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At least 1,513 records · Page 84Linked to original sources
PubMed1977

[Care for single paraplegics by conscentious objectors (author's transl)].

A practical example shows that the rehabilitation of a single, dependent paraplegic cannot be terminated with the completion of the medical rehabilitation phase and the provision of an adequate job. The complete integration necessitates well organized care and assistance. In the described case this has been achieved by personal initiative, because for this problem complex there is a gap in the state rehabilitation system. Private care by conscentious objectors is described and put to discussion.

Activities of Daily Living↗
PubMed1988

Role of protein kinase C (PKC) in short- and long-term cellular responses: inhibition of agonist-mediated calcium transients and down-regulation of PKC.

Active tumor promoters such as 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or membrane-diffusible synthetic diacylglycerols such as 1,2-dioctanoyl-sn-glycerol (DiC8), which specifically activate protein kinase C (PKC), inhibited the agonist-mediated rise in cytosolic calcium [(Ca2+)i] in a mast cell line (PB-3c) and human platelets. TPA inhibition of agonist-mediated calcium transient in platelets was readily reversed by the PKC inhibitor staurosporine. In contrast to DiCs, only active tumor promoters induced a time- and dose-dependent translocation of cytosolic PKC to membranes as determined both enzymatically or by immunoblotting. However, the concentration of TPA required to induce a half-maximal subcellular redistribution of immunodetectable PKC activity was an order of magnitude greater than the half-maximal dose required to inhibit the intracellular rise in (Ca2+)i. Thus, activation of PKC seems not to be exclusively coupled to its translocation to membranes, suggesting that translocation of PKC is mainly involved in the down-regulation of PKC. Down-regulation of immunoprecipitable PKC was studied in various human breast cancer cell lines that display differential growth inhibitory responses toward the tumor promoter. TPA induced translocation of [35S]methionine-prelabeled cytosolic 80 kDa PKC to membranes followed by complete degradation of the enzyme (t1/2 = 2 h) without affecting PKC synthesis. During prolonged TPA exposure, 20-80% of total 80 kDa PKC of control cells was still synthetized as a membrane-bound 74/80 kDa PKC doublet. Although both proteins lacked PKC activity and phorbol ester binding, they revealed structural similarity with the active 80 kDa PKC form of untreated cells.(ABSTRACT TRUNCATED AT 250 WORDS)

Calcium↗
PubMedDate not supplied

Reviving a distinctive medical ethic.

Our culture is well on its way to reducing medical ethics to legal requirements, general citizen ethics, or personal values. A distinctive ethic for medicine provides critical distance and moral meaning for the profession and an enriched societal ethic.

Codes of Ethics↗
PubMed1977

[The responsibility of medicine doctor (author's transl)].

Through the history of Medicine the author considers the mission of medical profession, its highs and downs. He specially analizes the responsibility of the doctors toward their patients. The author considers that anybody who is not able or self-sacrificed and has no true vocation, should no select the Medicine as his profession.

Conscience↗