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At least 1,513 records · Page 84Linked to original sources
PubMed1986

Preliminary observations on the results of combined temporary 192iridium implantation and external beam irradiation for carcinoma of the prostate.

We treated 43 patients with adenocarcinoma of the prostate confined to the pelvis with a combination of staging pelvic lymphadenectomy, temporary implantation of the prostate with 192iridium and external beam irradiation. The procedure was relatively safe with low early morbidity. However, there were significant late complications. Of these patients 29 had needle biopsy of the prostate 1 year after completion of therapy and 15 demonstrated residual tumor. Clinical stage C and poorly differentiated tumors were not well controlled.

Adenocarcinoma↗
PubMed1976

Radiotherapy in the management of stage C carcinoma of the prostate.

A small number of patients with limited stage C carcinoma of the prostate have been treated with combined interstitial and external beam radiotherapy with gratifying results. Whereas more patients will have to be followed for at least 10 to 15 years to completely evaluate this modality of treatment, the results continue to encourage us in its use.

Biopsy↗
PubMed1975

Extended biopsy followup after full course radiation for resectable prostatic carcinoma.

Extended biopsy followup of 17 relatively young men with resectable prostatic cancer treated by external supervoltage radiotherapy is presented. Although 6 of the 8 surviving patients now have negative biopsies, the over-all survival rate and the over-all incidence of negative biopsies are not so encouraging, with only 35 per cent rendered free of tumor. Thus, the role of radiotherapy in resectable prostatic carcinoma should be critically scrutinized. More accurate staging is needed. Hopefully, more sophisticated studies of diagnostic and prognostic value will be available in the near future.

Adult↗
PubMed1975

Clinical experience with supervoltage radiotherapy in carcinoma of the prostate: a preliminary report.

A review was done on 88 cases of carcinoma of the prostate treated with supervoltage radiotherapy and evaluated at regular intervals with post-treatment needle biopsies. A disturbing 58 per cent (45 of 77 cases) had histologic evidence of residual carcinoma at 1 year post-radiation. In 47 per cent (21 of 45 cases) of patients receiving 7,000 to 7,500R the biopsies were positive. No undue morbidity was experienced with radiation levels at 7,000R. Prostatic needle biopsy is considered mandatory for adequate clinical evaluation post-radiation. Since 41 per cent of patients judged radioresponsive on rectal palpation had positive biopsies at 12 months the data indicate considerable error in the clinical assessment of the irradiated prostate when reliance is placed solely on digital evaluation.

Aged↗
PubMed1974

Gonorrhea today.

Explore the source record for details and available documents.

Carrier State↗
PubMed1992

Distribution of mesalamine enemas in patients with active distal ulcerative colitis.

Mesalamine (5-aminosalicylic acid), a topically administered anti-inflammatory agent, is effective treatment by enema for distal ulcerative colitis; it lacks many of the side effects of orally administered sulfasalazine. In this study, we determined the colonic distribution of a 60-ml mesalamine enema in eight patients (five women and three men, 18 to 48 years old) with active distal ulcerative colitis that ranged from 12 to 40 cm proximal to the anal verge. On 3 consecutive days, each patient self-administered a 4-g (60-ml) 5-aminosalicylic acid enema that contained 3.7 MBq of [99mTc]technetium-sulfur colloid. Anterior and posterior images were obtained at 0, 30, 60, 120, and 240 minutes. During the 4-hour study period, all patients retained the enemas. The enemas spread to the sigmoid region in 24 of 24 studies, to the splenic flexure region in 22 of 24, and to the transverse colon in 1 of 24. Most of the enema was retained in the sigmoid colon. Therefore, we conclude that a 60-ml enema, when administered as recommended clinically, routinely flows retrograde as far as the splenic flexure but rarely spreads beyond this point. These results support the use of intrarectally administered 5-aminosalicylic acid for segmental colitis of the descending colon.

Adolescent↗
PubMed1990

Genital herpes simplex virus infections.

There has been a dramatic increase in patient visits to physicians for evaluation and treatment of genital herpes infections. This has resulted in part from an increase in genital herpes infections, particularly severe, first-episode genital herpes infections in adults without prior HSV-1 infection. Virus culture remains the most sensitive and specific method for diagnosis, and use of viral cultures is encouraged. Type-specific antibody tests have been employed in studies documenting the role of asymptomatic shedding of HSV in transmission of genital infections, the role of genital HSV in transmission of HIV, the predominance of asymptomatic and unrecognized infections in those infected with HSV-2, and the presence of past asymptomatic or unrecognized acquisition of HSV-2 in 25% of persons presenting with first-episode genital herpes. Unfortunately, commercially available serologic tests do not reliably differentiate between antibody to HSV-1 and HSV-2. Recent studies suggest that the annual risk of transmission from a sexual partner with genital herpes is about 10% in heterosexual couples. Currently, promotion of "safe sex" is the only available approach for prevention of transmission. However, ongoing research is focused on the development of an effective vaccine. Acyclovir should be used routinely in persons with first-episode genital herpes, but careful evaluation is needed in persons with recurrent genital herpes to determine whether episodic or suppressive treatment is indicated. Acyclovir should also be used routinely for episodic or suppressive treatment of HSV infections in persons with AIDS. Additional antiviral agents are needed for more effective suppressive therapy and for treatment of ACV-resistant HSV infections in the immunocompromised host.

Acyclovir↗
PubMed1986

Clinical approach to intestinal infections in homosexual men.

The list of infectious agents that cause intestinal disorders in homosexual men is polymicrobial. Classic enteric pathogens, anorectal venereal pathogens, and more recently, opportunistic pathogens have been reported to occur in high prevalences in both symptomatic and asymptomatic homosexual men. This article reviews the epidemiology, clinical presentation, diagnosis, and treatment of these infections.

Acquired Immunodeficiency Syndrome↗