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PubMed2003

Renal hemodynamic and tubular responses to salt in women using oral contraceptives.

BACKGROUND: The use of oral contraceptives is associated with an increased risk of developing hypertension but the mechanisms of this hypertensive effect are not completely defined. The purpose of the present study was to assess prospectively the systemic and renal hemodynamic and tubular responses to salt in women taking oral contraceptives. METHODS: Twenty seven young healthy normotensive women taking oral contraceptives containing monophasic combination of 30 microg ethynilestradiol and 150 microg desogestrel for>6 months were enrolled. All women were assigned at random to receive a low (40 mmol/day) or a high (250 mmol/day) sodium diet for 1 week on two consecutive menstrual cycles during the active oral contraceptive phase. At the end of each diet period, 24-hour ambulatory blood pressure, renal hemodynamics, sodium handling, and hormonal profile were measured. RESULTS: The blood pressure response to salt on oral contraceptives was characterized by a salt-resistant pattern with a normal circadian rhythm. Salt loading results in an increase in glomerular filtration rate (GFR) (P < 0.05 vs. low salt), with no change in the renal plasma flow, thus leading to an increase in the filtration fraction (P < 0.05). At the tubular level, women on oral contraceptives responded to a low salt intake with a marked increased in proximal sodium conservation (P < 0.01 vs. high salt) and with an almost complete reabsorption of sodium reaching the distal tubule. After sodium loading, both the proximal and the distal reabsorption of sodium decreased significantly (P < 0.01). CONCLUSION: The use of oral contraceptives is not associated with an increased blood pressure response to salt in young normotensive women. However, oral contraceptives affect the renal hemodynamic response to salt, a high salt intake leading to an increase in GFR and filtration fraction. This effect is possibly mediated by the estrogen-induced activation of the renin-angiotensin system. Oral contraceptives also appear to increase the tubular responsiveness to changes in sodium intake. Taken together, these data point out evidence that synthetic sex steroids have a significant impact on renal function in women. The renal effects of oral contraceptives should be taken into account when managing young women with renal diseases.

Adult↗
PubMed2003

Association of hormonal contraception and HIV-seroprevalence in Nairobi, Kenya.

Among women attending family planning clinics in Nairobi, Kenya, the HIV-seroprevalence rates for different contraceptive methods were: depomedroxyprogesterone acetate (DMPA) 431/3279 (13.1%), combination oral contraceptive pill 114/1073 (10.6%), and progesterone-only contraceptive pill (POCP) 45/741 (6.1%). After adjusting for age, marital status, and parity, women using the POCP had a lower HIV seroprevalence (adjusted odds ratio 0.5, 95% confidence interval 0.3-0.7) than women using DMPA. This association was most pronounced among POCP users of lower parity.

Adolescent↗
PubMedDate not supplied

Female sexual health problems in a drug dependency unit.

The Government of the United Kingdom has produced a strategic plan called the Health of the Nation aimed at achieving better health in key areas including a reduction in rates of unwanted pregnancies, sexually transmitted diseases and cervical cancer. Conventional health care systems fail some groups with special needs. This cross-sectional interview study was undertaken to determine the level and type of contraceptive use, and the attitudes of female opiate abusers to the use and availability of contraceptives and cytology services. The subjects were 201 opiate-dependent women enrolled in a methadone maintenance programme in a large drug dependency unit: 169 (84.5%) were sexually active and 65 (44.2%) of non-pregnant sexually active women did not use a contraceptive method. Thirty-six (43.9%) of those using a contraceptive were using condoms, with which the majority were dissatisfied. Sixty-one (30.3%) had never had a cervical cytology smear and of those who had, 21.4% reported an abnormal result. The contraceptive practices and uptake of cervical screening services by the women studied are inadequate, reflecting poor use of conventional health care services. In addition to providing information on safer sexual practices, particularly promotion of condom use, we suggest that drug dependency units should expand their role to provide educational and preventative services to include aspects of women's health.

Adolescent↗
PubMed2005

Predictors of men's acceptance of modern contraceptive practice: study in rural Vietnam.

Studies have shown family planning adoption is likely to be more effective for women when men are actively involved. The transtheoretical model of behavior change was used to examine men's involvement in general contraception and intrauterine device (IUD) use by their wives. The study was carried out in rural Vietnam with 651 eligible participants. Cons of IUD use for men in precontemplation and contemplation/preparation were significantly higher than those in the action/maintenance stages, whereas the reverse was true for pros of IUD. The self-efficacy for convincing wife to have IUD in precontemplation was significantly lower than for those in higher stages. Women's education and ages, spontaneous recall of modern contraceptive method, cons for IUD, and self-efficacy for contraception and for convincing wives to get IUD inserted (or continue use) were significant predictors of men's readiness to accept IUD. Interventions are targeted to reduce cons and increase self-efficacy for IUD use.

Adult↗
PubMed2006

Working women and contraception: History, health, and choices.

Contraception is not a new concept. Historically, various contraceptive methods and practices have been used throughout the world. Contraception is often a topic of great interest to working women because family planning helps them balance work and home more effectively. Occupational health nurses can play a vital role in supporting these women by providing education regarding health, contraception, and contraceptive choices.

Choice Behavior↗
PubMed2002

Emergency contraception (post-coital Contraception).

Emergency Contraception is a post-coital contraceptive for women who have had unprotected intercourse or have reason to believe that their contraceptive method has failed. The article focuses mainly on Emergency Contraceptive Pills (ECPs) because they are the most frequently used form of post-coital contraception. In 1997 the FDA approved the "off-label" use of high dose of oral contraceptives for use as post-coital contraception. Since then, they have been approved for repackaging and marketed solely for use as post-coital emergency contraception. The first dose of ECPs must be administered within 72 hours of the act of unprotected intercourse. The second dose is taken 12 hours later. ECPs are believed to work in one of three ways depending on where the woman is in her menstrual cycle when she seeks treatment. It can delay or prevent ovulation, impair formation of the corpus luteum, or cause histological or biochemical changes within the endometrium, thus preventing implantation. Their effectiveness is approximately 75%, being most effective when administered as quickly as possible after the act of unprotected intercourse. The pills can cause nausea and vomiting, so the pre-administration of an anti-emetic may help alleviate these symptoms. A major issue concerning the ECPs is the lack of knowledge and availability. Very few health-care providers discuss ECPs with their patients. Most people cited the media as the primary source of information. The 72-hour window in which the ECPs must be administered makes it important for women to have easy access to these post-coital contraceptives. However, women who seek treatment will often find that their health-care provider will require a physical exam and/or a pregnancy test before writing a prescription. Yet, studies show that ECPs do not affect an implanted fetus, and there are no emergency contraceptive protocols that require pregnancy tests or physical exams prior to treatment. The AMA is encouraging physicians to better educate their patients about emergency contraceptives. Several health-care organizations are encouraging providers to supply women with an advance prescription for ECPs so that they will have immediate access to them, especially since most acts of unprotected intercourse occur at night or on weekends, when most clinics are closed. There is a possibility that ECPs might be available over-the-counter for women to have better access to the emergency contraceptive pills.

Consumer Product Safety↗
PubMed1983

Postmolar trophoblastic disease in women using hormonal contraception with and without estrogen.

One hundred thirteen patients with a molar pregnancy evacuated from January 5, 1976, through February 15, 1980, had close follow-up at the Los Angeles County-University of Southern California Women's Hospital. Twenty-seven patients (23.9%) developed postmolar trophoblastic disease, all of whom achieved remission with treatment. Of the 113 patients, 71 (62.8%) used only oral contraceptives, 32 patients (28.3%) used only intramuscular medroxyprogesterone acetate, seven patients (6.2%) used both oral contraceptives and medroxyprogesterone acetate, and three patients (2.7%) used nonhormonal contraception after evacuation of their molar pregnancy and before titer remission. Analysis of significant clinical and laboratory correlates of postmolar trophoblastic disease for the study group revealed no substantial bias in assignment of contraceptive method. There was no significant difference between the oral contraceptive and the medroxyprogesterone acetate groups with respect to the development of postmolar trophoblastic disease or the time to spontaneous titer remission. The study shows no apparent adverse effect of the estrogen (50 mg mestranol) component in oral contraceptives on the frequency of postmolar trophoblastic disease.

Chorionic Gonadotropin↗
PubMed1994

[Prevention of conception in adolescence].

The adolescent girl needs affection and understanding for all of her problems. She often does not find a satisfying measure of both in her familiar surroundings. Very often sex instruction is faulty, although the AIDS campaigns have led to remarkable improvements (condoms). Instructions for sexual behaviour should take place at home or at school, but not in the street. Nevertheless, the first intercourse occurs mostly unprotected. Teenage pregnancies present not only physical but also psychological problems. Termination of pregnancy means an especially difficult decision for the adolescent girl, often causes crisis and occasionally leads to negative consequences for later fertility. The choice of appropriate contraceptive methods for girls under 16 years of age may also have legal problems. Condoms and barrier methods are possible alternatives to the much safer hormonal contraception with the combination, sequence or minipill. Under certain circumstances, a progestin injection every three months or the 'morning-after pill' as postcoital contraception or, in the case of an abortion or of pregnancy termination, even an intrauterine device can be an alternative for adolescent girls under those exceptional circumstances.

Abortion, Induced↗
PubMed1976

[Side-effects of oral contraceptives under psychological-sociological aspects. Results of an empirical study on 345 women].

Do women without experience in taking oral contraceptives expect more side-effects than women, who use this contraceptive method, ever experienced? This question was examined on 345 women in pregnancy and childbed Psychological and sociological data, as personality factors, general well-being, school education, intelligence and age were evaluated. The attitude towards the pill depended on the families opinion of the pill, fear of cancer, knowledge about the pill and experience of menstruation. Half of the women had never taken the pill. Those women expected more side-effects than women, who had taken the pill had experienced (p less than 0,05). Those women who had never taken the pill stated frequently, that their partner (p less than 0,001) and mother (p less than 0,001) rejected the pill. Three fourth of women without experiences in taking the pill doubted thepill to be safe. Two thirds of these women were anxious the pill might cause cancer. Four fifth of the questioned women thought a pregnancy would mean more stress than taking the pill, women without experience in taking the pill more frequently thought the pill to be more disturbing (p less than 0,01). Women who had never taken the pill, suffered more often from reduced well-being (p less than 0,05) and were also more often introverted (p less than 0,1). The more irregular and painful menstruations were, the more women accepted the pill (p less than 0,01). Women with experience in taking the pill had often higher intelligence (p less than 0,05) and a higher education level (p less than 0,01). This is important for the interpretation of the results. The results were statistically checked by the x2-method.

Conditioning, Psychological↗
PubMed1992

The progestin-only oral contraceptive--its place in postpartum contraception.

The progestin-only oral contraceptive (POC) is not a widely-used method of contraception, possibly due to competition from other contemporary contraceptive methods or misunderstanding and prejudices among clients and/or service providers. Because of its underuse, the POC, as a contraceptive method, is under-studied. This article evaluates the general merits of the POC and its disadvantages relative to combined oral contraceptives (COCs) and other contraceptive methods, specifically during the postpartum period and particularly for breastfeeding women. We find that the POC appears to be a safe and acceptable contraceptive method for postpartum women who are fully or nearly fully breastfeeding at six months postpartum or when menstruation returns. The POC could be considered for use at any time by non-breastfeeding postpartum women. The need for empirical studies of the POC is also discussed.

Contraception↗
PubMed1986

Contraception with the cervical cap: effectiveness, safety, continuity of use, and user satisfaction.

With the growing interest in barrier contraceptive methods, the cervical cap has come back into use in North America. We examined the cap's effectiveness, safety, continuity of use, and user satisfaction among 617 women who were fitted at a family planning clinic in Toronto, Canada, between May 1981 and November 1983. Follow-up information was available for 516 of these women. Using a life table analysis with Bayesian adjustment, the probability of becoming pregnant after 12 months of use was 0.166 with a standard error of 0.022. There is evidence that after 1 year of use the caps deteriorate and that this deterioration may increase the risk of pregnancy. Many of the women in this study were very satisfied with the cervical cap; however, such problems as dislodgement, discomfort to user and partner, difficulty with insertion and removal, and unpleasant odour affected acceptability and continuity of use. It is likely that these problems could be alleviated by improving the quality of or changing the materials, modifying the design to improve the fit, and providing a greater range of sizes.

Adolescent↗
PubMed1999

[A randomized multicentre clinical trial on different doses of mifepristone alone and in combination with anordrin as emergency contraception].

OBJECTIVES: To investigate the effectiveness and side-effects of different doses of mifepristone alone or in combination with anordrin given orally within 96 hours after unprotected intercourse as an emergency contraceptive. METHODS: 2,400 cases of healthy women were recruited and allocated randomly in 4 groups: single dose of 25 mg mifepristone, 25 mg mifepristone plus 7.5 mg anordrin, 10 mg mifepristone plus 5 mg anordrin and 10 mg mifepristone alone. The efficacy rates of contraception were estimated according to Dixon method. RESULTS: The total expected number of pregnancy was 171.9 for 2,387 subjects enrolled in the study. The number of observed pregnancies related to method failure was 32 cases. The contraceptive effectiveness rates for the above 4 groups were 80.9%, 85.3%, 90.6% and 67.3%, respectively. For the group received 10 mg mifepristone plus 5 mg anordrin, pregnancy rate was 0.7% which was significantly lower than that in 10 mg mifepristone alone group (2.2%, P < 0.05). The incidences of withdrawal bleeding were 9.2%, 4.9%, 3.4% and 6.7% for the 4 group respectively. Two groups received mifepristone in combination with anordrin showed significant lower incidence of withdrawal bleeding than those in mifepristone alone groups. CONCLUSION: Single oral administration of 25 mg mifepristone alone, and the combination of 10 mg mifepristone plus 5 mg anordrin were safe and effective treatment regimen for emergency contraception with no serious adverse reaction and disturbance on menstrual pattern.

Adolescent↗
PubMedDate not supplied

Beliefs related to the use of oral contraceptives by African American women, ages 18-35.

This study looked at modal, salient beliefs regarding intention to use and use of oral contraceptives (OC) in a group of African American women aged 18-35 in a midwest urban community. Data were collected in face-to-face audio taped interviews using a format devised by Ajzen and Fishbein. Questions related to the identified behavior of deliberate action to avoid unwanted pregnancy by instituting the use of a contraceptive method. Twenty-five women consented to participate. Of these, 20 women (80%) reported using oral contraceptives as their primary birth control method. The study reports on women's perceptions of the advantages and disadvantages of OC acquisition and use and important social referents approving or disapproving of OC acquisition and use. Perceived barriers and facilitators to OC acquisition and use are also reported. Identification of individual and group attitudes regarding contraceptive behavior may be valuable in enhancing the provision of successful family planning services to women wishing to avoid delay of childbearing.

Adult↗
PubMedDate not supplied

Seroprevalence of human immunodeficiency virus type I (HIV-1) antibodies in a family-planning population.

Blind testing of 743 women who attended an inner-city hospital family-planning clinic showed 8 (1.1%) patients to have serum antibodies to human immunodeficiency virus type I (HIV-1). A retrospective chart survey did not show an association between HIV-1 antibody seropositivity and ethnicity, marital status, education, history of sexually transmitted diseases, drug and/or alcohol use, and contraceptive method. This failure to establish previously reported correlation may be a function of methods, sample size, or reflect a different population. Nonetheless, the seroprevalence the authors found shows that all patients in a family-planning clinic setting should be offered HIV-1 antibody testing.

Adult↗
PubMed2002

Hormones and weight change.

Dysregulation of body weight has been a common complaint of women on hormonal contraception but an inconsistent event in controlled clinical studies. In a prospective trial to evaluate the relationship between depot medroxyprogesterone acetate (DMPA) and change in energy intake, energy expenditure and weight change, no effect from DMPA could be documented. These results refute a causal relationship between use of DPMA and increased weight. While weight gain and use of contraception may be common concomitant events in a population with a substantial propensity for weight fluctuation, the objective data suggest that factors other than contraceptive method are important. The controlled data have major implications for appropriate management and counseling of women seeking a highly effective method of protection against pregnancy.

Contraceptive Agents, Female↗
PubMedDate not supplied

The effectiveness of contingency-planning counseling.

A longitudinal study assessed the effectiveness of contingency-planning counselling on contraceptive use and pregnancy outcomes among patients at a family planning clinic. Of 914 women enrolled in the study, 502 received traditional family planning counseling that focused on the provision of information and the selection of a contraceptive method, and 412 received contingency-planning counseling, which provided additional attention to possible problems that might arise with contraceptive use and the particular method selected. Although contingency-planning counseling was favorably received by both patients and staff members, patients in the two groups did not differ significantly on most of the outcomes considered. The two counseling groups had remarkably similar rates of clinic continuation at both the six- and 12-month follow-ups and analogous patterns of contraceptive use. In an exception to this pattern, the six-month pregnancy rate was significantly reduced among contingency-counseled patients who had ever been pregnant. However, the effectiveness of the intervention in reducing the likelihood of unintended pregnancy was short-lived: At 12 months, the pregnancy rate among ever-pregnant women was the same for traditionally counseled patients as for those receiving contingency-planning counseling.

Counseling↗
PubMed1993

Male fertility regulation: the challenges for the year 2000.

The search for new, safe, effective and reversible contraceptive methods for men is being pursued by several agencies. The most likely developments before the year 2000 would appear to be: the introduction of more easily reversed procedures of vas occlusion; hormonal means of sperm suppression based on infrequent injections of androgens either alone or combined with other gonadotrophin-suppressing agents. Methods based on new drugs or vaccines are unlikely to be developed by the end of the decade. Research is needed to understand the basis of the differences in efficacy of contraceptive steroids in men of different ethnic origin. Equally there is a need to monitor the safety and acceptability of hormonal methods for men. New targets for drug intervention should be pursued through support of basic science, taking advantage of modern cellular and molecular biological techniques. Finally, the subject of Andrology needs to be strengthened throughout the world so that scientists in developing countries can participate fully in this work.

Contraception↗
PubMed1977

Sexuality and contraceptive acceptability.

A woman's sexuality may influence the particular choice and acceptance of a contraceptive method which, in turn, may also affect her sexual response. The type of contraceptive recommended should be determined following both physical and psychological assessment of the woman. A method that is not psychologically acceptance is likely to result in discontinuation. Positive and negative effects of the oral contraceptive pill are considered. Pharmacologically induced symptoms are difficult to specify. There appears to be a much greater incidence of psychological problems.

Animals↗