Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Data Compression”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,513 records · Page 84Linked to original sources

Lumbar spinal root compression caused by Brucella granuloma.

STUDY DESIGN: A case report of rarely seen extradural brucellosis granuloma causing spinal root compression in the lumbar region. OBJECTIVE: To point out the possibility of extradural compression caused by brucellosis. SUMMARY OF BACKGROUND DATA: Many investigators have indicated that myelopathy or radiculopathy caused by irritation or compression by tiny abscess, disc herniation, or extradural granuloma may occur in brucellosis. Failure to make the correct diagnosis is possible because of the absence of such symptoms of brucellosis as fever, sweating, or fatigue and because findings of physical examination, radiography, and myelography indicate intervertebral disc herniation. METHODS: Review and discussion of the case history are presented. RESULTS: Brucella granuloma compressing the right L5 root and dural sac was diagnosed on computed tomographic scans and was excised subtotally after laminectomy and facetectomy. CONCLUSION: The possibility of extradural compression caused by brucellosis should be considered in endemic areas and must be differentiated from an intervertebral disc herniation by means of agglutination testing and bone scan.

Brucellosis↗

Effects of disc height and distractive forces on graft compression in an anterior cervical discectomy model.

STUDY DESIGN: An in vitro biomechanical study using a calibrated distractor and a subminiature load cell in a cadaver anterior cervical discectomy construct was conducted. OBJECTIVE: To study the interrelations of preoperative disc height, graft height, and compressive and distractive forces in an anterior cervical discectomy model. SUMMARY OF BACKGROUND DATA: The effects of graft size on compressive and distractive forces in a discectomy model remain unknown. Larger grafts afford neural decompression through anterior column distraction. This distraction may subject the graft and vertebral bodies to excessive loads, increasing graft fracture, and subsidence risk. METHODS: Disc height was measured radiographically in 18 specimens. A Smith-Robinson discectomy was performed, and the superior and inferior ends of the specimens were embedded in polyester resin. Distraction was applied through a calibrated Caspar distractor to measure the distractive force applied while steel spacers rigidly fixed to a subminiature load cell were introduced. After distraction was removed, immediate compressive force was measured. RESULTS: Distractive forces of 112.4 N and 189.9 N were required to insert the 6-mm and 8-mm grafts, respectively. When this distractive force was removed, immediate compressive loads of 8.8 N and 21.5 N on the graft were noted. When a compressive load of 45 N was applied in a loading frame, measured graft loads of 16.2 N and 29.2 N also increased. No statistically significant relation was observed between preoperative disc height and distractive force or compression of the graft. Significantly lower distractive and compressive forces were associated with insertion of the 6-mm rather than 8-mm graft. CONCLUSIONS: Significantly higher distractive and compressive forces were recorded with larger grafts. Preoperative disc height was not an accurate predictor of graft loads.

Aged↗

Effectiveness of an ethics course delivered in traditional and non-traditional formats.

This paper details a three-credit-hour undergraduate ethics course that was delivered using traditional, distance, and compressed formats. OLS 263: Ethical Decisions in Leadership is a 200-level course offered by the Department of Organizational Leadership and Supervision in the Purdue School of Engineering and Technology at Indiana University Purdue University Indianapolis (IUPUI). Students in engineering, technology, business, nursing, and other majors take the course. In an effort to determine student perceptions of course and instructor effectiveness, end-of-course student survey data were compared using data from traditional, distance, and compressed sections of the course. In addition, learning outcomes from the final course project were evaluated using a standardized assessment rubric and scores on the course project.

Consumer Behavior↗

Microvascular relations of the trigeminal nerve. An anatomical study with clinical correlation.

The vascular relationships of the trigeminal nerve root entry zone were examined bilaterally in 20 cadavers of individuals known to be free of facial pain. Fourteen of 40 nerves made contact with an artery, but only four of these showed evidence of compression or distortion of the nerve. In addition, the vascular relationships of 40 trigeminal nerves exposed surgically for treatment of trigeminal neuralgia were studied, and 31 nerves showed compression by adjacent arteries. Venous compression was seen in four of the cadaver nerves and in eight nerves from patients with trigeminal neuralgia. These data support the hypothesis that arterial compression of the trigeminal nerve is associated with trigeminal neuralgia.

Humans↗

The venous return simulator: an effective tool for investigating the effects of external compression on the venous hemodynamics--first results after thigh compression.

BACKGROUND: To present a virtual model, the venous return simulator (VRS), designed to compute venous hemodynamic variations when compression is applied to the leg. METHODS: The VRS defines a numerical network of the lower extremity and computes the dynamic variables (flow rate, venous diameter and internal pressure) for a defined external pressure. The VRS was based on physiological data from the literature and clinical studies on healthy subjects. Clinical correlations were required to confirm its validity; for this purpose, we carried out experiments simulating the conditions of a clinical trial, in which the diameter of superficial and deep veins was measured while increasing pressures (20, 40 and 60 mmHg.) were applied to the thighs of patients enduring deep valvular insufficiency and venous ulcers. The diameters and flow rates calculated using our VRS model were compared with the experimental data obtained at the same thigh compression levels. RESULTS: The numerical results of VRS are in good agreement with the clinical data obtained by Duplex, (R2 = 0.96). In accordance with the in vivo measurement the computed results show that only a pressure greater than 40 mmHg is able to reduce the venous diameter at thigh-level, both in the great saphenous vein and in the femoral vein. CONCLUSION: The venous return simulator computes lower limb hemodynamic parameters under static conditions. The good correlation existing between the VRS and the data obtained in a previous clinical study shows that this numerical approach could provide a useful means of predicting the hemodynamic consequences of compression therapy.

Bandages↗

Effect of particle size and compression force on compaction behavior and derived mathematical parameters of compressibility.

PURPOSE: To analyze the influence of inherent densification and deformation properties of paracetamol on the mathematical parameters derived from Heckel, Walker, Kawakita, and Adams equations and to correlate these with single particle nominal fracture strength and bulk compression parameters using confined compression on a fully instrumented rotary tablet press. MATERIALS AND METHODS: Force-displacement data were captured during in-die compression for four different particle size fractions (150-250, 300-450, 500-650, and 700-1,000 microm) of paracetamol each at compression force of 5.2, 8.6, and 17.3 kN. Nominal single particle fracture strength was obtained by micro tensile testing. RESULTS: Apparent mean yield pressure (Py) from Heckel analysis was significantly affected by the applied pressure, and was influenced by elastic energy and Young's modulus. The single particle fracture strength correlated to parameters obtained from Heckel, Walker, Kawakita, and Adams equations. Results obtained from bulk compression and single particle measurements were consistent with, and polynomially related to Py, Kawakita (1/b), and Adams parameter (tau0'). CONCLUSIONS: Values of Py, 1/b, and tau0' obtained from Heckel, Kawakita, and Adams equations, respectively, can be interpreted as a measure of single particle nominal fracture strength during confined compression loading. Walker and Adams parameters were less affected, than Heckel and Kawakita parameters, by the applied pressure.

Acetaminophen↗

Biomechanical evaluation of the percutaneous compression plating system for hip fractures.

OBJECTIVE: To investigate the biomechanical properties of the percutaneous compression plating system for intertrochanteric hip fractures. DESIGN: A biomechanical laboratory investigation on human cadaveric upper femora was conducted. SETTING: Biomechanical laboratory. PATIENTS: Sixteen femora from cadavers of patients aged 60 to 85 years. INTERVENTION: An intertrochanteric fracture was performed along the intertrochanteric line and fixed with the percutaneous compression plating system. MAIN OUTCOME MEASUREMENTS: Postfixation and postcycling bending and torsional stiffnesses, and load to failure at 0, 7, and 25 degrees of adduction. RESULT: The normalized postfixation bending and torsional stiffnesses in the neutral position were 65% and 59%, respectively, and higher with adduction. After percutaneous compression plating fixation, bending stiffness increased to 72% following cyclic loading ( < 0.05). It was comparable to that of similar fixation constructs in the literature, whereas the torsional stiffness was somewhat higher. The mode of failure was distal femoral neck sagging, indicating good femoral head fixation. No varus displacement and cutouts were observed. CONCLUSIONS: Our biomechanical data indicate that the percutaneous compression plating provides adequate bending stiffness and torsional stability. With sliding capability this fixation leads to controlled fracture impaction, which is further enhanced by cyclic loading.

Aged↗

The effect of compressive axial preload on the flexibility of the thoracolumbar spine.

STUDY DESIGN: An in vitro flexibility study of the human thoracolumbar spine under compressive preload. OBJECTIVE: To attain kinematics descriptive of the thoracolumbar spine in vitro by applying a pure bending moment under a range of physiologic compressive preloads. SUMMARY OF BACKGROUND DATA: Many studies on the mechanical behavior of the spine under pure moment have been conducted; however, little is known regarding variations in the range of motion of the thoracolumbar spine attributable to simulated body weight and other physiologic load conditions. METHODS: Five fresh human cadaveric thoracolumbar spine specimens (T9-L3) were used. Five compressive axial preloads ranging from 75 to 975 N were applied to each specimen along the spinal curvature through four adjustable brackets attached to each vertebral body. Flexibility measurements were taken by applying a maximum of 5 Nm pure bending moment to the specimen in flexion and extension. The flexibilities in flexion and extension for each loading case were compared. RESULTS: The thoracolumbar spine supported compressive preloads as much as 975 N without damage or instability in the sagittal plane when the preload was applied along the natural curvature of the spine through estimated centers of rotation. The flexibility in bending (flexion/extension) of the ligamentous thoracolumbar spine decreased with increasing compressive preload. CONCLUSION: A higher bending stiffness was reached after the compressive load exceeded 500 N. Such knowledge could be used to establish better testing guidelines for implant evaluation and more realistic loading conditions.

Aged↗

Pulmonary surfactant protein C containing lipid films at the air-water interface as a model for the surface of lung alveoli.

The pulmonary surfactant lines as a complex monolayer of lipids and proteins the alveolar epithelial surface. The monolayer dynamically adapts the surface tension of this interface to the varying surface areas during inhalation and exhalation. Its presence in the alveoli is thus a prerequisite for a proper lung function. The lipid moiety represents about 90% of the surfactant and contains mainly dipalmitoylphosphatidylcholine (DPPC) and phosphatidylglycerol (PG). The surfactant proteins involved in the surface tension adaption are called SP-A, SP-B and SP-C. The aim of the present investigation is to analyse the properties of monolayer films made from pure SP-C and from mixtures of DPPC, DPPG and SP-C in order to mimic the surfactant monolayer with minimal compositional requirement. Pressure-area diagrams were taken. Ellipsometric measurements at the air-water interface of a Langmuir film balance allowed measurement of the changes in monolayer thickness upon compression. Isotherms of pure SP-C monolayers exhibit a plateau between 22 and 25 mN/m. A further plateau is reached at higher compression. Structures of the monolayer formed during compression are reversible during expansion. Together with ellipsometric data which show a stepwise increase in film thickness (coverage) during compression, we conclude that pure SP-C films rearrange reversibly into multilayers of homogenous thickness. Lipid monolayers collapse locally and irreversibly if films are compressed to approximately 0.4 nm2/molecule. In contrast, mixed DPPG/SP-C monolayers with less than 5 mol% protein collapse in a controlled and reversible way. The pressure-area diagrams exhibit a plateau at 20 mN/m, indicating partial demixing of SP-C and DPPG.(ABSTRACT TRUNCATED AT 250 WORDS)

Air↗

Lumbar sagittal contour after posterior interbody fusion: threaded devices alone versus vertical cages plus posterior instrumentation.

STUDY DESIGN: An observational radiographic study examining lumbar sagittal contour of patients undergoing posterior interbody arthrodesis. OBJECTIVES: To compare operative alterations of lumbar sagittal contour after posterior interbody fusion using threaded interbody devices alone versus vertical cages combined with posterior compression instrumentation. SUMMARY OF BACKGROUND DATA: Technique-related alterations of lumbar sagittal contour during interbody arthrodesis have received little attention in the spinal literature. METHODS: Standing lumbar radiographs were measured for preoperative and postoperative segmental lordosis at levels undergoing posterior interbody arthrodesis using either stand-alone side-by-side threaded devices or vertical cages combined with posterior transpedicular compression instrumentation. Sagittal plane segmental correction (or loss of correction) was calculated and statistically compared. RESULTS: The radiographs of 30 patients (34 spinal segments) undergoing lumbar or lumbosacral arthrodesis were compared. Seventeen patients (18 segments) had undergone interbody fusion using threaded cages,whereas 13 patients (16 segments) underwent fusion using vertically oriented mesh cages combined with posterior compression instrumentation. Preoperative segmental lordosis averaged 8 degrees for both groups. For patients undergoing fusion with threaded cages, there was a mean lordotic loss of 3 degrees/segment. For patients undergoing fusion with vertically oriented mesh cages combined with posterior compression instrumentation,there was a mean lordotic gain of 5 degrees/segment. This difference in segmental sagittal plane contour was highly significant (P = 0.00). CONCLUSION: Threaded fusion devices placed under interbody distraction with the endplates parallel fail to preserve or reestablish segmental lordosis. Vertical cages, however, when combined with posterior compression instrumentation, not only maintain segmental lordosis, but also can correct sagittal plane deformity.

Humans↗

Lossy compression in nuclear medicine images.

The goal of image compression is to reduce the amount of data needed to represent images. In medical applications, it is not desirable to lose any information and thus lossless compression methods are often used. However, medical imaging systems have intrinsic noise associated to it. The application of a lossy technique, which acts as a low pass filter, reduces the amount of data at a higher rate without any noticeable loss in the information contained in the images. We have compressed images of nuclear medicine using the discrete cosine transform algorithm. The decompressed images were considered reliable for visual inspection. Furthermore, a parameter was computed from these images and no discernible change was found from the results obtained using the original uncompressed images.

Algorithms↗

BRAVO/TeleTrend: a comprehensive WWW-based neuromonitoring system for the neurosurgery ICU.

This paper describes BRAVO/TeleTrend--a comprehensive client/server-based system for remote access, review and analyses of continuously acquired multiparametric physiological data from Intensive Care unit (ICU) patients. The system is designed as a distributed three tier model and implemented in Java (Sun Microsystems). TeleTrend is a data review package, which interfaces to existing physiological bedside monitors such as the BRAVO suite of products (Nicolet Biomedical, Madison, WI) and the vital signs monitors compatible with the Unity Network (Marquette Electronics, Milwaukee, WI). It does not transfer over the web the entire patient record, which can be hundreds of megabytes. Instead, it provides tools to view a compressed representation of the raw data in a trend display and to zoom into the raw data if needed. Thus, it eliminates the need for a high-bandwidth Internet connection and makes possible the use of a slower modem access to the vast amount of physiological data acquired per patient. In addition, TeleTrend features a rule-based module capable of generating clinical alerts, which is a potentially useful tool for neurointensivists and other critical care personnel. Finally, TeleTrend is intended as a multi-user, semi real-time telemedical application, which features built-in white-board and chat components. These components allow several physicians at different locations around the world to simultaneously view and brainstorm over critical chunks of continuously recorded raw and trend data. By allowing the end-user user to switch on-the-fly from monitoring patients in one ICU to those in another, and by integrating an HL7 interface TeleTrend steps over the boundaries of a single ICU. Thus, it can be provide a medical enterprise-wide solution to the remote access of an important component of the electronic patient medical record. Currently in house validation, verification and alpha testing of the system are underway.

Electroencephalography↗

[The pelvic digital image data bank. Experiences after 18 months in clinical practice].

The simultaneous availability of clinical data and radiographs for orthopedic or traumatology studies is still unsatisfactory. The retrieval of radiological files is especially time-consuming and costly. An existing database holding clinical data for about 2200 consecutive patients after pelvic or acetabular fractures (1972-1995) was supplemented by integration of a commercially available picture database. Data acquisition is performed by a digital photo camera, which is easy to use and provides sufficient resolution (1524 x 1012 pixels). The picture data are optimized but not compressed and, for example, an a.p. pelvic view requires only between 800 KB and 1.5 MB of storage room. Mass storage is performed first on magneto-optical discs and later for permanent storage on CD-ROM. "Clinical" and picture databases are linked by a macro, so the search functions of both databases are available. Thus the clinical data for single patients or group of patients can be analyzed parallel to the corresponding radiographs. By the use of a CD changer, more than 4200 radiographs remain in immediate access. So far more than 3000 radiographs for 350 patients have been acquired. The quality was sufficient for even detailed subclassification and reclassification procedures in over 95% of the cases. Using standard formats and interfaces, the pictures can be either printed in photographic quality or processed as slides for presentation. Using a standard format they have complete access to electronic publishing and mailing. The relatively low price (20,000-30,000 DM) for the complete system and the exclusive use of standard, commercially available hard and software components provide an excellent price/quality relationship and make digital radiograph storage now available for smaller working groups and institutions.

Acetabulum↗

Variation in patient routine costliness in U.S. psychiatric facilities.

BACKGROUND: The Balanced Budget Refinement Act of 1999 included a Congressional mandate to develop a patient-level case mix prospective payment system (PPS) for all Medicare beneficiaries treated in PPS-exempt psychiatric facilities. Payment levels by case mix category have been proposed by the government based on claims and facility cost reports. Because of claims data limitations, these levels do not account for patient-specific staffing costs within a facility's routine units, nor are certain key patient characteristics considered for higher payment. AIMS OF THE STUDY: This study uses novel primary data to quantify heretofore unmeasured differences in daily staffing intensity on routine units among Medicare patients. The data are used to test for compression (or narrowing) in case mix payment weights that would result from using only Medicare claims and facility cost reports to quantify daily routine costliness. METHODS: Primary data on patient and staff times in over 20 activities were collected from 40 psychiatric facilities and 66 psychiatric units, nation-wide. Patient times were reported on all inpatients on each shift over a 7-day study period. A resource intensity measure (in Registered Nurse (RN)-equivalent minutes) was constructed on a daily basis for 4,149 Medicare and 4,667 non-Medicare patient days. The routine measure is converted into daily cost using cost report per diems and ancillary costs added using submitted claims. Descriptive tables isolate key cost drivers for Medicare patients. Classification and Regression Trees (CART) clustering identifies 16 potential case mix groups. Multivariate regression is used to compare case mix, day-of-stay, and facility effects using 4 alternative measures of daily routine and ancillary costs. RESULTS: Patient daily routine intensity of care is found to vary by a factor of 3 or more between the top and bottom 10% of days. Medicare patient days were 12.5% more staff intensive than non-Medicare days, which may have been due to age and other differences. Older dementia and "residual diagnosis" patients are more intensive while schizophrenia and substance-related patients are less intensive. Age, psychiatric and medical severity, deficits in Activities in Daily Living (ADLs), dangerous behaviors, and electroconvulsive therapy (ECT) also contribute substantially to higher staffing intensity. Other patient characteristics were insignificant within broad diagnostic groups. Routine costs based on a single facility per diem produced narrower case mix cost differences--often by a factor of 2 or more--for 10 of 12 groups with significantly higher costs. Adding patient-specific ancillary to uniform per diem costs only marginally decompressed costs. Day of-stay costs were similarly compressed when using only cost reports. DISCUSSION: Claims-based costing using Medicare cost reports unduly compresses (narrows) estimates of inter-group case mix cost differences. Also, by not capturing ADL deficits and dangerous behaviors, administrative data sets fail to identify small, but very resource intensive, patient groups. ECT treatment regimens, although rare, significantly increase costs on a daily basis. IMPLICATIONS FOR HEALTH POLICIES: Medicare's recently proposed prospective payment system for psychiatric inpatients uses claims-based costing methods based on widely available administrative data. Consequently, fewer high cost groups are identified due to non-reported patient characteristics such as ADL deficits. Moreover, inter-group relative cost differences are likely understated. It is also possible that any standardized dollar amount applied to group relative weights is understated because Medicare patients appear more intensive per day on routine units. IMPLICATIONS FOR FUTURE RESEARCH: Larger primary samples of special psychiatric units (e.g., med-psych, child/adolescent) could improve estimates of daily routine costliness. Larger samples could also support stronger tests of case mix and cost differences by facility type and teaching status. Medical records information on non-Medicare patients could quantify any systematic differences in average daily costs holding case mix constant. Similar primary studies of psychiatric patients treated outside PPS-exempt units in acute general hospitals could result in a fully integrated payment system for all mentally ill Medicare patients, thereby avoiding payment inefficiencies and inequities.

Activities of Daily Living↗

[Tophaceous gout of the cervical spine, causing cord compression. Case report and review of the literature].

We present the case of a 74-year-old patient with long-standing gout who developed C4-C5 tophaceous gout causing cord compression. The patient had undergone 4 years earlier for a disco-osteophytic cord compression (anterior C4-C5 and C5-C6 discectomy). When admitted, the patient presented quadriparesia which had developed during the previous week in association with acute tophaceous gout on the knees, and the metarsophalangeal articulations, in the context of a bronchial infection. The diagnosis of spondylodiscitis was initially retained because of the clinical features of severe infection and the radiological data (C4-C5 cord compression, with anterior epidural lesions in MRI). The intervention allowed decompression and pathological diagnosis of tophaceous gout. Spinal gout is well-known, and very rarely responsible for cord compression: only 15 cases of cervical gout have been described in the literature. Radiological findings are not specific, and treatment is surgical in the event of medullar compression despite medical treatment.

Aged↗

Compression injury of mammalian spinal cord in vitro and the dynamics of action potential conduction failure.

1. White matter strips from the ventral spinal cord of adult guinea pigs were isolated in vitro, and their electrophysiological characteristics and response to controlled focal compression injury were examined. A double sucrose gap technique was used for stimulation and recording at opposite ends of a 12.5 mm-diam central well superfused with oxygenated Krebs solution. 2. The compound action potential recorded with the sucrose gap was similar in form to single fiber potentials recorded with intra-axonal electrodes, including the presence of a prolonged depolarizing afterpotential. 3. Three types of conduction block resulting from compression were identified: an immediate, spontaneously reversible component, which may result from a transient increase in membrane permeability and consequent disturbance of ionic distribution; a second component that was irreversible within 1-2 h of recording, perhaps resulting from complete axolemmal disruption; and a third component, which may have been due to disruption of the myelin sheath, that appeared to be reversible with application of 10-100 microM of the potassium channel blocker 4-aminopyridine. 4. Conduction deficits--decreased amplitude and increased latency of the compound potential--were stable between 5 and 60 min postinjury, and their intensity corellated with the extent of initial compression over a full range of severity. 5. Stimulus-response data indicate that mechanical damage to axons in compression was evenly distributed across the caliber spectrum, suggesting that the susceptibility of large caliber axons seen histopathologically after injury in vivo may be based on delayed, secondary processes. 6. The model provides the ability to monitor changes in the properties of central myelinated axons after compression injury in the absence of pathological variables related to vascular damage. This initial investigation found no evidence of secondary deterioration of axons in the 1st h after injury, although there was evidence of both transient and lasting mechanical damage to axons and their myelin sheaths.

4-Aminopyridine↗

Compressive properties of mouse articular cartilage determined in a novel micro-indentation test method and biphasic finite element model.

The mechanical properties of articular cartilage serve as important measures of tissue function or degeneration, and are known to change significantly with osteoarthritis. Interest in small animal and mouse models of osteoarthritis has increased as studies reveal the importance of genetic background in determining predisposition to osteoarthritis. While indentation testing provides a method of determining cartilage mechanical properties in situ, it has been of limited value in studying mouse joints due to the relatively small size of the joint and thickness of the cartilage layer. In this study, we developed a micro-indentation testing system to determine the compressive and biphasic mechanical properties of cartilage in the small joints of the mouse. A nonlinear optimization program employing a genetic algorithm for parameter estimation, combined with a biphasic finite element model of the micro-indentation test, was developed to obtain the biphasic, compressive material properties of articular cartilage. The creep response and material properties of lateral tibial plateau cartilage were obtained for wild-type mouse knee joints, by the micro-indentation testing and optimization algorithm. The newly developed genetic algorithm was found to be efficient and accurate when used with the finite element simulations for nonlinear optimization to the experimental creep data. The biphasic mechanical properties of mouse cartilage in compression (average values: Young's modulus, 2.0 MPa; Poisson's ratio, 0.20; and hydraulic permeability, 1.1 x 10(-16) m4/N-s) were found to be of similar orders of magnitude as previous findings for other animal cartilages, including human, bovine, rat, and rabbit and demonstrate the utility of the new test methods. This study provides the first available data for biphasic compressive properties in mouse cartilage and suggests a promising method for detecting altered cartilage mechanics in small animal models of osteoarthritis.

Animals↗

Lumbar spine mechanical response to axial compression load in vivo.

STUDY DESIGN: Lumbar spine kinematic response to a 1.0 body weight compressive load was measured in vivo by comparison of relaxed and loaded magnetic resonance image sets in the sagittal plane. OBJECTIVES: To identify and measure acute response mechanisms of the lumbar spine during compression loading. SUMMARY OF BACKGROUND DATA: The isolated ligamentous spine buckles under small loads (88 N); yet, the spine supports >10 times that load in daily activities. Mechanical function of the lumbar spine in vivo is not well understood, and only a few studies examined the spine during in vivo loading. METHODS: Magnetic resonance imaging scans of subjects were taken while subjects were relaxed and while supporting a 1.0 body weight compressive load. Vertebral bodies and disc perimeters were digitized, and relative centroid positions were measured and compared between conditions. Lumbar rotation, bending, compression, and disc translation were determined. Two parameter ensembles were analyzed to describe mechanisms of "spine shrinkage" (decrease of projected spine length) and lumbosacral response. RESULTS: All subjects underwent spine shrinkage (-3.9 +/- 1.2 mm) dominated by cumulative bending, except in three subjects where the rotation component dominated. Levels L2-L4 extended, while L5 flexed, and dL2 through dL4 translated anterior, while dL5 translated posterior. Significant segmental deformations were as follows: L3 extension (-3.3 +/- 3.1 degrees ), dL5 disc translation (-1.4 +/- 1.4 mm), and posterior sacral rotation (3.2 +/- 4.7 degrees ). CONCLUSIONS: Spine shrinkage occurred mainly from spine bending and rotation, with only small contribution from spine compression (shortening along the spine curvature). Response pattern groupings indicated at least two unique subgroups, but the cause remains to be determined.

Adult↗