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The gas-chromatographic method is confronted with the amply used colorimetric method in the determination of the urinary oestriol. The two methods give practically the some results, even so the gas-chromatographic is to be preferred for its specificity, for salvaging accuracy, and for the possibility to receive hormonal profiles with only one determination.
We carried the values of the oestrioluria received examining n o 755 samples of urine of women with normal pregnancies using the gas-chromatographic method. The gas-chromatographic method makes possible a "fascia" of normal values superimposable to those received from others AA. with the colorimetric method in the first months of pregnancy, where we have a major tendency to the dispersion of the values in the last months of pregnancy.
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The levels of oestriol in urine of 30 healthy pregnant women in the last 22 to 25 days of pregnancy were determined and the statistical analysis was performed. It was found that the levels of oestriol in urine were the highest in 19-th and 9-th days before labour. This form of curve of oestriol levels was found to be characteristic for pregnant women before normal labour.
The level of oestriol in amniotic fluid was estimated in 17 women in pregnancy and in labour. The correlation between level of oestriol and the time of labour was found. However no influence of foetal sex and weight on the level of oestriol was observed. There was also no correlation between the level of oestriol and placenta weight and the type of employment of these women.
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It is established that during human pregnancy maternal and fetal serum dehydroepiandrosterone sulfate (DHAS), which has been shown to arise mainly by adrenal secretion, serves as a substrate in the biosynthesis of placental oestrogen. The conversion to oestrogen is reflected by decreased DHAS and increased oestrogen concentration in the peripheral maternal blood. Impaired uteroplacental perfusion has been shown to play a role in the pathogenesis of some complicated pregnancies with placenta insufficiency. Apart from this, lower oestrogen, magnesium and zinc levels are found in many of these conditions in the third trimester with placenta insufficiency. In this study, we examined the effect of 4 mg Dexamethasone intravenously on dehydroepiandrosterone sulfate, since materal cortisol or synthetic corticosteroids cross the placental barrier and inhibit the release of dehydroepiandrosterone sulfate in fetal adrenals. Dexamethasone was found to suppress dehydroepiandrosterone sulfate levels in all groups but a significant difference in suppression was found between the Chemiron--a hematinic combination--and the single iron therapy control groups. Our preliminary results showed that Chemiron has a protective effect on the development of placenta insufficiency during the third trimester of pregnancy.
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