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Over-the-counter decorative contact lenses: Cosmetic or Medical Devices? A Case Series.

PURPOSE: To illustrate the implications of the unauthorized sale and unmonitored wearing of decorative cosmetic contact lenses resulting in ocular complications and to determine the prevalence of the use of cosmetic contact lenses obtained from unlicensed providers by adolescents. METHODS: Observational case report, structured interview, and survey in a retrospective, observational, clinical practice setting. Reported sources of contact lenses were categorized as provider and nonprovider, and associations within the data were reviewed by using a Pearson correlation and chi-square test. RESULTS: Twelve patients (eight female and four male) were seen urgently for acute eye pain and redness after wearing plano decorative contact lenses. None of the patients had previously worn a contact lens. None of the lenses were dispensed by eye care professionals. Four patients developed blinding infections requiring hospital admission. Causative organisms included staphylococci, Pseudomonas, and acanthamoeba. One patient required a penetrating keratoplasty. One hundred fifty-nine patients were surveyed. Thirty-seven (23%) used decorative contact lenses. Lenses were obtained from an unlicensed provider 51% of the time. Education about lens care and handling was significantly associated with acquiring lenses from licensed providers (R = 0.74, P < 0.0001). CONCLUSIONS: Colored noncorrective contact lenses are being dispensed without a prescription or fitting from unlicensed vendors. Patients who acquire lenses from unauthorized providers are significantly less likely to be instructed on appropriate lens use and care. Consequently, uninformed lens wearers are experiencing acute vision-threatening infections and inflammation.

Adolescent↗

[Study of the intracardiac flow by real-time bidimensional color-coded Doppler echocardiography. Preliminary experience].

The new technique of real-time two-dimensional color Doppler echocardiography has been recently developed to allow visualization of the blood flow inside the cardiac chambers. The blood flow informations are color coded and displayed in real-time into the two-dimensional echocardiographic images of the cardiac structures. The flow informations which are given are velocity, direction and variance, calculated from the Doppler signals obtained from all the sample points. Flow directed toward the transducer is coded in red; flow away from the transducer is coded in blue, while the echoes from the cardiac structures are imaged in gray scale. The magnitude of the velocity of flow is represented by the brightness of the color, with an 8-steps scale of brightness, beginning from the lowest grade, which is not colored on the screen. To represent the velocity spectrum variance, green is added to each color in proportion to the extent of turbulence. We report our preliminary experience with this technique in 91 subjects by using an Aloka SSD 880 commercial equipment (age range 18 days-82 years): 5 were normal, 15 had cardiomyopathy, 21 had congenital, 40 valvular, 6 ischemic and 4 other forms of heart disease. Color display of intracavitary flow allowed to identify normal and abnormal patterns. Valvular regurgitation and abnormal intracavitary shunts were easy to identify, suggesting the possibility of a semiquantitative assessment of the lesions. The possibility of a quantitative approach should be further investigated in the future.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗

Femoro-femoral graft after unilateral obstruction of aorto-bifemoral bypass.

BACKGROUND: Thrombosis is the most frequent late complication of surgical procedures in the aortofemoral area. In the presence of aortobifemoral bypass, graft limb occlusion generally occurs within the first two years. Various techniques have been proposed to revascularize the ischemic limb. Personal experience in the treatment of occlusions of aorto-femoral bypasses branch by femoro-femoral bypasses is reported and the immediate and long-term results are analyzed. METHODS: The study was retrospective and the medium follow-up was 51 months (1-14 years). The patients were all operated from 1976 to 1995 in the Division of Vascular Surgery of the University of Bari. The group consisted of 40 patients affected by unilateral occlusion that occurred after aorto-femoral bypass. The femoro-femoral bypass was performed using non-ringed 6 or 8 mm Dacron prostheses; the proximal anastomosis was made a few cm above the femoral anastomosis of the permeable branch of the existing aorto-bifemoral bypass and the distal anastomosis on the cross-leg profunda femoris. Postoperative follow-up consisted of clinical examination, continuous wave Doppler examination or US-color-Doppler scan in order to assess the permeability of the graft. RESULTS: The immediate results showed 2 and long-term results 9 occlusions of the bypass. No perioperative mortality was observed. CONCLUSIONS: In conclusion the authors consider the use of femoro-femoral bypass indicated in a high number of patients affected by unilateral occlusion of the aorto-bifemoral bypass.

Aged↗

Preliminary results after application of absorbable metal stents in patients with critical limb ischemia.

PURPOSE: To report the preliminary 3-month follow-up of a recently developed absorbable metal stent (AMS) for treatment of infrapopliteal lesions in patients with critical limb ischemia (CLI). METHODS: Between December 2003 and January 2004, 20 patients (10 men; mean age 76 years, range 59-96) with symptomatic critical limb ischemia (CLI) due to high-grade (80% to 100%) infrapopliteal stenoses received 1 or 2 AMS devices for suboptimal angioplasty. Clinical examination and color-flow duplex imaging were performed in all patients at discharge and at 1 and 3 months. RESULTS: Angiographic procedural success was achieved in all 20 patients. One patient died (non-procedure-related) during the periprocedural period. Three months after the procedure, primary clinical patency was 89.5% (17/19). No major or minor amputation was necessary in any of the patients, yielding a limb salvage rate of 100%. The average improvement in Rutherford class was 2.3 at the 3-month assessment. A comparison of postprocedural and 1-month color-flow duplex ultrasound and magnetic resonance images clearly indicated the ongoing absorption process of the AMS. CONCLUSIONS: After 3 months, the primary clinical patency and limb salvage rates suggest a potentially promising performance of these AMS devices in the treatment of below-knee lesions in CLI patients.

Absorbable Implants↗

[Postoperative duplex ultrasonic surveillance of infrainguinal arterial reconstructions].

Postoperative bypass surveillance can identify graft-related stenoses in 25% of grafts during the first two years after surgery. Correction of the stenoses before they lead to graft occlusion improves the patency significantly. Clinical assessment including distal pressure measurements is of poor sensitivity. Surveillance is best performed with color duplex scanning. Ideally, grafts are examined first after one to two months, thereafter every three months and, after one year, at intervals of six months. Graft surveillance beyond two years is hardly justified, as is the case with prosthetic grafts. Symptom-producing and tight stenoses should be corrected. Percutaneous transluminal angioplasty is appropriate for short stenoses, whereas stenoses longer than 2 to 3 cm are best treated surgically.

Angioplasty, Balloon↗

Severe hemolytic anemia after repair of primum septal defect and cleft mitral valve.

Two cases are described in which severe mechanical hemolytic anemia developed after surgical repair of primum atrial septal defect (ASD) and cleft mitral valve. In both cases there was residual mitral regurgitation after repair. Moderate mitral regurgitation and collision of the regurgitant jet with the teflon patch used for repair of the primum ASD were detected by color-Doppler echocardiography imaging. Laboratory tests showed normochromic normocytic anemia, increased indirect serum bilirubin, decreased plasma haptoglobin and hemoglobinuria. The peripheral blood smear contained numerous fragmented red cells. Following another surgical correction of the mitral valve (repair or mitral valve replacement), there was no more hemolysis. The two presented cases show that foreign materials in association with localized intracardiac turbulence may cause severe hemolysis.

Anemia, Hemolytic↗

Valvular emergencies.

Valvular emergencies result from a wide variety of causes, including infectious, inflammatory, ischemic, traumatic, degenerative, and recently iatrogenic processes. In addition, prosthetic valves have brought new valvular emergencies that present unique challenges in diagnosis and therapy. The advent of color Doppler and TEE have provided significant enhancements to our diagnostic armamentarium. Similarly, thrombolytic therapy has also found a place in the treatment of a common prosthetic valve emergency--thrombosed mechanical valves. Because of the likelihood of serious consequences, rapid diagnosis and aggressive management of valvular emergencies are needed, but the results can be very gratifying and lead to excellent short- and long-term outcomes.

Aortic Dissection↗

[Aortic valve replacement using aortic donor valves of human origin].

OBJECTIVE: To evaluate the experiences of aortic valve replacement with cryopreserved aortic allografts in the subcoronary position. DESIGN: Descriptive clinical study. SETTING: Thorax Centre of Rotterdam University Hospital. METHOD: In the period July 1988-March 1993, 68 patients (45 men and 23 women) with a mean age of 45 years underwent 69 operations. One woman was operated twice. Main criteria for aortic valve replacement by an allograft were age and endocarditis. The pathology leading to aortic valve dysfunction had been: endocarditis (38%), congenital lesions (32%), rheumatic lesions (19%), senile degeneration (7%), paravalvular leakage (3%) and an active autoimmune disease (1%). RESULTS: Hospital mortality was 4%. The mean follow-up was 22 months, with a cumulative follow-up of 126 patient years. One patient died of lung cancer during this period. Six patients needed a second operation (9%); 4 of these were among the first 15 patients operated on. One of these reoperations was necessary to treat a recurrent endocarditis. Only one other late valve-related event took place: a transient ischaemic attack 2 years postoperatively. Ninety-one per cent of the patients with an allograft in situ were in NYHA class I at their last outpatient clinic visit. The other patients were in class II. Pre-cordial color Doppler echocardiography showed no or mild aortic regurgitation in 95% of these patients. The remaining 3 patients had moderate aortic regurgitation. CONCLUSION: Aortic valve replacement with an allograft was performed with low hospital mortality. The expected advantages are greatest in young patients and patients with endocarditis; these patients, therefore, should have priority in allograft allocation.

Adolescent↗

[Usefulness of magnetic resonance imaging for managing patients with prosthetic carbon valve in the mitral position].

The safety, findings and clinical usefulness of magnetic resonance (MR) imaging were assessed in patients with a prosthetic carbon valve in the mitral position. In vitro deflection, heating and image distortion due to the magnetic field of a 1.5 tesla MR machine were examined in three carbon valves (CarboMedics, St. Jude Medical and Björk-Shiley valves). In vivo MR imaging of the left ventricular horizontal long-axis, vertical long-axis and short-axis views was performed by electrocardiographically synchronized spin echo and field (gradient) echo techniques in eight patients with prosthetic mitral carbon valves, consisting of six CarboMedics valves, one St. Jude Medical valve and one Björk-Shiley valve. No deflection and significant heating was seen in all three valves in vitro. Although little image distortion was shown in the CarboMedics and St. Jude Medical valves, a small distortion toward the frequency encoded direction was seen in the Björk-Shiley valve but caused no difficulty in assessing the surrounding images. Four of the eight patients had normal sinus rhythm and the other four had atrial fibrillation. The prosthetic valves were depicted as signal voids in the images taken by both spin echo and field echo techniques in vivo. Clear structural information with little image distortion of the adjacent tissues of the prosthetic valves were obtained in all patients, although the image of the Björk-Shiley valve which contained stainless steel in the frame had a slightly stronger distortion than those of the CarboMedics and St. Jude Medical valves which contained titanium. The stainless wire suture material used to close the sternal incision was depicted as a signal void, and the areas of the signal loss were larger in the images taken by the field echo technique than those by the spin echo technique. The images taken by the spin echo technique in patients with atrial fibrillation had reduced quality due to the irregularity of repetition time. Cine MR imaging by the field echo technique showed physiological mitral regurgitant jets as signal loss within the flowing blood, which appeared as high signal intensity, bidirectionally in the bileaflet mechanical valve and unidirectionally in the monoleaflet mechanical valve. An abnormal cavity was seen behind the basal left ventricular myocardium in one patient with a CarboMedics valve. The wall of the abnormal cavity was disrupted abruptly and the rest of the wall consisted of pericardium and adjacent tissue in the image taken by the spin echo technique. The image taken by the field echo technique showed an abnormal jet flow from the basal part of the left ventricular cavity into the abnormal cavity, which was compatible with left ventricular pseudoaneurysm. Two-dimensional echocardiography and Doppler color flow mapping disclosed the abnormal cavity and the abnormal flow inside, but failed to show the connection between the left ventricle and the cavity due to reverberation of the ultrasound signal by the prosthetic valve. These findings suggest that MR imaging is a safe and promising method to assess the complications and valvular function in patients with a prosthetic carbon valve in the mitral position.

Aged↗

Evaluation of the effects of restorative materials used for occlusal surfaces of implant-supported prostheses on force distribution.

In this study, the functional stresses in alveolar bone created by restorative materials used in implant-supported prostheses were determined by the photoelastic stress analysis method. A photoelastic resin mandibular model, hollow-cylinder implants (3.5 mm diameter, 10 mm length), and fixtures and superstructures made of five different prosthetic materials were used. Vertical and 45-degree inclined loads were applied to the model. Subsequently, color photographs of the force line distribution observed on a polariscope were taken. Differences between vertical and inclined loads were statistically significant for all prosthetic materials (P < 0.01). The greatest stress distribution around the apex of the implant was observed with Ceramco II porcelain, followed by Biodent acrylic. The ArtGlass and Elcebond CCV composite materials had equal values, whereas Verebond Ni-Cr alloy showed minimum stress distribution.

Acrylic Resins↗

[Evaluation of prosthetic valvular regurgitation by color Doppler echocardiography].

Prosthetic valvular regurgitation was evaluated by color Doppler echocardiography in 107 patients with prostheses. Regurgitant jets were detected in 37 (35%) prostheses, 76% of them were transvalvular and 24% of them were perivalvular. The ratio of bioprostheses with increased intensity and transvalvular regurgitant jets increased parallel to the duration after replacement. Of those bioprostheses replaced more than 6 years, 23% developed regurgitation with a higher degree. Transvalvular regurgitation was detected in 25% of St. Jude Medical prostheses recently replaced, but the degree was low.

Aortic Valve↗

Patterns of normal transvalvular regurgitation in mechanical valve prostheses.

The magnitude and spatial distribution of normal leakage through mechanical prosthetic valves were studied in an in vitro model of mitral regurgitation. The effective regurgitant orifice was calculated from regurgitant rate at different transvalvular pressure differences and flow velocities. This effective orifice area was 0.6 to 2 mm2 for three tilting disc prostheses (Medtronic-Hall sizes 21, 25 and 29) and 0.2 to 1.1 mm2 for three bileaflet valves (St. Jude Medical sizes 21, 25 and 33). In the single disc valves, Doppler color flow examination disclosed a prominent central regurgitant jet around the central hole for the strut, accompanied by minor leakage along the rim of the disc (central to peripheral jet area ratio 3.3 +/- 1.2). The bileaflet prostheses showed a peculiar complex pattern: in planes parallel to the two disc axes, convergent peripherally arising jets were visualized, whereas in orthogonal planes several diverging jets were seen. Mounting the disc and bileaflet valves on a water-filled tube allowed reproduction and interpretation of this pattern: for the bileaflet valve, the jets originated predominantly from valve ring protrusions that contained the axis hinge points and created a converging V pattern in planes parallel to the leaflets and a diverging V pattern in orthogonal planes. Similar patterns were observed during transesophageal echocardiography in 20 patients with a normally functioning St. Jude prosthesis. In 10 patients with a Medtronic-Hall valve, a dominant central jet was observed with one or more smaller peripheral jets. The median central to peripheral jet area ratio was 5 to 1.(ABSTRACT TRUNCATED AT 250 WORDS)

Blood Flow Velocity↗

Erectile dysfunction in uremic dialysis patients: diagnostic evaluation in the sildenafil era.

The two words that mean sexual dysfunction, impotence and erectile dysfunction (ED), express two different concepts. Impotence is a general male sexual dysfunction that includes libidinal, orgasmic, and ejaculatory dysfunction. ED is the inability to achieve or maintain an erection sufficient to allow satisfactory sexual intercourse and is part of the general male sexual dysfunction termed impotence that includes libidinal, orgasmic, and ejaculatory dysfunction. Uremic men of different ages report a variety of sexual problems, including sexual hormonal pattern alterations, reduction in or loss of libido, infertility, and impotence, conditioning their well-being status. In evaluating and treating sexual dysfunction, a nephrologist must consider factors involved in its pathogenesis, such as hypothalamic-pituitary-gonadal axis alterations, psychological problems related to chronic disease, secondary hyperparathyroidism, anemia, autonomic neuropathy, derangements in arterial supply or venous outflow, and the normal structure of cavernous body smooth muscle cells. The introduction of sildenafil to treat impotent patients has completely changed the approach to evaluating these subjects because this drug is considered an effective well-tolerated treatment for men with ED. In the past, we proposed an algorithm that gave the opportunity to explore the previously mentioned factors using such instrumental interventions as the nocturnal penile tumescence test, penile echo color Doppler, nervous conduction velocity, and cavernous body biopsy, addressed to prescribe needed surgical or medical interventions. The complexity of the proposed algorithm requires many diagnostic procedures and much time and economic resources to localize the pathological lesions responsible for ED. Because of the new oral drug sildenafil, we propose a new algorithm to test the possibility of obtaining an erection and classify patients as responders or nonresponders to the sildenafil test.

Bromocriptine↗

Mitral allograft with chordal support: echocardiographic evaluation in sheep.

The in vivo echocardiographic behavior of a new mitral allograft design that incorporates ePTFE patches and chordae to enhance durability has been evaluated in sheep. A strip of pericardium was sewn around the anulus margin and an ePTFE patch of 0.4 mm thickness placed over the truncated papillary muscle tip. In four out of ten cases, 5/0 ePTFE sutures were used additionally to reinforce the native chordae of the anterior leaflet. The allografts were cold-stored at 4 degrees C after antibiotic treatment and implanted in weanling sheep. Valvular function was first examined intraoperatively by transesophageal echocardiography and again after a mean follow up of 153 +/- 8 days by epicardial echo. In all six long term survivors, valve motion was unimpaired and similar to that of the natural mitral valve. There was sufficient coaptation and concentric opening action of the leaflets. Ventricular contraction was enhanced by maintaining the annulo-ventricular connection of the native valve. Color and pulsed Doppler revealed a physiologic biphasic flow pattern and only minor regurgitation in one case. Mean transvalvular pressure gradient was 3.3 +/- 2.1 mmHg on average which correlates well with values obtained from subsequent cardiac catheterization. In conclusion, this new design of a mitral allograft shows excellent in vivo echocardiographic behavior after five months of implantation. Therefore, human allografts of this type could be recommended for clinical application.

Animals↗

Echocardiographic findings and clinical features of left ventricular pseudoaneurysm after mitral valve replacement.

We studied the echocardiographic findings and clinical features of left ventricular pseudoaneurysm after mitral valve replacement. From December 1979 to March 1991, 1050 patients underwent mitral valve replacement at our institute, and eight patients (0.8%) had left ventricular pseudoaneurysm. In all eight patients, left ventricular pseudoaneurysm developed after the second mitral valve replacement. The incidence of left ventricular pseudoaneurysm among 253 patients who had had previous mitral valve surgery was 3.1%. Seven of the eight patients were still alive and were followed up from 5 to 136 months (mean, 57 months) after the development of left ventricular pseudoaneurysm; these patients had no complications. One patient died as a result of low cardiac output after mitral valve replacement in spite of repair of the left ventricular pseudoaneurysm. This patient had a long and wide myocardial laceration near the left ventricular pseudoaneurysm. In the other seven patients, transthoracic echocardiography demonstrated a large extraventricular cavity along the posterobasal left ventricle. In five of these patients, a turbulent flow in the neck of the left ventricular pseudoaneurysm was recorded both in systole and diastole by pulsed and color Doppler echocardiography. Transesophageal echocardiography clearly showed the narrow neck of the left ventricular pseudoaneurysm and an abnormal flow between the left ventricle and the left ventricular pseudoaneurysm. Generally, when left ventricular pseudoaneurysm develops after mitral valve replacement, surgical repair is the first choice of therapy. Our study demonstrated, however, that the development of left ventricular pseudoaneurysm was not always associated with a poor prognosis without surgical intervention.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗

Doppler study of precordial musical murmurs.

Using phonocardiography, continuous- and pulsed-wave Doppler, 51 patients with precordial "musical" murmurs (49 with cardiac abnormalities) and 21 patients with noisy murmurs were examined. With M-mode echocardiography, fine fluttering of the structure generating the murmur was evident in 23 patients with musical murmurs and in 5 with noisy murmurs. A continuous-wave Doppler spectral signal characterized by parallel harmonics (Doppler musical signal) was evident in all patients with musical murmurs and in none with a noisy murmur. With pulsed-wave Doppler, the musical signal had less defined spectral features because of range ambiguity. Such a signal was experimentally reproduced by activating a diapason bathed in saline solution. The source of the musical murmur was established in all 51 patients by Doppler. The musical signal was associated with a valvular regurgitation signal in 36 patients and with a ventricular septal defect in 1 patient. The musical signal always disappeared when the pulsed-wave Doppler sample volume was placed 2 cm away from the generating structure. In 11 patients with musical murmur examined by color Doppler, no abnormal bidirectional flow signal was observed in the structures generating the signal. In 6 of the patients without valvular regurgitation, no flow disturbance was found. In conclusion, Doppler is valuable in determining the source of musical murmurs, and musical murmurs are caused by a vibrating structure even in the absence of flow turbulence.

Aortic Valve Insufficiency↗

[Development of thromboses in hip joint endoprostheses. A study with color-coded duplex ultrasound].

After 102 hip replacements in a surgical technique that avoids bone-marrow intravasation as much as possible, color-coded duplex sonography revealed thigh thrombi in only 4 cases without any signs of thrombosis. This rate is lower than that found in all other comparable studies. The investigations stress the role of bone-marrow intravasation in the induction of deep vein thrombosis in hip replacement. With an optimal surgical technique, thigh thrombi can be greatly reduced in hip replacements, which have a higher rate than all other operations.

Aged↗

Telephone speech comprehension in children with multichannel cochlear implants.

Telephone speech comprehension is being evaluated in six prelingually deaf children implanted with the Nucleus 22 prosthesis fitted with the Speak strategy. All of them have had at least 1.5 years of experience with their implant. When the tests began, they had already had at least 2 months' experience with the same map in their speech processor. The children were trained in the use of the telephone as part of the rehabilitation program. None of them used it regularly but as a game that they found very entertaining. A special battery, the Bate-fon (batería para teléfono = telephone battery), was designed for training and evaluation purposes. It includes the five Spanish vowels in isolation, diphthongs, onomatopoetic animal voices, two-syllable, and three-syllable words. The tests were administered 1.5-2 years after the switch-on of their speech processor. Standard acoustic telephone coupling was used. The speech material was presented to the child on colored cards. Stimuli were presented twice. Children were informed when the response was incorrect. Averaged results indicated that the percentages of correct responses for all the speech material increase in the second presentation. All children have shown some degree of telephone communication abilities. As a result of the training, some of the children are using the telephone to communicate with their families.

Child, Preschool↗