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At least 1,513 records · Page 84Linked to original sources
PubMed1985

[Effect of cisapride on contractile activity of the gastrointestinal tract].

Cisapride strongly stimulates gastrointestinal motor activity simultaneously from stomach to jejunum in the interdigestive state. The contractile pattern in the stomach was quite similar to that of the natural interdigestive mingrating contractions (IMC) in all respects, frequency, contractile force, and coordination between the gastric body and antrum. However, the cisapride-induced IMC-like contractions in the stomach did not migrate along the small intestine, nor were accompanied by an increase of plasma motilin concentration. Furthermore, both motilin and cisapride, given during the period of phase III, did not affect the phase III activity, but carbachol abruptly stopped phase III activity if it was given during phase III activity. On the contrary, cisapride-induced contractions in the stomach are completely inhibited by atropine, pentagastrin, CCK-octapeptide, but not by secretin. These findings provide additional evidence to indicate that the cisapride-induced contractions in the stomach are identical with the natural IMC in the respect of reactons to hormonal substances. No noticeable side effects were observed. In conclusion, cisapride is a unique compound to initiate IMC-like contractions in the stomach, but the contractions were not accompanied by an increase in plasma motilin concentration and did not migrate the small intestine.

Animals↗
PubMed1985

Varying expression of cytokeratin and neurofilaments in neuroendocrine tumors of human gastrointestinal tract.

Twelve cases of gastrointestinal neuroendocrine tumors, including eight carcinoids and four pancreatic islet cell tumors or their metastases, were immunohistochemically analyzed for the expression of different types of intermediate filament proteins. All of the tumors showed cytokeratin positivity in immunostaining, and the Western blotting technique revealed 45- and 52-kilodalton cytokeratins in carcinoid tumors. Three of the islet cell tumors, but none of the carcinoid tumors, showed, in addition, varying numbers of neurofilament-positive tumor cells when evaluated with rabbit and mouse monoclonal antineurofilament antibodies. The presence of only the 70-kilodalton neurofilament and cytokeratin polypeptides in an islet cell tumor was revealed also by using the Western blotting technique. On the other hand, both fetal and adult pancreatic islet cells showed only cytokeratin positivity. Neurofilament-positive epithelial cells were not found in normal small intestines either. The results show epithelial characteristics in normal gastrointestinal neuroendocrine cells and neuroendocrine tumors by their expression of cytokeratin. In addition, some islet cell tumors display the 70-kilodalton neurofilament protein which suggests the acquisition of a new type of intermediate filament during the neoplastic change.

Adenoma, Islet Cell↗
PubMed1979

Phycomycosis of the gastrointestinal tract.

A case of gastrointestinal phycomycosis, a highly lethal fungal infection, is presented. Radiographic, operative and histopathologic features are discussed. Pathogenesis of the disease and the importance of underlying illness, malnutrition, immunosuppression and antibiotic therapy are considered. The literature is reviewed and current approaches to diagnosis and management are summarized. Greater awareness of the clinical setting in which gastrointestinal phycomycosis may develop and earlier consideration of the diagnosis are prerequisite to improved survival.

Female↗
PubMed1998

[Endoscopic palliative treatment of tumors of the gastrointestinal tract].

Patients with nonresectable gastrointestinal tumors have a life expectancy of a few months only. Effective palliative treatment has to ensure a good quality of life with minimal morbidity and mortality. Esophageal carcinoma: Endoscopic intubation or stent implantation guarantee a prompt improvement of dysphagia with minimal morbidity and mortality in esophageal carcinoma. Only in cervical or noncircumferential stenosis laser therapy is preferable. Obstructive jaundice: Metal stents offer the best quality of life after palliative treatment of malignant obstructive jaundice. However, in patients with bad general conditions and a short life expectancy a pigtail catheter is less expensive. Colorectal cancer: Laser therapy and cryosurgery offer uncomplicated nonsurgical therapy in rectal carcinoma. Stents in the colorectum have a high complication rate. Endoscopic palliative treatment of gastrointestinal tumors can be performed with minimal morbidity and mortality. However, it is essential that a surgeon is involved in the decisionmaking between endoscopic or operative treatment.

Endoscopes↗
PubMed2006

Normalized dose data for upper gastrointestinal tract contrast studies performed to infants.

The aim of the current study was to (a) provide normalized dose data for the estimation of the radiation dose from upper gastrointestinal tract contrast (UGIC) studies carried out to infants and (b) estimate the average patient dose and risks associated with radiation from UGIC examinations performed in our institution. Organ and effective doses, normalized to entrance skin dose (ESD) and dose area product (DAP) were estimated for UGIC procedures utilizing the Monte Carlo N-particle (MCNP) transport code and two mathematical phantoms, one corresponding to the size of a newborn and one to the size of a 1-year-old child. The validity of the MCNP results was verified by comparison with dose data obtained in physical anthropomorphic phantoms simulating a newborn and a 1-year-old infant using thermoluminescence dosimetry (TLD). Data were also collected from 25 consecutive UGIC examinations performed to infants. Study participants were (a) 12 infants aged from 0.5 to 5.9 months (group 1) and (b) 13 infants aged from 6 to 15 months (group 2). For each examination, ESD and dose to comforters were measured using TLD. Patient effective doses were estimated using normalized dose data obtained in the simulation study. The risk for fatal cancer induction was estimated using appropriate coefficients. The results consist of tabulated dose data normalized to ESD or DAP for the estimation of patient dose. Conversion coefficients were estimated for various tube potentials and beam filtration values. The mean total fluoroscopy time was 1.26 and 1.62 min for groups 1 and 2, respectively. The average effective dose was 1.6 mSv for group 1 and 1.9 mSv for group 2. The risk of cancer attributable to the radiation exposure associated with a typical UGIC study was found to be up to 3 per 10 000 infants undergoing an UGIC examination. The mean radiation dose absorbed by the hands of comforters was 47 microGy. In conclusion, estimation of radiation doses associated with UGIC studies performed to infants can be made using the normalized dose data provided in the current study. Radiation dose values associated with UGIC examinations carried out to infants are not low and should be minimized as much as possible.

Body Burden↗
PubMed2002

Endoluminal sonography of the genitourinary and gastrointestinal tracts.

OBJECTIVE: Endoluminal sonography with high-frequency catheter-based transducers is a technique well suited to imaging structures beyond the lumen of the hollow viscus. The purpose of this article was to review some aspects of endoluminal sonography, including instrumentation, clinical applications in the gastrointestinal and genitourinary tracts, and its three-dimensional reconstruction. METHODS: The development of 6F to 10F catheter-based ultrasonic probes has made this technique available for use within a variety of lumina. Endoluminal sonography with frequencies of 9 to 20 MHz has been used for evaluation of a wide range of abnormalities in both the genitourinary and gastrointestinal tracts. RESULTS: Uses in the gastrointestinal tract include quantification of esophageal varices, distinguishing between various submucosal lesions, and measuring the degree of fibrosis in scleroderma. In the genitourinary system, endoluminal sonography has been used to guide collagen injection, to diagnose urethral diverticula and upper tract neoplasms, to locate crossing vessels and septa for guiding endopyelotomy, and to identify submucosal calculi. CONCLUSIONS: High-resolution endoluminal sonography is a new sonographic approach for evaluation of the genitourinary and gastrointestinal tracts. This should lead to the expansion of the diagnostic capabilities of sonography, providing important information for decision making relative to patient care and minimally invasive interventional procedures. Reconstructed three-dimensional endoluminal sonography has the potential to become a valuable tool in both the research and clinical areas.

Digestive System↗
PubMed2004

Endoscopic fluorescence spectroscopic imaging in the gastrointestinal tract.

Fluorescence detection is one of a series of new optical biopsy techniques that have been adapted and evaluated for implementation in gastrointestinal endoscopy. Endogenous fluorescence enables the detection of metabolic and structural changes in human tissue and thus may offer information for the detection of early stage dysplastic and malignant lesions of the mucosa that remain invisible in white light endoscopy. Tissue fluorescence can be detected by point-spectroscopic sampling of the mucosa or by processing the fluorescence information to generate an endoscopic image. Different approaches have been evaluated in pilot studies, and the results in terms of high diagnostic sensitivity and specificity are encouraging. However, large multi-center trials are necessary to evaluate the accuracy and predictability of these new optical tools for the endoscopic diagnosis of early cancerous lesions in the gastrointestinal tract.

Endoscopy, Gastrointestinal↗
PubMedDate not supplied

[The complex assessment of gastrointestinal tract function in chronic kidney failure].

The presented results of studying, morphofunctional disturbances of the gastrointestinal tract in patients with chronic renal failure revealed a myxedema, decreased hydrolytic and transport activity, increased elimination of nitrogen substances into the gastrointestinal lumen, replacement of obligate microflora by pathogenic bacterial associations, as well as a system of morphologic changes in gastrointestinal mucosa, ultrastructural abnormalities of enterocytes and their compounds.

Animals↗
PubMed2002

The EORTC Gastrointestinal Tract Cancer Group: 40 years of research contributing to improved GI cancer management.

The Gastrointestinal (GI) Tract Cancer Group's aims are to develop protocols concerning the different aspects of gastrointestinal tract malignancies, diagnosis, biology and mainly treatment. Prior to approval, new project proposals are discussed within different committees of the group and in the presence of specialists concerned, according to the type of trial. There are three main committees in the GI Group, chemotherapy, surgery and research. All projects of GI tract cancer are discussed first in the relevant committee before being discussed in the multidisciplinary plenary scientific session of the Group meeting. Multidisciplinarity has always been one of the major principles of the Group. This is well illustrated by the fact that the Chairman of the Group has been alternately a medical oncologist and a surgeon and is presently a surgeon. Radiation therapists also participate in the activity of the group. Like other EORTC groups, the GI Group has developed high standards of quality. Officers and members work in close co-operation with the staff of the Data Center in Brussels and in particular medical advisors, statisticians and data managers. Members from 32 different countries participate in the activities of the Group, mostly from European countries, but also from Russia, Egypt, Hong Kong, Israel, Peru, Russia, South Africa and many others through intergroup activities such as Australia, Canada and the USA.

Clinical Trials as Topic↗
PubMed1997

Clinical evaluation of cimetidine, sucralfate, and misoprostol for prevention of gastrointestinal tract bleeding in dogs undergoing spinal surgery.

OBJECTIVE: To determine the incidence of gastrointestinal (GI) tract bleeding in dogs undergoing spinal surgery with adjunct corticosteroid treatment, and to determine the protective efficacy of cimetidine, sucralfate, and misoprostol against such bleeding in these dogs. ANIMALS: 40 dogs that underwent spinal surgery. PROCEDURES: Myelography and surgery were performed on the first or second day of hospitalization. Methylprednisolone sodium succinate was given at a dosage of 30 mg/kg of body weight prior to myelography, followed by a second full or half dose 2 to 4 hours later at clinician discretion. Spinal surgery was performed in conventional manner, postoperative administration of analgesics was done, and dogs were fed a diet lacking red meat. Dogs were assigned at random to 1 of the 3 treatment groups or to the control group. Dogs of the treatment groups received cimetidine, sucralfate, or misoprostol. Physical examination and determination of PCV and serum total protein values were performed daily. A fecal sample was examined daily for gross and occult blood. RESULTS: 36 of 40 dogs had GI tract bleeding during a hospitalization period of 3 to 6 days. There was no significant difference in development of bleeding between the control group and any of the treatment groups. CONCLUSIONS: Gastrointestinal tract bleeding occurred in 90% of dogs undergoing spinal surgery combined with administration of methylprednisilone sodium succinate, a higher rate than that found in previous studies. This bleeding was not life-threatening. Prophylactic benefit from any of the GI protectants tested was not found.

Adrenal Cortex Hormones↗
PubMed2005

[Leśniowski-Crohn's disease in the upper part of the gastrointestinal tract].

Leśniowski-Crohn's disease (L-CD) includes several clinical and pathological pictures which are manifestations of transmural inflammation. L-CD may affect any portion of the gastrointestinal tract (GI) and in the upper part of GI it has been described in 0.5%-13.0% of all cases of this disease. In the upper part of GI, in the course of L-CD, there appears a considerable variety of endoscopical and morphological pictures. Advances which have been achieved in endoscopic methods, along with very precise histopathological description, allow us to diagnose a greater number of incidences of L-CD in the upper part of GI, compared to previous years.

Crohn Disease↗
PubMed2007

Kit signaling is essential for development and maintenance of interstitial cells of Cajal and electrical rhythmicity in the embryonic gastrointestinal tract.

Interstitial cells of Cajal (ICC) are specialized cells in smooth muscle organs that generate and propagate pacemaker activity, receive inputs from motor neurons, and serve as mechanosensors. In the gastrointestinal tract, development and maintenance of the ICC phenotype have been linked to intracellular signaling via Kit, but its role in development of ICC during embryogenesis is controversial. Here we have studied the development of functional ICC-MY during the late gestational period in mice. Blocking Kit with a neutralizing antibody before and after development of spontaneous electrical activity (E17 to P0) caused loss of ICC-MY networks and pacemaker activity. ICC-MY and pacemaker activity developed normally in W/+ and W(V)/+ heterozygotes, but failed to develop between E17 to P0 in W/W(V) embryos with compromised Kit function. Muscles treated with Kit neutralizing antibody or the tyrosine kinase inhibitor, imatinib mesylate (STI571), from E17-P0 for 3 days caused loss of functionally developed ICC-MY networks, but ICC-MY and pacemaker activity recovered within 9 days after discontinuing treatment with neutralizing antibody or imatinib mesylate. These data suggest that Kit signaling is an important factor in lineage decision and in the development of functional ICC in late gestation. ICC-MY demonstrate significant plasticity in gastrointestinal tissues. Manipulation of the ICC phenotype might provide useful therapies in gastrointestinal disease where the Kit-positive cell population is either lost or amplified.

Animals↗
PubMed1980

Surgical management of carcinoid tumors of the gastrointestinal tract.

Between the years 1950 and 1976, 76 patients with carcinoid tumors of the gastrointestinal tract were seen at the Hines Veterans Administration Hospital, Hines, Illinois; of these, 48 tumors were recognized clinically. Five- and ten-year survivals were 56 and 44 per cent, respectively. The best survivals were seen in patients with carcinoids originating in the appendix, followed by the small bowel, rectum, and then the colon.

Adult↗
PubMed2006

Probiotic properties of Lactobacillus and Bifidobacterium strains isolated from porcine gastrointestinal tract.

One strain of Lactobacillus salivarius, two strains of Lactobacillus reuteri and Lactobacillus amylovorus, and two strains of Bifidobacterium thermacidophilum with antagonistic effect against Clostridium perfringens were isolated from porcine gastrointestinal tract. Isolates were assayed for their ability to survive in synthetic gastric juice at pH 2.5 and were examined for their ability to grow on agar plate containing porcine bile extract. There was a large variation in the survival of the isolates in gastric juice and growth in the medium containing 0.3% (w/v) bile. L. salivarius G11 and L. amylovorus S6 adhered to the HT-29 epithelial cell line. Cell-free supernatant of L. amylovorus S6 showed higher antagonistic activity as effective as the antibiotics such as neomycin, chlortetracycline, and oxytetracycline against bacterial pathogens including C. perfringens, Salmonella typhimurium, Staphylococcus aureus, Vibrio cholerae, Edwardsiella tarda, and Aeromonas salmonicida subsp. salmonicida.

Animals↗
PubMed1993

Expression of the breast cancer-associated protein pS2 in adenosquamous carcinomas of the gastrointestinal tract.

The breast cancer-associated protein pS2 is also present in many human gastrointestinal tumors. In contrast to breast carcinomas, gastrointestinal tumors do not express estrogen receptors, indicating that the expression of pS2 is not estrogen-dependent. The pS2 expression was analyzed in 14 adenosquamous tumors of the human gastrointestinal tract. The aim was to investigate if the cell type specific localization of pS2 was limited to the glandular part. The data clearly confirm such a specific compartmentation of the pS2 expression, suggesting pS2 to be a secreted protein. Due to the specific expression, pS2 may become a new and useful diagnostic marker of adenocarcinoma.

Adenocarcinoma↗