular function. In the present study, the symmetry of VEMP was evaluated in 23 healthy subjects using automatic analysis. In response to binaural clicks with a stimulus repetition rate of 4/s all subjects revealed significant VEMP on both sides. The ipsilateral response to monaural clicks was similar to the response to binaural clicks. Although there were large interindividual variations in amplitude, there were only small variations in latency. VEMP measurements were also assessed using different stimulus rates. At the higher stimulus rates there was a decrease in the VEMP amplitude but there were only small changes in the latency. These findings might suggest that amplitude measures are more likely than latency measures to reveal small vestibular lesions.

Adult↗

Centric and eccentric VOR tests in patients with Menière's disease and vestibular Menière's disease.

Pendular rotation in the eccentric position produces the same angular stimulation as that in conventional pendular rotation and, in addition, involves linear centrifugal and tangential acceleration forces which act on the otolith organs. In the eccentric position, normal subjects showed an increase in gain at 0.64 Hz, when compared with the gain with the head in the centered position. Therefore, we concluded that it is possible to diagnose otolith dysfunction by this comparison. In this study, we applied centric and eccentric pendular rotation tests to patients with Menière's disease and vestibular Menière's disease and investigated their otolith function. Patients with Menière's disease or vestibular Menière's disease within 1 month after the first attack or the most recent attack showed no gain enhancement with eccentric rotation. However, others showed gain enhancement with eccentric rotation. Therefore, we concluded that there seems to be no difference in the otolith function, especially in utricular function between Meniere's disease and vestibular Menière's disease.

Adult↗

High-frequency autorotational testing of the vestibulo-ocular reflex.

Rotational testing is useful for clinical evaluation of vestibular dysfunction affecting the vestibulo-ocular reflex (VOR). Early applications relied on visual observation of nystagmus following turning. In modern use, control theory descriptors (e.g., gain and phase) are applied to patient data for comparisons with normal values. Motorized rotational chairs are used to passively oscillate patients with sinusoidal harmonic acceleration (SHA) stimulus profiles, usually at low frequencies (0.02 to 0.2 Hz). Changes in low-frequency phase and asymmetry, relative to normal values, provide useful indications of pathology. Vestibular autorotation testing (VAT) is a new, portable testing technique that utilizes microcomputers and patients' active head movements at high frequencies (2 to 6 Hz) to test both horizontal and vertical VOR responses. A head strap contains sensors and microelectronics for monitoring both head and eye movements. Higher-frequency VOR testing offers the advantages that the VOR is most active during locomotion at these frequencies and that other ocular motor systems are functionally insensitive above about 1 Hz. Results from VAT evaluation of patients with acute-stage Ménière's disease showed high vertical VOR gains, whereas patients receiving cisplatin chemotherapy showed pronounced low horizontal VOR gains and reduced phase lags. Practical experience in 4 years' clinical testing with the VAT has shown that this test is comfortable, efficient, clinically accurate, portable, and low cost, without requiring the dedicated, installed facility characteristic of other vestibular tests.

Eye Movements↗