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PubMed1998

Effects of false weight feedback on mood, self-evaluation, and food intake in restrained and unrestrained eaters.

Restrained and unrestrained eaters were weighted 5 lb (2.27 kg) heavier or 5 lb lighter than their actual weight or were not weighed at all. Unrestrained eaters and restrained eaters who were told they weighed 5 lb less were not affected by the false weight feedback. However, restrained eaters who were informed that they weighted 5 lb more reported lower self-esteem, less positive moods, and more negative moods than did restrained eaters in the other 2 conditions. Furthermore, restrained eaters who were led to believe that they weighed heavier ate significantly more food during a subsequent "taste test" than did each of the other groups. Restrained eaters who believed that they were heavier experienced lowered self-worth and a worsening of mood that led them to relinquish their dietary restraint and overindulge in available food. Implications for patients with eating disorders are discussed.

Affect↗
PubMed2001

Establishing good dietary habits -- capturing the minds of children.

OBJECTIVE: To review the psycho-social research with respect to relevance for the development of nutritional education strategies. RESULTS: The eating behaviour of the newborn baby is controlled by innate preferences and dislikes, and by biological self-regulation. These innate control-systems are modified by learning processes, most importantly by the mere exposure to unknown food, by social influences, and by associating the physiological consequences of food intake with taste cues. The last decades have witnessed a change of the social meaning of food and eating, and the social context of eating is subject to dramatic changes. While on the one hand, prevalence of overweight and obesity is increasing, even young children deliberately practise weight control measures ranging from selective food choice to self-induced vomiting thus including behaviours which are clearly symptomatic of eating disorders. Such behaviour is motivated by unrealistic conceptions of a healthy body weight and shape. Children are interested in a range of nutrition topics. However, these topics have to be related to direct perceivable benefits from nutrition. CONCLUSIONS: Educational strategies should: firstly, focus on providing a variety of foods, including a range of nutrient-dense 'healthy' food and encouraging children to taste it; secondly, provide a stable and predictive pattern of social eating occasions to promote the social meaning and importance of eating and to enable social learning of food preferences; and finally, encourage a positive body image by providing advice and reassurance regarding the range of healthy and acceptable body weights and shapes.

Adolescent↗
PubMed2005

Taste, olfactory, and food texture processing in the brain, and the control of food intake.

Complementary neurophysiological recordings in macaques and functional neuroimaging in humans show that the primary taste cortex in the rostral insula and adjoining frontal operculum provides separate and combined representations of the taste, temperature, and texture (including viscosity and fat texture) of food in the mouth independently of hunger and thus of reward value and pleasantness. One synapse on, in the orbitofrontal cortex, these sensory inputs are for some neurons combined by learning with olfactory and visual inputs. Different neurons respond to different combinations, providing a rich representation of the sensory properties of food. In the orbitofrontal cortex, feeding to satiety with one food decreases the responses of these neurons to that food, but not to other foods, showing that sensory-specific satiety is computed in the primate (including human) orbitofrontal cortex. Consistently, activation of parts of the human orbitofrontal cortex correlates with subjective ratings of the pleasantness of the taste and smell of food. Cognitive factors, such as a word label presented with an odour, influence the pleasantness of the odour, and the activation produced by the odour in the orbitofrontal cortex. These findings provide a basis for understanding how what is in the mouth is represented by independent information channels in the brain; how the information from these channels is combined; and how and where the reward and subjective affective value of food is represented and is influenced by satiety signals. Activation of these representations in the orbitofrontal cortex may provide the goal for eating, and understanding them helps to provide a basis for understanding appetite and its disorders.

Animals↗
PubMed1992

Sick building syndrome and related workplace disorders.

It has been estimated that as many as 1.2 million commercial buildings have characteristics of sick building syndrome. That is, persons who work in these buildings describe a cluster of symptoms--irritation of eyes, nose, throat, and skin, respiratory ailments, headaches, dizziness, confusion, and unusual odor or taste sensations--that occur during occupation of the building but diminish when these persons leave these buildings. There have been a number of factors that have been implicated in the development of sick building syndrome. These include type of building ventilation, light intensity, tobacco smoke, wall-to-wall carpeting, crowding, work satisfaction, gender, and presence of volatile organic compounds. Sick building syndrome has many signs and symptoms of other workplace disorders (e.g., neurotoxic disorders, mass psychogenic illness), each of which manifest in rather imprecise psychological and somatic symptoms. There are, however, specific characteristics that distinguish these disorders. It is likely that the development and persistence of the sick building syndrome is not caused solely by building characteristics or simply a result of psychological variables. Rather, a synergistic relationship exists between building, environmental, and individual factors.

Air Pollution, Indoor↗
PubMed2000

Comparison ratings of pureed versus molded fruits: preliminary results.

Food molds change the appearance of pureed items to resemble typically prepared food. The present study examined the perceptions of 12 adults with normal swallowing and two adults with impaired swallowing for typical pureed versus molded pureed fruits (peach and pear). Results are presented for ratings of overall liking, taste, texture, appearance, and ease of chewing and swallowing. The present findings indicated that the pureed food molds did not positively influence attribute ratings. For both groups of adults, the typical method of pureed food presentation was rated higher or very similar to the molded pureed fruit. Results are discussed in terms of scaling methods, criteria applied for ratings, and implication of altering the viscosity of pureed foods.

Adult↗
PubMed1987

Taste and bulimia.

Binge-eating episodes in bulimia often involve sweet or fat-containing foods. Sensory perceptions and preferences for sweetness and fat content were examined in 16 normal-weight women with a diagnosis of DSM IIIR bulimia and in 16 normal-weight volunteer controls. Taste stimuli were 15 semi-liquid mixtures of dessert-type soft white cheese ("fromage blanc") containing 0, 3 or 7 grams of fat per 100 g, and sweetened with 1, 5, 10, 20, or 40% sucrose (wt./wt.). The subjects used 9-point category scales to rate the perceived sweetness and fat content of the stimuli, and assigned a pleasantness (hedonic) rating to each sample. Taste preferences were modelled using the Response Surface Method (RSM). Mean estimates of sweetness intensity and fat content were generally similar for bulimic patients and controls. In contrast, profiles of taste preference differed significantly between groups. Optimal stimulus sweetness was 15% sucrose wt./wt. for bulimic patients and only 9% for controls, while optimal fat levels were lower for bulimic patients relative to controls. The present data are consistent with previous reports that patients with eating disorders crave sweetness but show reduced sensory preferences for fat-containing foods.

Adult↗
PubMedDate not supplied

Taste preference and rating of commercial and natural thickeners.

Dysphagia can negatively affect quality of life, nutritional status, and pulmonary status of individuals. The most common intervention for dysphagia is the use of thickening agents for liquids. This group study (n = 43) investigated the taste preference, taste ratings, and ranking for nectar-thick hot and cold beverages using three types of thickeners: SimplyThick, Thick-It, and noncommercially prepared natural thickeners. Results demonstrated a significant difference between the taste ratings of two commercial thickeners and between one commercial and the natural thickener for the ranking of taste with hot beverages. Every participant rated at least one of the thickener beverages as having an acceptable taste for the hot chocolate and fruit juice beverages. Exploring individual preferences is critical to selecting a beverage that increases compliance to clinical recommendations.

Adult↗
PubMedDate not supplied

[Psychological aspects of diet therapy of children and adolescents suffering from digestive system diseases].

Clinicopsychological investigations of 361 patients, aged from 6 to 17 years, suffering from diseases of the gastrointestinal tract, have revealed in 60.7% of them negative psychological attitude to the dietotherapy they received. Among children and adolescents with concomitant neurotic disorders such attitude was noted in 79.6%. A system of special measures has been developed including three main elements: 1) psychotherapeutic mediation of dietotherapy before its administration and in the process of the therapy; 2) creation of the psychologic attitude to the diet adherence; 3) alteration of the patient's taste stereotype. Realization of such measures has been conducive to higher effectiveness of the dietotherapy.

Adolescent↗
PubMed1989

Dietary restraint in young adolescent girls: a functional analysis.

An investigation of dietary restraint during adolescence was conducted in two phases. First, two school classes of 12- and 14-year-old girls completed a restraint questionnaire. Second, the functional nature of the restraint scores was assessed in 24 girls from each age group using a procedure previously shown to lead to overeating in restrained adults. A wide distribution of restraint scores was found, with restrained individuals present in both age groups. Restraint was found to be functional, predicting higher food consumption in a taste test after imagining eating highly palatable foods. Hunger ratings were elevated by the imagination procedure, although the extent of this increase was similar for both restrained and unrestrained girls. The girls' body weight index was significantly correlated with degree of restraint. The existence and breakdown of restraint at this young age is regarded with concern, particularly in view of the links between dieting and eating disorders.

Adolescent↗
PubMed2001

Perceptual ratings for pureed and molded peaches for individuals with and without impaired swallowing.

Food molds have been created to alter the appearance of pureed foods by making the pureed consistencies look more like typically prepared foods. This study examined the perceptions of 15 adults with impaired swallowing and 15 adults with nonimpaired swallowing for three different types of pureed peach: a typically prepared pureed peach, a pureed peach with a thickening agent added, and a pureed peach with a thickening agent added and molded to look like peach slices. Results are presented for the attribute ratings of overall liking: liking of taste, texture, and appearance; and ease of chewing and swallowing. The results showed that the adults with impaired swallowing rated the attributes of chewing and swallowing significantly lower (i.e.. more difficult) for each type of puree. Significant differences within samples also were found for the attributes of overall liking and liking of taste. Overall, the pureed peach molds were not perceived favorably for any of the examined attributes. In addition, the molded peach was rated lower (more difficult) in its ease of chewing. The implications of these findings and ideas for further research are discussed.

Adult↗
PubMed2000

Deficits in memory and motor performance in synaptotagmin IV mutant mice.

Synaptotagmin (Syt) IV is a synaptic vesicle protein. Syt IV expression is induced in the rat hippocampus after systemic kainic acid treatment. To examine the functional role of this protein in vivo, we derived Syt IV null [Syt IV(-/-)] mutant mice. Studies with the rotorod revealed that the Syt IV mutants have impaired motor coordination, a result consistent with constitutive Syt IV expression in the cerebellum. Because Syt IV is thought to modulate synaptic function, we also have examined Syt IV mutant mice in learning and memory tests. Our studies show that the Syt IV mutation disrupts contextual fear conditioning, a learning task sensitive to hippocampal and amygdala lesions. In contrast, cued fear conditioning is normal in the Syt IV mutants, suggesting that this mutation did not disrupt amygdala function. Conditioned taste aversion, which also depends on the amygdala, is normal in the Syt IV mutants. Consistent with the idea that the Syt IV mutation preferentially affects hippocampal function, Syt IV mutant mice also display impaired social transmission of food preference. These studies demonstrate that Syt IV is critical for brain function and suggest that the Syt IV mutation affects hippocampal-dependent learning and memory, as well as motor coordination.

Acoustic Stimulation↗
PubMed2005

Selective and nonselective serotonin antagonists block the aversive stimulus properties of MK212 and m-chlorophenylpiperazine (mCPP) in mice.

Serotonin(2C) (5-HT(2C)) receptors have been implicated to treat mood disorders such as depression and anxiety. In the present study, the capacities of two 5-HT(2C) agonists, MK212 and mCPP, to produce conditioned taste aversions in mice were evaluated. On two training days, Swiss-Webster male mice (19-34g) were trained to associate the flavor of a novel solution with the injection of various doses of MK212 or mCPP. On two alternate training days, mice were trained to associate a different flavored solution with an injection of saline. For testing, both flavored solutions were presented simultaneously and an avoidance of the MK212 or mCPP-paired solution indicated conditioned taste aversion. Robust conditioned taste aversions were observed to solutions paired with 1.0 or 10mg/kg MK212 or mCPP. Acquisition of conditioned taste aversions was blocked by nonselective serotonin antagonists cyproheptadine, bromo-LSD, metergoline, methysergide and mianserin. Selective 5-HT(2B/2C) antagonist SB206,553 blocked both MK212- and mCPP-induced conditioned taste aversion although selective 5-HT(2B/2C) antagonist SB200,646 only blocked mCPP-induced conditioned taste aversion. In a single-bottle procedure, MK212, bromo-LSD, and mianserin failed to alter acquisition rate of a LiCl-induced conditioned taste aversion. Taken together, these data indicate that the serotonin agonists MK212 and mCPP produce conditioned taste aversion and that these effects are mediated predominantly through 5-HT(2C) receptors.

Animals↗
PubMed2004

The insular lobe of Reil--its anatamico-functional, behavioural and neuropsychiatric attributes in humans--a review.

There is considerable clinical and experimental research to explore the anatamico-functional correlations of the limbic lobe to establish its relevance in modern neuroscience. The insula being a pivotal structure in the concept of the greater limbic lobe, we have attempted to highlight in this review the topographical anatomy and development, the remarkable heterogeneity of the insular cortical architecture, the widespread multifaceted spectrum of functional connectivity patterns and how this is translated to its behavioural specialisation in humans. The insula serves as an intergration cortex for multimodal convergence of distributed neural networks such as the somesthetic-limbic, insulo-limbic, insulo-orbito-temporal and the prefrontal-striato-pallidal-basal forebrain. This provides the conceptual framework to facilitate functional and clinical considerations relevant to the various behavioural and neuropsychiatric disorders outlined in this review. The functional role of the insula in these disorders with particular reference to the current functional neuroimaging data has been also reviewed in this article.

Cerebral Cortex↗
PubMed2006

Analysis of reports of human exposure to Micotil 300 (tilmicosin injection).

OBJECTIVE: To identify clinical signs associated with and outcome of human exposure to Micotil 300 (tilmicosin injection). DESIGN: Retrospective case series. STUDY POPULATION: Reports of 3,168 human exposures to Micotil 300. PROCEDURES: Reports of human exposure to Micotil 300 submitted to the Elanco Animal Health Pharmacovigilance Unit between March 1992 and March 2005 were reviewed. RESULTS: At least 1 clinical sign was described in 1,404 (44%) reports, whereas the remaining 1,764 (56%) exposures were presumably asymptomatic. Eighty percent of exposures involved males; mean age was 38 years. Sixty-one percent of exposures were a result of accidental injection, with injection site pain, bleeding, swelling, or inflammation being the most common signs, followed by nausea, tachycardia, dizziness, anxiety, an abnormal taste, headache, lightheadedness, limb pain, paresthesia, chest pain, and soreness. Only 156 (5%) reports involved serious adverse effects (ie, tachycardia, bradycardia, hypertension, hypotension, heart disorder, chest pain, tachypnea, or death). There were reports of 13 deaths following tilmicosin exposure, but only 2 of those deaths were related to accidental exposure. Time to onset of clinical signs was < or = 60 minutes in 63 of the 156 (40%) reports involving serious adverse effects. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that the overall risk of accidental human exposure to tilmicosin resulting in serious adverse effects is low (approx 2 people for every 1 million doses administered). Nevertheless, safe handling and proper use should be emphasized.

Accidents, Occupational↗
PubMed1992

Perspectives on an oral motor activity: the use of rubber tubing as a "chewy".

Among school-aged children with learning and behavioral problems, a therapeutic tool found to be helpful is a "chewy." A chewy is a cylindrical piece of rubber tubing, the ends of which are placed in the mouth and are chewed or sucked on. This behavior appears to have a calming, organizing, and focusing effect on the child. In addition, for some children who put nonedible items in their mouths, a chewy can provide an appropriate sensory substitute or alternative. A literature review supporting the benefits of oral motor input is discussed. Three case studies of children using a chewy are presented. A discussion follows regarding the therapeutic benefits of the use of a chewy and the consideration of it as part of a child's sensory diet. Important guidelines regarding the appearance, taste, length, durability, and sanitation of the chewy are reviewed.

Child↗
PubMed2004

[Diagnostic problems in case of environmental exposure to tetraethyl lead].

UNLABELLED: The aim of this study was the presentation of the chronic tetraethyl lead poisoning of the 4 person family in the place of settlement. CASE REPORT: 15.5-years-old man was admitted to the regional Pediatric Ward because of changes of behavior, hallucinations, agitation. Nausea, vomiting, metallic taste and diarrhea were observed prior to the admission. In the case history, there were no data suggested of the toxic origin of the disorder . The CSF examination and CT of the brain were normal. Increased activity of CPK, ALT, AST, GTP, LDH in the blood were found. Paranoid syndrome was diagnosed by psychiatric evaluation. The patients' mother presented similar signs in almost the same time. The laboratory tests of the blood taken from the patients' father and older brother revealed the increase activity of the same enzymes (CPK, ALT, AST, LDH). All family was admitted to the Department of Clinical Toxicology in Kraków because of suspicion of the heavy metal poisoning. The toxicological laboratory test showed in all described patients the toxic serum lead concentration accordingly: 440 microg/l--older brother, 490 microg/l--father, 508 microg/l--mother and 635 microg/l--primary described patient. Because of the fact, that were no characteristic for lead poisoning changes in blood picture, the toxicological investigations were continued. As a result of these examinations presence of a diethyl lead in urine was confirmed. In the evaluation of the multiorgan damages connected with tetraethyl lead poisoning, we paid special attention on CSN dysfunctions. The USG and scintigraphy examinations revealed the liver damage. The different kinds of arrhythmias indicated on cardiovascular system damage. Based on clinical presentation and laboratory investigations the chronic tetraethyl lead poisoning was diagnosed.

Adolescent↗