[Effect of neurotropic compounds on the content of catecholamines in the brain tissue in reflex dystrophies].
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It has been established that the lesion of the sciatic nerve, accompanied by a disturbance of normal neurotrophic provision of a kidney as a result of coming to the organ of the perverted nervous stimuli (by the neuro-conductive path through sympathetic nerves and by participation of the hypothalamus--hypophysis--peripheral glands system), leads to disturbance of functioning of mineral-corticoid receptors of kidneys. It has been also established that simultaneous pharmacological blockade of neuro-conductive and humoral pathways of transmission to the kidney of pathological stimuli from the central stump of the cut sciatic nerve prevents the development of trophic organ disturbances, tested by the state of the kidney mineral-corticoid receptor apparatus, while pharmacological stimulation of sympathetic nervous system leads to the greater disturbance of aldosterone reception by the cells of kidney channels. A valid conclusion can be made that propranolol is a substance, which may weaken possible non-adequate reactions of peripheral tissues to the action of physiologically active substances during the development of the consequences of the lesion of the nervous system and thus to prevent the development of neurogenic dystrophies.
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The clinical signs and symptoms in 441 patients with post-traumatic dystrophy were recorded. This form of dystrophy occurred three times as often in females as in males and twice as often in the arms as in the legs. In 5% of the patients the first symptom is a cold extremity; these patients run a greater risk of major sequelae. Exacerbation of the symptoms under influence of muscular exercise proved to be an important prognostic factor. A large proportion of the referred patients proved to have undergone a treatment aimed at elimination of the sympathetic nervous system, without success. Post-traumatic dystrophy can impede all structures and functions of the affected extremity and may result in major sequelae and disablement. The pseudoparalysis of the later phase may be mistaken for conversion.
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