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PubMed1978

Non-metric variation of the infracranial skeleton.

196 skeletons of known age, sex and rac from the Terry Collection were studied in order to document 30 non-metric infracranial traits. Each trait had the ability to be expressed bilaterally, although significant side dimorphism was not observed. Sex differences were statistically significant for some of the traits within a racial group, but these differences were not as pronounced as the differences generated by non-metric cranial traits in the same populations, and were not effective in all racial groups. In general, these infracranial traits show some age dependency when correlation statistics are used, but this dependency is lost when the more robust chi 2 statistic is used. These data suggest that infracranial non-metric traits may be superior to cranial non-metric traits for population comparisons. Infracranial traits may be more durable than cranial traits having regard to the nature of most archaeological material.

Adult↗
PubMed1983

[Effect of adjuvant immunotherapy with Nocardia rubra cell-wall skeleton in lung cancer].

A randomized clinical trial of intrapleural Nocardia rubra cell-wall skeleton (N-CWS) followed by intradermal N-CWS was performed against lung cancer patients from November, 1977 to June 1981. Totally, 190 patients were entered into this trial. The N-CWS treatment was effective in terms of prolongation of remission duration against not only operable but also inoperable patients. However, significant improvement of survival rate was observed only in operable patients, especially curative+relatively curative resection-group (p less than 0.05). The mode of recurrence was classified as local recurrence and distant metastasis in the curative+relatively curative resection-group. The rates of distant metastasis were 34.1 and 17.6%, respectively, in the control and the N-CWS groups. The rate of local recurrence was 13.6% in the control group, however, no local recurrence was observed in the C-NWS group. These results indicate the clinical effectiveness of the N-CWS treatment especially in curatively resectable lung cancer. No serious side effect was experienced during this trial.

Adenocarcinoma↗
PubMed1983

[Immunotherapy of resectable lung cancer using Nocardia rubra cell wall skeleton].

A randomized controlled study of adjuvant immunotherapy was performed using Nocardia rubra cell wall skeleton (N-CWS) for inoperable lung cancer patients in 5 institutions from October, 1978 to June, 1981. All patients without pleural effusions were treated according to common protocol including chemotherapy and/or radiotherapy, and the patients on performance status 0 to 3 were randomized to control and N-CWS group. In N-CWS group, 400 micrograms N-CWS was injected once or twice into the bronchial tumor using fiberoptic bronchoscope, and sequentially 200 micrograms N-CWS was injected once a month into the skin from shoulder to upper arms. One year survival rate of 118 N-CWS-treated patients was excellent when compared to that of 108 control patients, but statistically not significant. According to histological type, survival period of the patients with small cell carcinoma was prolonged significantly in N-CWS group. The eligible patients with pleural effusions were initially randomized to control group and N-CWS group and treated under tube thoracostomy. In control group adriamycin was injected into the affected pleural cavity. In N-CWS group adriamycin and N-CWS were injected with the same method, and intracutaneous injections of 200 micrograms N-CWS were added once every month. Not only response rate for pleural effusions but also survival rate were statistically excellent in N-CWS group. Main adverse reactions of N-CWS were skin lesions in the injected sites and fever, but these were transient and not serious.

Adenocarcinoma↗
PubMed1984

Randomized clinical trial of non-specific immunotherapy with cell-wall skeleton of Nocardia rubra.

A randomized clinical trial of intrapleural Nocardia rubra cell-wall skeleton (N-CWS) followed by intradermal N-CWS was performed against lung cancer patients from November, 1977 to June, 1981. Totally, 190 patients were entered into this trial. The N-CWS treatment was effective in terms of prolongation of remission duration against not only operable but also inoperable patients. However, significant improvement of survival rate was observed only in operable patients, especially curative operation group (p less than 0.05). The mode of recurrence was classified as local recurrence and distant metastasis in the curative operation group. The rates of distant metastasis were 34.1 and 17.6% respectively, in the control and the N-CWS groups. The rate of local recurrence was 13.6% in the control group, although no local recurrence was observed in the N-CWS group. These results indicate the clinical effectiveness of the N-CWS treatment especially in curatively resectable lung cancer. Major and frequent side-effects of the N-CWS treatment were fever up to 40 degrees C with an average duration of 2 days following intrapleural instillation and skin reaction at the site of intradermal injections. No serious side effect was experienced during this trial.

Adult↗
PubMed1984

[Morphological studies of facial skeleton asymmetry in pongidae and hominid primates].

On the question of asymmetry in the upper facial skeleton, ten samples of hominoid primates were investigated in a comparative metrical analysis. Generally, there was a slight dominance in the right-handed measurements. With one exception these findings could be confirmed statistically, whereas sexual dimorphism could not be shown to be significant in this respect. The question, whether the differences between right and left measurements show a bimodal distribution and so suggest a certain amount of reversed asymmetry, could not be answered clearly because the sample size was limited. Most of the distributions are explicable in accordance with this assumption.

Animals↗
PubMed1980

[Performance behaviour of the physically handicapped. Selected approaches and a comprehensive skeleton concept (author's transl)].

The article shows that psychology's current situation with its confusing variety of theories and methods and, accordingly, heterogeneous examination findings, is also reflected in the discussion about the performance behaviour of the physically handicapped. This fact made it necessary to apply different concepts of the so-called normal psychology to this particular field. On the basis of limited approaches which place organic impairments - perceptual disorders and motor disturbances due to organic brain damage - in the foreground, a description of other research lines is crried out, which not only permit the taking into account of the performance aspects, but also motivational, interpersonal and social viewpoints. The continuous expansion of this field of consideration results in a skeleton concept which encompasses the whole of the person-environment relations and not only individual and isolated fields. In this connection the methodical consequences of this concept, i.e., the attempt to create biotic study situations, are discussed. It is hoped that in the future such new psychological approaches will also assist in the practical study of problems of the physically handicapped.

Brain Damage, Chronic↗
PubMed1984

The development of pneumatisation in the postcranial skeleton of the domestic fowl.

The development of pneumatisation in the postcranial skeleton has been investigated in a flock of Golden Comet pullets from hatching to 182 days posthatching. The timing of development of pneumatisation in the vertebral column, vertebral ribs, sternum and humerus has been demonstrated. No pneumatisation was encountered in the sternal ribs, os coxae or coracoid. Development of pneumatisation in the coracoid and humerus was also studied in a flock of White Leghorn pullets and cockerels from hatching to 126 days posthatching. In this group, regular pneumatisation of the humerus occurred after the time of onset and the coracoid was frequently pneumatised unlike the Golden Comets. The rate of development of pneumatisation in the humerus was more rapid in White Leghorn pullets than in cockerels and also more rapid than in Golden Comet pullets.

Air↗
PubMed1984

Phase I study of intravenous mycobacterial cell wall skeleton and trehalose dimycolate attached to oil droplets.

The toxic, clinical, and immunological effects of suspensions of mycobacterial cell wall skeleton (CWS) and trehalose dimycolate (TDM) attached to oil droplets and given intravenously in doses of 100-2,000 micrograms/m2 (CWS) every 1 or 2 weeks was investigated in this Phase I study. The major limiting side effects were fever and chills at a dose of 2 mg/m2 body surface area. There was no significant hematopoietic, renal, hepatic, or pulmonary toxicity. Evaluation of changes in the white cell count and lymphocyte and monocyte populations and function showed an increase in the white blood count, an increase in the number of T cells, and a decrease in blood monocytes. Measurements of lymphocyte blastogenesis, monocyte suppressor activity, and monocyte cytostasis showed no consistent changes. Intravenous therapy with oil/CWS/TDM was associated with complete regression of a bronchial squamous cell carcinoma in one of three patients receiving 2 mg/m2 weekly. Subsequent Phase II studies can be conducted at a weekly dose of 1-2 mg/m2.

Adjuvants, Immunologic↗
PubMed1978

Suppression by Nocardia rubra cell wall skeleton mammary DNA synthesis, plasma prolactin level, and spontaneous mammary tumorigenesis in mice.

The effects of the cell wall skeleton of Nocardia rubra on mammary gland DNA synthesis, plasma prolactin levels, and spontaneous mammary tumorigenesis in mice were studied. Female SHN mice received s.c. injections of 100 microgram N. rubra cell wall every 7 days between 2 and 12 months of age. The treatment resulted in the marked inhibition of mammary tumorigenesis; incidence was significantly lower in the experimental mice than in the controls except at 9 and 12 months of age. The age of onset of mammary tumors was significantly higher in the former than in the latter. In association with these findings, the treatment also reduced normal mammary gland DNA synthesis and prolactin levels in the circulation, both of which are primary factors for mammary tumorigenesis.

Age Factors↗
PubMed1984

Comparison of antimetastatic effect against Lewis lung carcinoma after intratumoral and intravenous injections of cell-wall skeleton of Propionibacterium acnes C7 in C57BL/6 mice.

Antimetastatic activity of cell-wall skeleton of Propionibacterium acnes C7 (P. acnes-CWS) in C57BL/6 mice varied depending on the injection route. The kinetics of antimetastatic effect against Lewis lung carcinoma (3LL) revealed that the sooner intratumoral (it) injection of P. acnes-CWS was carried out, the better the result. However, intravenous (iv) injection of P. acnes-CWS produced the best result if P. acnes-CWS was injected at about the time when metastases began to develop in the lungs. Pretreatment with intrafootpad (ifp) injection of P. acnes-CWS inhibited primary tumor growth and subsequent pulmonary metastases especially when given 7 days before tumor inoculation into the same footpad, but tended to enhance artificial pulmonary metastases when given 7 days before iv injection of tumor cells. In contrast, pretreatment with iv injection of P. acnes-CWS enhanced spontaneous pulmonary metastases especially when given 7 days before ifp inoculation of tumor cells, but inhibited artificial pulmonary metastases when given one day or 7 days before iv injection of tumor cells. These results suggest the difficulty of treatment of tumor metastases with immunological adjuvants. In T-cell-deprived mice, it injection of P. acnes-CWS showed no antimetastatic effect against 3LL, but iv injection was still effective. This indicates that T-cells are required for the antimetastatic effect of it injection of P. acnes-CWS, but iv injection of P. acnes-CWS is able to inhibit pulmonary metastases in T-cell-deprived mice.

Animals↗
PubMed1983

Randomized controlled study of adjuvant immunotherapy with Nocardia rubra cell wall skeleton for inoperable lung cancer.

In order to evaluate the clinical benefit of Nocardia rubra cell wall skeleton (N-CWS), a randomized controlled study was performed with inoperable lung cancer patients entered in 5 institutions from October 1978 to June 1981. Patients without pleural effusions were treated initially with conventional therapies such as chemotherapy and/or radiotherapy, according to common protocol, and then patients in performance statuses 0 to 3 were randomized into control and N-CWS groups with stratification into 16 categories according to 4 histological types and 4 clinical stages In the N-CWS group, 400 micrograms N-CWS were initially injected once or twice into the bronchial tumor using a fiberoptic bronchoscope, and subsequently 200 micrograms of N-CWS were injected at monthly intervals into the skin from the shoulders to upper arms. Of 309 patients, 118 patients in the N-CWS group and 108 patients in the control group were eligible for statistical analysis. There was statistically no significant difference in survival rate between the control and the N-CWS groups. According to histological type, significant prolongation of the survival period was observed in patients with small-cell carcinoma. The 97 patients with pleural effusions were initially randomized into control and N-CWS groups. In the control group, local chemotherapy with Adriamycin was performed and, in the N-CWS group, local administrations and monthly intracutaneous injections of N-CWS were given. Tube thoracostomy was performed in both groups. The local response rate was statistically greater in the N-CWS group than in the control group, and survival period was also prolonged significantly in the N-CWS group. The main adverse reactions to N-CWS were skin lesions in the injected sites and fever, but these were temporary and not serious.

Aged↗
PubMedDate not supplied

[Radiograms of the paranasal sinuses as a principle of identifying catastrophe victims and unknown skeletons].

The paper is devoted to the identification on the base of X-ray of frontal sinuses. These sinuses, developed in puberty doesn't change its shape during aging. Differentiation of the size and shape of sinuses is remarkable and probably is one of the individual features of the man. The system of classification of sinuses is proposed, basing on the area size, shape and symmetry. In the current everyday practice all X-ray radiograms are destroyed after five years of storage in Poland. For identification purpose all radiograms of sinuses and A-P punctures of skull should be stored in radiology departments, and arranged according to proposed classification system. The case is presented, in which the pictures of skull were the base of successful identification of skeleton.

Disasters↗
PubMed1983

Radiation doses during panoramic zonography, linear tomography and plain film radiography of maxillo-facial skeleton. A comparative study.

The radiation doses to the organs and the skin of the head and neck during plain film radiography, a-p and p-a linear tomography and panoramic zonography of the maxillo-facial skeleton were measured on a sliced anatomic Alderson skull phantom with LiF (TLD-100) thermoluminescence chips. The doses were clearly highest during the linear tomography. Also the doses during the plain film radiography were quite high. Compared to the conventional methods the doses from the panoramic Zonography were minimal.

Cervical Vertebrae↗
PubMed1983

Recovery of the rat skeleton from the adverse effects of simulated weightlessness.

A rat model that involves total mechanical unloading of the hind limbs has been used to simulate some aspects of weightlessness. In a previous study, the presence of marked skeletal abnormalities in the proximal tibial and humeral metaphyses of unloaded rats was detected. In the current study, the rats were removed from the model after a 2-week suspension period and allowed to recover for 2 weeks in individual metabolic cages before sacrifice. Tetracycline derivatives were administered on three separate occasions to evaluate radial and longitudinal bone growth. Periosteal bone formation in the tibial diaphysis of suspended animals was significantly depressed during the suspension period but approached control levels during the recovery period. Periosteal bone formation in the humeral diaphysis was not affected by simulated weightlessness. In the proximal tibial and humeral metaphyses, longitudinal bone growth, the amount of mineralized tissue, and the fat content of the bone marrow, all of which were previously determined to be abnormal after 2 weeks of simulated weightlessness, returned to control levels during the recovery period. The previously observed decline in the osteoblast population and increased numbers of osteoclasts adjacent to the growth plate in suspended animals also proved to be reversible at both skeletal sites. This study demonstrates that the skeleton of growing rats is capable of a rapid recovery from the adverse effects of simulated weightlessness.

Animals↗
PubMed1983

Transbilayer mobility of phospholipids in the erythrocyte membrane. Influence of the membrane skeleton.

Oxidative treatment of erythrocytes results in a strong enhancement of transbilayer reorientation of exogenous lysophospholipids. Only upon selective oxidation of SH-groups and concomitant crosslinking of spectrin by diamide, however, asymmetry of distribution of inner layer phospholipids, phosphatidylethanolamine and phosphatidylserine in the erythrocyte membrane becomes lost. This indicates that asymmetry is not due to a low transbilayer reorientation of the inner layer phospholipids, but that phosphatidylethanolamine and phosphatidylserine do not have access to the flip sites in the native membrane. A role of membrane skeleton proteins in the suppression of access of inner layer phospholipids to the flip sites is indicated by the loss of asymmetry of both phospholipids in spectrin depleted inside out vesicles and in vesicles produced by heat denaturation of spectrin. This idea is further supported by the observation that inner layer phospholipids analogues lysophosphatidylethanolamine and lysophosphatidylserine spontaneously accumulate in the inner layer of native erythrocytes, whereas lysolecithin does not. Moreover, this asymmetry is abolished in inside out vesicles.

Erythrocyte Membrane↗
PubMed1984

Inhibition of pulmonary metastasis by Nocardia rubra cell wall skeleton, with special reference to macrophage activation.

The antimetastatic activity of Nocardia rubra cell wall skeleton (N-CWS) with or without cyclophosphamide was examined in an experimental model of pulmonary metastasis induced by Lewis lung carcinoma in C57BL/6 mice. Lewis lung carcinoma cells were implanted into the footpads of mice, and the implanted tumors were removed 9 to 10 days later. Pulmonary metastatic nodules began to develop a few days after the implanted tumor was removed. The inhibitory effect of N-CWS was evaluated from the number of pulmonary surface nodules about 3 weeks after tumor implantation. The antimetastatic activity of N-CWS depended upon the dose, time, and route of its injection. Injection of N-CWS i.v. after removal of the implanted tumor caused the greatest inhibition of development of pulmonary metastases. Therapy with N-CWS plus cyclophosphamide prolonged significantly the survival of mice with metastases. The cytotoxic activities of peritoneal macrophages and macrophages in the lung against Lewis lung carcinoma cells were enhanced in mice treated with N-CWS. Injection i.v. of peritoneal macrophages activated with N-CWS inhibited pulmonary metastases. The role of macrophages in inhibition of micrometastasis in the lung is discussed.

Animals↗
PubMed1984

Pathologic changes in aging sacroiliac joints. A study of dissecting-room skeletons.

Pathologic changes of the sacroiliac joints were observed in 1986 skeletons from dissecting rooms in St. Louis, Missouri and Johannesburg, South Africa. In addition to being the largest population samples ever studied from this standpoint, these samples are the first to include blacks. Para-articular osteophytosis culminating in ankylosis is considered first, followed by the less common intraarticular changes that also occasionally culminate in ankylosis. Expressed as "average involvement" by decade, sex, laterality, and ethnic group, these joint changes are shown clearly to worsen progressively from the age of about 40 years. Osteophytosis especially becomes more common in black males, both American and African Bantu, than in American white males, and generally more common in males than in females. When occurring only (or mainly) unilaterally, the changes average out in favor of the right side, but only slightly. Joint mobility, or lack thereof, is assigned a large etiologic role.

Adult↗
PubMed1984

Carcinoma of the breast metastatic to the skeleton.

A review of 319 patients with breast carcinoma metastatic to the skeleton revealed a large variation in age at diagnosis, interval between diagnosis of primary disease and metastasis, and survival time with metastasis. The presence of bony metastasis only is a good prognostic sign, and the presence of neurologic defects without successful correction is a poor prognostic sign. Bone lesions are radiosensitive, and fractures usually heal with radiation. It is difficult to define impending fractures, but large lytic lesions, increased body weight, increased activity, and areas of high stress are factors that can be used to determine the risk of fracture. Femoral neck fractures should be treated by endoprostheses or total hip arthroplasty and femoral shaft fractures by appropriate internal fixation. In the present series humeral fractures were successfully managed conservatively, but it is possible that with a wider data base the advantages of immediate rigid fixation by internal fixation with methylmethacrylate cement would be more obvious. Use of methylmethacrylate should be restricted to patients with short-term survival expectancies and large defects. Most spinal metastases can be treated by radiation and orthoses, but an aggressive approach is indicated for patients with neurologic deficits. Laminectomy is indicated for lesions that produce posterior compression, anterior decompression for lesions producing anterior compression, and stabilization for alignment deformities or instability.

Adult↗